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<br /> ARCHIVE<br /> VOLUME 111 NUMBER 1 JANUARY 2016<br /> www.nature.com/ajg<br /> official publication of the american college of gastroenterology<br /> LEADING ARTICLES OF THE MONTH<br /> The Red Section: EndoTech Update<br /> 6 Just Clip It: Endoscopic Clipping in the 21st Century<br /> B. Joseph Elmunzer<br /> Practice Guidelines<br /> 30 ACG Clinical Guideline: Diagnosis and Management of Barrett’s<br /> Esophagus CME<br /> N.J. Shaheen, G.W. Falk, P.G. Iyer and L.B. Gerson<br /> Clinical and Systematic Reviews<br /> 53 Diagnosis and Management of Functional Heartburn CME<br /> C. Hachem and N.J. Shaheen<br /> Endoscopy<br /> 63 Effect of Dynamic Position Changes on Adenoma Detection during<br /> Colonoscope Withdrawal: A Randomized Controlled Multicenter Trial<br /> S.-W. Lee, J.H. Chang, J.-S. Ji et al.<br /> Liver<br /> 78 Diagnosis of Minima<a title="AJG_Vol.111.No.11 page 1" href="http://viewer.zmags.com/publication/11303066?page=1"> ARCHIVE VOLUME 111 NUMBER 1 JANUARY 2016 www.nat</a> <a title="AJG_Vol.111.No.11 page 2" href="http://viewer.zmags.com/publication/11303066?page=2"> VOLUME 111 NUMBER 11 NOVEMBER 2016 www.nature.c</a> <a title="AJG_Vol.111.No.11 page 3" href="http://viewer.zmags.com/publication/11303066?page=3"> * *by patients in clinical trials† In </a> <a title="AJG_Vol.111.No.11 page 4" href="http://viewer.zmags.com/publication/11303066?page=4"> The following is a brief summary only; see full P</a> <a title="AJG_Vol.111.No.11 page 5" href="http://viewer.zmags.com/publication/11303066?page=5"> www.nature.com/ajg The American Journal o</a> <a title="AJG_Vol.111.No.11 page 6" href="http://viewer.zmags.com/publication/11303066?page=6"> FOR PATIENTS WITH ACTIVE, MILD TO MODERATE ULCERA</a> <a title="AJG_Vol.111.No.11 page 7" href="http://viewer.zmags.com/publication/11303066?page=7"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This bri</a> <a title="AJG_Vol.111.No.11 page 8" href="http://viewer.zmags.com/publication/11303066?page=8"> Patients of any HCV genotype can now be cured wit</a> <a title="AJG_Vol.111.No.11 page 9" href="http://viewer.zmags.com/publication/11303066?page=9"> Albert Einstein used with permission of the HUJ/G</a> <a title="AJG_Vol.111.No.11 page 10" href="http://viewer.zmags.com/publication/11303066?page=10"> NOW APPROVED THE FIRST AND ONLY PAN-GENOTYPIC ONC</a> <a title="AJG_Vol.111.No.11 page 11" href="http://viewer.zmags.com/publication/11303066?page=11"> HARVONI® (ledipasvir 90 mg and sofosbuvir 400 mg)</a> <a title="AJG_Vol.111.No.11 page 12" href="http://viewer.zmags.com/publication/11303066?page=12"> Brief Summary (cont.) Postmarketing Experience: B</a> <a title="AJG_Vol.111.No.11 page 13" href="http://viewer.zmags.com/publication/11303066?page=13"> EPCLUSA® (sofosbuvir 400 mg and velpatasvir 100 m</a> <a title="AJG_Vol.111.No.11 page 14" href="http://viewer.zmags.com/publication/11303066?page=14"> Brief Summary (cont.) DRUG INTERACTIONS: Sofosbuv</a> <a title="AJG_Vol.111.No.11 page 15" href="http://viewer.zmags.com/publication/11303066?page=15"> RECOMMEND THE MOST POWERFUL OTC PPI FROM THE STAR</a> <a title="AJG_Vol.111.No.11 page 16" href="http://viewer.zmags.com/publication/11303066?page=16"> PROVIDING ACHALASIA PATIENTS WITH OPTIONS INSTEAD</a> <a title="AJG_Vol.111.No.11 page 17" href="http://viewer.zmags.com/publication/11303066?page=17"> official publication of the american college</a> <a title="AJG_Vol.111.No.11 page 18" href="http://viewer.zmags.com/publication/11303066?page=18"> WHAT ARE BIOSIMILARS? Let’s Clarify Biosimilar</a> <a title="AJG_Vol.111.No.11 page 19" href="http://viewer.zmags.com/publication/11303066?page=19"> Another Miracle? No, it's MiraFIBER™ </a> <a title="AJG_Vol.111.No.11 page 20" href="http://viewer.zmags.com/publication/11303066?page=20"> CONTENTS VOLUME 111 NUMBER 11 NOVEMBER 2016 </a> <a title="AJG_Vol.111.No.11 page 21" href="http://viewer.zmags.com/publication/11303066?page=21"> CONTENTS </a> <a title="AJG_Vol.111.No.11 page 22" href="http://viewer.zmags.com/publication/11303066?page=22"> Control.1 Control.2 Control.3 Control.4 Control.5</a> <a title="AJG_Vol.111.No.11 page 23" href="http://viewer.zmags.com/publication/11303066?page=23"> INDICATION AND IMPORTANT SAFETY INFORMATION FOR H</a> <a title="AJG_Vol.111.No.11 page 24" href="http://viewer.zmags.com/publication/11303066?page=24"> Achieve UC remission— with HUMIRA1 MODERATE TO </a> <a title="AJG_Vol.111.No.11 page 25" href="http://viewer.zmags.com/publication/11303066?page=25"> HUMIRA® (adalimumab) </a> <a title="AJG_Vol.111.No.11 page 26" href="http://viewer.zmags.com/publication/11303066?page=26"> Use with Anakinra Concurrent use of anakinra (an </a> <a title="AJG_Vol.111.No.11 page 27" href="http://viewer.zmags.com/publication/11303066?page=27"> week was similar to the safety profile seen in pa</a> <a title="AJG_Vol.111.No.11 page 28" href="http://viewer.zmags.com/publication/11303066?page=28"> The first treatment in nearly 20 years for PBC1 </a> <a title="AJG_Vol.111.No.11 page 29" href="http://viewer.zmags.com/publication/11303066?page=29"> Delivered Significant, Sustained Reductions </a> <a title="AJG_Vol.111.No.11 page 30" href="http://viewer.zmags.com/publication/11303066?page=30"> For patients with PBC who have had an inadequate </a> <a title="AJG_Vol.111.No.11 page 31" href="http://viewer.zmags.com/publication/11303066?page=31"> Brief Summary of Prescribing Information for OCAL</a> <a title="AJG_Vol.111.No.11 page 32" href="http://viewer.zmags.com/publication/11303066?page=32"> [see Clinical Pharmacology (12.3) in Full Prescri</a> <a title="AJG_Vol.111.No.11 page 33" href="http://viewer.zmags.com/publication/11303066?page=33"> 2017 ACG EASTERN REGIONAL POSTGRADUATE COURSE </a> <a title="AJG_Vol.111.No.11 page 34" href="http://viewer.zmags.com/publication/11303066?page=34"> Treat IBS-Di erently A 2-week treatment for IBS-</a> <a title="AJG_Vol.111.No.11 page 35" href="http://viewer.zmags.com/publication/11303066?page=35"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This Bri</a> <a title="AJG_Vol.111.No.11 page 36" href="http://viewer.zmags.com/publication/11303066?page=36"> is on Instagram! Follow us @murphys_lab Use #</a> <a title="AJG_Vol.111.No.11 page 37" href="http://viewer.zmags.com/publication/11303066?page=37"> APPLY for an ACG Institute Research Award Dea</a> <a title="AJG_Vol.111.No.11 page 38" href="http://viewer.zmags.com/publication/11303066?page=38"> 65 Years of GI Endoscopy Innovation in One Powerf</a> <a title="AJG_Vol.111.No.11 page 39" href="http://viewer.zmags.com/publication/11303066?page=39"> NEW THE FIRST AND ONLY INTERLEUKIN-12 AND INTERLE</a> <a title="AJG_Vol.111.No.11 page 40" href="http://viewer.zmags.com/publication/11303066?page=40"> + STELARA® combines a single intravenous (I</a> <a title="AJG_Vol.111.No.11 page 41" href="http://viewer.zmags.com/publication/11303066?page=41"> Brief Summary of Prescribing Information for STEL</a> <a title="AJG_Vol.111.No.11 page 42" href="http://viewer.zmags.com/publication/11303066?page=42"> STELARA® (ustekinumab) Table 2: Common adverse re</a> <a title="AJG_Vol.111.No.11 page 43" href="http://viewer.zmags.com/publication/11303066?page=43"> LIALDA (mesalamine) </a> <a title="AJG_Vol.111.No.11 page 44" href="http://viewer.zmags.com/publication/11303066?page=44"> For patients with active, mild to moderate ulcera</a> <a title="AJG_Vol.111.No.11 page 45" href="http://viewer.zmags.com/publication/11303066?page=45"> BRIEF SUMMARY: Consult the Full Prescribing Infor</a> <a title="AJG_Vol.111.No.11 page 46" href="http://viewer.zmags.com/publication/11303066?page=46"> not always possible to reliably estimate their fr</a> <a title="AJG_Vol.111.No.11 page 47" href="http://viewer.zmags.com/publication/11303066?page=47"> GI QUALITY IMPROVEMENT CONSORTIUM LTD 3 Se ing</a> <a title="AJG_Vol.111.No.11 page 48" href="http://viewer.zmags.com/publication/11303066?page=48"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This Br</a> <a title="AJG_Vol.111.No.11 page 49" href="http://viewer.zmags.com/publication/11303066?page=49"> Hepatic Encephalopathy (HE) CAUSES EPISODIC NEURO</a> <a title="AJG_Vol.111.No.11 page 50" href="http://viewer.zmags.com/publication/11303066?page=50"> THE RED SECTION 1505 see related edito</a> <a title="AJG_Vol.111.No.11 page 51" href="http://viewer.zmags.com/publication/11303066?page=51"> 1506 THE RED SECTION </a> <a title="AJG_Vol.111.No.11 page 52" href="http://viewer.zmags.com/publication/11303066?page=52"> THE RED SECTION 1507 MID MID</a> <a title="AJG_Vol.111.No.11 page 53" href="http://viewer.zmags.com/publication/11303066?page=53"> 1508 THE RED SECTION </a> <a title="AJG_Vol.111.No.11 page 54" href="http://viewer.zmags.com/publication/11303066?page=54"> worsening symptoms, treatment escalation, travel </a> <a title="AJG_Vol.111.No.11 page 55" href="http://viewer.zmags.com/publication/11303066?page=55"> 1510 THE RED SECTION Despite the i</a> <a title="AJG_Vol.111.No.11 page 56" href="http://viewer.zmags.com/publication/11303066?page=56"> THE RED SECTION 1511 see related edito</a> <a title="AJG_Vol.111.No.11 page 57" href="http://viewer.zmags.com/publication/11303066?page=57"> 1512 THE RED SECTION Table 1. Breakdown of</a> <a title="AJG_Vol.111.No.11 page 58" href="http://viewer.zmags.com/publication/11303066?page=58"> nature publishing group </a> <a title="AJG_Vol.111.No.11 page 59" href="http://viewer.zmags.com/publication/11303066?page=59"> 1514 THE RED SECTION Gorgojos Chinos (Flou</a> <a title="AJG_Vol.111.No.11 page 60" href="http://viewer.zmags.com/publication/11303066?page=60"> THE RED SECTION 1515 A Strange Periampulla</a> <a title="AJG_Vol.111.No.11 page 61" href="http://viewer.zmags.com/publication/11303066?page=61"> 1516 THE RED SECTION Video of the Month E</a> <a title="AJG_Vol.111.No.11 page 62" href="http://viewer.zmags.com/publication/11303066?page=62"> ORIGINAL CONTRIBUTIONS 1517 see related</a> <a title="AJG_Vol.111.No.11 page 63" href="http://viewer.zmags.com/publication/11303066?page=63"> 1518 Yadlapati et al. ESOPHAGUS INTRODUCTI</a> <a title="AJG_Vol.111.No.11 page 64" href="http://viewer.zmags.com/publication/11303066?page=64"> institution. At the conclusion of the PPI therapy</a> <a title="AJG_Vol.111.No.11 page 65" href="http://viewer.zmags.com/publication/11303066?page=65"> 1520 Yadlapati et al. 236 Patients scree</a> <a title="AJG_Vol.111.No.11 page 66" href="http://viewer.zmags.com/publication/11303066?page=66"> Oropharyngeal pH Monitoring Does Not Predict PPI </a> <a title="AJG_Vol.111.No.11 page 67" href="http://viewer.zmags.com/publication/11303066?page=67"> 1522 Yadlapati et al. ESOPHAGUS change in </a> <a title="AJG_Vol.111.No.11 page 68" href="http://viewer.zmags.com/publication/11303066?page=68"> concept and design, analysis and interpretation o</a> <a title="AJG_Vol.111.No.11 page 69" href="http://viewer.zmags.com/publication/11303066?page=69"> 1524 Yadlapati et al. ESOPHAGUS 36. Friedm</a> <a title="AJG_Vol.111.No.11 page 70" href="http://viewer.zmags.com/publication/11303066?page=70"> EDITORIAL 1525 see related article on </a> <a title="AJG_Vol.111.No.11 page 71" href="http://viewer.zmags.com/publication/11303066?page=71"> 1526 Vaezi ESOPHAGUS pharyngeal probe with</a> <a title="AJG_Vol.111.No.11 page 72" href="http://viewer.zmags.com/publication/11303066?page=72"> 3. Hom C, Vaezi MF. Extraesophageal manifestatio</a> <a title="AJG_Vol.111.No.11 page 73" href="http://viewer.zmags.com/publication/11303066?page=73"> 1528 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.11 page 74" href="http://viewer.zmags.com/publication/11303066?page=74"> NSAIDs have been shown in experimental studies </a> <a title="AJG_Vol.111.No.11 page 75" href="http://viewer.zmags.com/publication/11303066?page=75"> 1530 Thrift et al. ESOPHAGUS Statistical a</a> <a title="AJG_Vol.111.No.11 page 76" href="http://viewer.zmags.com/publication/11303066?page=76"> NSAIDs and Risk of Barrett's Esophagus 1531 </a> <a title="AJG_Vol.111.No.11 page 77" href="http://viewer.zmags.com/publication/11303066?page=77"> 1532 Thrift et al. ESOPHAGUS Table 2. ORs </a> <a title="AJG_Vol.111.No.11 page 78" href="http://viewer.zmags.com/publication/11303066?page=78"> Table 3. Adjusted ORs and 95% CIs for the associa</a> <a title="AJG_Vol.111.No.11 page 79" href="http://viewer.zmags.com/publication/11303066?page=79"> 1534 Thrift et al. ESOPHAGUS strengths. Wi</a> <a title="AJG_Vol.111.No.11 page 80" href="http://viewer.zmags.com/publication/11303066?page=80"> 12. Zhang S, Zhang XQ, Ding XW et al. Cyclooxygen</a> <a title="AJG_Vol.111.No.11 page 81" href="http://viewer.zmags.com/publication/11303066?page=81"> 1536 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.11 page 82" href="http://viewer.zmags.com/publication/11303066?page=82"> INTRODUCTION Achalasia is a rare, chronic esophag</a> <a title="AJG_Vol.111.No.11 page 83" href="http://viewer.zmags.com/publication/11303066?page=83"> 1538 Chrystoja et al. ESOPHAGUS Study outc</a> <a title="AJG_Vol.111.No.11 page 84" href="http://viewer.zmags.com/publication/11303066?page=84"> Achalasia-Specific Quality of Life After Dilation</a> <a title="AJG_Vol.111.No.11 page 85" href="http://viewer.zmags.com/publication/11303066?page=85"> 1540 Chrystoja et al. ESOPHAGUS Table 1. B</a> <a title="AJG_Vol.111.No.11 page 86" href="http://viewer.zmags.com/publication/11303066?page=86"> Achalasia-Specific Quality of Life After Dilation</a> <a title="AJG_Vol.111.No.11 page 87" href="http://viewer.zmags.com/publication/11303066?page=87"> 1542 Chrystoja et al. LES press</a> <a title="AJG_Vol.111.No.11 page 88" href="http://viewer.zmags.com/publication/11303066?page=88"> Achalasia-Specific Quality of Life After Dilation</a> <a title="AJG_Vol.111.No.11 page 89" href="http://viewer.zmags.com/publication/11303066?page=89"> 1544 Chrystoja et al. ESOPHAGUS ACKNOWLEDG</a> <a title="AJG_Vol.111.No.11 page 90" href="http://viewer.zmags.com/publication/11303066?page=90"> 25. Pandolfino JE, Kwiatek MA, Nealis T et al. Ac</a> <a title="AJG_Vol.111.No.11 page 91" href="http://viewer.zmags.com/publication/11303066?page=91"> 1546 ORIGINAL CONTRIBUTIONS ENDOSCOPY see rel</a> <a title="AJG_Vol.111.No.11 page 92" href="http://viewer.zmags.com/publication/11303066?page=92"> systematically, efficiently, and in the right pla</a> <a title="AJG_Vol.111.No.11 page 93" href="http://viewer.zmags.com/publication/11303066?page=93"> 1548 Almario et al. ENDOSCOPY the previous</a> <a title="AJG_Vol.111.No.11 page 94" href="http://viewer.zmags.com/publication/11303066?page=94"> 348 excluded: 3 with incomplete data 34</a> <a title="AJG_Vol.111.No.11 page 95" href="http://viewer.zmags.com/publication/11303066?page=95"> 1550 Almario et al. ENDOSCOPY Table 1. Pat</a> <a title="AJG_Vol.111.No.11 page 96" href="http://viewer.zmags.com/publication/11303066?page=96"> Table 3. Patient satisfaction assessment CG-CAHPS</a> <a title="AJG_Vol.111.No.11 page 97" href="http://viewer.zmags.com/publication/11303066?page=97"> 1552 Almario et al. ENDOSCOPY Table 5. Pat</a> <a title="AJG_Vol.111.No.11 page 98" href="http://viewer.zmags.com/publication/11303066?page=98"> submitted. Shahzad Ahmed, MD: Conducting the stud</a> <a title="AJG_Vol.111.No.11 page 99" href="http://viewer.zmags.com/publication/11303066?page=99"> 1554 Almario et al. 25. Cohen J. A powe</a> <a title="AJG_Vol.111.No.11 page 100" href="http://viewer.zmags.com/publication/11303066?page=100"> Impact of NIH GI PROMIS 1555 APPENDIX T</a> <a title="AJG_Vol.111.No.11 page 101" href="http://viewer.zmags.com/publication/11303066?page=101"> 1556 Almario et al. APPENDIX TABLE 3 </a> <a title="AJG_Vol.111.No.11 page 102" href="http://viewer.zmags.com/publication/11303066?page=102"> EDITORIAL 1557 see related article on </a> <a title="AJG_Vol.111.No.11 page 103" href="http://viewer.zmags.com/publication/11303066?page=103"> 1558 Gracie et al. ENDOSCOPY 502 patients </a> <a title="AJG_Vol.111.No.11 page 104" href="http://viewer.zmags.com/publication/11303066?page=104"> ORIGINAL CONTRIBUTIONS 1559 see relate</a> <a title="AJG_Vol.111.No.11 page 105" href="http://viewer.zmags.com/publication/11303066?page=105"> 1560 Kaitha et al. ENDOSCOPY processing on</a> <a title="AJG_Vol.111.No.11 page 106" href="http://viewer.zmags.com/publication/11303066?page=106"> Phase 1 n =456 EGD n =131 Colonoscopy </a> <a title="AJG_Vol.111.No.11 page 107" href="http://viewer.zmags.com/publication/11303066?page=107"> 1562 Kaitha et al. ENDOSCOPY Table 2. Devi</a> <a title="AJG_Vol.111.No.11 page 108" href="http://viewer.zmags.com/publication/11303066?page=108"> unintended consequences on outcomes would certain</a> <a title="AJG_Vol.111.No.11 page 109" href="http://viewer.zmags.com/publication/11303066?page=109"> 1564 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.11 page 110" href="http://viewer.zmags.com/publication/11303066?page=110"> to follow bowel preparation instructions (1). Thu</a> <a title="AJG_Vol.111.No.11 page 111" href="http://viewer.zmags.com/publication/11303066?page=111"> 1566 Rice et al. randomization. The sc</a> <a title="AJG_Vol.111.No.11 page 112" href="http://viewer.zmags.com/publication/11303066?page=112"> Diet Education Video Does Not Improve CLS Bowel P</a> <a title="AJG_Vol.111.No.11 page 113" href="http://viewer.zmags.com/publication/11303066?page=113"> 1568 Rice et al. ENDOSCOPY Table 1. Demogr</a> <a title="AJG_Vol.111.No.11 page 114" href="http://viewer.zmags.com/publication/11303066?page=114"> interventions were excluded, as some procedures d</a> <a title="AJG_Vol.111.No.11 page 115" href="http://viewer.zmags.com/publication/11303066?page=115"> 1570 Rice et al. ENDOSCOPY 35 Patients</a> <a title="AJG_Vol.111.No.11 page 116" href="http://viewer.zmags.com/publication/11303066?page=116"> statistically significant differences in age, rac</a> <a title="AJG_Vol.111.No.11 page 117" href="http://viewer.zmags.com/publication/11303066?page=117"> 1572 ORIGINAL CONTRIBUTIONS CME LIVER</a> <a title="AJG_Vol.111.No.11 page 118" href="http://viewer.zmags.com/publication/11303066?page=118"> ORIGINAL CONTRIBUTIONS 1573 sCeMeErelat</a> <a title="AJG_Vol.111.No.11 page 119" href="http://viewer.zmags.com/publication/11303066?page=119"> 1574 Yang et al. LIVER It is clear th</a> <a title="AJG_Vol.111.No.11 page 120" href="http://viewer.zmags.com/publication/11303066?page=120"> Table 1. Clinical characteristics Diabetes (+) </a> <a title="AJG_Vol.111.No.11 page 121" href="http://viewer.zmags.com/publication/11303066?page=121"> 1576 Yang et al. HCC probability (%) L</a> <a title="AJG_Vol.111.No.11 page 122" href="http://viewer.zmags.com/publication/11303066?page=122"> Etiology Specific Effect of Diabetes on HCC Risk </a> <a title="AJG_Vol.111.No.11 page 123" href="http://viewer.zmags.com/publication/11303066?page=123"> 1578 Yang et al. LIVER Diabetes has bee</a> <a title="AJG_Vol.111.No.11 page 124" href="http://viewer.zmags.com/publication/11303066?page=124"> Ju Dong Yang; collecting and interpreting data, a</a> <a title="AJG_Vol.111.No.11 page 125" href="http://viewer.zmags.com/publication/11303066?page=125"> 1580 Yang et al. LIVER 37. Paradis V, Darg</a> <a title="AJG_Vol.111.No.11 page 126" href="http://viewer.zmags.com/publication/11303066?page=126"> ORIGINAL CONTRIBUTIONS 1581 CME Con</a> <a title="AJG_Vol.111.No.11 page 127" href="http://viewer.zmags.com/publication/11303066?page=127"> 1582 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.11 page 128" href="http://viewer.zmags.com/publication/11303066?page=128"> Patients who achieve a reduction in hepatic venou</a> <a title="AJG_Vol.111.No.11 page 129" href="http://viewer.zmags.com/publication/11303066?page=129"> 1584 Kim et al. proportion of responde</a> <a title="AJG_Vol.111.No.11 page 130" href="http://viewer.zmags.com/publication/11303066?page=130"> Carvedilol vs. Propranolol in Reducing Portal Pre</a> <a title="AJG_Vol.111.No.11 page 131" href="http://viewer.zmags.com/publication/11303066?page=131"> 1586 Kim et al. LIVER develop a prediction</a> <a title="AJG_Vol.111.No.11 page 132" href="http://viewer.zmags.com/publication/11303066?page=132"> Carvedilol vs. Propranolol in Reducing Portal Pre</a> <a title="AJG_Vol.111.No.11 page 133" href="http://viewer.zmags.com/publication/11303066?page=133"> 1588 Kim et al. LIVER liver cirrhosis, whi</a> <a title="AJG_Vol.111.No.11 page 134" href="http://viewer.zmags.com/publication/11303066?page=134"> the combined non-selective β-adrenergic and </a> <a title="AJG_Vol.111.No.11 page 135" href="http://viewer.zmags.com/publication/11303066?page=135"> 1590 Kim et al. LIVER 15. De BK, Das D, Se</a> <a title="AJG_Vol.111.No.11 page 136" href="http://viewer.zmags.com/publication/11303066?page=136"> ORIGINAL CONTRIBUTIONS 1591 see relate</a> <a title="AJG_Vol.111.No.11 page 137" href="http://viewer.zmags.com/publication/11303066?page=137"> 1592 Patel et al. LIVER lifestyles, and in</a> <a title="AJG_Vol.111.No.11 page 138" href="http://viewer.zmags.com/publication/11303066?page=138"> which in humans is encoded by the group specific </a> <a title="AJG_Vol.111.No.11 page 139" href="http://viewer.zmags.com/publication/11303066?page=139"> 1594 Patel et al. 90 80 70 60 50 </a> <a title="AJG_Vol.111.No.11 page 140" href="http://viewer.zmags.com/publication/11303066?page=140"> Vitamin D Not Associated With NAFLD Severity </a> <a title="AJG_Vol.111.No.11 page 141" href="http://viewer.zmags.com/publication/11303066?page=141"> 1596 Patel et al. LIVER The presence of </a> <a title="AJG_Vol.111.No.11 page 142" href="http://viewer.zmags.com/publication/11303066?page=142"> for underlying renal function was also considered</a> <a title="AJG_Vol.111.No.11 page 143" href="http://viewer.zmags.com/publication/11303066?page=143"> 1598 Patel et al. LIVER REFERENCES 1. Rin</a> <a title="AJG_Vol.111.No.11 page 144" href="http://viewer.zmags.com/publication/11303066?page=144"> ORIGINAL CONTRIBUTIONS 1599 see related</a> <a title="AJG_Vol.111.No.11 page 145" href="http://viewer.zmags.com/publication/11303066?page=145"> 1600 Targan et al. INFLAMMATORY BOWEL DISEA</a> <a title="AJG_Vol.111.No.11 page 146" href="http://viewer.zmags.com/publication/11303066?page=146"> on the intent-to-treat principle. Safety end poin</a> <a title="AJG_Vol.111.No.11 page 147" href="http://viewer.zmags.com/publication/11303066?page=147"> 1602 Targan et al. RESULTS The study w</a> <a title="AJG_Vol.111.No.11 page 148" href="http://viewer.zmags.com/publication/11303066?page=148"> Brodalumab and Crohn's Disease 1603 </a> <a title="AJG_Vol.111.No.11 page 149" href="http://viewer.zmags.com/publication/11303066?page=149"> 1604 Targan et al. cant difference amo</a> <a title="AJG_Vol.111.No.11 page 150" href="http://viewer.zmags.com/publication/11303066?page=150"> Brodalumab and Crohn's Disease 1605 Tabl</a> <a title="AJG_Vol.111.No.11 page 151" href="http://viewer.zmags.com/publication/11303066?page=151"> 1606 Targan et al. INFLAMMATORY BOWEL DISEA</a> <a title="AJG_Vol.111.No.11 page 152" href="http://viewer.zmags.com/publication/11303066?page=152"> 3. Kawalec P, Mikrut A, Wisniewska N et al. Tumo</a> <a title="AJG_Vol.111.No.11 page 153" href="http://viewer.zmags.com/publication/11303066?page=153"> 1608 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.11 page 154" href="http://viewer.zmags.com/publication/11303066?page=154"> offspring (10,11,19,20). The impact of paternal u</a> <a title="AJG_Vol.111.No.11 page 155" href="http://viewer.zmags.com/publication/11303066?page=155"> 1610 Larsen et al. INFLAMMATORY BOWEL DISEA</a> <a title="AJG_Vol.111.No.11 page 156" href="http://viewer.zmags.com/publication/11303066?page=156"> disease, 138 children had fathers with the underl</a> <a title="AJG_Vol.111.No.11 page 157" href="http://viewer.zmags.com/publication/11303066?page=157"> 1612 Larsen et al. INFLAMMATORY BOWEL DISEA</a> <a title="AJG_Vol.111.No.11 page 158" href="http://viewer.zmags.com/publication/11303066?page=158"> Potential competing interests: None. Permissions:</a> <a title="AJG_Vol.111.No.11 page 159" href="http://viewer.zmags.com/publication/11303066?page=159"> 1614 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.11 page 160" href="http://viewer.zmags.com/publication/11303066?page=160"> in development of the disease (4–7). Despite thes</a> <a title="AJG_Vol.111.No.11 page 161" href="http://viewer.zmags.com/publication/11303066?page=161"> 1616 Khalili et al. for each participa</a> <a title="AJG_Vol.111.No.11 page 162" href="http://viewer.zmags.com/publication/11303066?page=162"> Table 1. Characteristics of participants at mid-p</a> <a title="AJG_Vol.111.No.11 page 163" href="http://viewer.zmags.com/publication/11303066?page=163"> 1618 Khalili et al. Cases / </a> <a title="AJG_Vol.111.No.11 page 164" href="http://viewer.zmags.com/publication/11303066?page=164"> positive associations were present, their cl</a> <a title="AJG_Vol.111.No.11 page 165" href="http://viewer.zmags.com/publication/11303066?page=165"> 1620 Khalili et al. INFLAMMATORY BOWEL DISE</a> <a title="AJG_Vol.111.No.11 page 166" href="http://viewer.zmags.com/publication/11303066?page=166"> ORIGINAL CONTRIBUTIONS 1621 see related</a> <a title="AJG_Vol.111.No.11 page 167" href="http://viewer.zmags.com/publication/11303066?page=167"> 1622 Wong et al. COLON/SMALL BOWEL INTRODU</a> <a title="AJG_Vol.111.No.11 page 168" href="http://viewer.zmags.com/publication/11303066?page=168"> Split dosing was recommended to the subjects, and</a> <a title="AJG_Vol.111.No.11 page 169" href="http://viewer.zmags.com/publication/11303066?page=169"> 1624 Wong et al. COLON/SMALL BOWEL Table 1</a> <a title="AJG_Vol.111.No.11 page 170" href="http://viewer.zmags.com/publication/11303066?page=170"> history of CRC” as a reference group, those with </a> <a title="AJG_Vol.111.No.11 page 171" href="http://viewer.zmags.com/publication/11303066?page=171"> 1626 Wong et al. COLON/SMALL BOWEL Table 3</a> <a title="AJG_Vol.111.No.11 page 172" href="http://viewer.zmags.com/publication/11303066?page=172"> Family History and Colorectal Neoplasia 1627 </a> <a title="AJG_Vol.111.No.11 page 173" href="http://viewer.zmags.com/publication/11303066?page=173"> 1628 Wong et al. COLON/SMALL BOWEL CONFLIC</a> <a title="AJG_Vol.111.No.11 page 174" href="http://viewer.zmags.com/publication/11303066?page=174"> 26. Peduzzi P, Concato J, Kemper E et al. A simul</a> <a title="AJG_Vol.111.No.11 page 175" href="http://viewer.zmags.com/publication/11303066?page=175"> 1630 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.11 page 176" href="http://viewer.zmags.com/publication/11303066?page=176"> have not been tested rigorously in safety net hea</a> <a title="AJG_Vol.111.No.11 page 177" href="http://viewer.zmags.com/publication/11303066?page=177"> 1632 Gupta et al. Age eligible patients </a> <a title="AJG_Vol.111.No.11 page 178" href="http://viewer.zmags.com/publication/11303066?page=178"> control groups, which may occur when consent is r</a> <a title="AJG_Vol.111.No.11 page 179" href="http://viewer.zmags.com/publication/11303066?page=179"> 1634 Gupta et al. P=0.32 P=0.07 P =</a> <a title="AJG_Vol.111.No.11 page 180" href="http://viewer.zmags.com/publication/11303066?page=180"> Financial Incentives for CRC Screening 1635 </a> <a title="AJG_Vol.111.No.11 page 181" href="http://viewer.zmags.com/publication/11303066?page=181"> 1636 Gupta et al. COLON/SMALL BOWEL CONFLI</a> <a title="AJG_Vol.111.No.11 page 182" href="http://viewer.zmags.com/publication/11303066?page=182"> EDITORIAL 1637 see related article on </a> <a title="AJG_Vol.111.No.11 page 183" href="http://viewer.zmags.com/publication/11303066?page=183"> 1638 Adler and Dominitz COLON/SMALL BOWEL </a> <a title="AJG_Vol.111.No.11 page 184" href="http://viewer.zmags.com/publication/11303066?page=184"> REFERENCES 1. Sabatino SA, White MC, Thompson TD</a> <a title="AJG_Vol.111.No.11 page 185" href="http://viewer.zmags.com/publication/11303066?page=185"> 1640 ORIGINAL CONTRIBUTIONS CME COLON</a> <a title="AJG_Vol.111.No.11 page 186" href="http://viewer.zmags.com/publication/11303066?page=186"> ORIGINAL CONTRIBUTIONS 1641 sCeMeErela</a> <a title="AJG_Vol.111.No.11 page 187" href="http://viewer.zmags.com/publication/11303066?page=187"> 1642 Faleck et al. COLON/SMALL BOWEL hospi</a> <a title="AJG_Vol.111.No.11 page 188" href="http://viewer.zmags.com/publication/11303066?page=188"> 39,535 unique adult patients admitted to </a> <a title="AJG_Vol.111.No.11 page 189" href="http://viewer.zmags.com/publication/11303066?page=189"> 1644 Faleck et al. COLON/SMALL BOWEL Table</a> <a title="AJG_Vol.111.No.11 page 190" href="http://viewer.zmags.com/publication/11303066?page=190"> Table 2. Characteristics during treatment in inte</a> <a title="AJG_Vol.111.No.11 page 191" href="http://viewer.zmags.com/publication/11303066?page=191"> 1646 Faleck et al. COLON/SMALL BOWEL previ</a> <a title="AJG_Vol.111.No.11 page 192" href="http://viewer.zmags.com/publication/11303066?page=192"> who did not receive antibiotics. Concern for incr</a> <a title="AJG_Vol.111.No.11 page 193" href="http://viewer.zmags.com/publication/11303066?page=193"> 1648 Faleck et al. COLON/SMALL BOWEL 31. V</a> <a title="AJG_Vol.111.No.11 page 194" href="http://viewer.zmags.com/publication/11303066?page=194"> ORIGINAL CONTRIBUTIONS 1649 CME Con</a> <a title="AJG_Vol.111.No.11 page 195" href="http://viewer.zmags.com/publication/11303066?page=195"> 1650 ORIGINAL CONTRIBUTIONS PANCREAS AND BILIA</a> <a title="AJG_Vol.111.No.11 page 196" href="http://viewer.zmags.com/publication/11303066?page=196"> component n-recognin 2 (UBR2), which is expressed</a> <a title="AJG_Vol.111.No.11 page 197" href="http://viewer.zmags.com/publication/11303066?page=197"> 1652 Buijs et al. PANCREAS AND BILIARY TRAC</a> <a title="AJG_Vol.111.No.11 page 198" href="http://viewer.zmags.com/publication/11303066?page=198"> a 1.5 OD values 1.0 0.5 0.0 SAB Pur Ab </a> <a title="AJG_Vol.111.No.11 page 199" href="http://viewer.zmags.com/publication/11303066?page=199"> 1654 Buijs et al. collar workers. The </a> <a title="AJG_Vol.111.No.11 page 200" href="http://viewer.zmags.com/publication/11303066?page=200"> LETTERS TO THE EDITOR 1655 Statins a</a> <a title="AJG_Vol.111.No.11 page 201" href="http://viewer.zmags.com/publication/11303066?page=201"> 1656 Letters to the Editor Table 1. Adjus</a> <a title="AJG_Vol.111.No.11 page 202" href="http://viewer.zmags.com/publication/11303066?page=202"> evaluating mesalamine in the prevention of recurr</a> <a title="AJG_Vol.111.No.11 page 203" href="http://viewer.zmags.com/publication/11303066?page=203"> 1658 Letters to the Editor 3. Stollman</a> <a title="AJG_Vol.111.No.11 page 204" href="http://viewer.zmags.com/publication/11303066?page=204"> No Change in the Mucosal Gut Microbiome is Associ</a> <a title="AJG_Vol.111.No.11 page 205" href="http://viewer.zmags.com/publication/11303066?page=205"> 1660 Letters to the Editor a Control.1</a> <a title="AJG_Vol.111.No.11 page 206" href="http://viewer.zmags.com/publication/11303066?page=206"> 3. Richard ML, Lamas B, Liguori G et al. Gut Fu</a> <a title="AJG_Vol.111.No.11 page 207" href="http://viewer.zmags.com/publication/11303066?page=207"> 1662 Letters to the Editor the pancreat</a> <a title="AJG_Vol.111.No.11 page 208" href="http://viewer.zmags.com/publication/11303066?page=208"> Figure 1. Baseline small bowel biopsy on oxcarbaz</a> <a title="AJG_Vol.111.No.11 page 209" href="http://viewer.zmags.com/publication/11303066?page=209"> 1664 Letters to the Editor Volumetric M</a> <a title="AJG_Vol.111.No.11 page 210" href="http://viewer.zmags.com/publication/11303066?page=210"> ab cde Figure 2. (</a> <a title="AJG_Vol.111.No.11 page 211" href="http://viewer.zmags.com/publication/11303066?page=211"> 1666 Letters to the Editor 4. Gora MJ, </a> <a title="AJG_Vol.111.No.11 page 212" href="http://viewer.zmags.com/publication/11303066?page=212"> ANNOUNCEMENTS 1667 CALENDAR OF COURS</a> <a title="AJG_Vol.111.No.11 page 213" href="http://viewer.zmags.com/publication/11303066?page=213"> 1668 ERRATA, CORRIGENDA AND RETRACTIONS R</a> <a title="AJG_Vol.111.No.11 page 214" href="http://viewer.zmags.com/publication/11303066?page=214"> CLASSIFIEDS DIVISION CHIEF/PROFESSOR, GASTROENTER</a> <a title="AJG_Vol.111.No.11 page 215" href="http://viewer.zmags.com/publication/11303066?page=215"> LIFESTYLE WITH EXCEPTIONAL INCOME POTENTIAL IN CE</a> <a title="AJG_Vol.111.No.11 page 216" href="http://viewer.zmags.com/publication/11303066?page=216"> IMPORTANT SAFETY INFORMATION SUPREP® Bowel Prep K</a> <a title="AJG_Vol.111.No.11 page 217" href="http://viewer.zmags.com/publication/11303066?page=217"> THE #1 MOST PRESCRIBED, BRANDED BOWEL PREP KIT1 </a>