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<br /> DERMATOLOGY<br /> ISSN 2054-6211 December 2013 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EADV 2013<br /> Istanbul, Turkey<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 4<br /> CONGRESS REVIEW............................................................................................................................... 10<br /> • Review of the 22nd European Academy of Dermatology and Venereology (EADV)<br /> Congress, Istanbul, Turkey, 9th-12th October 2013<br /> RESISTANCE TO TARGETED THERAPIES IN MELANOMA: NEW INSIGHTS................................... 24<br /> • Giuseppe Palmieri, Maria Colombino, Maria Cristina Sini, Antonella Manca,<br /> Paolo Antonio Ascierto, Antonio Cossu<br /> SKIN REACTIONS SECONDARY TO ANTICANCER AG<a title="EMJ - Dermatology page 1" href="http://viewer.zmags.com/publication/17a5c02c?page=1"> DERMATOLOGY ISSN 2054-6211 </a> <a title="EMJ - Dermatology page 2" href="http://viewer.zmags.com/publication/17a5c02c?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ - Dermatology page 3" href="http://viewer.zmags.com/publication/17a5c02c?page=3"> DERMATOLOGY XERODERMA PIGMENTOSUM: A MULTIDISCI</a> <a title="EMJ - Dermatology page 4" href="http://viewer.zmags.com/publication/17a5c02c?page=4"> European Medical Journal Dermatology - De</a> <a title="EMJ - Dermatology page 5" href="http://viewer.zmags.com/publication/17a5c02c?page=5"> Dr Paolo Gisondi Adjunct Professor, Department </a> <a title="EMJ - Dermatology page 6" href="http://viewer.zmags.com/publication/17a5c02c?page=6"> </a> <a title="EMJ - Dermatology page 7" href="http://viewer.zmags.com/publication/17a5c02c?page=7"> Welcome Kelly-Ann Lazarus Editor, European Medica</a> <a title="EMJ - Dermatology page 8" href="http://viewer.zmags.com/publication/17a5c02c?page=8"> IN MILD/MODERATE ADULT ACNE PROVEN</a> <a title="EMJ - Dermatology page 9" href="http://viewer.zmags.com/publication/17a5c02c?page=9"> Foreword Anand Reddi and Prof. Robert P. Dellaval</a> <a title="EMJ - Dermatology page 10" href="http://viewer.zmags.com/publication/17a5c02c?page=10"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 11" href="http://viewer.zmags.com/publication/17a5c02c?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ - Dermatology page 12" href="http://viewer.zmags.com/publication/17a5c02c?page=12"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 13" href="http://viewer.zmags.com/publication/17a5c02c?page=13"> “Let it be the city where great minds meet once </a> <a title="EMJ - Dermatology page 14" href="http://viewer.zmags.com/publication/17a5c02c?page=14"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 15" href="http://viewer.zmags.com/publication/17a5c02c?page=15"> New system to detect skin cancer A NEW procedu</a> <a title="EMJ - Dermatology page 16" href="http://viewer.zmags.com/publication/17a5c02c?page=16"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 17" href="http://viewer.zmags.com/publication/17a5c02c?page=17"> Topical treatments for actinic keratosis improve </a> <a title="EMJ - Dermatology page 18" href="http://viewer.zmags.com/publication/17a5c02c?page=18"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 19" href="http://viewer.zmags.com/publication/17a5c02c?page=19"> Extinction of the double chin with ATX-101 “If </a> <a title="EMJ - Dermatology page 20" href="http://viewer.zmags.com/publication/17a5c02c?page=20"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 21" href="http://viewer.zmags.com/publication/17a5c02c?page=21"> Correlation found between psoriasis severity and </a> <a title="EMJ - Dermatology page 22" href="http://viewer.zmags.com/publication/17a5c02c?page=22"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 23" href="http://viewer.zmags.com/publication/17a5c02c?page=23"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjrevie</a> <a title="EMJ - Dermatology page 24" href="http://viewer.zmags.com/publication/17a5c02c?page=24"> RESISTANCE TO TARGETED THERAPIES IN MELANOMA: </a> <a title="EMJ - Dermatology page 25" href="http://viewer.zmags.com/publication/17a5c02c?page=25"> dabrafenib] MEK inhibitors [trametinib], and thei</a> <a title="EMJ - Dermatology page 26" href="http://viewer.zmags.com/publication/17a5c02c?page=26"> Interestingly, this molecule seems to be equally </a> <a title="EMJ - Dermatology page 27" href="http://viewer.zmags.com/publication/17a5c02c?page=27"> with significant inhibition of migration </a> <a title="EMJ - Dermatology page 28" href="http://viewer.zmags.com/publication/17a5c02c?page=28"> of BRAF (as well as MEK) inhibitors have always b</a> <a title="EMJ - Dermatology page 29" href="http://viewer.zmags.com/publication/17a5c02c?page=29"> Hence, the occurrence of a p53 deficiency o</a> <a title="EMJ - Dermatology page 30" href="http://viewer.zmags.com/publication/17a5c02c?page=30"> PDGFRβ MET-HGF AXIS IGF-1R/FGFR3 UPREGULATION RT</a> <a title="EMJ - Dermatology page 31" href="http://viewer.zmags.com/publication/17a5c02c?page=31"> Activated NRAS NRAS </a> <a title="EMJ - Dermatology page 32" href="http://viewer.zmags.com/publication/17a5c02c?page=32"> A subset of melanoma cells resistant to BR</a> <a title="EMJ - Dermatology page 33" href="http://viewer.zmags.com/publication/17a5c02c?page=33"> MEK inhibitors in both melanoma cells and t</a> <a title="EMJ - Dermatology page 34" href="http://viewer.zmags.com/publication/17a5c02c?page=34"> administration.74,121,122 Similarly, the </a> <a title="EMJ - Dermatology page 35" href="http://viewer.zmags.com/publication/17a5c02c?page=35"> colorectal cancer that is resistant to EGFR monoc</a> <a title="EMJ - Dermatology page 36" href="http://viewer.zmags.com/publication/17a5c02c?page=36"> analyses of patients with metastatic melanoma</a> <a title="EMJ - Dermatology page 37" href="http://viewer.zmags.com/publication/17a5c02c?page=37"> 2008;68:3429-39. 122. Tran MA et al. Targeting V6</a> <a title="EMJ - Dermatology page 38" href="http://viewer.zmags.com/publication/17a5c02c?page=38"> SKIN REACTIONS SECONDARY TO ANTICANCER</a> <a title="EMJ - Dermatology page 39" href="http://viewer.zmags.com/publication/17a5c02c?page=39"> the keratinocyte itself is involved in </a> <a title="EMJ - Dermatology page 40" href="http://viewer.zmags.com/publication/17a5c02c?page=40"> Table 2. Classification of severity of cutaneous a</a> <a title="EMJ - Dermatology page 41" href="http://viewer.zmags.com/publication/17a5c02c?page=41"> dasatinib and nilotinib, frequently cause</a> <a title="EMJ - Dermatology page 42" href="http://viewer.zmags.com/publication/17a5c02c?page=42"> decisions for patients and to choose anti-toxicit</a> <a title="EMJ - Dermatology page 43" href="http://viewer.zmags.com/publication/17a5c02c?page=43"> Nurs. 2001;5:221–33. 29. López E et al. Breast ca</a> <a title="EMJ - Dermatology page 44" href="http://viewer.zmags.com/publication/17a5c02c?page=44"> NAIL CHANGES IN RECENT AND OLD </a> <a title="EMJ - Dermatology page 45" href="http://viewer.zmags.com/publication/17a5c02c?page=45"> PREVALENCE OF NAIL CHANGES IN LEPROSY Limited st</a> <a title="EMJ - Dermatology page 46" href="http://viewer.zmags.com/publication/17a5c02c?page=46"> Neuropathy The main factor is neuropathy,</a> <a title="EMJ - Dermatology page 47" href="http://viewer.zmags.com/publication/17a5c02c?page=47"> phalange. During this process the </a> <a title="EMJ - Dermatology page 48" href="http://viewer.zmags.com/publication/17a5c02c?page=48"> Figure 4. Nail of foot with onychorrhexis. </a> <a title="EMJ - Dermatology page 49" href="http://viewer.zmags.com/publication/17a5c02c?page=49"> increased curvature of the nail plate, eith</a> <a title="EMJ - Dermatology page 50" href="http://viewer.zmags.com/publication/17a5c02c?page=50"> The pittings are staking shaped defects on the su</a> <a title="EMJ - Dermatology page 51" href="http://viewer.zmags.com/publication/17a5c02c?page=51"> Three patients </a> <a title="EMJ - Dermatology page 52" href="http://viewer.zmags.com/publication/17a5c02c?page=52"> of Guizhou Province, Peoples’ Republic of China. </a> <a title="EMJ - Dermatology page 53" href="http://viewer.zmags.com/publication/17a5c02c?page=53"> CALL FOR PAPERS IF YOU ARE INTERESTED IN SUBMITT</a> <a title="EMJ - Dermatology page 54" href="http://viewer.zmags.com/publication/17a5c02c?page=54"> XERODERMA PIGMENTOSUM: A MULTIDISCIPLINARY A</a> <a title="EMJ - Dermatology page 55" href="http://viewer.zmags.com/publication/17a5c02c?page=55"> In 1883, Albert Neisser made the link between XP </a> <a title="EMJ - Dermatology page 56" href="http://viewer.zmags.com/publication/17a5c02c?page=56"> repairs many types of DNA damage including </a> <a title="EMJ - Dermatology page 57" href="http://viewer.zmags.com/publication/17a5c02c?page=57"> DNA strand 5’ and 3’ to repair the damage</a> <a title="EMJ - Dermatology page 58" href="http://viewer.zmags.com/publication/17a5c02c?page=58"> Skin Cancers XP patients have a >10,000-fold </a> <a title="EMJ - Dermatology page 59" href="http://viewer.zmags.com/publication/17a5c02c?page=59"> proteins have an increased susceptibility.23,</a> <a title="EMJ - Dermatology page 60" href="http://viewer.zmags.com/publication/17a5c02c?page=60"> Of the eight genes implicated in XP, mutations in</a> <a title="EMJ - Dermatology page 61" href="http://viewer.zmags.com/publication/17a5c02c?page=61"> cancerous lesions, photographic monitori</a> <a title="EMJ - Dermatology page 62" href="http://viewer.zmags.com/publication/17a5c02c?page=62"> 14. Kraemer KH et al. Five complementation groups</a> <a title="EMJ - Dermatology page 63" href="http://viewer.zmags.com/publication/17a5c02c?page=63"> xeroderma pigmentosum. Brain. 2008;13</a> <a title="EMJ - Dermatology page 64" href="http://viewer.zmags.com/publication/17a5c02c?page=64"> NEW TRENDS IN CELLULITIS Laura Atzori, Franc</a> <a title="EMJ - Dermatology page 65" href="http://viewer.zmags.com/publication/17a5c02c?page=65"> Figure 2. Severe leg cellulitis with vesicles and</a> <a title="EMJ - Dermatology page 66" href="http://viewer.zmags.com/publication/17a5c02c?page=66"> A well-known diffuse and life-threatening conditi</a> <a title="EMJ - Dermatology page 67" href="http://viewer.zmags.com/publication/17a5c02c?page=67"> development of the disease. The precise incidence</a> <a title="EMJ - Dermatology page 68" href="http://viewer.zmags.com/publication/17a5c02c?page=68"> respect to patients treated with antibiotics alon</a> <a title="EMJ - Dermatology page 69" href="http://viewer.zmags.com/publication/17a5c02c?page=69"> interfere with a response to therapy or li</a> <a title="EMJ - Dermatology page 70" href="http://viewer.zmags.com/publication/17a5c02c?page=70"> Table 3. Cellulitis mimickers. Site of involvemen</a> <a title="EMJ - Dermatology page 71" href="http://viewer.zmags.com/publication/17a5c02c?page=71"> It is an unusual pathology, due to the exposure t</a> <a title="EMJ - Dermatology page 72" href="http://viewer.zmags.com/publication/17a5c02c?page=72"> Major causative pathogens </a> <a title="EMJ - Dermatology page 73" href="http://viewer.zmags.com/publication/17a5c02c?page=73"> CONCLUSION Cellulitis is an emergency conditi</a> <a title="EMJ - Dermatology page 74" href="http://viewer.zmags.com/publication/17a5c02c?page=74"> 41. Björnsdóttir S et al. Risk factors for </a> <a title="EMJ - Dermatology page 75" href="http://viewer.zmags.com/publication/17a5c02c?page=75"> carcinoma (carcinoma erysipeloides): an easi</a> <a title="EMJ - Dermatology page 76" href="http://viewer.zmags.com/publication/17a5c02c?page=76"> 135. Cohen PR. The skin in the gym: a comprehensi</a> <a title="EMJ - Dermatology page 77" href="http://viewer.zmags.com/publication/17a5c02c?page=77"> From a host of fourteen therapeutical areas, EURO</a> <a title="EMJ - Dermatology page 78" href="http://viewer.zmags.com/publication/17a5c02c?page=78"> PSORIASIS AND COMORBIDITIES Arz</a> <a title="EMJ - Dermatology page 79" href="http://viewer.zmags.com/publication/17a5c02c?page=79"> inflammation, thrombosis and system</a> <a title="EMJ - Dermatology page 80" href="http://viewer.zmags.com/publication/17a5c02c?page=80"> OBESITY AND METABOLIC SYNDROME Recently, a stron</a> <a title="EMJ - Dermatology page 81" href="http://viewer.zmags.com/publication/17a5c02c?page=81"> The underlying pathophysiology lin</a> <a title="EMJ - Dermatology page 82" href="http://viewer.zmags.com/publication/17a5c02c?page=82"> Crohn’s Disease and Ulcerative Colitis Crohn’s di</a> <a title="EMJ - Dermatology page 83" href="http://viewer.zmags.com/publication/17a5c02c?page=83"> 1,080 articles, indicated that there may be</a> <a title="EMJ - Dermatology page 84" href="http://viewer.zmags.com/publication/17a5c02c?page=84"> REFERENCES 1. Raychaudhuri SP, Farber EM. T</a> <a title="EMJ - Dermatology page 85" href="http://viewer.zmags.com/publication/17a5c02c?page=85"> transient ischaemic attack: an inception cohort s</a> <a title="EMJ - Dermatology page 86" href="http://viewer.zmags.com/publication/17a5c02c?page=86"> WHAT’S NEW Simple blood test for a better outcome</a> <a title="EMJ - Dermatology page 87" href="http://viewer.zmags.com/publication/17a5c02c?page=87"> DERMATOLOGY 33-year-old’s skin cancer missed 2 y</a> <a title="EMJ - Dermatology page 88" href="http://viewer.zmags.com/publication/17a5c02c?page=88"> WHAT’S NEW Stricter sunbed regulations needed “</a> <a title="EMJ - Dermatology page 89" href="http://viewer.zmags.com/publication/17a5c02c?page=89"> DERMATOLOGY Combination laser therapy: the answer</a> <a title="EMJ - Dermatology page 90" href="http://viewer.zmags.com/publication/17a5c02c?page=90"> WHAT’S NEW Laser lawsuits on the rise LAWSUITS re</a> <a title="EMJ - Dermatology page 91" href="http://viewer.zmags.com/publication/17a5c02c?page=91"> DERMATOLOGY Radical new therapy involving mice ma</a> <a title="EMJ - Dermatology page 92" href="http://viewer.zmags.com/publication/17a5c02c?page=92"> 3Gen/Dermlite Abacosm Ltd. 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