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<br /> ONCOLOGY<br /> ISSN 2054-619X November 2013 • emjreviews.com<br /> INSIDE<br /> Review of the<br /> European Cancer Congress 2013<br /> Amsterdam, the Netherlands<br /> ECCO-ESMO-ESTRO<br /> NOW LICENSED<br /> A NEW First-Line BRAF Inhibitor<br /> TAFINLAR is indicated in monotherapy for the treatment of adult patients<br /> with unresectable or metastatic melanoma with a BRAF V600 mutation<br /> Before taking TAFINLAR, patients must have confirmation of tumour BRAF V600 mutation using a validated test<br /> Prescribing Information<br /> (Please refer to full SmPC before prescribing)<br /> Tafinlar ® (dabrafenib) 50mg and 75mg capsules. Each capsule contains<br /> dabrafenib mesilate, equivalent to 50mg and 75mg of dabrafenib, respectively.<br /> Indication In monotherapy for adults with unresectable or metastatic melanoma<br /> with a BRAF V600 mutation. Dosage and administration Before<a title="EMJ - Oncology page 1" href="http://viewer.zmags.com/publication/17fce229?page=1"> ONCOLOGY ISSN 2054-619X </a> <a title="EMJ - Oncology page 2" href="http://viewer.zmags.com/publication/17fce229?page=2"> NOW LICENSED A NEW First-Line BRAF Inhibitor </a> <a title="EMJ - Oncology page 3" href="http://viewer.zmags.com/publication/17fce229?page=3"> Treatment with TAFINLAR was proven to significantl</a> <a title="EMJ - Oncology page 4" href="http://viewer.zmags.com/publication/17fce229?page=4"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ - Oncology page 5" href="http://viewer.zmags.com/publication/17fce229?page=5"> ONCOLOGY METASTASIS OF DUCTAL BREAST CARCINOMA </a> <a title="EMJ - Oncology page 6" href="http://viewer.zmags.com/publication/17fce229?page=6"> Editorial Board ONCOLOGY Prof Ross Abrams Prof</a> <a title="EMJ - Oncology page 7" href="http://viewer.zmags.com/publication/17fce229?page=7"> European Medical Journal Oncology - November 2013</a> <a title="EMJ - Oncology page 8" href="http://viewer.zmags.com/publication/17fce229?page=8"> For most metastatic colorectal cancer patients, </a> <a title="EMJ - Oncology page 9" href="http://viewer.zmags.com/publication/17fce229?page=9"> PRESCRIBING INFORMATION Refer to Avastin Summary </a> <a title="EMJ - Oncology page 10" href="http://viewer.zmags.com/publication/17fce229?page=10"> Foreword Prof Bill Heald, CBE </a> <a title="EMJ - Oncology page 11" href="http://viewer.zmags.com/publication/17fce229?page=11"> 1. Basil Morson, Personal communic</a> <a title="EMJ - Oncology page 12" href="http://viewer.zmags.com/publication/17fce229?page=12"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 13" href="http://viewer.zmags.com/publication/17fce229?page=13"> Welcome to the European Medical Journal review of</a> <a title="EMJ - Oncology page 14" href="http://viewer.zmags.com/publication/17fce229?page=14"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 15" href="http://viewer.zmags.com/publication/17fce229?page=15"> cancer screening programmes across th</a> <a title="EMJ - Oncology page 16" href="http://viewer.zmags.com/publication/17fce229?page=16"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 17" href="http://viewer.zmags.com/publication/17fce229?page=17"> Ipilimumab can increase survival rates in melanom</a> <a title="EMJ - Oncology page 18" href="http://viewer.zmags.com/publication/17fce229?page=18"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 19" href="http://viewer.zmags.com/publication/17fce229?page=19"> Diabetics beware: increased risks of breast and c</a> <a title="EMJ - Oncology page 20" href="http://viewer.zmags.com/publication/17fce229?page=20"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 21" href="http://viewer.zmags.com/publication/17fce229?page=21"> Aspirin improves colon cancer survival A CELL-S</a> <a title="EMJ - Oncology page 22" href="http://viewer.zmags.com/publication/17fce229?page=22"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 23" href="http://viewer.zmags.com/publication/17fce229?page=23"> Younger patients are at higher risk of detrimenta</a> <a title="EMJ - Oncology page 24" href="http://viewer.zmags.com/publication/17fce229?page=24"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 25" href="http://viewer.zmags.com/publication/17fce229?page=25"> Paving the way for personalised treatments THE </a> <a title="EMJ - Oncology page 26" href="http://viewer.zmags.com/publication/17fce229?page=26"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 27" href="http://viewer.zmags.com/publication/17fce229?page=27"> Anti-cancer drug T-DM1 may benefit women with adva</a> <a title="EMJ - Oncology page 28" href="http://viewer.zmags.com/publication/17fce229?page=28"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 29" href="http://viewer.zmags.com/publication/17fce229?page=29"> Cediranib improves survival in recurrent ovarian </a> <a title="EMJ - Oncology page 30" href="http://viewer.zmags.com/publication/17fce229?page=30"> ECC CONGRESS 2013 RAI EXHIBITION AND CONVENTION C</a> <a title="EMJ - Oncology page 31" href="http://viewer.zmags.com/publication/17fce229?page=31"> Everolimus: new hope for advanced papillary kidne</a> <a title="EMJ - Oncology page 32" href="http://viewer.zmags.com/publication/17fce229?page=32"> EVIDENCE-BASED TREATMENT PLANNING IN mCRC: </a> <a title="EMJ - Oncology page 33" href="http://viewer.zmags.com/publication/17fce229?page=33"> fluorouracil and oxaliplatin) together with t</a> <a title="EMJ - Oncology page 34" href="http://viewer.zmags.com/publication/17fce229?page=34"> Evidence-Based Treatment Planning </a> <a title="EMJ - Oncology page 35" href="http://viewer.zmags.com/publication/17fce229?page=35"> Dr Gill considered alternative scenarios for</a> <a title="EMJ - Oncology page 36" href="http://viewer.zmags.com/publication/17fce229?page=36"> III study (HORIZON III). J Clin Oncol. 2012</a> <a title="EMJ - Oncology page 37" href="http://viewer.zmags.com/publication/17fce229?page=37"> 38. Sobrero AF. Final results from study metas</a> <a title="EMJ - Oncology page 38" href="http://viewer.zmags.com/publication/17fce229?page=38"> THE FUTURE OF CHRONIC LYMPHOCYTIC LEUKAEMIA </a> <a title="EMJ - Oncology page 39" href="http://viewer.zmags.com/publication/17fce229?page=39"> monotherapy. The results showed that there was no</a> <a title="EMJ - Oncology page 40" href="http://viewer.zmags.com/publication/17fce229?page=40"> to be treated with chemoimmunotherapy</a> <a title="EMJ - Oncology page 41" href="http://viewer.zmags.com/publication/17fce229?page=41"> Table 1. Addition of rituximab to fludarabine and </a> <a title="EMJ - Oncology page 42" href="http://viewer.zmags.com/publication/17fce229?page=42"> A Phase III trial, CLL10 study, of the GCLLSG25 e</a> <a title="EMJ - Oncology page 43" href="http://viewer.zmags.com/publication/17fce229?page=43"> The Economic Burden of CLL Treatment Now and in t</a> <a title="EMJ - Oncology page 44" href="http://viewer.zmags.com/publication/17fce229?page=44"> Table 3. The present drug costs for chroni</a> <a title="EMJ - Oncology page 45" href="http://viewer.zmags.com/publication/17fce229?page=45"> 100 80 Patients (%) 60 40 20 0 Cause </a> <a title="EMJ - Oncology page 46" href="http://viewer.zmags.com/publication/17fce229?page=46"> is known that they simply will not survive</a> <a title="EMJ - Oncology page 47" href="http://viewer.zmags.com/publication/17fce229?page=47"> randomized GCLLSG CLL8 trial. J Clin Oncol. 2012;</a> <a title="EMJ - Oncology page 48" href="http://viewer.zmags.com/publication/17fce229?page=48"> EXTREME HYPOFRACTIONATED IMAGE-GUIDED RADIO</a> <a title="EMJ - Oncology page 49" href="http://viewer.zmags.com/publication/17fce229?page=49"> primary advantage, compared to conventional 3</a> <a title="EMJ - Oncology page 50" href="http://viewer.zmags.com/publication/17fce229?page=50"> where needles remain inserted into the pati</a> <a title="EMJ - Oncology page 51" href="http://viewer.zmags.com/publication/17fce229?page=51"> Table 1. Extreme hypofractionation studies. Autho</a> <a title="EMJ - Oncology page 52" href="http://viewer.zmags.com/publication/17fce229?page=52"> Figure 1.a Figure 1.b </a> <a title="EMJ - Oncology page 53" href="http://viewer.zmags.com/publication/17fce229?page=53"> Right- Lateral (cm) Left + 2.0 1.5 1.0 0.5 0.0 -</a> <a title="EMJ - Oncology page 54" href="http://viewer.zmags.com/publication/17fce229?page=54"> of treatment have been confirmed for volumes</a> <a title="EMJ - Oncology page 55" href="http://viewer.zmags.com/publication/17fce229?page=55"> radiotherapy for localized prostate cancer:</a> <a title="EMJ - Oncology page 56" href="http://viewer.zmags.com/publication/17fce229?page=56"> PROSTATE CANCER AND INFLAMMATION: </a> <a title="EMJ - Oncology page 57" href="http://viewer.zmags.com/publication/17fce229?page=57"> angiogenesis, and evasion from apopto</a> <a title="EMJ - Oncology page 58" href="http://viewer.zmags.com/publication/17fce229?page=58"> pro-inflammatory PDCD4, enhances the production of</a> <a title="EMJ - Oncology page 59" href="http://viewer.zmags.com/publication/17fce229?page=59"> CONCLUDING REMARKS Nowadays it is well-known </a> <a title="EMJ - Oncology page 60" href="http://viewer.zmags.com/publication/17fce229?page=60"> miRNA expression studies published where </a> <a title="EMJ - Oncology page 61" href="http://viewer.zmags.com/publication/17fce229?page=61"> ROLE OF POSITRON EMISSION TOMOGRAPHY WITH FLUO</a> <a title="EMJ - Oncology page 62" href="http://viewer.zmags.com/publication/17fce229?page=62"> receptor expression. In addition, the integr</a> <a title="EMJ - Oncology page 63" href="http://viewer.zmags.com/publication/17fce229?page=63"> significant advantages of FDG PET/CT over bone sci</a> <a title="EMJ - Oncology page 64" href="http://viewer.zmags.com/publication/17fce229?page=64"> FDG PET/CT detected 75% histopathologically- </a> <a title="EMJ - Oncology page 65" href="http://viewer.zmags.com/publication/17fce229?page=65"> Figure 4. A 70-year-old patient with rising PSA l</a> <a title="EMJ - Oncology page 66" href="http://viewer.zmags.com/publication/17fce229?page=66"> NOVEL PET TRACERS FOR PROSTATE CANCER In recent </a> <a title="EMJ - Oncology page 67" href="http://viewer.zmags.com/publication/17fce229?page=67"> 2003;70:311-5. 24. Schoder H et al. 2-[18F]fl</a> <a title="EMJ - Oncology page 68" href="http://viewer.zmags.com/publication/17fce229?page=68"> GENOMIC TESTING IN INTERNATIONAL GUIDELINES Peter</a> <a title="EMJ - Oncology page 69" href="http://viewer.zmags.com/publication/17fce229?page=69"> latest St. Gallen consensus lies in the midst of </a> <a title="EMJ - Oncology page 70" href="http://viewer.zmags.com/publication/17fce229?page=70"> most recently. The authors asserted that to</a> <a title="EMJ - Oncology page 71" href="http://viewer.zmags.com/publication/17fce229?page=71"> Low RS (<18) Intermediate RS (18-30) High RS (≥31</a> <a title="EMJ - Oncology page 72" href="http://viewer.zmags.com/publication/17fce229?page=72"> multigene array. The 21-gene RS was judged to be </a> <a title="EMJ - Oncology page 73" href="http://viewer.zmags.com/publication/17fce229?page=73"> IB and is mentioned as the only multigene array (</a> <a title="EMJ - Oncology page 74" href="http://viewer.zmags.com/publication/17fce229?page=74"> REFERENCES 1. Sorlie T. Gene expression patterns</a> <a title="EMJ - Oncology page 75" href="http://viewer.zmags.com/publication/17fce229?page=75"> AF_RCCM_LANCETONCOLOGY_21x27.pdf 1 11/1/13 </a> <a title="EMJ - Oncology page 76" href="http://viewer.zmags.com/publication/17fce229?page=76"> METASTASIS OF DUCTAL BREAST CARCINOMA TO THE </a> <a title="EMJ - Oncology page 77" href="http://viewer.zmags.com/publication/17fce229?page=77"> Figure 1. Histological examination of the vagina </a> <a title="EMJ - Oncology page 78" href="http://viewer.zmags.com/publication/17fce229?page=78"> Although the diagnosis of this breast tumour was </a> <a title="EMJ - Oncology page 79" href="http://viewer.zmags.com/publication/17fce229?page=79"> Involvement of the bone generally suggests </a> <a title="EMJ - Oncology page 80" href="http://viewer.zmags.com/publication/17fce229?page=80"> NEW CERVICAL CANCER SCREENING GUIDELINES </a> <a title="EMJ - Oncology page 81" href="http://viewer.zmags.com/publication/17fce229?page=81"> the HPV test in screening, and particularly how t</a> <a title="EMJ - Oncology page 82" href="http://viewer.zmags.com/publication/17fce229?page=82"> cannot be used to estimate the effect</a> <a title="EMJ - Oncology page 83" href="http://viewer.zmags.com/publication/17fce229?page=83"> account the impact of vaccinated cohorts on</a> <a title="EMJ - Oncology page 84" href="http://viewer.zmags.com/publication/17fce229?page=84"> A B 6 months cytology HPV- 5yy HPV/ cytology </a> <a title="EMJ - Oncology page 85" href="http://viewer.zmags.com/publication/17fce229?page=85"> Table 1. Synthesis of the recommendations of the </a> <a title="EMJ - Oncology page 86" href="http://viewer.zmags.com/publication/17fce229?page=86"> Table 2. Document conclusions, evidence statement</a> <a title="EMJ - Oncology page 87" href="http://viewer.zmags.com/publication/17fce229?page=87"> Netherlands The Committee concludes </a> <a title="EMJ - Oncology page 88" href="http://viewer.zmags.com/publication/17fce229?page=88"> Looking at the last 20 years of cervical cancer s</a> <a title="EMJ - Oncology page 89" href="http://viewer.zmags.com/publication/17fce229?page=89"> 2011;155(10):687-97. 19. Ronco G et al. Heal</a> <a title="EMJ - Oncology page 90" href="http://viewer.zmags.com/publication/17fce229?page=90"> INTENSITY-MODULATED RADIOTHERAPY IN THE TREATME</a> <a title="EMJ - Oncology page 91" href="http://viewer.zmags.com/publication/17fce229?page=91"> of IMRT is increasingly aimed at generating</a> <a title="EMJ - Oncology page 92" href="http://viewer.zmags.com/publication/17fce229?page=92"> Table 1. Intensity-Modulated Radiotherapy with co</a> <a title="EMJ - Oncology page 93" href="http://viewer.zmags.com/publication/17fce229?page=93"> Table 2. Dose-esclation Intensity-Modulated Radio</a> <a title="EMJ - Oncology page 94" href="http://viewer.zmags.com/publication/17fce229?page=94"> Table 3. Intensity-Modulated Radiotherapy wit</a> <a title="EMJ - Oncology page 95" href="http://viewer.zmags.com/publication/17fce229?page=95"> The dose-limiting toxicities were neutropaeni</a> <a title="EMJ - Oncology page 96" href="http://viewer.zmags.com/publication/17fce229?page=96"> Data of 39 patients with LAPC treated with RT usi</a> <a title="EMJ - Oncology page 97" href="http://viewer.zmags.com/publication/17fce229?page=97"> 9. Fuss M et al. Image-guided intensity- modulate</a> <a title="EMJ - Oncology page 98" href="http://viewer.zmags.com/publication/17fce229?page=98"> KEY ADVANCES IN THE SYSTEMIC THERAPY FOR SOFT TIS</a> <a title="EMJ - Oncology page 99" href="http://viewer.zmags.com/publication/17fce229?page=99"> combination is more active in uterine LMS and und</a> <a title="EMJ - Oncology page 100" href="http://viewer.zmags.com/publication/17fce229?page=100"> subgroup analyses, and was independent of the num</a> <a title="EMJ - Oncology page 101" href="http://viewer.zmags.com/publication/17fce229?page=101"> (8%), and dyspnoea, fatigue, nausea, an</a> <a title="EMJ - Oncology page 102" href="http://viewer.zmags.com/publication/17fce229?page=102"> Table 1. Important ongoing clinical studies in so</a> <a title="EMJ - Oncology page 103" href="http://viewer.zmags.com/publication/17fce229?page=103"> Mifamurtide (Mepact), also known as liposoma</a> <a title="EMJ - Oncology page 104" href="http://viewer.zmags.com/publication/17fce229?page=104"> 18. Demetri GD et al. Results of an intern</a> <a title="EMJ - Oncology page 105" href="http://viewer.zmags.com/publication/17fce229?page=105"> CALL FOR PAPERS IF YOU ARE INTERESTED IN SUBMITT</a> <a title="EMJ - Oncology page 106" href="http://viewer.zmags.com/publication/17fce229?page=106"> YOGA AS TREATMENT FOR INSOMNIA AMONG CANCER PA</a> <a title="EMJ - Oncology page 107" href="http://viewer.zmags.com/publication/17fce229?page=107"> YOGA A Holistic Mind-Body Mode of Exercise Yoga i</a> <a title="EMJ - Oncology page 108" href="http://viewer.zmags.com/publication/17fce229?page=108"> Table 1. Published Phase I-III clinical research </a> <a title="EMJ - Oncology page 109" href="http://viewer.zmags.com/publication/17fce229?page=109"> Sleep NC Measure(s): Pittsburgh Sleep Quality In</a> <a title="EMJ - Oncology page 110" href="http://viewer.zmags.com/publication/17fce229?page=110"> The interventions were deemed safe and </a> <a title="EMJ - Oncology page 111" href="http://viewer.zmags.com/publication/17fce229?page=111"> drift. The yoga prescription in the interve</a> <a title="EMJ - Oncology page 112" href="http://viewer.zmags.com/publication/17fce229?page=112"> Clinicians can provide important information </a> <a title="EMJ - Oncology page 113" href="http://viewer.zmags.com/publication/17fce229?page=113"> Table 3. Examples of exercise contraindications a</a> <a title="EMJ - Oncology page 114" href="http://viewer.zmags.com/publication/17fce229?page=114"> this study and the other smaller Phase I-II studi</a> <a title="EMJ - Oncology page 115" href="http://viewer.zmags.com/publication/17fce229?page=115"> and sleep quality in a randomized trial of the ef</a> <a title="EMJ - Oncology page 116" href="http://viewer.zmags.com/publication/17fce229?page=116"> WHAT’S NEW Innovative organ creation: Another ste</a> <a title="EMJ - Oncology page 117" href="http://viewer.zmags.com/publication/17fce229?page=117"> ONCOLOGY Cancer costs multi-billions to EU “We a</a> <a title="EMJ - Oncology page 118" href="http://viewer.zmags.com/publication/17fce229?page=118"> WHAT’S NEW Internet connects cancer patients CAN</a> <a title="EMJ - Oncology page 119" href="http://viewer.zmags.com/publication/17fce229?page=119"> ONCOLOGY UK PM announces continuation of Cancer D</a> <a title="EMJ - Oncology page 120" href="http://viewer.zmags.com/publication/17fce229?page=120"> WHAT’S NEW Continuity in primary care could accel</a> <a title="EMJ - Oncology page 121" href="http://viewer.zmags.com/publication/17fce229?page=121"> ONCOLOGY Is radiotherapy the way forward for blad</a> <a title="EMJ - Oncology page 122" href="http://viewer.zmags.com/publication/17fce229?page=122"> WHAT’S NEW Blood pressure drug improves effects o</a> <a title="EMJ - Oncology page 123" href="http://viewer.zmags.com/publication/17fce229?page=123"> Conference highlights: </a> <a title="EMJ - Oncology page 124" href="http://viewer.zmags.com/publication/17fce229?page=124"> BUYER’S GUIDE AAAS/Science Agendia Altos Solutio</a> <a title="EMJ - Oncology page 125" href="http://viewer.zmags.com/publication/17fce229?page=125"> OncoDNA OncoGenex Pharmaceuticals, Inc. 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