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<br /> RESPIRATORY<br /> ISSN 2054-3166 Vol 6.1 • November 2018 • europeanmedical-journal.com<br /> INSIDE<br /> Review of<br /> ERS 2018<br /> Paris, France<br /> Contents<br /> EDITORIAL BOARD 4<br /> WELCOME 7<br /> FOREWORD 9<br /> 01 CONGRESS REVIEW<br /> Review of ERS 2018, held in Paris, France, 15th–19th September 2018 12<br /> 02 INTERVIEWS WITH EMJ RESPIRATORY EDITORIAL BOARD<br /> Prof Dr Catharina Belge 27<br /> Dr Neil Holden <a title="EMJ Respiratory 6.1 2018 page 1" href="http://viewer.zmags.com/publication/192c5267?page=1"> RESPIRATORY ISSN 2054-3166 </a> <a title="EMJ Respiratory 6.1 2018 page 2" href="http://viewer.zmags.com/publication/192c5267?page=2"> Contents EDITORIAL BOARD </a> <a title="EMJ Respiratory 6.1 2018 page 3" href="http://viewer.zmags.com/publication/192c5267?page=3"> "A very warm welcome to EMJ Respiratory 6.1, </a> <a title="EMJ Respiratory 6.1 2018 page 4" href="http://viewer.zmags.com/publication/192c5267?page=4"> Editorial Board Editor-in-Chief Dr Antonio Rossi </a> <a title="EMJ Respiratory 6.1 2018 page 5" href="http://viewer.zmags.com/publication/192c5267?page=5"> Aims and Scope The European Medical Journal (EMJ)</a> <a title="EMJ Respiratory 6.1 2018 page 6" href="http://viewer.zmags.com/publication/192c5267?page=6"> EMJ Respir. Chief Executive Officer Spencer Gore </a> <a title="EMJ Respiratory 6.1 2018 page 7" href="http://viewer.zmags.com/publication/192c5267?page=7"> Welcome A very warm welcome to EMJ Respirat</a> <a title="EMJ Respiratory 6.1 2018 page 8" href="http://viewer.zmags.com/publication/192c5267?page=8"> ALPHA 1 ANTITRYPSIN DEFICIENCY (AATD) THERAPIES. </a> <a title="EMJ Respiratory 6.1 2018 page 9" href="http://viewer.zmags.com/publication/192c5267?page=9"> Foreword Dear colleagues and friends, It is my pl</a> <a title="EMJ Respiratory 6.1 2018 page 10" href="http://viewer.zmags.com/publication/192c5267?page=10"> Available now. </a> <a title="EMJ Respiratory 6.1 2018 page 11" href="http://viewer.zmags.com/publication/192c5267?page=11"> Discover inside: Congress Review + Review of </a> <a title="EMJ Respiratory 6.1 2018 page 12" href="http://viewer.zmags.com/publication/192c5267?page=12"> </a> <a title="EMJ Respiratory 6.1 2018 page 13" href="http://viewer.zmags.com/publication/192c5267?page=13"> Congress Review Review of the 28th </a> <a title="EMJ Respiratory 6.1 2018 page 14" href="http://viewer.zmags.com/publication/192c5267?page=14"> The involvement of patients at the congress inclu</a> <a title="EMJ Respiratory 6.1 2018 page 15" href="http://viewer.zmags.com/publication/192c5267?page=15"> Access to Green Space During Childhood is Benefici</a> <a title="EMJ Respiratory 6.1 2018 page 16" href="http://viewer.zmags.com/publication/192c5267?page=16"> Trained Artificial Intelligence More Accurate at D</a> <a title="EMJ Respiratory 6.1 2018 page 17" href="http://viewer.zmags.com/publication/192c5267?page=17"> TLD involves the delivery of radiofrequency </a> <a title="EMJ Respiratory 6.1 2018 page 18" href="http://viewer.zmags.com/publication/192c5267?page=18"> Simple Test Accurately Diagnoses Viral Infections</a> <a title="EMJ Respiratory 6.1 2018 page 19" href="http://viewer.zmags.com/publication/192c5267?page=19"> Paracetamol Use Linked to Increased Asthma Risk T</a> <a title="EMJ Respiratory 6.1 2018 page 20" href="http://viewer.zmags.com/publication/192c5267?page=20"> "As we learn more about the genes involved in ast</a> <a title="EMJ Respiratory 6.1 2018 page 21" href="http://viewer.zmags.com/publication/192c5267?page=21"> indicated that inhaled pollution particles c</a> <a title="EMJ Respiratory 6.1 2018 page 22" href="http://viewer.zmags.com/publication/192c5267?page=22"> The researchers intend to continue to follo</a> <a title="EMJ Respiratory 6.1 2018 page 23" href="http://viewer.zmags.com/publication/192c5267?page=23"> Until now there have been very few studies</a> <a title="EMJ Respiratory 6.1 2018 page 24" href="http://viewer.zmags.com/publication/192c5267?page=24"> "This study shows that Ureaplasma infection is</a> <a title="EMJ Respiratory 6.1 2018 page 25" href="http://viewer.zmags.com/publication/192c5267?page=25"> Macitentan: Safe and Effective for Portopulmonary</a> <a title="EMJ Respiratory 6.1 2018 page 26" href="http://viewer.zmags.com/publication/192c5267?page=26"> Xpert® MTB/RIF Ultra*, Xp</a> <a title="EMJ Respiratory 6.1 2018 page 27" href="http://viewer.zmags.com/publication/192c5267?page=27"> Interviews Hear from the newest members of the</a> <a title="EMJ Respiratory 6.1 2018 page 28" href="http://viewer.zmags.com/publication/192c5267?page=28"> precapillary hypertension such as lung diseases o</a> <a title="EMJ Respiratory 6.1 2018 page 29" href="http://viewer.zmags.com/publication/192c5267?page=29"> What are the biggest challenges in PAH? There is</a> <a title="EMJ Respiratory 6.1 2018 page 30" href="http://viewer.zmags.com/publication/192c5267?page=30"> I happened to be walking down a corridor w</a> <a title="EMJ Respiratory 6.1 2018 page 31" href="http://viewer.zmags.com/publication/192c5267?page=31"> AstraZeneca. Rob was an extremely inclusive super</a> <a title="EMJ Respiratory 6.1 2018 page 32" href="http://viewer.zmags.com/publication/192c5267?page=32"> I think, as an academic, the most importan</a> <a title="EMJ Respiratory 6.1 2018 page 33" href="http://viewer.zmags.com/publication/192c5267?page=33"> Research shows that a huge number of </a> <a title="EMJ Respiratory 6.1 2018 page 34" href="http://viewer.zmags.com/publication/192c5267?page=34"> Dr Joanna Porter @DrJoPorter University College L</a> <a title="EMJ Respiratory 6.1 2018 page 35" href="http://viewer.zmags.com/publication/192c5267?page=35"> the similarities between childhood and adult</a> <a title="EMJ Respiratory 6.1 2018 page 36" href="http://viewer.zmags.com/publication/192c5267?page=36"> in ILD. This will not only ensure that we offer p</a> <a title="EMJ Respiratory 6.1 2018 page 37" href="http://viewer.zmags.com/publication/192c5267?page=37"> Introducing the latest Pulmonary Innovations Cor</a> <a title="EMJ Respiratory 6.1 2018 page 38" href="http://viewer.zmags.com/publication/192c5267?page=38"> Focussing on the Patient: Future P</a> <a title="EMJ Respiratory 6.1 2018 page 39" href="http://viewer.zmags.com/publication/192c5267?page=39"> AATD plans to ensure highly specialised healthcar</a> <a title="EMJ Respiratory 6.1 2018 page 40" href="http://viewer.zmags.com/publication/192c5267?page=40"> follow-up, facilitate patient recruitment </a> <a title="EMJ Respiratory 6.1 2018 page 41" href="http://viewer.zmags.com/publication/192c5267?page=41"> diagnosed,9 with an average delay in diagnosis of</a> <a title="EMJ Respiratory 6.1 2018 page 42" href="http://viewer.zmags.com/publication/192c5267?page=42"> No Lab, No Diagnosis: How to Align Testing</a> <a title="EMJ Respiratory 6.1 2018 page 43" href="http://viewer.zmags.com/publication/192c5267?page=43"> the clinical reality is that weekly trips </a> <a title="EMJ Respiratory 6.1 2018 page 44" href="http://viewer.zmags.com/publication/192c5267?page=44"> Table 1: Pooled data from the RAPID randomised co</a> <a title="EMJ Respiratory 6.1 2018 page 45" href="http://viewer.zmags.com/publication/192c5267?page=45"> (79.9%). Other reasons cited included lack of con</a> <a title="EMJ Respiratory 6.1 2018 page 46" href="http://viewer.zmags.com/publication/192c5267?page=46"> antitrypsin deficiency. Respir Med. 2006;100(3):46</a> <a title="EMJ Respiratory 6.1 2018 page 47" href="http://viewer.zmags.com/publication/192c5267?page=47"> Back to Basics in Asthma and COPD: Optimisin</a> <a title="EMJ Respiratory 6.1 2018 page 48" href="http://viewer.zmags.com/publication/192c5267?page=48"> he explained how the properties of these devices </a> <a title="EMJ Respiratory 6.1 2018 page 49" href="http://viewer.zmags.com/publication/192c5267?page=49"> from the first 8 years have been promising,</a> <a title="EMJ Respiratory 6.1 2018 page 50" href="http://viewer.zmags.com/publication/192c5267?page=50"> The Importance of Inhaler Training Across the spe</a> <a title="EMJ Respiratory 6.1 2018 page 51" href="http://viewer.zmags.com/publication/192c5267?page=51"> Patients (%) 100 90 80 70 60 50 40 30 20 10 </a> <a title="EMJ Respiratory 6.1 2018 page 52" href="http://viewer.zmags.com/publication/192c5267?page=52"> specific genetic, biomarker, phenotypic, o</a> <a title="EMJ Respiratory 6.1 2018 page 53" href="http://viewer.zmags.com/publication/192c5267?page=53"> Summary Professor Mika Mäkelä Disease control </a> <a title="EMJ Respiratory 6.1 2018 page 54" href="http://viewer.zmags.com/publication/192c5267?page=54"> of budesonide/formoterol fumarate Easyhaler® for </a> <a title="EMJ Respiratory 6.1 2018 page 55" href="http://viewer.zmags.com/publication/192c5267?page=55"> State-of-the-Art Session: Respiratory Infections </a> <a title="EMJ Respiratory 6.1 2018 page 56" href="http://viewer.zmags.com/publication/192c5267?page=56"> Current Knowledge Gaps in the Treatment of Bronch</a> <a title="EMJ Respiratory 6.1 2018 page 57" href="http://viewer.zmags.com/publication/192c5267?page=57"> for the treatment of patients with P. aeruginosa </a> <a title="EMJ Respiratory 6.1 2018 page 58" href="http://viewer.zmags.com/publication/192c5267?page=58"> ciliary clearance, which causes neutrophi</a> <a title="EMJ Respiratory 6.1 2018 page 59" href="http://viewer.zmags.com/publication/192c5267?page=59"> that commonly affects patients who do not h</a> <a title="EMJ Respiratory 6.1 2018 page 60" href="http://viewer.zmags.com/publication/192c5267?page=60"> azithromycin, which has shown moderate in vi</a> <a title="EMJ Respiratory 6.1 2018 page 61" href="http://viewer.zmags.com/publication/192c5267?page=61"> management of adult bronchiectasis. Eur Respir J.</a> <a title="EMJ Respiratory 6.1 2018 page 62" href="http://viewer.zmags.com/publication/192c5267?page=62"> Discovering Asthma Paradigms in an Evolving L</a> <a title="EMJ Respiratory 6.1 2018 page 63" href="http://viewer.zmags.com/publication/192c5267?page=63"> needs of patients with uncontrolled persistent as</a> <a title="EMJ Respiratory 6.1 2018 page 64" href="http://viewer.zmags.com/publication/192c5267?page=64"> IL-33 IL-13 Eosinophil TSLP IL-25 ILC2 cell </a> <a title="EMJ Respiratory 6.1 2018 page 65" href="http://viewer.zmags.com/publication/192c5267?page=65"> manifestations of Type 2 inflammatory disease, inc</a> <a title="EMJ Respiratory 6.1 2018 page 66" href="http://viewer.zmags.com/publication/192c5267?page=66"> A B 100 Type 2 inflammation ↑ F</a> <a title="EMJ Respiratory 6.1 2018 page 67" href="http://viewer.zmags.com/publication/192c5267?page=67"> maintain normal activity levels, and minimis</a> <a title="EMJ Respiratory 6.1 2018 page 68" href="http://viewer.zmags.com/publication/192c5267?page=68"> Asthma phenotyping requires consideration o</a> <a title="EMJ Respiratory 6.1 2018 page 69" href="http://viewer.zmags.com/publication/192c5267?page=69"> risk of comorbid Type 2 inflammatory diseases, whi</a> <a title="EMJ Respiratory 6.1 2018 page 70" href="http://viewer.zmags.com/publication/192c5267?page=70"> 31. Whiteley J et al. The burden of atopic </a> <a title="EMJ Respiratory 6.1 2018 page 71" href="http://viewer.zmags.com/publication/192c5267?page=71"> Abstract Reviews Discover the latest research a</a> <a title="EMJ Respiratory 6.1 2018 page 72" href="http://viewer.zmags.com/publication/192c5267?page=72"> Table 1: Outcomes after omalizumab treatment. B</a> <a title="EMJ Respiratory 6.1 2018 page 73" href="http://viewer.zmags.com/publication/192c5267?page=73"> Zn, Ti, Co, Cu, Zr, and Pb (<1.0%); and traces of</a> <a title="EMJ Respiratory 6.1 2018 page 74" href="http://viewer.zmags.com/publication/192c5267?page=74"> Daily Physical Activity in Patients with Severe </a> <a title="EMJ Respiratory 6.1 2018 page 75" href="http://viewer.zmags.com/publication/192c5267?page=75"> In conclusion, this novel study shows significantl</a> <a title="EMJ Respiratory 6.1 2018 page 76" href="http://viewer.zmags.com/publication/192c5267?page=76"> been discharged and always remain at the centre o</a> <a title="EMJ Respiratory 6.1 2018 page 77" href="http://viewer.zmags.com/publication/192c5267?page=77"> Looking to the future, we are excited about the o</a> <a title="EMJ Respiratory 6.1 2018 page 78" href="http://viewer.zmags.com/publication/192c5267?page=78"> were present in 24.19%, and ≥3 comorbidities were</a> <a title="EMJ Respiratory 6.1 2018 page 79" href="http://viewer.zmags.com/publication/192c5267?page=79"> Does Talc Increase Risk of Subsequent Non-</a> <a title="EMJ Respiratory 6.1 2018 page 80" href="http://viewer.zmags.com/publication/192c5267?page=80"> pleural fluid metabolic activity and systemic</a> <a title="EMJ Respiratory 6.1 2018 page 81" href="http://viewer.zmags.com/publication/192c5267?page=81"> References 1. Davies HE et al. Effect of an </a> <a title="EMJ Respiratory 6.1 2018 page 82" href="http://viewer.zmags.com/publication/192c5267?page=82"> when there is little or no pleural fluid present w</a> <a title="EMJ Respiratory 6.1 2018 page 83" href="http://viewer.zmags.com/publication/192c5267?page=83"> <50%.8 Adherence can be improved through mor</a> <a title="EMJ Respiratory 6.1 2018 page 84" href="http://viewer.zmags.com/publication/192c5267?page=84"> chronic obstructive pulmonary disease. Co</a> <a title="EMJ Respiratory 6.1 2018 page 85" href="http://viewer.zmags.com/publication/192c5267?page=85"> prevalence of using inhalers correctly was 31% an</a> <a title="EMJ Respiratory 6.1 2018 page 86" href="http://viewer.zmags.com/publication/192c5267?page=86"> The National Institute for Health and Care Ex</a> <a title="EMJ Respiratory 6.1 2018 page 87" href="http://viewer.zmags.com/publication/192c5267?page=87"> endobronchial valves, namely bronchoscopic lun</a> <a title="EMJ Respiratory 6.1 2018 page 88" href="http://viewer.zmags.com/publication/192c5267?page=88"> Before Zephyr Valve placement </a> <a title="EMJ Respiratory 6.1 2018 page 89" href="http://viewer.zmags.com/publication/192c5267?page=89"> it is very gratifying to have seen the positive </a> <a title="EMJ Respiratory 6.1 2018 page 90" href="http://viewer.zmags.com/publication/192c5267?page=90"> Asthma in Childhood: Current Perspectives </a> <a title="EMJ Respiratory 6.1 2018 page 91" href="http://viewer.zmags.com/publication/192c5267?page=91"> INTRODUCTION Asthma is currently characterised, i</a> <a title="EMJ Respiratory 6.1 2018 page 92" href="http://viewer.zmags.com/publication/192c5267?page=92"> articles consisted of both narrative an</a> <a title="EMJ Respiratory 6.1 2018 page 93" href="http://viewer.zmags.com/publication/192c5267?page=93"> Spirometry is also useful for the assessmen</a> <a title="EMJ Respiratory 6.1 2018 page 94" href="http://viewer.zmags.com/publication/192c5267?page=94"> conducted.31 This study, from the Childhood A</a> <a title="EMJ Respiratory 6.1 2018 page 95" href="http://viewer.zmags.com/publication/192c5267?page=95"> Although the Th2 inflammation hypothesis p</a> <a title="EMJ Respiratory 6.1 2018 page 96" href="http://viewer.zmags.com/publication/192c5267?page=96"> Table 1: Novel biologic therapies currently found</a> <a title="EMJ Respiratory 6.1 2018 page 97" href="http://viewer.zmags.com/publication/192c5267?page=97"> TREATMENT OPTIONS OTHER CURRENT Despite the pros</a> <a title="EMJ Respiratory 6.1 2018 page 98" href="http://viewer.zmags.com/publication/192c5267?page=98"> References 1. Anderson GP. Endotyping asthma</a> <a title="EMJ Respiratory 6.1 2018 page 99" href="http://viewer.zmags.com/publication/192c5267?page=99"> inflammation between mildly allergic 54. asth</a> <a title="EMJ Respiratory 6.1 2018 page 100" href="http://viewer.zmags.com/publication/192c5267?page=100"> Noninvasive Ventilation: Challenges and Pitfalls </a> <a title="EMJ Respiratory 6.1 2018 page 101" href="http://viewer.zmags.com/publication/192c5267?page=101"> patient shows signs of muscle fatigue), NIV is of</a> <a title="EMJ Respiratory 6.1 2018 page 102" href="http://viewer.zmags.com/publication/192c5267?page=102"> ventilator is still in the expiratory phase and i</a> <a title="EMJ Respiratory 6.1 2018 page 103" href="http://viewer.zmags.com/publication/192c5267?page=103"> and a decrease in oxygen diffusion capacity. Appl</a> <a title="EMJ Respiratory 6.1 2018 page 104" href="http://viewer.zmags.com/publication/192c5267?page=104"> invasive ventilation. This leaves increasing FiO </a> <a title="EMJ Respiratory 6.1 2018 page 105" href="http://viewer.zmags.com/publication/192c5267?page=105"> NIV have been shown to have higher tidal v</a> <a title="EMJ Respiratory 6.1 2018 page 106" href="http://viewer.zmags.com/publication/192c5267?page=106"> Box 1: Predictors of noninvasive ventilation fail</a> <a title="EMJ Respiratory 6.1 2018 page 107" href="http://viewer.zmags.com/publication/192c5267?page=107"> 6. Brochard L. Intrinsic (or auto-) </a> <a title="EMJ Respiratory 6.1 2018 page 108" href="http://viewer.zmags.com/publication/192c5267?page=108"> 2015;30(6):1390-4. 48. L'her E et al. Physiologi</a> <a title="EMJ Respiratory 6.1 2018 page 109" href="http://viewer.zmags.com/publication/192c5267?page=109"> Anti-Programmed Death Receptor 1 Signalling I</a> <a title="EMJ Respiratory 6.1 2018 page 110" href="http://viewer.zmags.com/publication/192c5267?page=110"> Herein, the authors summarise the main ongoing re</a> <a title="EMJ Respiratory 6.1 2018 page 111" href="http://viewer.zmags.com/publication/192c5267?page=111"> The concurrent use of anti-PD1/PD-L1 antibodies w</a> <a title="EMJ Respiratory 6.1 2018 page 112" href="http://viewer.zmags.com/publication/192c5267?page=112"> Table 1: Clinical trials of adjuvant anti-program</a> <a title="EMJ Respiratory 6.1 2018 page 113" href="http://viewer.zmags.com/publication/192c5267?page=113"> Table 2: Clinical trials of neoadjuvant anti-prog</a> <a title="EMJ Respiratory 6.1 2018 page 114" href="http://viewer.zmags.com/publication/192c5267?page=114"> In the neoadjuvant setting, some published d</a> <a title="EMJ Respiratory 6.1 2018 page 115" href="http://viewer.zmags.com/publication/192c5267?page=115"> non-small-cell lung cancer (KEYNOTE-010): A rando</a> <a title="EMJ Respiratory 6.1 2018 page 116" href="http://viewer.zmags.com/publication/192c5267?page=116"> 49. Merck Sharp & Dohme Corp. Neoadjuvan</a> <a title="EMJ Respiratory 6.1 2018 page 117" href="http://viewer.zmags.com/publication/192c5267?page=117"> Alternative Exercise and Breathing Intervention</a> <a title="EMJ Respiratory 6.1 2018 page 118" href="http://viewer.zmags.com/publication/192c5267?page=118"> INTRODUCTION Chronic obstructive pulmonary diseas</a> <a title="EMJ Respiratory 6.1 2018 page 119" href="http://viewer.zmags.com/publication/192c5267?page=119"> The purpose of this study was to identify,</a> <a title="EMJ Respiratory 6.1 2018 page 120" href="http://viewer.zmags.com/publication/192c5267?page=120"> Table 2: Description and rationale for alternativ</a> <a title="EMJ Respiratory 6.1 2018 page 121" href="http://viewer.zmags.com/publication/192c5267?page=121"> of 105 participants compared to controls (MD: -3.</a> <a title="EMJ Respiratory 6.1 2018 page 122" href="http://viewer.zmags.com/publication/192c5267?page=122"> Compared to LBE training, WBE improved the endura</a> <a title="EMJ Respiratory 6.1 2018 page 123" href="http://viewer.zmags.com/publication/192c5267?page=123"> be ideal for people with COPD who prefer to exerc</a> <a title="EMJ Respiratory 6.1 2018 page 124" href="http://viewer.zmags.com/publication/192c5267?page=124"> 6–24 weeks duration compared with control (fi</a> <a title="EMJ Respiratory 6.1 2018 page 125" href="http://viewer.zmags.com/publication/192c5267?page=125"> the issue of delivery of the interventions </a> <a title="EMJ Respiratory 6.1 2018 page 126" href="http://viewer.zmags.com/publication/192c5267?page=126"> and New Zealand pulmonary rehabilitation guidelin</a> <a title="EMJ Respiratory 6.1 2018 page 127" href="http://viewer.zmags.com/publication/192c5267?page=127"> 185-92. </a> <a title="EMJ Respiratory 6.1 2018 page 128" href="http://viewer.zmags.com/publication/192c5267?page=128"> Buyer's Guide > 3D SYSTEMS HEALTHCARE > 3M > ACTE</a> <a title="EMJ Respiratory 6.1 2018 page 129" href="http://viewer.zmags.com/publication/192c5267?page=129"> > MEDI-GLOBE GMBH > MEDISOFT > MEDTRONIC > MEHOW </a> <a title="EMJ Respiratory 6.1 2018 page 130" href="http://viewer.zmags.com/publication/192c5267?page=130"> Never miss an update again. J</a>