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<br /> CARDIOLOGY<br /> ISSN 2054-3174 Vol 3.2 • October 2015 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ESC 2015<br /> London, UK<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 4<br /> CONGRESS REVIEW........................................................................................................................................ 12<br /> • Review of the European Society of Cardiology Congress held in London, UK,<br /> 29th August-2nd September 2015<br /> INTERVIEWS WITH EMJ CARDIOLOGY EDITORIAL BOARD AND AUTHORS.................................. 31<br /> SYMPOSIUM REVIEWS<br /> • TREATMENT OF HYPERTENSION IN NEW FRONTIERS................................................................... 44<br /> • NEW PARADIGMS IN HEART FAILURE: RAAS INHIBITION AND<a title="EMJ Cardiology 3.2 2015 page 1" href="http://viewer.zmags.com/publication/132ffaed?page=1"> CARDIOLOGY ISSN 2054-3174 </a> <a title="EMJ Cardiology 3.2 2015 page 2" href="http://viewer.zmags.com/publication/132ffaed?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Cardiology 3.2 2015 page 3" href="http://viewer.zmags.com/publication/132ffaed?page=3"> CARDIOLOGY • Diabetes and Cardiovascular Diseas</a> <a title="EMJ Cardiology 3.2 2015 page 4" href="http://viewer.zmags.com/publication/132ffaed?page=4"> Editorial Board Editor-in-Chief: Dr Fernando A</a> <a title="EMJ Cardiology 3.2 2015 page 5" href="http://viewer.zmags.com/publication/132ffaed?page=5"> Cardiology Prof Jawahar L. Mehta, Professor o</a> <a title="EMJ Cardiology 3.2 2015 page 6" href="http://viewer.zmags.com/publication/132ffaed?page=6"> European Medical Journal EMJ Cardiology Vol 3.2</a> <a title="EMJ Cardiology 3.2 2015 page 7" href="http://viewer.zmags.com/publication/132ffaed?page=7"> Welcome Greetings, and a very warm welcome to </a> <a title="EMJ Cardiology 3.2 2015 page 8" href="http://viewer.zmags.com/publication/132ffaed?page=8"> Think Real World. Think XANTUS. The First Publish</a> <a title="EMJ Cardiology 3.2 2015 page 9" href="http://viewer.zmags.com/publication/132ffaed?page=9"> Foreword </a> <a title="EMJ Cardiology 3.2 2015 page 10" href="http://viewer.zmags.com/publication/132ffaed?page=10"> Available Now EMJ Cardiology 3.1 201</a> <a title="EMJ Cardiology 3.2 2015 page 11" href="http://viewer.zmags.com/publication/132ffaed?page=11"> Editor’s Pick: State of the Art of Aortic Valve I</a> <a title="EMJ Cardiology 3.2 2015 page 12" href="http://viewer.zmags.com/publication/132ffaed?page=12"> ESC ANNUAL CONGRESS 2015 EXCEL CENTRE, LONDON, U</a> <a title="EMJ Cardiology 3.2 2015 page 13" href="http://viewer.zmags.com/publication/132ffaed?page=13"> Welcome to the European Medical Journal review of</a> <a title="EMJ Cardiology 3.2 2015 page 14" href="http://viewer.zmags.com/publication/132ffaed?page=14"> ESC ANNUAL CONGRESS 2015 clearly displayed dur</a> <a title="EMJ Cardiology 3.2 2015 page 15" href="http://viewer.zmags.com/publication/132ffaed?page=15"> H IGHLIGHTS Positive Impact of Bysta</a> <a title="EMJ Cardiology 3.2 2015 page 16" href="http://viewer.zmags.com/publication/132ffaed?page=16"> ESC ANNUAL CONGRESS 2015 new data presented at E</a> <a title="EMJ Cardiology 3.2 2015 page 17" href="http://viewer.zmags.com/publication/132ffaed?page=17"> “Empirical left atrial appendage isolati</a> <a title="EMJ Cardiology 3.2 2015 page 18" href="http://viewer.zmags.com/publication/132ffaed?page=18"> ESC ANNUAL CONGRESS 2015 The new research, which</a> <a title="EMJ Cardiology 3.2 2015 page 19" href="http://viewer.zmags.com/publication/132ffaed?page=19"> The LEADLESS II trial included 526 patients </a> <a title="EMJ Cardiology 3.2 2015 page 20" href="http://viewer.zmags.com/publication/132ffaed?page=20"> ESC ANNUAL CONGRESS 2015 Spotlight sessions 26 </a> <a title="EMJ Cardiology 3.2 2015 page 21" href="http://viewer.zmags.com/publication/132ffaed?page=21"> “Our findings suggest that focussing resources on </a> <a title="EMJ Cardiology 3.2 2015 page 22" href="http://viewer.zmags.com/publication/132ffaed?page=22"> ESC ANNUAL CONGRESS 2015 “Our study highlights th</a> <a title="EMJ Cardiology 3.2 2015 page 23" href="http://viewer.zmags.com/publication/132ffaed?page=23"> syndromes. Moreover, air pollution affects </a> <a title="EMJ Cardiology 3.2 2015 page 24" href="http://viewer.zmags.com/publication/132ffaed?page=24"> ESC ANNUAL CONGRESS 2015 The st</a> <a title="EMJ Cardiology 3.2 2015 page 25" href="http://viewer.zmags.com/publication/132ffaed?page=25"> the association between television viewing </a> <a title="EMJ Cardiology 3.2 2015 page 26" href="http://viewer.zmags.com/publication/132ffaed?page=26"> ESC ANNUAL CONGRESS 2015 included 386 middle</a> <a title="EMJ Cardiology 3.2 2015 page 27" href="http://viewer.zmags.com/publication/132ffaed?page=27"> Young Adults Living in Polluted Cities May Be at </a> <a title="EMJ Cardiology 3.2 2015 page 28" href="http://viewer.zmags.com/publication/132ffaed?page=28"> ESC ANNUAL CONGRESS 2015 on patients premature</a> <a title="EMJ Cardiology 3.2 2015 page 29" href="http://viewer.zmags.com/publication/132ffaed?page=29"> “The association between STEMI and air pollution </a> <a title="EMJ Cardiology 3.2 2015 page 30" href="http://viewer.zmags.com/publication/132ffaed?page=30"> HYPERKALEMIA THE THREAT IS REAL. Hyperkalemia put</a> <a title="EMJ Cardiology 3.2 2015 page 31" href="http://viewer.zmags.com/publication/132ffaed?page=31"> INTERVIEWS Carl J. Pepine Professor of Medicine, </a> <a title="EMJ Cardiology 3.2 2015 page 32" href="http://viewer.zmags.com/publication/132ffaed?page=32"> INTERVIEWS In past years, management of pat</a> <a title="EMJ Cardiology 3.2 2015 page 33" href="http://viewer.zmags.com/publication/132ffaed?page=33"> have a wide variety of non-physician provid</a> <a title="EMJ Cardiology 3.2 2015 page 34" href="http://viewer.zmags.com/publication/132ffaed?page=34"> INTERVIEWS University, and I have been there eve</a> <a title="EMJ Cardiology 3.2 2015 page 35" href="http://viewer.zmags.com/publication/132ffaed?page=35"> could governments and healthcare providers do to </a> <a title="EMJ Cardiology 3.2 2015 page 36" href="http://viewer.zmags.com/publication/132ffaed?page=36"> INTERVIEWS Q: One aspect of your research concer</a> <a title="EMJ Cardiology 3.2 2015 page 37" href="http://viewer.zmags.com/publication/132ffaed?page=37"> responsible for restenosis (smooth muscle cells),</a> <a title="EMJ Cardiology 3.2 2015 page 38" href="http://viewer.zmags.com/publication/132ffaed?page=38"> INTERVIEWS consume. As such, South Asians (</a> <a title="EMJ Cardiology 3.2 2015 page 39" href="http://viewer.zmags.com/publication/132ffaed?page=39"> therapies for the benefit of patients – all of whi</a> <a title="EMJ Cardiology 3.2 2015 page 40" href="http://viewer.zmags.com/publication/132ffaed?page=40"> INTERVIEWS Q: In a recent paper that you co-auth</a> <a title="EMJ Cardiology 3.2 2015 page 41" href="http://viewer.zmags.com/publication/132ffaed?page=41"> valuable data on their disease: arrhythmia burden</a> <a title="EMJ Cardiology 3.2 2015 page 42" href="http://viewer.zmags.com/publication/132ffaed?page=42"> INTERVIEWS Martino Pepe Interventional Cardiologi</a> <a title="EMJ Cardiology 3.2 2015 page 43" href="http://viewer.zmags.com/publication/132ffaed?page=43"> SUBSCRIBE Follow us: FREE TO OUR YOUTUBE CHA</a> <a title="EMJ Cardiology 3.2 2015 page 44" href="http://viewer.zmags.com/publication/132ffaed?page=44"> TREATMENT OF HYPERTENSION IN NEW FRONTIERS This s</a> <a title="EMJ Cardiology 3.2 2015 page 45" href="http://viewer.zmags.com/publication/132ffaed?page=45"> Welcome and Introduction Professor Bryan Wi</a> <a title="EMJ Cardiology 3.2 2015 page 46" href="http://viewer.zmags.com/publication/132ffaed?page=46"> this country where the rates of awareness (50%), </a> <a title="EMJ Cardiology 3.2 2015 page 47" href="http://viewer.zmags.com/publication/132ffaed?page=47"> Table 1: Determinants of the burden of hypertensi</a> <a title="EMJ Cardiology 3.2 2015 page 48" href="http://viewer.zmags.com/publication/132ffaed?page=48"> Table 2: Prevalence of risk factors in Latin Amer</a> <a title="EMJ Cardiology 3.2 2015 page 49" href="http://viewer.zmags.com/publication/132ffaed?page=49"> algorithms for diagnosis, treatment, and fol</a> <a title="EMJ Cardiology 3.2 2015 page 50" href="http://viewer.zmags.com/publication/132ffaed?page=50"> Clinical studies have demonstrated that </a> <a title="EMJ Cardiology 3.2 2015 page 51" href="http://viewer.zmags.com/publication/132ffaed?page=51"> systematic analysis for the Global Burden of Dis</a> <a title="EMJ Cardiology 3.2 2015 page 52" href="http://viewer.zmags.com/publication/132ffaed?page=52"> 46. Poldermans D et al. Tolerability and bl</a> <a title="EMJ Cardiology 3.2 2015 page 53" href="http://viewer.zmags.com/publication/132ffaed?page=53"> NEW PARADIGMS IN HEART FAILURE: RAAS INHIBITION </a> <a title="EMJ Cardiology 3.2 2015 page 54" href="http://viewer.zmags.com/publication/132ffaed?page=54"> Current practice is to discontinue or reduce the </a> <a title="EMJ Cardiology 3.2 2015 page 55" href="http://viewer.zmags.com/publication/132ffaed?page=55"> The main reasons for underuse of thes</a> <a title="EMJ Cardiology 3.2 2015 page 56" href="http://viewer.zmags.com/publication/132ffaed?page=56"> Current treatment options for patients with systo</a> <a title="EMJ Cardiology 3.2 2015 page 57" href="http://viewer.zmags.com/publication/132ffaed?page=57"> (Kayexalate®), which is neither a pleasant </a> <a title="EMJ Cardiology 3.2 2015 page 58" href="http://viewer.zmags.com/publication/132ffaed?page=58"> The future prospects for the treatment of HF are </a> <a title="EMJ Cardiology 3.2 2015 page 59" href="http://viewer.zmags.com/publication/132ffaed?page=59"> the AT1R. It is currently being tested in a Phase</a> <a title="EMJ Cardiology 3.2 2015 page 60" href="http://viewer.zmags.com/publication/132ffaed?page=60"> REFERENCES 1. McMurray JJ et al; ESC Committee f</a> <a title="EMJ Cardiology 3.2 2015 page 61" href="http://viewer.zmags.com/publication/132ffaed?page=61"> 35. Healthcare Cost and Utilization Project. US A</a> <a title="EMJ Cardiology 3.2 2015 page 62" href="http://viewer.zmags.com/publication/132ffaed?page=62"> BEST ABSTRACT AWARD WINNERS AWARD WINNERS AT </a> <a title="EMJ Cardiology 3.2 2015 page 63" href="http://viewer.zmags.com/publication/132ffaed?page=63"> ...future studies of risk factors for SAH should </a> <a title="EMJ Cardiology 3.2 2015 page 64" href="http://viewer.zmags.com/publication/132ffaed?page=64"> BEST ABSTRACT AWARD WINNERS </a> <a title="EMJ Cardiology 3.2 2015 page 65" href="http://viewer.zmags.com/publication/132ffaed?page=65"> ACS) compared with age and gender-matched co</a> <a title="EMJ Cardiology 3.2 2015 page 66" href="http://viewer.zmags.com/publication/132ffaed?page=66"> ABSTRACT REVIEWS MANAGEMENT OF VERY HIGH-RI</a> <a title="EMJ Cardiology 3.2 2015 page 67" href="http://viewer.zmags.com/publication/132ffaed?page=67"> ESC Prasugrel and ticagrelor are faster-acti</a> <a title="EMJ Cardiology 3.2 2015 page 68" href="http://viewer.zmags.com/publication/132ffaed?page=68"> ABSTRACT REVIEWS 7. Bonello L et al. Onset </a> <a title="EMJ Cardiology 3.2 2015 page 69" href="http://viewer.zmags.com/publication/132ffaed?page=69"> ESC Subsequently, Tang and colleagues3 s</a> <a title="EMJ Cardiology 3.2 2015 page 70" href="http://viewer.zmags.com/publication/132ffaed?page=70"> ABSTRACT REVIEWS arteries: comparison between ac</a> <a title="EMJ Cardiology 3.2 2015 page 71" href="http://viewer.zmags.com/publication/132ffaed?page=71"> ESC SAFETY AND EFFICACY OF DAPTOMYCIN I</a> <a title="EMJ Cardiology 3.2 2015 page 72" href="http://viewer.zmags.com/publication/132ffaed?page=72"> ABSTRACT REVIEWS In conclusion, these results sh</a> <a title="EMJ Cardiology 3.2 2015 page 73" href="http://viewer.zmags.com/publication/132ffaed?page=73"> ESC can be found, remains unclear. Finally, our </a> <a title="EMJ Cardiology 3.2 2015 page 74" href="http://viewer.zmags.com/publication/132ffaed?page=74"> ABSTRACT REVIEWS DIABETES AND CARDIOVASCULAR </a> <a title="EMJ Cardiology 3.2 2015 page 75" href="http://viewer.zmags.com/publication/132ffaed?page=75"> ESC 100 80 60 40 20 0 Blood pressure contr</a> <a title="EMJ Cardiology 3.2 2015 page 76" href="http://viewer.zmags.com/publication/132ffaed?page=76"> ABSTRACT REVIEWS cardioprotection in a clinic</a> <a title="EMJ Cardiology 3.2 2015 page 77" href="http://viewer.zmags.com/publication/132ffaed?page=77"> ESC compared with other ethnic groups. Asian Ind</a> <a title="EMJ Cardiology 3.2 2015 page 78" href="http://viewer.zmags.com/publication/132ffaed?page=78"> ABSTRACT REVIEWS ENVIRONMENTAL EFFECTS ON </a> <a title="EMJ Cardiology 3.2 2015 page 79" href="http://viewer.zmags.com/publication/132ffaed?page=79"> ESC phrased as a ‘gateway’ or ‘renorma</a> <a title="EMJ Cardiology 3.2 2015 page 80" href="http://viewer.zmags.com/publication/132ffaed?page=80"> ABSTRACT REVIEWS with acute events leading to lo</a> <a title="EMJ Cardiology 3.2 2015 page 81" href="http://viewer.zmags.com/publication/132ffaed?page=81"> ESC or induced pluripotent stem cells. Interesti</a> <a title="EMJ Cardiology 3.2 2015 page 82" href="http://viewer.zmags.com/publication/132ffaed?page=82"> INTERNATIONAL, LARGE-SCALE, REAL-WORLD CL</a> <a title="EMJ Cardiology 3.2 2015 page 83" href="http://viewer.zmags.com/publication/132ffaed?page=83"> Food and Drug Administration (FDA) and the </a> <a title="EMJ Cardiology 3.2 2015 page 84" href="http://viewer.zmags.com/publication/132ffaed?page=84"> throughout the 1-year study period, which is of c</a> <a title="EMJ Cardiology 3.2 2015 page 85" href="http://viewer.zmags.com/publication/132ffaed?page=85"> 4.0% 3.5% 3.0% 2.5% Incidence 2.0% 1.5%</a> <a title="EMJ Cardiology 3.2 2015 page 86" href="http://viewer.zmags.com/publication/132ffaed?page=86"> was used to identify major bleeding-rel</a> <a title="EMJ Cardiology 3.2 2015 page 87" href="http://viewer.zmags.com/publication/132ffaed?page=87"> Safety: mortality rates The researchers observe</a> <a title="EMJ Cardiology 3.2 2015 page 88" href="http://viewer.zmags.com/publication/132ffaed?page=88"> 4. Sanna T et al. Cryptogenic stroke and underlyi</a> <a title="EMJ Cardiology 3.2 2015 page 89" href="http://viewer.zmags.com/publication/132ffaed?page=89"> REAL-WORLD REGISTRY STUDY CONFIRMS FONDAPA</a> <a title="EMJ Cardiology 3.2 2015 page 90" href="http://viewer.zmags.com/publication/132ffaed?page=90"> Based on these results suggesting a better benefit</a> <a title="EMJ Cardiology 3.2 2015 page 91" href="http://viewer.zmags.com/publication/132ffaed?page=91"> angiography/angioplasty or heart surgery for any </a> <a title="EMJ Cardiology 3.2 2015 page 92" href="http://viewer.zmags.com/publication/132ffaed?page=92"> Logistic regression was used to determine the OR </a> <a title="EMJ Cardiology 3.2 2015 page 93" href="http://viewer.zmags.com/publication/132ffaed?page=93"> Acknowledgements Medical writing assistance was p</a> <a title="EMJ Cardiology 3.2 2015 page 94" href="http://viewer.zmags.com/publication/132ffaed?page=94"> SELF-EXPANDING CORONARY STENTS: RATIONALE, </a> <a title="EMJ Cardiology 3.2 2015 page 95" href="http://viewer.zmags.com/publication/132ffaed?page=95"> vascular indications and also stretches </a> <a title="EMJ Cardiology 3.2 2015 page 96" href="http://viewer.zmags.com/publication/132ffaed?page=96"> 03/02/2 0 010 15:57:04 093 (19 mm) 03/05/ 0 20</a> <a title="EMJ Cardiology 3.2 2015 page 97" href="http://viewer.zmags.com/publication/132ffaed?page=97"> particularly applicable to the first-generation Bx</a> <a title="EMJ Cardiology 3.2 2015 page 98" href="http://viewer.zmags.com/publication/132ffaed?page=98"> IVUS. Compared with other causes of M</a> <a title="EMJ Cardiology 3.2 2015 page 99" href="http://viewer.zmags.com/publication/132ffaed?page=99"> vein graft interventions are examples of ea</a> <a title="EMJ Cardiology 3.2 2015 page 100" href="http://viewer.zmags.com/publication/132ffaed?page=100"> AC Proximal </a> <a title="EMJ Cardiology 3.2 2015 page 101" href="http://viewer.zmags.com/publication/132ffaed?page=101"> are also known to precipitate adverse cardi</a> <a title="EMJ Cardiology 3.2 2015 page 102" href="http://viewer.zmags.com/publication/132ffaed?page=102"> Potential Self-Expanding Stent Limitations Sx st</a> <a title="EMJ Cardiology 3.2 2015 page 103" href="http://viewer.zmags.com/publication/132ffaed?page=103"> Table 2 continued. Stent Study name Pts. </a> <a title="EMJ Cardiology 3.2 2015 page 104" href="http://viewer.zmags.com/publication/132ffaed?page=104"> to date not being powered to address clini</a> <a title="EMJ Cardiology 3.2 2015 page 105" href="http://viewer.zmags.com/publication/132ffaed?page=105"> coronary chronic total occlusion. 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