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<br /> NEUROLOGY<br /> ISSN 2054-4529 Vol 4.1 • July 2016 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EAN 2016<br /> Copenhagen, Denmark<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 4<br /> CONGRESS REVIEW........................................................................................................................................ 12<br /> • Review of the 2nd Congress of the European Academy of Neurology (EAN),<br /> held in Copenhagen, Denmark, 28th-31st May 2016<br /> INTERVIEWS WITH EMJ NEUROLOGY EDITORIAL BOARD................................................................. 28<br /> SYMPOSIUM REVIEW<br /> • BRAIN HEALTH: TRANSLATING SCIENTIFIC EVIDENCE INTO CLINICAL PRACTICE IN<br /> <a title="EMJ Neurology 4.1 2016 page 1" href="http://viewer.zmags.com/publication/113a1967?page=1"> NEUROLOGY ISSN 2054-4529 </a> <a title="EMJ Neurology 4.1 2016 page 2" href="http://viewer.zmags.com/publication/113a1967?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Neurology 4.1 2016 page 3" href="http://viewer.zmags.com/publication/113a1967?page=3"> NEUROLOGY • DEVELOPMENT AND TRANSLATION OF THER</a> <a title="EMJ Neurology 4.1 2016 page 4" href="http://viewer.zmags.com/publication/113a1967?page=4"> Editorial Board Editor-in-Chief: Prof László V</a> <a title="EMJ Neurology 4.1 2016 page 5" href="http://viewer.zmags.com/publication/113a1967?page=5"> Neurology Prof Nils Erik Gilhus, Professor of</a> <a title="EMJ Neurology 4.1 2016 page 6" href="http://viewer.zmags.com/publication/113a1967?page=6"> SUBSCRIBE TOTHEEMJ NEWSLETTER NwEwwW.newSs.eLmjEr</a> <a title="EMJ Neurology 4.1 2016 page 7" href="http://viewer.zmags.com/publication/113a1967?page=7"> Welcome Welcome to EMJ Neurology, an edition fi</a> <a title="EMJ Neurology 4.1 2016 page 8" href="http://viewer.zmags.com/publication/113a1967?page=8"> SUBSCRIBE Follow us: FREE TO OUR YOUTUBE CHA</a> <a title="EMJ Neurology 4.1 2016 page 9" href="http://viewer.zmags.com/publication/113a1967?page=9"> Foreword </a> <a title="EMJ Neurology 4.1 2016 page 10" href="http://viewer.zmags.com/publication/113a1967?page=10"> MIGRAINE: THE SEVENTH DISABLER Frovatriptan i</a> <a title="EMJ Neurology 4.1 2016 page 11" href="http://viewer.zmags.com/publication/113a1967?page=11"> EFFICACY IN THE TREATMENT OF MIGRAINE Migraine w</a> <a title="EMJ Neurology 4.1 2016 page 12" href="http://viewer.zmags.com/publication/113a1967?page=12"> 12 NEUROLOGY • July 2016 </a> <a title="EMJ Neurology 4.1 2016 page 13" href="http://viewer.zmags.com/publication/113a1967?page=13"> NEUROLOGY • July 2016 </a> <a title="EMJ Neurology 4.1 2016 page 14" href="http://viewer.zmags.com/publication/113a1967?page=14"> 14 NEUROLOGY • July 2016 </a> <a title="EMJ Neurology 4.1 2016 page 15" href="http://viewer.zmags.com/publication/113a1967?page=15"> Congress Highlights Cultivating a Ne</a> <a title="EMJ Neurology 4.1 2016 page 16" href="http://viewer.zmags.com/publication/113a1967?page=16"> Making the correct decision when treating a </a> <a title="EMJ Neurology 4.1 2016 page 17" href="http://viewer.zmags.com/publication/113a1967?page=17"> Indeed, with 60 countries and territories re</a> <a title="EMJ Neurology 4.1 2016 page 18" href="http://viewer.zmags.com/publication/113a1967?page=18"> we will need medical, ethical, and legal gu</a> <a title="EMJ Neurology 4.1 2016 page 19" href="http://viewer.zmags.com/publication/113a1967?page=19"> Experts unveiled a five-phase framework at th</a> <a title="EMJ Neurology 4.1 2016 page 20" href="http://viewer.zmags.com/publication/113a1967?page=20"> disease, designed to standardise clinical</a> <a title="EMJ Neurology 4.1 2016 page 21" href="http://viewer.zmags.com/publication/113a1967?page=21"> Prehistoric finds show that skulls were being trep</a> <a title="EMJ Neurology 4.1 2016 page 22" href="http://viewer.zmags.com/publication/113a1967?page=22"> The findings determined that low levels of f</a> <a title="EMJ Neurology 4.1 2016 page 23" href="http://viewer.zmags.com/publication/113a1967?page=23"> Advances in migraine prevention give hope that we</a> <a title="EMJ Neurology 4.1 2016 page 24" href="http://viewer.zmags.com/publication/113a1967?page=24"> Impairment to Sexuality Underestimated in Neurolo</a> <a title="EMJ Neurology 4.1 2016 page 25" href="http://viewer.zmags.com/publication/113a1967?page=25"> Previous studies have suggested that the str</a> <a title="EMJ Neurology 4.1 2016 page 26" href="http://viewer.zmags.com/publication/113a1967?page=26"> Dr Cláudia Borbinha, Department o</a> <a title="EMJ Neurology 4.1 2016 page 27" href="http://viewer.zmags.com/publication/113a1967?page=27"> Praise for Scandinavian Research at European Neur</a> <a title="EMJ Neurology 4.1 2016 page 28" href="http://viewer.zmags.com/publication/113a1967?page=28"> Valery L. Feigin Professor of Epidemiology and N</a> <a title="EMJ Neurology 4.1 2016 page 29" href="http://viewer.zmags.com/publication/113a1967?page=29"> >200 investigators from 61 countries involved in </a> <a title="EMJ Neurology 4.1 2016 page 30" href="http://viewer.zmags.com/publication/113a1967?page=30"> already suffering from these disorders. However, </a> <a title="EMJ Neurology 4.1 2016 page 31" href="http://viewer.zmags.com/publication/113a1967?page=31"> in theory this should allow for the development o</a> <a title="EMJ Neurology 4.1 2016 page 32" href="http://viewer.zmags.com/publication/113a1967?page=32"> strains on our society. Another impressive change</a> <a title="EMJ Neurology 4.1 2016 page 33" href="http://viewer.zmags.com/publication/113a1967?page=33"> other on the ‘Brain and Mind in Ancient Greek Med</a> <a title="EMJ Neurology 4.1 2016 page 34" href="http://viewer.zmags.com/publication/113a1967?page=34"> populations, another unique feature of the resear</a> <a title="EMJ Neurology 4.1 2016 page 35" href="http://viewer.zmags.com/publication/113a1967?page=35"> Q: Have you had any mentors during your career th</a> <a title="EMJ Neurology 4.1 2016 page 36" href="http://viewer.zmags.com/publication/113a1967?page=36"> BRAIN HEALTH: TRANSLATING SCIENTIFIC EVIDENCE I</a> <a title="EMJ Neurology 4.1 2016 page 37" href="http://viewer.zmags.com/publication/113a1967?page=37"> Brain Volume Loss in Multiple Sclerosis: </a> <a title="EMJ Neurology 4.1 2016 page 38" href="http://viewer.zmags.com/publication/113a1967?page=38"> could eventually lead to neuronal dysfunctio</a> <a title="EMJ Neurology 4.1 2016 page 39" href="http://viewer.zmags.com/publication/113a1967?page=39"> treatments and may be more apparent in white matt</a> <a title="EMJ Neurology 4.1 2016 page 40" href="http://viewer.zmags.com/publication/113a1967?page=40"> However, measurements of brain volume (whole brai</a> <a title="EMJ Neurology 4.1 2016 page 41" href="http://viewer.zmags.com/publication/113a1967?page=41"> opportunity to enter extension studies.50-52 In C</a> <a title="EMJ Neurology 4.1 2016 page 42" href="http://viewer.zmags.com/publication/113a1967?page=42"> QUESTION AND ANSWER SESSION Prof Sørensen note</a> <a title="EMJ Neurology 4.1 2016 page 43" href="http://viewer.zmags.com/publication/113a1967?page=43"> Annu Rev Neurosci. 2008;31:247-69. 16. Sorbara CD</a> <a title="EMJ Neurology 4.1 2016 page 44" href="http://viewer.zmags.com/publication/113a1967?page=44"> with Alemtuzumab: CARE-MS II. DX02. Presented at </a> <a title="EMJ Neurology 4.1 2016 page 45" href="http://viewer.zmags.com/publication/113a1967?page=45"> EMJ EUROPEAN MEDICAL </a> <a title="EMJ Neurology 4.1 2016 page 46" href="http://viewer.zmags.com/publication/113a1967?page=46"> Abstract Reviews FROM CHEMOTHERAPY TO TARGETED</a> <a title="EMJ Neurology 4.1 2016 page 47" href="http://viewer.zmags.com/publication/113a1967?page=47"> EAN 2016 with cryptogenic stroke <55 years of ag</a> <a title="EMJ Neurology 4.1 2016 page 48" href="http://viewer.zmags.com/publication/113a1967?page=48"> Abstract Reviews Cohen–Mansfield Agitation </a> <a title="EMJ Neurology 4.1 2016 page 49" href="http://viewer.zmags.com/publication/113a1967?page=49"> EAN 2016 THE IMPACT OF BILINGU</a> <a title="EMJ Neurology 4.1 2016 page 50" href="http://viewer.zmags.com/publication/113a1967?page=50"> Abstract Reviews REFERENCES 1. Bak TH. The neuro</a> <a title="EMJ Neurology 4.1 2016 page 51" href="http://viewer.zmags.com/publication/113a1967?page=51"> EAN 2016 specifically highlight the Yale-Global T</a> <a title="EMJ Neurology 4.1 2016 page 52" href="http://viewer.zmags.com/publication/113a1967?page=52"> Abstract Reviews blown Tourette’s syndrome’), </a> <a title="EMJ Neurology 4.1 2016 page 53" href="http://viewer.zmags.com/publication/113a1967?page=53"> EAN 2016 (antipsychotics) are the most effective</a> <a title="EMJ Neurology 4.1 2016 page 54" href="http://viewer.zmags.com/publication/113a1967?page=54"> Abstract Reviews syndrome and other tic disorder</a> <a title="EMJ Neurology 4.1 2016 page 55" href="http://viewer.zmags.com/publication/113a1967?page=55"> If you are interested in submitting a paper to </a> <a title="EMJ Neurology 4.1 2016 page 56" href="http://viewer.zmags.com/publication/113a1967?page=56"> EDITORS PICK The s</a> <a title="EMJ Neurology 4.1 2016 page 57" href="http://viewer.zmags.com/publication/113a1967?page=57"> other neuropsychiatric illnesses, such as depress</a> <a title="EMJ Neurology 4.1 2016 page 58" href="http://viewer.zmags.com/publication/113a1967?page=58"> CHALLENGES IN DIAGNOSIS There are many overlappi</a> <a title="EMJ Neurology 4.1 2016 page 59" href="http://viewer.zmags.com/publication/113a1967?page=59"> Apathy 51% Depression 26% Pure apath 29% y </a> <a title="EMJ Neurology 4.1 2016 page 60" href="http://viewer.zmags.com/publication/113a1967?page=60"> closer than those between apathy and depression; </a> <a title="EMJ Neurology 4.1 2016 page 61" href="http://viewer.zmags.com/publication/113a1967?page=61"> Correspondingly, reward circuits and dopamine</a> <a title="EMJ Neurology 4.1 2016 page 62" href="http://viewer.zmags.com/publication/113a1967?page=62"> Associations with other neuropsychiatric conditio</a> <a title="EMJ Neurology 4.1 2016 page 63" href="http://viewer.zmags.com/publication/113a1967?page=63"> and Depression: Separate Factors in Parkinson</a> <a title="EMJ Neurology 4.1 2016 page 64" href="http://viewer.zmags.com/publication/113a1967?page=64"> DEVELOPMENT AND TRANSLATION OF THERAPIES FOR </a> <a title="EMJ Neurology 4.1 2016 page 65" href="http://viewer.zmags.com/publication/113a1967?page=65"> most common type of SMA.11 Disease onset occurs b</a> <a title="EMJ Neurology 4.1 2016 page 66" href="http://viewer.zmags.com/publication/113a1967?page=66"> degradation by the proteasome.34 The proteasome h</a> <a title="EMJ Neurology 4.1 2016 page 67" href="http://viewer.zmags.com/publication/113a1967?page=67"> Table 1: Current overview of clinical trials for </a> <a title="EMJ Neurology 4.1 2016 page 68" href="http://viewer.zmags.com/publication/113a1967?page=68"> Table 1 continued. Trial number Study Sta</a> <a title="EMJ Neurology 4.1 2016 page 69" href="http://viewer.zmags.com/publication/113a1967?page=69"> While the first-generation of SMN-dependen</a> <a title="EMJ Neurology 4.1 2016 page 70" href="http://viewer.zmags.com/publication/113a1967?page=70"> FUTURE DEVELOPMENT AND CONCLUDING REMARKS At pr</a> <a title="EMJ Neurology 4.1 2016 page 71" href="http://viewer.zmags.com/publication/113a1967?page=71"> 8. Hamilton G, Gillingwater TH. Spinal muscular </a> <a title="EMJ Neurology 4.1 2016 page 72" href="http://viewer.zmags.com/publication/113a1967?page=72"> Defects in Intestine in Severe Spinal Muscul</a> <a title="EMJ Neurology 4.1 2016 page 73" href="http://viewer.zmags.com/publication/113a1967?page=73"> exon of human Survival Motor Neuron is regulated </a> <a title="EMJ Neurology 4.1 2016 page 74" href="http://viewer.zmags.com/publication/113a1967?page=74"> WILSON’S DISEASE: AN INHERITED, SILENT, </a> <a title="EMJ Neurology 4.1 2016 page 75" href="http://viewer.zmags.com/publication/113a1967?page=75"> A </a> <a title="EMJ Neurology 4.1 2016 page 76" href="http://viewer.zmags.com/publication/113a1967?page=76"> Figure 1 continued. functionally disrupted.22 Du</a> <a title="EMJ Neurology 4.1 2016 page 77" href="http://viewer.zmags.com/publication/113a1967?page=77"> supported by a trial in which clinical and geneti</a> <a title="EMJ Neurology 4.1 2016 page 78" href="http://viewer.zmags.com/publication/113a1967?page=78"> In most Wilson’s disease patients presenting</a> <a title="EMJ Neurology 4.1 2016 page 79" href="http://viewer.zmags.com/publication/113a1967?page=79"> A Clinical symptoms </a> <a title="EMJ Neurology 4.1 2016 page 80" href="http://viewer.zmags.com/publication/113a1967?page=80"> However, LA-ICP-MS imaging studies ha</a> <a title="EMJ Neurology 4.1 2016 page 81" href="http://viewer.zmags.com/publication/113a1967?page=81"> facilitate the otherwise cumbersome diagnosti</a> <a title="EMJ Neurology 4.1 2016 page 82" href="http://viewer.zmags.com/publication/113a1967?page=82"> foods, and to treat any damage of the liver and t</a> <a title="EMJ Neurology 4.1 2016 page 83" href="http://viewer.zmags.com/publication/113a1967?page=83"> accumulation and late-onset hepatic nodular</a> <a title="EMJ Neurology 4.1 2016 page 84" href="http://viewer.zmags.com/publication/113a1967?page=84"> MULTIPLE SCLEROSIS: WHERE DO WE GO FROM HERE? </a> <a title="EMJ Neurology 4.1 2016 page 85" href="http://viewer.zmags.com/publication/113a1967?page=85"> EPIDEMIOLOGY OF MULTIPLE SCLEROSIS MS can be </a> <a title="EMJ Neurology 4.1 2016 page 86" href="http://viewer.zmags.com/publication/113a1967?page=86"> without relapses, known as primary progressi</a> <a title="EMJ Neurology 4.1 2016 page 87" href="http://viewer.zmags.com/publication/113a1967?page=87"> triggered by an infectious agent and evolve into </a> <a title="EMJ Neurology 4.1 2016 page 88" href="http://viewer.zmags.com/publication/113a1967?page=88"> Table 1: Aetiopathology of multiple sclerosis. En</a> <a title="EMJ Neurology 4.1 2016 page 89" href="http://viewer.zmags.com/publication/113a1967?page=89"> Clinical The cornerstone of the MS diagnosis</a> <a title="EMJ Neurology 4.1 2016 page 90" href="http://viewer.zmags.com/publication/113a1967?page=90"> most important CSF test finding, and is a red flag </a> <a title="EMJ Neurology 4.1 2016 page 91" href="http://viewer.zmags.com/publication/113a1967?page=91"> Table 2 continued. Biomarkers Source MS fi</a> <a title="EMJ Neurology 4.1 2016 page 92" href="http://viewer.zmags.com/publication/113a1967?page=92"> regardless of disease activity. An incr</a> <a title="EMJ Neurology 4.1 2016 page 93" href="http://viewer.zmags.com/publication/113a1967?page=93"> miR-23a, and miR-15b are decreased in PPMS and ar</a> <a title="EMJ Neurology 4.1 2016 page 94" href="http://viewer.zmags.com/publication/113a1967?page=94"> social aspects in a clinical cohort. J Neur</a> <a title="EMJ Neurology 4.1 2016 page 95" href="http://viewer.zmags.com/publication/113a1967?page=95"> 73. Miller DH et al. Role of magnetic resonance </a> <a title="EMJ Neurology 4.1 2016 page 96" href="http://viewer.zmags.com/publication/113a1967?page=96"> WHOLE SPECTRUM OF NATURAL PROGRESSION OF HAEM</a> <a title="EMJ Neurology 4.1 2016 page 97" href="http://viewer.zmags.com/publication/113a1967?page=97"> which were highly suggestive of HB. A screening u</a> <a title="EMJ Neurology 4.1 2016 page 98" href="http://viewer.zmags.com/publication/113a1967?page=98"> Figure 3: Gross specimen of the </a> <a title="EMJ Neurology 4.1 2016 page 99" href="http://viewer.zmags.com/publication/113a1967?page=99"> therefore justified with en bloc removal of </a> <a title="EMJ Neurology 4.1 2016 page 100" href="http://viewer.zmags.com/publication/113a1967?page=100"> REFERENCES 1. Chu LZ et al. Multifocal central n</a> <a title="EMJ Neurology 4.1 2016 page 101" href="http://viewer.zmags.com/publication/113a1967?page=101"> ADVANCES IN THE MANAGEMENT OF TRANSIENT </a> <a title="EMJ Neurology 4.1 2016 page 102" href="http://viewer.zmags.com/publication/113a1967?page=102"> TIA by a stroke specialist, its use is supported </a> <a title="EMJ Neurology 4.1 2016 page 103" href="http://viewer.zmags.com/publication/113a1967?page=103"> or tenecteplase) and/or endovascular procedures.3</a> <a title="EMJ Neurology 4.1 2016 page 104" href="http://viewer.zmags.com/publication/113a1967?page=104"> of treatment in most patients with cryptoge</a> <a title="EMJ Neurology 4.1 2016 page 105" href="http://viewer.zmags.com/publication/113a1967?page=105"> The timing and amount of mobilisat</a> <a title="EMJ Neurology 4.1 2016 page 106" href="http://viewer.zmags.com/publication/113a1967?page=106"> and minor ischemic stroke From noncerebro</a> <a title="EMJ Neurology 4.1 2016 page 107" href="http://viewer.zmags.com/publication/113a1967?page=107"> new clinical construct. Lancet Neurol. 2014;1</a> <a title="EMJ Neurology 4.1 2016 page 108" href="http://viewer.zmags.com/publication/113a1967?page=108"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Neurology 4.1 2016 page 109" href="http://viewer.zmags.com/publication/113a1967?page=109"> Buyer’s Guide • ABBVIE, INC. • ACTELION PHAR</a> <a title="EMJ Neurology 4.1 2016 page 110" href="http://viewer.zmags.com/publication/113a1967?page=110"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS, NE</a>