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<br /> SUBSCRIBE<br /> TO RECEIVE<br /> THE LATEST<br /> PUBLICATIONS<br /> NEWSLETTERS<br /> & UPDATES<br /> FROM A HOST OF 14<br /> THERAPEUTIC AREAS<br /> www.emjreviews.com<br /> If you are interested in submitting a paper<br /> to EMJ, contact editor@emjreviews.com<br /> DERMATOLOGY<br /> ISSN 2054-6211 December 2013 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EADV 2013<br /> Istanbul, Turkey<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 4<br /> CONGRESS REVIEW............................................................................................................................... 10<br /> • Review of the 22nd European Academy of Der<a title="EMJ - Dermatology page 1" href="http://viewer.zmags.com/publication/17a5c02c?page=1"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS NEW</a> <a title="EMJ - Dermatology page 2" href="http://viewer.zmags.com/publication/17a5c02c?page=2"> DERMATOLOGY ISSN 2054-6211 </a> <a title="EMJ - Dermatology page 3" href="http://viewer.zmags.com/publication/17a5c02c?page=3"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ - Dermatology page 4" href="http://viewer.zmags.com/publication/17a5c02c?page=4"> DERMATOLOGY XERODERMA PIGMENTOSUM: A MULTIDISCI</a> <a title="EMJ - Dermatology page 5" href="http://viewer.zmags.com/publication/17a5c02c?page=5"> European Medical Journal Dermatology - De</a> <a title="EMJ - Dermatology page 6" href="http://viewer.zmags.com/publication/17a5c02c?page=6"> Dr Paolo Gisondi Adjunct Professor, Department </a> <a title="EMJ - Dermatology page 7" href="http://viewer.zmags.com/publication/17a5c02c?page=7"> </a> <a title="EMJ - Dermatology page 8" href="http://viewer.zmags.com/publication/17a5c02c?page=8"> Welcome Kelly-Ann Lazarus Editor, European Medica</a> <a title="EMJ - Dermatology page 9" href="http://viewer.zmags.com/publication/17a5c02c?page=9"> IN MILD/MODERATE ADULT ACNE PROVEN</a> <a title="EMJ - Dermatology page 10" href="http://viewer.zmags.com/publication/17a5c02c?page=10"> Foreword Anand Reddi and Prof. Robert P. Dellaval</a> <a title="EMJ - Dermatology page 11" href="http://viewer.zmags.com/publication/17a5c02c?page=11"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 12" href="http://viewer.zmags.com/publication/17a5c02c?page=12"> Welcome to the European Medical Journal review of</a> <a title="EMJ - Dermatology page 13" href="http://viewer.zmags.com/publication/17a5c02c?page=13"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 14" href="http://viewer.zmags.com/publication/17a5c02c?page=14"> “Let it be the city where great minds meet once </a> <a title="EMJ - Dermatology page 15" href="http://viewer.zmags.com/publication/17a5c02c?page=15"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 16" href="http://viewer.zmags.com/publication/17a5c02c?page=16"> New system to detect skin cancer A NEW procedu</a> <a title="EMJ - Dermatology page 17" href="http://viewer.zmags.com/publication/17a5c02c?page=17"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 18" href="http://viewer.zmags.com/publication/17a5c02c?page=18"> Topical treatments for actinic keratosis improve </a> <a title="EMJ - Dermatology page 19" href="http://viewer.zmags.com/publication/17a5c02c?page=19"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 20" href="http://viewer.zmags.com/publication/17a5c02c?page=20"> Extinction of the double chin with ATX-101 “If </a> <a title="EMJ - Dermatology page 21" href="http://viewer.zmags.com/publication/17a5c02c?page=21"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 22" href="http://viewer.zmags.com/publication/17a5c02c?page=22"> Correlation found between psoriasis severity and </a> <a title="EMJ - Dermatology page 23" href="http://viewer.zmags.com/publication/17a5c02c?page=23"> EADV CONGRESS 2013 ICC ISTANBUL CONGRESS CENTER T</a> <a title="EMJ - Dermatology page 24" href="http://viewer.zmags.com/publication/17a5c02c?page=24"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjrevie</a> <a title="EMJ - Dermatology page 25" href="http://viewer.zmags.com/publication/17a5c02c?page=25"> RESISTANCE TO TARGETED THERAPIES IN MELANOMA: </a> <a title="EMJ - Dermatology page 26" href="http://viewer.zmags.com/publication/17a5c02c?page=26"> dabrafenib] MEK inhibitors [trametinib], and thei</a> <a title="EMJ - Dermatology page 27" href="http://viewer.zmags.com/publication/17a5c02c?page=27"> Interestingly, this molecule seems to be equally </a> <a title="EMJ - Dermatology page 28" href="http://viewer.zmags.com/publication/17a5c02c?page=28"> with significant inhibition of migration </a> <a title="EMJ - Dermatology page 29" href="http://viewer.zmags.com/publication/17a5c02c?page=29"> of BRAF (as well as MEK) inhibitors have always b</a> <a title="EMJ - Dermatology page 30" href="http://viewer.zmags.com/publication/17a5c02c?page=30"> Hence, the occurrence of a p53 deficiency o</a> <a title="EMJ - Dermatology page 31" href="http://viewer.zmags.com/publication/17a5c02c?page=31"> PDGFRβ MET-HGF AXIS IGF-1R/FGFR3 UPREGULATION RT</a> <a title="EMJ - Dermatology page 32" href="http://viewer.zmags.com/publication/17a5c02c?page=32"> Activated NRAS NRAS </a> <a title="EMJ - Dermatology page 33" href="http://viewer.zmags.com/publication/17a5c02c?page=33"> A subset of melanoma cells resistant to BR</a> <a title="EMJ - Dermatology page 34" href="http://viewer.zmags.com/publication/17a5c02c?page=34"> MEK inhibitors in both melanoma cells and t</a> <a title="EMJ - Dermatology page 35" href="http://viewer.zmags.com/publication/17a5c02c?page=35"> administration.74,121,122 Similarly, the </a> <a title="EMJ - Dermatology page 36" href="http://viewer.zmags.com/publication/17a5c02c?page=36"> colorectal cancer that is resistant to EGFR monoc</a> <a title="EMJ - Dermatology page 37" href="http://viewer.zmags.com/publication/17a5c02c?page=37"> analyses of patients with metastatic melanoma</a> <a title="EMJ - Dermatology page 38" href="http://viewer.zmags.com/publication/17a5c02c?page=38"> 2008;68:3429-39. 122. Tran MA et al. Targeting V6</a> <a title="EMJ - Dermatology page 39" href="http://viewer.zmags.com/publication/17a5c02c?page=39"> SKIN REACTIONS SECONDARY TO ANTICANCER</a> <a title="EMJ - Dermatology page 40" href="http://viewer.zmags.com/publication/17a5c02c?page=40"> the keratinocyte itself is involved in </a> <a title="EMJ - Dermatology page 41" href="http://viewer.zmags.com/publication/17a5c02c?page=41"> Table 2. Classification of severity of cutaneous a</a> <a title="EMJ - Dermatology page 42" href="http://viewer.zmags.com/publication/17a5c02c?page=42"> dasatinib and nilotinib, frequently cause</a> <a title="EMJ - Dermatology page 43" href="http://viewer.zmags.com/publication/17a5c02c?page=43"> decisions for patients and to choose anti-toxicit</a> <a title="EMJ - Dermatology page 44" href="http://viewer.zmags.com/publication/17a5c02c?page=44"> Nurs. 2001;5:221–33. 29. López E et al. Breast ca</a> <a title="EMJ - Dermatology page 45" href="http://viewer.zmags.com/publication/17a5c02c?page=45"> NAIL CHANGES IN RECENT AND OLD </a> <a title="EMJ - Dermatology page 46" href="http://viewer.zmags.com/publication/17a5c02c?page=46"> PREVALENCE OF NAIL CHANGES IN LEPROSY Limited st</a> <a title="EMJ - Dermatology page 47" href="http://viewer.zmags.com/publication/17a5c02c?page=47"> Neuropathy The main factor is neuropathy,</a> <a title="EMJ - Dermatology page 48" href="http://viewer.zmags.com/publication/17a5c02c?page=48"> phalange. During this process the </a> <a title="EMJ - Dermatology page 49" href="http://viewer.zmags.com/publication/17a5c02c?page=49"> Figure 4. Nail of foot with onychorrhexis. </a> <a title="EMJ - Dermatology page 50" href="http://viewer.zmags.com/publication/17a5c02c?page=50"> increased curvature of the nail plate, eith</a> <a title="EMJ - Dermatology page 51" href="http://viewer.zmags.com/publication/17a5c02c?page=51"> The pittings are staking shaped defects on the su</a> <a title="EMJ - Dermatology page 52" href="http://viewer.zmags.com/publication/17a5c02c?page=52"> Three patients </a> <a title="EMJ - Dermatology page 53" href="http://viewer.zmags.com/publication/17a5c02c?page=53"> of Guizhou Province, Peoples’ Republic of China. </a> <a title="EMJ - Dermatology page 54" href="http://viewer.zmags.com/publication/17a5c02c?page=54"> CALL FOR PAPERS IF YOU ARE INTERESTED IN SUBMITT</a> <a title="EMJ - Dermatology page 55" href="http://viewer.zmags.com/publication/17a5c02c?page=55"> XERODERMA PIGMENTOSUM: A MULTIDISCIPLINARY A</a> <a title="EMJ - Dermatology page 56" href="http://viewer.zmags.com/publication/17a5c02c?page=56"> In 1883, Albert Neisser made the link between XP </a> <a title="EMJ - Dermatology page 57" href="http://viewer.zmags.com/publication/17a5c02c?page=57"> repairs many types of DNA damage including </a> <a title="EMJ - Dermatology page 58" href="http://viewer.zmags.com/publication/17a5c02c?page=58"> DNA strand 5’ and 3’ to repair the damage</a> <a title="EMJ - Dermatology page 59" href="http://viewer.zmags.com/publication/17a5c02c?page=59"> Skin Cancers XP patients have a >10,000-fold </a> <a title="EMJ - Dermatology page 60" href="http://viewer.zmags.com/publication/17a5c02c?page=60"> proteins have an increased susceptibility.23,</a> <a title="EMJ - Dermatology page 61" href="http://viewer.zmags.com/publication/17a5c02c?page=61"> Of the eight genes implicated in XP, mutations in</a> <a title="EMJ - Dermatology page 62" href="http://viewer.zmags.com/publication/17a5c02c?page=62"> cancerous lesions, photographic monitori</a> <a title="EMJ - Dermatology page 63" href="http://viewer.zmags.com/publication/17a5c02c?page=63"> 14. Kraemer KH et al. Five complementation groups</a> <a title="EMJ - Dermatology page 64" href="http://viewer.zmags.com/publication/17a5c02c?page=64"> xeroderma pigmentosum. Brain. 2008;13</a> <a title="EMJ - Dermatology page 65" href="http://viewer.zmags.com/publication/17a5c02c?page=65"> NEW TRENDS IN CELLULITIS Laura Atzori, Franc</a> <a title="EMJ - Dermatology page 66" href="http://viewer.zmags.com/publication/17a5c02c?page=66"> Figure 2. Severe leg cellulitis with vesicles and</a> <a title="EMJ - Dermatology page 67" href="http://viewer.zmags.com/publication/17a5c02c?page=67"> A well-known diffuse and life-threatening conditi</a> <a title="EMJ - Dermatology page 68" href="http://viewer.zmags.com/publication/17a5c02c?page=68"> development of the disease. The precise incidence</a> <a title="EMJ - Dermatology page 69" href="http://viewer.zmags.com/publication/17a5c02c?page=69"> respect to patients treated with antibiotics alon</a> <a title="EMJ - Dermatology page 70" href="http://viewer.zmags.com/publication/17a5c02c?page=70"> interfere with a response to therapy or li</a> <a title="EMJ - Dermatology page 71" href="http://viewer.zmags.com/publication/17a5c02c?page=71"> Table 3. Cellulitis mimickers. Site of involvemen</a> <a title="EMJ - Dermatology page 72" href="http://viewer.zmags.com/publication/17a5c02c?page=72"> It is an unusual pathology, due to the exposure t</a> <a title="EMJ - Dermatology page 73" href="http://viewer.zmags.com/publication/17a5c02c?page=73"> Major causative pathogens </a> <a title="EMJ - Dermatology page 74" href="http://viewer.zmags.com/publication/17a5c02c?page=74"> CONCLUSION Cellulitis is an emergency conditi</a> <a title="EMJ - Dermatology page 75" href="http://viewer.zmags.com/publication/17a5c02c?page=75"> 41. Björnsdóttir S et al. Risk factors for </a> <a title="EMJ - Dermatology page 76" href="http://viewer.zmags.com/publication/17a5c02c?page=76"> carcinoma (carcinoma erysipeloides): an easi</a> <a title="EMJ - Dermatology page 77" href="http://viewer.zmags.com/publication/17a5c02c?page=77"> 135. Cohen PR. The skin in the gym: a comprehensi</a> <a title="EMJ - Dermatology page 78" href="http://viewer.zmags.com/publication/17a5c02c?page=78"> From a host of fourteen therapeutical areas, EURO</a> <a title="EMJ - Dermatology page 79" href="http://viewer.zmags.com/publication/17a5c02c?page=79"> PSORIASIS AND COMORBIDITIES Arz</a> <a title="EMJ - Dermatology page 80" href="http://viewer.zmags.com/publication/17a5c02c?page=80"> inflammation, thrombosis and system</a> <a title="EMJ - Dermatology page 81" href="http://viewer.zmags.com/publication/17a5c02c?page=81"> OBESITY AND METABOLIC SYNDROME Recently, a stron</a> <a title="EMJ - Dermatology page 82" href="http://viewer.zmags.com/publication/17a5c02c?page=82"> The underlying pathophysiology lin</a> <a title="EMJ - Dermatology page 83" href="http://viewer.zmags.com/publication/17a5c02c?page=83"> Crohn’s Disease and Ulcerative Colitis Crohn’s di</a> <a title="EMJ - Dermatology page 84" href="http://viewer.zmags.com/publication/17a5c02c?page=84"> 1,080 articles, indicated that there may be</a> <a title="EMJ - Dermatology page 85" href="http://viewer.zmags.com/publication/17a5c02c?page=85"> REFERENCES 1. Raychaudhuri SP, Farber EM. 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