If you are visually impaired or blind, you can visit the PDF version by Pressing CONTROL + ALT + 4
<br /> DIABETES<br /> ISSN 2054-6181 Vol 3.1 • November 2015 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EASD 2015<br /> Stockholm, Sweden<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 4<br /> CONGRESS REVIEW........................................................................................................................................ 10<br /> • Review of the 51st Annual Meeting of the European Association for the Study of<br /> Diabetes, held in Stockholm, Sweden, 14th–18th September 2015<br /> INTERVIEWS WITH EMJ DIABETES EDITORIAL BOARD....................................................................... 21<br /> SYMPOSIUM REVIEW<br /> • SHOULD TYPE 2 DIABETES MANAGEMENT BE MORE OF A PRIORITY IN POST-ACUTE<br /><a title="EMJ Diabetes 3.1 2015 page 1" href="http://viewer.zmags.com/publication/11363866?page=1"> DIABETES ISSN 2054-6181 </a> <a title="EMJ Diabetes 3.1 2015 page 2" href="http://viewer.zmags.com/publication/11363866?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Diabetes 3.1 2015 page 3" href="http://viewer.zmags.com/publication/11363866?page=3"> DIABETES • MODERATE HYPOXIA EXPOSURE: A NOVEL S</a> <a title="EMJ Diabetes 3.1 2015 page 4" href="http://viewer.zmags.com/publication/11363866?page=4"> Editorial Board Editor-in-Chief: Prof Jörg Hub</a> <a title="EMJ Diabetes 3.1 2015 page 5" href="http://viewer.zmags.com/publication/11363866?page=5"> Diabetes Dr Gill Hood, Research Delivery Mana</a> <a title="EMJ Diabetes 3.1 2015 page 6" href="http://viewer.zmags.com/publication/11363866?page=6"> European Medical Journal EMJ Diabetes Vol 3.1 N</a> <a title="EMJ Diabetes 3.1 2015 page 7" href="http://viewer.zmags.com/publication/11363866?page=7"> Welcome Hello and a very warm welcome to Europ</a> <a title="EMJ Diabetes 3.1 2015 page 8" href="http://viewer.zmags.com/publication/11363866?page=8"> When managing patients with type 2 diab</a> <a title="EMJ Diabetes 3.1 2015 page 9" href="http://viewer.zmags.com/publication/11363866?page=9"> Foreword </a> <a title="EMJ Diabetes 3.1 2015 page 10" href="http://viewer.zmags.com/publication/11363866?page=10"> EASD ANNUAL CONGRESS 2015 STOCKHOLMSMÄSSAN, STOC</a> <a title="EMJ Diabetes 3.1 2015 page 11" href="http://viewer.zmags.com/publication/11363866?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ Diabetes 3.1 2015 page 12" href="http://viewer.zmags.com/publication/11363866?page=12"> EASD ANNUAL CONGRESS 2015 diabetes mellitus and </a> <a title="EMJ Diabetes 3.1 2015 page 13" href="http://viewer.zmags.com/publication/11363866?page=13"> H IGHLIGHTS by glycated haemoglo</a> <a title="EMJ Diabetes 3.1 2015 page 14" href="http://viewer.zmags.com/publication/11363866?page=14"> EASD ANNUAL CONGRESS 2015 patients with T2D indi</a> <a title="EMJ Diabetes 3.1 2015 page 15" href="http://viewer.zmags.com/publication/11363866?page=15"> “Women with diabetes have a roughly 40% greater </a> <a title="EMJ Diabetes 3.1 2015 page 16" href="http://viewer.zmags.com/publication/11363866?page=16"> EASD ANNUAL CONGRESS 2015 1,209 abstracts were </a> <a title="EMJ Diabetes 3.1 2015 page 17" href="http://viewer.zmags.com/publication/11363866?page=17"> The results showed that exposure to any type of p</a> <a title="EMJ Diabetes 3.1 2015 page 18" href="http://viewer.zmags.com/publication/11363866?page=18"> EASD ANNUAL CONGRESS 2015 determined the con</a> <a title="EMJ Diabetes 3.1 2015 page 19" href="http://viewer.zmags.com/publication/11363866?page=19"> factor for the development of Type 2 diabetes. At</a> <a title="EMJ Diabetes 3.1 2015 page 20" href="http://viewer.zmags.com/publication/11363866?page=20"> SUBSCRIBE Follow us: FREE TO OUR YOUTUBE CHA</a> <a title="EMJ Diabetes 3.1 2015 page 21" href="http://viewer.zmags.com/publication/11363866?page=21"> Q: in th A: A EDITORIAL BOARD INTERVIEWS Coe</a> <a title="EMJ Diabetes 3.1 2015 page 22" href="http://viewer.zmags.com/publication/11363866?page=22"> EDITORIAL BOARD INTERVIEWS much work is yet to b</a> <a title="EMJ Diabetes 3.1 2015 page 23" href="http://viewer.zmags.com/publication/11363866?page=23"> Q: What are the most significant advances that you</a> <a title="EMJ Diabetes 3.1 2015 page 24" href="http://viewer.zmags.com/publication/11363866?page=24"> EDITORIAL BOARD INTERVIEWS Q: Is there anything </a> <a title="EMJ Diabetes 3.1 2015 page 25" href="http://viewer.zmags.com/publication/11363866?page=25"> the insulin signalling cascade and the numerous r</a> <a title="EMJ Diabetes 3.1 2015 page 26" href="http://viewer.zmags.com/publication/11363866?page=26"> EDITORIAL BOARD INTERVIEWS Lorenzo Pasquali Junio</a> <a title="EMJ Diabetes 3.1 2015 page 27" href="http://viewer.zmags.com/publication/11363866?page=27"> model in which the underlying causal variants are</a> <a title="EMJ Diabetes 3.1 2015 page 28" href="http://viewer.zmags.com/publication/11363866?page=28"> EDITORIAL BOARD INTERVIEWS level of frustrat</a> <a title="EMJ Diabetes 3.1 2015 page 29" href="http://viewer.zmags.com/publication/11363866?page=29"> Q: What are the greatest hurdles facing Europe in</a> <a title="EMJ Diabetes 3.1 2015 page 30" href="http://viewer.zmags.com/publication/11363866?page=30"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Diabetes 3.1 2015 page 31" href="http://viewer.zmags.com/publication/11363866?page=31"> SHOULD TYPE 2 DIABETES MANAGEMENT BE MORE OF </a> <a title="EMJ Diabetes 3.1 2015 page 32" href="http://viewer.zmags.com/publication/11363866?page=32"> disease (CVD) is rare. Only the DPP-4 alogliptin </a> <a title="EMJ Diabetes 3.1 2015 page 33" href="http://viewer.zmags.com/publication/11363866?page=33"> control in patients with T2D and CVD are very gen</a> <a title="EMJ Diabetes 3.1 2015 page 34" href="http://viewer.zmags.com/publication/11363866?page=34"> Data from 530,083 participants (adjusted for age,</a> <a title="EMJ Diabetes 3.1 2015 page 35" href="http://viewer.zmags.com/publication/11363866?page=35"> Treatment decisions are even more complex fo</a> <a title="EMJ Diabetes 3.1 2015 page 36" href="http://viewer.zmags.com/publication/11363866?page=36"> Table 1: Baseline characteristics comparison of t</a> <a title="EMJ Diabetes 3.1 2015 page 37" href="http://viewer.zmags.com/publication/11363866?page=37"> The detailed results of the EMPA-REG-OUTCOME stud</a> <a title="EMJ Diabetes 3.1 2015 page 38" href="http://viewer.zmags.com/publication/11363866?page=38"> influences the nature and severity of coronar</a> <a title="EMJ Diabetes 3.1 2015 page 39" href="http://viewer.zmags.com/publication/11363866?page=39"> Would you like to write for the EMJ blog? Interac</a> <a title="EMJ Diabetes 3.1 2015 page 40" href="http://viewer.zmags.com/publication/11363866?page=40"> ABSTRACT REVIEWS LIPIDOME AS A PRED</a> <a title="EMJ Diabetes 3.1 2015 page 41" href="http://viewer.zmags.com/publication/11363866?page=41"> EASD application based on the lipid panel. </a> <a title="EMJ Diabetes 3.1 2015 page 42" href="http://viewer.zmags.com/publication/11363866?page=42"> ABSTRACT REVIEWS Results from the patient global</a> <a title="EMJ Diabetes 3.1 2015 page 43" href="http://viewer.zmags.com/publication/11363866?page=43"> EASD Levels of HbA1c were reduced by a me</a> <a title="EMJ Diabetes 3.1 2015 page 44" href="http://viewer.zmags.com/publication/11363866?page=44"> ABSTRACT REVIEWS order to compare the efficacy a</a> <a title="EMJ Diabetes 3.1 2015 page 45" href="http://viewer.zmags.com/publication/11363866?page=45"> EASD (57–60%). No notable differences were </a> <a title="EMJ Diabetes 3.1 2015 page 46" href="http://viewer.zmags.com/publication/11363866?page=46"> ABSTRACT REVIEWS knowledge and competence to a s</a> <a title="EMJ Diabetes 3.1 2015 page 47" href="http://viewer.zmags.com/publication/11363866?page=47"> EASD (15 higher and 13 lower) than after SG (9 l</a> <a title="EMJ Diabetes 3.1 2015 page 48" href="http://viewer.zmags.com/publication/11363866?page=48"> ABSTRACT REVIEWS beta cells. Moreover, the n</a> <a title="EMJ Diabetes 3.1 2015 page 49" href="http://viewer.zmags.com/publication/11363866?page=49"> EASD protocol used to acquire images, and the de</a> <a title="EMJ Diabetes 3.1 2015 page 50" href="http://viewer.zmags.com/publication/11363866?page=50"> ABSTRACT REVIEWS LONG-CHAIN ACYLCARNITINES INDUCE</a> <a title="EMJ Diabetes 3.1 2015 page 51" href="http://viewer.zmags.com/publication/11363866?page=51"> EASD Pronounced accumulation of l</a> <a title="EMJ Diabetes 3.1 2015 page 52" href="http://viewer.zmags.com/publication/11363866?page=52"> ABSTRACT REVIEWS of albuminuria that occurred in</a> <a title="EMJ Diabetes 3.1 2015 page 53" href="http://viewer.zmags.com/publication/11363866?page=53"> EASD validation in the remaining study popu</a> <a title="EMJ Diabetes 3.1 2015 page 54" href="http://viewer.zmags.com/publication/11363866?page=54"> ABSTRACT REVIEWS The mean age of patients was 29</a> <a title="EMJ Diabetes 3.1 2015 page 55" href="http://viewer.zmags.com/publication/11363866?page=55"> EASD IL-6, and IL-12 (an additional signal requi</a> <a title="EMJ Diabetes 3.1 2015 page 56" href="http://viewer.zmags.com/publication/11363866?page=56"> If you are interested in submitting a paper to </a> <a title="EMJ Diabetes 3.1 2015 page 57" href="http://viewer.zmags.com/publication/11363866?page=57"> WHY ARE INCRETIN-BASED THERAPIES MORE EFFIC</a> <a title="EMJ Diabetes 3.1 2015 page 58" href="http://viewer.zmags.com/publication/11363866?page=58"> INTRODUCTION Rapidly increasing Type 2 diabetes </a> <a title="EMJ Diabetes 3.1 2015 page 59" href="http://viewer.zmags.com/publication/11363866?page=59"> test (IVGTT). Our previous studies, from as early</a> <a title="EMJ Diabetes 3.1 2015 page 60" href="http://viewer.zmags.com/publication/11363866?page=60"> Insulin resistance is best characterised by HOMA-</a> <a title="EMJ Diabetes 3.1 2015 page 61" href="http://viewer.zmags.com/publication/11363866?page=61"> that DPP-4 activity is enhanced in T2D,48 little </a> <a title="EMJ Diabetes 3.1 2015 page 62" href="http://viewer.zmags.com/publication/11363866?page=62"> βP Sex 0.0</a> <a title="EMJ Diabetes 3.1 2015 page 63" href="http://viewer.zmags.com/publication/11363866?page=63"> improving glucose-induced insulin secretion a</a> <a title="EMJ Diabetes 3.1 2015 page 64" href="http://viewer.zmags.com/publication/11363866?page=64"> REFERENCES 1. International Diabetes Federation.</a> <a title="EMJ Diabetes 3.1 2015 page 65" href="http://viewer.zmags.com/publication/11363866?page=65"> type 2 diabetes patients and healthy control</a> <a title="EMJ Diabetes 3.1 2015 page 66" href="http://viewer.zmags.com/publication/11363866?page=66"> BENEFITS OF BARIATRIC SURGERY AND PERIOPERATI</a> <a title="EMJ Diabetes 3.1 2015 page 67" href="http://viewer.zmags.com/publication/11363866?page=67"> Effectiveness of Bariatric Surgery – Weight Chang</a> <a title="EMJ Diabetes 3.1 2015 page 68" href="http://viewer.zmags.com/publication/11363866?page=68"> Iaconelli et al.17 observed that 10 years after B</a> <a title="EMJ Diabetes 3.1 2015 page 69" href="http://viewer.zmags.com/publication/11363866?page=69"> Table 1: Type of bariatric surgery and rates of a</a> <a title="EMJ Diabetes 3.1 2015 page 70" href="http://viewer.zmags.com/publication/11363866?page=70"> deficient in vitamins A (23%), B12 (17%), and D (8</a> <a title="EMJ Diabetes 3.1 2015 page 71" href="http://viewer.zmags.com/publication/11363866?page=71"> 19. Wing RR et al. Cardiovascular effects of inte</a> <a title="EMJ Diabetes 3.1 2015 page 72" href="http://viewer.zmags.com/publication/11363866?page=72"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Diabetes 3.1 2015 page 73" href="http://viewer.zmags.com/publication/11363866?page=73"> MODERATE HYPOXIA EXPOSURE: A NOVEL STRATEGY T</a> <a title="EMJ Diabetes 3.1 2015 page 74" href="http://viewer.zmags.com/publication/11363866?page=74"> that living at high altitude, where oxygen partia</a> <a title="EMJ Diabetes 3.1 2015 page 75" href="http://viewer.zmags.com/publication/11363866?page=75"> brown adipose tissue has been described in mouse </a> <a title="EMJ Diabetes 3.1 2015 page 76" href="http://viewer.zmags.com/publication/11363866?page=76"> under hypoxia (approximately 14–15% O ) evoked </a> <a title="EMJ Diabetes 3.1 2015 page 77" href="http://viewer.zmags.com/publication/11363866?page=77"> gluconeogenesis in the liver and may thereb</a> <a title="EMJ Diabetes 3.1 2015 page 78" href="http://viewer.zmags.com/publication/11363866?page=78"> Likewise, hypoxia seems to improve skeletal muscl</a> <a title="EMJ Diabetes 3.1 2015 page 79" href="http://viewer.zmags.com/publication/11363866?page=79"> Advances in Chemical Sensors (2012), Rijeka: </a> <a title="EMJ Diabetes 3.1 2015 page 80" href="http://viewer.zmags.com/publication/11363866?page=80"> THE CONCEPT OF EARLY VASCULAR AGEING – </a> <a title="EMJ Diabetes 3.1 2015 page 81" href="http://viewer.zmags.com/publication/11363866?page=81"> disease, as well as elucidation of why many of th</a> <a title="EMJ Diabetes 3.1 2015 page 82" href="http://viewer.zmags.com/publication/11363866?page=82"> THE PREVALENCE OF EARLY VASCULAR AGEING IN DEFINE</a> <a title="EMJ Diabetes 3.1 2015 page 83" href="http://viewer.zmags.com/publication/11363866?page=83"> factors.28,29 Measurement of arterial stiffne</a> <a title="EMJ Diabetes 3.1 2015 page 84" href="http://viewer.zmags.com/publication/11363866?page=84"> associations between vascular ageing and bra</a> <a title="EMJ Diabetes 3.1 2015 page 85" href="http://viewer.zmags.com/publication/11363866?page=85"> for the control of arterial ageing. EVA is a new </a> <a title="EMJ Diabetes 3.1 2015 page 86" href="http://viewer.zmags.com/publication/11363866?page=86"> invasive Investigation of Large Arteries. J Hyper</a> <a title="EMJ Diabetes 3.1 2015 page 87" href="http://viewer.zmags.com/publication/11363866?page=87"> REST/NRSF TARGET GENES IN NEURONAL AND</a> <a title="EMJ Diabetes 3.1 2015 page 88" href="http://viewer.zmags.com/publication/11363866?page=88"> RE-1-SILENCING TRANSCRIPTION FACTOR/NEURON-RESTRI</a> <a title="EMJ Diabetes 3.1 2015 page 89" href="http://viewer.zmags.com/publication/11363866?page=89"> apoptosis, which ultimately leads to death </a> <a title="EMJ Diabetes 3.1 2015 page 90" href="http://viewer.zmags.com/publication/11363866?page=90"> Similarly to neurons, REST/NRSF is present </a> <a title="EMJ Diabetes 3.1 2015 page 91" href="http://viewer.zmags.com/publication/11363866?page=91"> Table 2: REST/NRSF target genes that control neur</a> <a title="EMJ Diabetes 3.1 2015 page 92" href="http://viewer.zmags.com/publication/11363866?page=92"> Therefore, within different brain regions</a> <a title="EMJ Diabetes 3.1 2015 page 93" href="http://viewer.zmags.com/publication/11363866?page=93"> REST/NRSF activity and the subsequent decrease of</a> <a title="EMJ Diabetes 3.1 2015 page 94" href="http://viewer.zmags.com/publication/11363866?page=94"> 2005;280:401-7. 18. Naruse Y et al. Neural </a> <a title="EMJ Diabetes 3.1 2015 page 95" href="http://viewer.zmags.com/publication/11363866?page=95"> β-cell mass in response to increased metabol</a> <a title="EMJ Diabetes 3.1 2015 page 96" href="http://viewer.zmags.com/publication/11363866?page=96"> TRANSFORMING GROWTH FACTOR BETA-BASED THERAPIES, </a> <a title="EMJ Diabetes 3.1 2015 page 97" href="http://viewer.zmags.com/publication/11363866?page=97"> major histocompatibility complex (MHC) molecules </a> <a title="EMJ Diabetes 3.1 2015 page 98" href="http://viewer.zmags.com/publication/11363866?page=98"> inducing the appropriate developmental/surviva</a> <a title="EMJ Diabetes 3.1 2015 page 99" href="http://viewer.zmags.com/publication/11363866?page=99"> properties of TGFβ from the unwanted fibrotic/ tum</a> <a title="EMJ Diabetes 3.1 2015 page 100" href="http://viewer.zmags.com/publication/11363866?page=100"> kidney capsule of diabetic NOD mice recipients, a</a> <a title="EMJ Diabetes 3.1 2015 page 101" href="http://viewer.zmags.com/publication/11363866?page=101"> REFERENCES 1. Jeker LT et al. Breakdown in perip</a> <a title="EMJ Diabetes 3.1 2015 page 102" href="http://viewer.zmags.com/publication/11363866?page=102"> cells. Diabetes. 2013;62(9):3132-42. 46. Nayak S,</a> <a title="EMJ Diabetes 3.1 2015 page 103" href="http://viewer.zmags.com/publication/11363866?page=103"> Buyer’s Guide • A.MENARINI DIAGNOSTICS • ABB</a> <a title="EMJ Diabetes 3.1 2015 page 104" href="http://viewer.zmags.com/publication/11363866?page=104"> UPCOMING EVENTS 5th World Congress on Controversi</a> <a title="EMJ Diabetes 3.1 2015 page 105" href="http://viewer.zmags.com/publication/11363866?page=105"> DIABETES The 9th International Conference on Adva</a> <a title="EMJ Diabetes 3.1 2015 page 106" href="http://viewer.zmags.com/publication/11363866?page=106"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS, PUBL</a>