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<br /> EUROPEAN MEDICAL JOURNAL<br /> ISSN 2397-6764 Vol 2.4 • November 2017 • europeanmedical-journal.com<br /> CONTENTS<br /> EDITORIAL BOARD...................................................................................................................................... 4<br /> FEATURES<br /> • HOW TO IMPLEMENT GUIDELINES INTO CLINICAL PRACTICE.................................................. 12<br /> Theo M. de Reijke<br /> • THE TREATMENT APPROACH OF IDIOPATHIC INFLAMMATORY MYOPATHIES..................... 14<br /> Matthew J.S. Parker, Hector Chinoy<br /> SYMPOSIUM REVIEWS<br /> • SUSTAINING CANCER CARE THROUGH COLLABORATIVE STEWARDSHIP............................ 20<br /> • TACKLING THE INFLAMMATORY BURDEN OF PSORIASIS: A MULTIDISCIPLINARY<br /> APPROACH.........................................................................................................................................<a title="EMJ 2.4 2017 page 1" href="http://viewer.zmags.com/publication/0355e128?page=1"> EUROPEAN MEDICAL JOURNAL ISSN 2397-6764 </a> <a title="EMJ 2.4 2017 page 2" href="http://viewer.zmags.com/publication/0355e128?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ 2.4 2017 page 3" href="http://viewer.zmags.com/publication/0355e128?page=3"> EUROPEAN MEDICAL JOURNAL • EPIDEMIOLOGY, HEALTH</a> <a title="EMJ 2.4 2017 page 4" href="http://viewer.zmags.com/publication/0355e128?page=4"> EDITORIAL BOARD EDITOR-IN-CHIEF Prof Markus Pec</a> <a title="EMJ 2.4 2017 page 5" href="http://viewer.zmags.com/publication/0355e128?page=5"> EUROPEAN MEDICAL JOURNAL AIMS AND SCOPE • T</a> <a title="EMJ 2.4 2017 page 6" href="http://viewer.zmags.com/publication/0355e128?page=6"> EUROPEAN MEDICAL JOURNAL 2.4 NOVEMBER 2017 Direc</a> <a title="EMJ 2.4 2017 page 7" href="http://viewer.zmags.com/publication/0355e128?page=7"> Welcome A very warm welcome to the final 2017 e</a> <a title="EMJ 2.4 2017 page 8" href="http://viewer.zmags.com/publication/0355e128?page=8"> If you are interested in submitting a paper to</a> <a title="EMJ 2.4 2017 page 9" href="http://viewer.zmags.com/publication/0355e128?page=9"> Foreword Prof Ahmad Awada Jules Bordet In</a> <a title="EMJ 2.4 2017 page 10" href="http://viewer.zmags.com/publication/0355e128?page=10"> SUBSCRIBE FREE TO OUR YOUTUBE CHANNEL www.youtub</a> <a title="EMJ 2.4 2017 page 11" href="http://viewer.zmags.com/publication/0355e128?page=11"> Watch our exclusive videos from a variet of event</a> <a title="EMJ 2.4 2017 page 12" href="http://viewer.zmags.com/publication/0355e128?page=12"> HOW TO IMPLEMENT GUIDELINES INTO CLINICAL PRACTIC</a> <a title="EMJ 2.4 2017 page 13" href="http://viewer.zmags.com/publication/0355e128?page=13"> evidence and high grade of recommendation is</a> <a title="EMJ 2.4 2017 page 14" href="http://viewer.zmags.com/publication/0355e128?page=14"> THE TREATMENT APPROACH OF IDIOPATHIC </a> <a title="EMJ 2.4 2017 page 15" href="http://viewer.zmags.com/publication/0355e128?page=15"> onset IIM cases.4 In such cases, treatment of the</a> <a title="EMJ 2.4 2017 page 16" href="http://viewer.zmags.com/publication/0355e128?page=16"> Azathioprine One small prospective study of </a> <a title="EMJ 2.4 2017 page 17" href="http://viewer.zmags.com/publication/0355e128?page=17"> tacrolimus in a group of patients with interstiti</a> <a title="EMJ 2.4 2017 page 18" href="http://viewer.zmags.com/publication/0355e128?page=18"> REFERENCES 1. Enders FB et al. Consensus-ba</a> <a title="EMJ 2.4 2017 page 19" href="http://viewer.zmags.com/publication/0355e128?page=19"> Would you like to write for the EMJ blog? Interac</a> <a title="EMJ 2.4 2017 page 20" href="http://viewer.zmags.com/publication/0355e128?page=20"> SUSTAINING CANCER CARE THROUGH COLLABORATIVE</a> <a title="EMJ 2.4 2017 page 21" href="http://viewer.zmags.com/publication/0355e128?page=21"> how pharmacists can improve system-wide efficienc</a> <a title="EMJ 2.4 2017 page 22" href="http://viewer.zmags.com/publication/0355e128?page=22"> the highest quality healthcare can do harm; there</a> <a title="EMJ 2.4 2017 page 23" href="http://viewer.zmags.com/publication/0355e128?page=23"> According to the Organisation for Economic C</a> <a title="EMJ 2.4 2017 page 24" href="http://viewer.zmags.com/publication/0355e128?page=24"> more expensive, treatments. For example, it has b</a> <a title="EMJ 2.4 2017 page 25" href="http://viewer.zmags.com/publication/0355e128?page=25"> Information/evidence HTA/economic evaluation De</a> <a title="EMJ 2.4 2017 page 26" href="http://viewer.zmags.com/publication/0355e128?page=26"> 17 countries. Eur J Heal Econ. 2010; 10(Sup</a> <a title="EMJ 2.4 2017 page 27" href="http://viewer.zmags.com/publication/0355e128?page=27"> TACKLING THE INFLAMMATORY BURDEN OF PSORIASIS: A</a> <a title="EMJ 2.4 2017 page 28" href="http://viewer.zmags.com/publication/0355e128?page=28"> Dr Gecse reviewed the aetiology, disease course, </a> <a title="EMJ 2.4 2017 page 29" href="http://viewer.zmags.com/publication/0355e128?page=29"> Registered* </a> <a title="EMJ 2.4 2017 page 30" href="http://viewer.zmags.com/publication/0355e128?page=30"> Several studies have shown that biosimilar </a> <a title="EMJ 2.4 2017 page 31" href="http://viewer.zmags.com/publication/0355e128?page=31"> Turning to diabetes and metabolic risks, Pr</a> <a title="EMJ 2.4 2017 page 32" href="http://viewer.zmags.com/publication/0355e128?page=32"> generations, which was not the case. First-degree</a> <a title="EMJ 2.4 2017 page 33" href="http://viewer.zmags.com/publication/0355e128?page=33"> In rheumatology, only around 30% of patient</a> <a title="EMJ 2.4 2017 page 34" href="http://viewer.zmags.com/publication/0355e128?page=34"> IBD patients undergoing anti-TNF treatment can sh</a> <a title="EMJ 2.4 2017 page 35" href="http://viewer.zmags.com/publication/0355e128?page=35"> based on available evidence. Ann Rheum Dis. 2012;</a> <a title="EMJ 2.4 2017 page 36" href="http://viewer.zmags.com/publication/0355e128?page=36"> HEREDITARY ANGIOEDEMA: THE DAWN OF A NEW ERA </a> <a title="EMJ 2.4 2017 page 37" href="http://viewer.zmags.com/publication/0355e128?page=37"> doses of ≤200 mg/day and 2 mg/day, respectively, </a> <a title="EMJ 2.4 2017 page 38" href="http://viewer.zmags.com/publication/0355e128?page=38"> every 4–5 days. Both patients experienced a</a> <a title="EMJ 2.4 2017 page 39" href="http://viewer.zmags.com/publication/0355e128?page=39"> number of attacks) and the time-normalised n</a> <a title="EMJ 2.4 2017 page 40" href="http://viewer.zmags.com/publication/0355e128?page=40"> -2.4* </a> <a title="EMJ 2.4 2017 page 41" href="http://viewer.zmags.com/publication/0355e128?page=41"> for both lower and higher dose CSL830, and were s</a> <a title="EMJ 2.4 2017 page 42" href="http://viewer.zmags.com/publication/0355e128?page=42"> concentrate in patients with recurrent angioe</a> <a title="EMJ 2.4 2017 page 43" href="http://viewer.zmags.com/publication/0355e128?page=43"> DEVELOPMENTS IN THE TREATMENT AND MANAGEMENT OF</a> <a title="EMJ 2.4 2017 page 44" href="http://viewer.zmags.com/publication/0355e128?page=44"> the distribution of improvement measures in psori</a> <a title="EMJ 2.4 2017 page 45" href="http://viewer.zmags.com/publication/0355e128?page=45"> and response in different strata (PASI 75, 90, an</a> <a title="EMJ 2.4 2017 page 46" href="http://viewer.zmags.com/publication/0355e128?page=46"> Poster Presentation P1726: Associati</a> <a title="EMJ 2.4 2017 page 47" href="http://viewer.zmags.com/publication/0355e128?page=47"> Poster Presentation P1812: D</a> <a title="EMJ 2.4 2017 page 48" href="http://viewer.zmags.com/publication/0355e128?page=48"> The Phase II trial consisted of patients w</a> <a title="EMJ 2.4 2017 page 49" href="http://viewer.zmags.com/publication/0355e128?page=49"> and adalimumab in the Phase III clinical t</a> <a title="EMJ 2.4 2017 page 50" href="http://viewer.zmags.com/publication/0355e128?page=50"> C Difference and 95% CI Ad</a> <a title="EMJ 2.4 2017 page 51" href="http://viewer.zmags.com/publication/0355e128?page=51"> Prior psoriasis therapies included non-biolog</a> <a title="EMJ 2.4 2017 page 52" href="http://viewer.zmags.com/publication/0355e128?page=52"> LINKING PATHOPHYSIOLOGY TO CLINICAL OPTIONS IN PS</a> <a title="EMJ 2.4 2017 page 53" href="http://viewer.zmags.com/publication/0355e128?page=53"> antigen-presenting cells that express HLA-Cw6</a> <a title="EMJ 2.4 2017 page 54" href="http://viewer.zmags.com/publication/0355e128?page=54"> hypothesis that EAE was a Th1-mediated disease. H</a> <a title="EMJ 2.4 2017 page 55" href="http://viewer.zmags.com/publication/0355e128?page=55"> Cytokines secreted by Th17 cells, particularly IL</a> <a title="EMJ 2.4 2017 page 56" href="http://viewer.zmags.com/publication/0355e128?page=56"> 100 80 60 Patients (%) 40 20 0 85.1 73.3 </a> <a title="EMJ 2.4 2017 page 57" href="http://viewer.zmags.com/publication/0355e128?page=57"> Question and Answer Session Q: If psoriasis is</a> <a title="EMJ 2.4 2017 page 58" href="http://viewer.zmags.com/publication/0355e128?page=58"> Autoimmun Rev. 2014;13(12):1174-81. 21. The Human</a> <a title="EMJ 2.4 2017 page 59" href="http://viewer.zmags.com/publication/0355e128?page=59"> EDITOR’S PICK This must-read paper f</a> <a title="EMJ 2.4 2017 page 60" href="http://viewer.zmags.com/publication/0355e128?page=60"> a deadly disease. It was estimated that th</a> <a title="EMJ 2.4 2017 page 61" href="http://viewer.zmags.com/publication/0355e128?page=61"> Table 1: Risk factors associated with pancreatic </a> <a title="EMJ 2.4 2017 page 62" href="http://viewer.zmags.com/publication/0355e128?page=62"> on a positive CA 19-9 at the 37 U/mL threshold, s</a> <a title="EMJ 2.4 2017 page 63" href="http://viewer.zmags.com/publication/0355e128?page=63"> In high-risk patients, the incidence of abnormali</a> <a title="EMJ 2.4 2017 page 64" href="http://viewer.zmags.com/publication/0355e128?page=64"> showed no improvement in accuracy compared to CA </a> <a title="EMJ 2.4 2017 page 65" href="http://viewer.zmags.com/publication/0355e128?page=65"> There can be an interval of >1 decade for genetic</a> <a title="EMJ 2.4 2017 page 66" href="http://viewer.zmags.com/publication/0355e128?page=66"> 7. Conroy T et al. FOLFIRINOX versus gemcitabine </a> <a title="EMJ 2.4 2017 page 67" href="http://viewer.zmags.com/publication/0355e128?page=67"> analysis. Cancer Epidemiol Biomarkers Prev. 19</a> <a title="EMJ 2.4 2017 page 68" href="http://viewer.zmags.com/publication/0355e128?page=68"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ 2.4 2017 page 69" href="http://viewer.zmags.com/publication/0355e128?page=69"> HEPATOPULMONARY SYNDROME: </a> <a title="EMJ 2.4 2017 page 70" href="http://viewer.zmags.com/publication/0355e128?page=70"> a typical vascular alteration of HPS; it may be l</a> <a title="EMJ 2.4 2017 page 71" href="http://viewer.zmags.com/publication/0355e128?page=71"> process of bacterial translocation. The migration</a> <a title="EMJ 2.4 2017 page 72" href="http://viewer.zmags.com/publication/0355e128?page=72"> Table 1: Serum enzyme levels, blood gases, and al</a> <a title="EMJ 2.4 2017 page 73" href="http://viewer.zmags.com/publication/0355e128?page=73"> BRAIN BBB Neuron Astrocy</a> <a title="EMJ 2.4 2017 page 74" href="http://viewer.zmags.com/publication/0355e128?page=74"> muscle strength may affect the respiratory muscle</a> <a title="EMJ 2.4 2017 page 75" href="http://viewer.zmags.com/publication/0355e128?page=75"> of cirrhosis. J Cachexia Sarcopenia Muscl</a> <a title="EMJ 2.4 2017 page 76" href="http://viewer.zmags.com/publication/0355e128?page=76"> EPIDEMIOLOGY, HEALTH ECONOMIC CONTEXT, AND M</a> <a title="EMJ 2.4 2017 page 77" href="http://viewer.zmags.com/publication/0355e128?page=77"> DISCUSSION Prevalence of Chronic Kidney Disease B</a> <a title="EMJ 2.4 2017 page 78" href="http://viewer.zmags.com/publication/0355e128?page=78"> are more common in people of sub-Saharan African </a> <a title="EMJ 2.4 2017 page 79" href="http://viewer.zmags.com/publication/0355e128?page=79"> The average is 1,010 pmp in European countries,15</a> <a title="EMJ 2.4 2017 page 80" href="http://viewer.zmags.com/publication/0355e128?page=80"> may be responsible for indirect costs (travel cos</a> <a title="EMJ 2.4 2017 page 81" href="http://viewer.zmags.com/publication/0355e128?page=81"> Suppl. 2005;(97):S82-6. 28. Kramer A et al. Renal</a> <a title="EMJ 2.4 2017 page 82" href="http://viewer.zmags.com/publication/0355e128?page=82"> THE IMPACT OF VITRIFICATION IN ARTIFICIAL REPRODU</a> <a title="EMJ 2.4 2017 page 83" href="http://viewer.zmags.com/publication/0355e128?page=83"> THE PRINCIPLE OF CRYOBIOLOGY The basic princip</a> <a title="EMJ 2.4 2017 page 84" href="http://viewer.zmags.com/publication/0355e128?page=84"> disease transmission during vitrification.26 Howev</a> <a title="EMJ 2.4 2017 page 85" href="http://viewer.zmags.com/publication/0355e128?page=85"> seven RCT revealed a significantly higher embryo c</a> <a title="EMJ 2.4 2017 page 86" href="http://viewer.zmags.com/publication/0355e128?page=86"> Oocyte Freezing for Ethical Reasons Until recent</a> <a title="EMJ 2.4 2017 page 87" href="http://viewer.zmags.com/publication/0355e128?page=87"> with caution as most of the studies come from don</a> <a title="EMJ 2.4 2017 page 88" href="http://viewer.zmags.com/publication/0355e128?page=88"> meeting: Indications, results and future perspect</a> <a title="EMJ 2.4 2017 page 89" href="http://viewer.zmags.com/publication/0355e128?page=89"> congregations/cfaith/documents/ rc_con_cfaith_doc</a> <a title="EMJ 2.4 2017 page 90" href="http://viewer.zmags.com/publication/0355e128?page=90"> RENAL PHYSIOLOGY AND ROBOTIC </a> <a title="EMJ 2.4 2017 page 91" href="http://viewer.zmags.com/publication/0355e128?page=91"> Renal Cell Carcinoma There are common pathologica</a> <a title="EMJ 2.4 2017 page 92" href="http://viewer.zmags.com/publication/0355e128?page=92"> Cardiovascular Stimulation of baroreceptors in th</a> <a title="EMJ 2.4 2017 page 93" href="http://viewer.zmags.com/publication/0355e128?page=93"> Importantly, the patient may be taking various dr</a> <a title="EMJ 2.4 2017 page 94" href="http://viewer.zmags.com/publication/0355e128?page=94"> regions may also occur.37 Some centres routinely </a> <a title="EMJ 2.4 2017 page 95" href="http://viewer.zmags.com/publication/0355e128?page=95"> continued perioperatively, although a Cochran</a> <a title="EMJ 2.4 2017 page 96" href="http://viewer.zmags.com/publication/0355e128?page=96"> 33(10):1579-84. 17. Chang DTS, Lawrentsc</a> <a title="EMJ 2.4 2017 page 97" href="http://viewer.zmags.com/publication/0355e128?page=97"> THE ROLE OF INSULIN RESISTANCE ON FGF-21 </a> <a title="EMJ 2.4 2017 page 98" href="http://viewer.zmags.com/publication/0355e128?page=98"> proinflammatory markers, and in the non-IR g</a> <a title="EMJ 2.4 2017 page 99" href="http://viewer.zmags.com/publication/0355e128?page=99"> and experimental studies,13,14,23,24 sugges</a> <a title="EMJ 2.4 2017 page 100" href="http://viewer.zmags.com/publication/0355e128?page=100"> external face of the rectus abdominis muscl</a> <a title="EMJ 2.4 2017 page 101" href="http://viewer.zmags.com/publication/0355e128?page=101"> Nutrition Counselling Energy intake was set at le</a> <a title="EMJ 2.4 2017 page 102" href="http://viewer.zmags.com/publication/0355e128?page=102"> Table 1B: Correlations analysis. Variables </a> <a title="EMJ 2.4 2017 page 103" href="http://viewer.zmags.com/publication/0355e128?page=103"> weight change (a reduction of approximately 6 kg)</a> <a title="EMJ 2.4 2017 page 104" href="http://viewer.zmags.com/publication/0355e128?page=104"> These data may contribute to a greater understand</a> <a title="EMJ 2.4 2017 page 105" href="http://viewer.zmags.com/publication/0355e128?page=105"> Regulator of FGF21. Cell Physiol Biochem. 2016;38</a> <a title="EMJ 2.4 2017 page 106" href="http://viewer.zmags.com/publication/0355e128?page=106"> PROTEOMIC ANALYSIS OF ANTIPROTEASE IMMU</a> <a title="EMJ 2.4 2017 page 107" href="http://viewer.zmags.com/publication/0355e128?page=107"> Another possible mechanism of CU is t</a> <a title="EMJ 2.4 2017 page 108" href="http://viewer.zmags.com/publication/0355e128?page=108"> with the vasectomy and possible systemic exposure</a> <a title="EMJ 2.4 2017 page 109" href="http://viewer.zmags.com/publication/0355e128?page=109"> Sample blots were compared against control blots </a> <a title="EMJ 2.4 2017 page 110" href="http://viewer.zmags.com/publication/0355e128?page=110"> A B </a> <a title="EMJ 2.4 2017 page 111" href="http://viewer.zmags.com/publication/0355e128?page=111"> PROTEASOME-ASSOCIATED IgE AND IgG AUTOREACTIVE SP</a> <a title="EMJ 2.4 2017 page 112" href="http://viewer.zmags.com/publication/0355e128?page=112"> to undergo cleavage by papain causing non-IgE med</a> <a title="EMJ 2.4 2017 page 113" href="http://viewer.zmags.com/publication/0355e128?page=113"> immune recognition. Semin Immunol. 2007;19(1):</a> <a title="EMJ 2.4 2017 page 114" href="http://viewer.zmags.com/publication/0355e128?page=114"> ROLE OF GENETIC VARIATIONS IN DETERMINING TREA</a> <a title="EMJ 2.4 2017 page 115" href="http://viewer.zmags.com/publication/0355e128?page=115"> and carcinogenesis (matrix metalloproteinas</a> <a title="EMJ 2.4 2017 page 116" href="http://viewer.zmags.com/publication/0355e128?page=116"> Table 1: Table showing the single nucleotide vari</a> <a title="EMJ 2.4 2017 page 117" href="http://viewer.zmags.com/publication/0355e128?page=117"> complete response rate, event-free survival, and </a> <a title="EMJ 2.4 2017 page 118" href="http://viewer.zmags.com/publication/0355e128?page=118"> drugs.44 p73 also functions in transduction </a> <a title="EMJ 2.4 2017 page 119" href="http://viewer.zmags.com/publication/0355e128?page=119"> analysis, including TP53 mutational status, showe</a> <a title="EMJ 2.4 2017 page 120" href="http://viewer.zmags.com/publication/0355e128?page=120"> Intern Med. 1997;126(8):608-14. 16. Black A</a> <a title="EMJ 2.4 2017 page 121" href="http://viewer.zmags.com/publication/0355e128?page=121"> membrane bound Fas(CD95) ligand to its solu</a> <a title="EMJ 2.4 2017 page 122" href="http://viewer.zmags.com/publication/0355e128?page=122"> PATHOGENESIS, DIAGNOSTICS, AND TREATMENT OF HER</a> <a title="EMJ 2.4 2017 page 123" href="http://viewer.zmags.com/publication/0355e128?page=123"> A Sloughed cells blood loss 1–2 mg/day Liver </a> <a title="EMJ 2.4 2017 page 124" href="http://viewer.zmags.com/publication/0355e128?page=124"> in the body’s tissues and organs, particula</a> <a title="EMJ 2.4 2017 page 125" href="http://viewer.zmags.com/publication/0355e128?page=125"> concentration levels, the expression of TfR1</a> <a title="EMJ 2.4 2017 page 126" href="http://viewer.zmags.com/publication/0355e128?page=126"> A Iron overload disease Haemochromatosis Neonatal</a> <a title="EMJ 2.4 2017 page 127" href="http://viewer.zmags.com/publication/0355e128?page=127"> It interacts with the TfR required for iron impor</a> <a title="EMJ 2.4 2017 page 128" href="http://viewer.zmags.com/publication/0355e128?page=128"> in men and usually after menopause in women. Type</a> <a title="EMJ 2.4 2017 page 129" href="http://viewer.zmags.com/publication/0355e128?page=129"> Clinical suspicion and diagnosis of iron storage </a> <a title="EMJ 2.4 2017 page 130" href="http://viewer.zmags.com/publication/0355e128?page=130"> general established guidelines, genetic testing i</a> <a title="EMJ 2.4 2017 page 131" href="http://viewer.zmags.com/publication/0355e128?page=131"> or activity stimulators) could provide a mo</a> <a title="EMJ 2.4 2017 page 132" href="http://viewer.zmags.com/publication/0355e128?page=132"> absorption and their regulation by hepcid</a> <a title="EMJ 2.4 2017 page 133" href="http://viewer.zmags.com/publication/0355e128?page=133"> 20 Suppl 1:S31-9. 62. Wallace DF et al. </a> <a title="EMJ 2.4 2017 page 134" href="http://viewer.zmags.com/publication/0355e128?page=134"> ANKYLOSING SPONDYLITIS: A REVIEW Fa</a> <a title="EMJ 2.4 2017 page 135" href="http://viewer.zmags.com/publication/0355e128?page=135"> include the diagnosis of nr-axSpA. It should be n</a> <a title="EMJ 2.4 2017 page 136" href="http://viewer.zmags.com/publication/0355e128?page=136"> pulmonary fibrosis, and renal disease secondary to</a> <a title="EMJ 2.4 2017 page 137" href="http://viewer.zmags.com/publication/0355e128?page=137"> Plain radiographs of the sacroiliac joints can sh</a> <a title="EMJ 2.4 2017 page 138" href="http://viewer.zmags.com/publication/0355e128?page=138"> possible association between disease acti</a> <a title="EMJ 2.4 2017 page 139" href="http://viewer.zmags.com/publication/0355e128?page=139"> Patients with severe deformity may need referral </a> <a title="EMJ 2.4 2017 page 140" href="http://viewer.zmags.com/publication/0355e128?page=140"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS, NEW</a>