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<br /> DIABETES<br /> ISSN 2054-6181 Vol 6.1 • November 2018 • europeanmedical-journal.com<br /> INSIDE<br /> Review of<br /> EASD 2018<br /> Berlin, Germany<br /> Contents<br /> EDITORIAL BOARD 4<br /> WELCOME 7<br /> FOREWORD 9<br /> 01 CONGRESS REVIEW<br /> Review of EASD 2018, held in Berlin, Germany, 1st–5th October 2018 12<br /> BUYER'S GUIDE 26<br /> 02 INTERVIEWS WITH EMJ DIABETES EDITORIAL BOARD<br /> Dr Gijs Goossens <a title="EMJ Diabetes 6.1 2018 page 1" href="http://viewer.zmags.com/publication/1f8692ad?page=1"> DIABETES ISSN 2054-6181 </a> <a title="EMJ Diabetes 6.1 2018 page 2" href="http://viewer.zmags.com/publication/1f8692ad?page=2"> Contents EDITORIAL BOARD </a> <a title="EMJ Diabetes 6.1 2018 page 3" href="http://viewer.zmags.com/publication/1f8692ad?page=3"> “The 5-day celebration of the advances made to</a> <a title="EMJ Diabetes 6.1 2018 page 4" href="http://viewer.zmags.com/publication/1f8692ad?page=4"> Editorial Board Editor-in-Chief Prof Jörg Huber </a> <a title="EMJ Diabetes 6.1 2018 page 5" href="http://viewer.zmags.com/publication/1f8692ad?page=5"> Aims and Scope The European Medical Journal (EMJ)</a> <a title="EMJ Diabetes 6.1 2018 page 6" href="http://viewer.zmags.com/publication/1f8692ad?page=6"> EMJ Diabet. Chief Executive Officer Spencer Gore </a> <a title="EMJ Diabetes 6.1 2018 page 7" href="http://viewer.zmags.com/publication/1f8692ad?page=7"> Welcome A very warm welcome to the hotly anticipa</a> <a title="EMJ Diabetes 6.1 2018 page 8" href="http://viewer.zmags.com/publication/1f8692ad?page=8"> A leading partner in the field </a> <a title="EMJ Diabetes 6.1 2018 page 9" href="http://viewer.zmags.com/publication/1f8692ad?page=9"> Foreword Dear colleagues and friends, Welcome to </a> <a title="EMJ Diabetes 6.1 2018 page 10" href="http://viewer.zmags.com/publication/1f8692ad?page=10"> INTRODUCING THE AFINION™ 2 ANALYSER SIMPLY MORE </a> <a title="EMJ Diabetes 6.1 2018 page 11" href="http://viewer.zmags.com/publication/1f8692ad?page=11"> CLINICAL CONFIDENCE IN 3 MINUTES FOR DIABETES. Wi</a> <a title="EMJ Diabetes 6.1 2018 page 12" href="http://viewer.zmags.com/publication/1f8692ad?page=12"> </a> <a title="EMJ Diabetes 6.1 2018 page 13" href="http://viewer.zmags.com/publication/1f8692ad?page=13"> Congress Review Review of the 54</a> <a title="EMJ Diabetes 6.1 2018 page 14" href="http://viewer.zmags.com/publication/1f8692ad?page=14"> the stage to Prof Joachim Spranger, the Ch</a> <a title="EMJ Diabetes 6.1 2018 page 15" href="http://viewer.zmags.com/publication/1f8692ad?page=15"> Updated Guidelines for the Management of Hypergly</a> <a title="EMJ Diabetes 6.1 2018 page 16" href="http://viewer.zmags.com/publication/1f8692ad?page=16"> While these guidelines now represent the most up-</a> <a title="EMJ Diabetes 6.1 2018 page 17" href="http://viewer.zmags.com/publication/1f8692ad?page=17"> "As the vast majority of people with T2DM go thr</a> <a title="EMJ Diabetes 6.1 2018 page 18" href="http://viewer.zmags.com/publication/1f8692ad?page=18"> The authors of the study commented on the importa</a> <a title="EMJ Diabetes 6.1 2018 page 19" href="http://viewer.zmags.com/publication/1f8692ad?page=19"> as possible. “Clinicians should be aware th</a> <a title="EMJ Diabetes 6.1 2018 page 20" href="http://viewer.zmags.com/publication/1f8692ad?page=20"> 20 DIABETES • November 2018 </a> <a title="EMJ Diabetes 6.1 2018 page 21" href="http://viewer.zmags.com/publication/1f8692ad?page=21"> Berliner Dom Landmark in Berli</a> <a title="EMJ Diabetes 6.1 2018 page 22" href="http://viewer.zmags.com/publication/1f8692ad?page=22"> This change to intestinal flora can have a direct </a> <a title="EMJ Diabetes 6.1 2018 page 23" href="http://viewer.zmags.com/publication/1f8692ad?page=23"> The trial included 6,979 patients with T2DM</a> <a title="EMJ Diabetes 6.1 2018 page 24" href="http://viewer.zmags.com/publication/1f8692ad?page=24"> In the 38-week, international, open-label</a> <a title="EMJ Diabetes 6.1 2018 page 25" href="http://viewer.zmags.com/publication/1f8692ad?page=25"> The trial gave rise to a clinically signifi</a> <a title="EMJ Diabetes 6.1 2018 page 26" href="http://viewer.zmags.com/publication/1f8692ad?page=26"> Buyer's Guide > A. MENARINI DIAGNOSTICS SRL ></a> <a title="EMJ Diabetes 6.1 2018 page 27" href="http://viewer.zmags.com/publication/1f8692ad?page=27"> Detect and quantify early signs of sensory neurop</a> <a title="EMJ Diabetes 6.1 2018 page 28" href="http://viewer.zmags.com/publication/1f8692ad?page=28"> Interviews How do the experts approach diabetes</a> <a title="EMJ Diabetes 6.1 2018 page 29" href="http://viewer.zmags.com/publication/1f8692ad?page=29"> tests, and quantify the amount of lipids in the m</a> <a title="EMJ Diabetes 6.1 2018 page 30" href="http://viewer.zmags.com/publication/1f8692ad?page=30"> oxygenation in humans to be able to link this to </a> <a title="EMJ Diabetes 6.1 2018 page 31" href="http://viewer.zmags.com/publication/1f8692ad?page=31"> appreciated the rather informal setting of the an</a> <a title="EMJ Diabetes 6.1 2018 page 32" href="http://viewer.zmags.com/publication/1f8692ad?page=32"> families in their own experiences of diabetes. Wh</a> <a title="EMJ Diabetes 6.1 2018 page 33" href="http://viewer.zmags.com/publication/1f8692ad?page=33"> even in the most difficult of times, as t</a> <a title="EMJ Diabetes 6.1 2018 page 34" href="http://viewer.zmags.com/publication/1f8692ad?page=34"> *When connected*tWo thenincotenrnecttevida taoc</a> <a title="EMJ Diabetes 6.1 2018 page 35" href="http://viewer.zmags.com/publication/1f8692ad?page=35"> Abstract Reviews A selection of insightful, ha</a> <a title="EMJ Diabetes 6.1 2018 page 36" href="http://viewer.zmags.com/publication/1f8692ad?page=36"> defensive eating basis. On the other hand, for no</a> <a title="EMJ Diabetes 6.1 2018 page 37" href="http://viewer.zmags.com/publication/1f8692ad?page=37"> HR was maintained in Zone 2 and 3, rising to Zone</a> <a title="EMJ Diabetes 6.1 2018 page 38" href="http://viewer.zmags.com/publication/1f8692ad?page=38"> and grants from DC-Ingredients Denmark, outside t</a> <a title="EMJ Diabetes 6.1 2018 page 39" href="http://viewer.zmags.com/publication/1f8692ad?page=39"> translate into an increased systemic inflammatory </a> <a title="EMJ Diabetes 6.1 2018 page 40" href="http://viewer.zmags.com/publication/1f8692ad?page=40"> Table 1: Vitamin D levels of all participants in </a> <a title="EMJ Diabetes 6.1 2018 page 41" href="http://viewer.zmags.com/publication/1f8692ad?page=41"> 4. Karohl C et al. Heritability and seasonal v</a> <a title="EMJ Diabetes 6.1 2018 page 42" href="http://viewer.zmags.com/publication/1f8692ad?page=42"> collected from all hospital admissions and o</a> <a title="EMJ Diabetes 6.1 2018 page 43" href="http://viewer.zmags.com/publication/1f8692ad?page=43"> Programme to Dr Amisten and Prof Persaud and a Di</a> <a title="EMJ Diabetes 6.1 2018 page 44" href="http://viewer.zmags.com/publication/1f8692ad?page=44"> In summary, our data reveal that Cxcl14 exhibits </a> <a title="EMJ Diabetes 6.1 2018 page 45" href="http://viewer.zmags.com/publication/1f8692ad?page=45"> variation with Type 2 diabetes mellitus (T2DM) an</a> <a title="EMJ Diabetes 6.1 2018 page 46" href="http://viewer.zmags.com/publication/1f8692ad?page=46"> How Can We Develop More Effective Strategies </a> <a title="EMJ Diabetes 6.1 2018 page 47" href="http://viewer.zmags.com/publication/1f8692ad?page=47"> centric concept has so far failed to emphasise th</a> <a title="EMJ Diabetes 6.1 2018 page 48" href="http://viewer.zmags.com/publication/1f8692ad?page=48"> of multiple risk factors has a major impact on th</a> <a title="EMJ Diabetes 6.1 2018 page 49" href="http://viewer.zmags.com/publication/1f8692ad?page=49"> dysfunction that may explain the progressive</a> <a title="EMJ Diabetes 6.1 2018 page 50" href="http://viewer.zmags.com/publication/1f8692ad?page=50"> Genetic and environmental factors Increase in in</a> <a title="EMJ Diabetes 6.1 2018 page 51" href="http://viewer.zmags.com/publication/1f8692ad?page=51"> A paradigm shift from a glucose-centric</a> <a title="EMJ Diabetes 6.1 2018 page 52" href="http://viewer.zmags.com/publication/1f8692ad?page=52"> 2012;59(3):187-95. 36. Saisho Y et al. Associati</a> <a title="EMJ Diabetes 6.1 2018 page 53" href="http://viewer.zmags.com/publication/1f8692ad?page=53"> Update on the Management of Diabetic Dyslipidae</a> <a title="EMJ Diabetes 6.1 2018 page 54" href="http://viewer.zmags.com/publication/1f8692ad?page=54"> pathways, increased concentrations of fre</a> <a title="EMJ Diabetes 6.1 2018 page 55" href="http://viewer.zmags.com/publication/1f8692ad?page=55"> Predominance of Small, Dense Low-Density Lipoprot</a> <a title="EMJ Diabetes 6.1 2018 page 56" href="http://viewer.zmags.com/publication/1f8692ad?page=56"> filtration rate.20,21 Emerging data suggest t</a> <a title="EMJ Diabetes 6.1 2018 page 57" href="http://viewer.zmags.com/publication/1f8692ad?page=57"> improvements in lipid levels.10,25 Dietary fats a</a> <a title="EMJ Diabetes 6.1 2018 page 58" href="http://viewer.zmags.com/publication/1f8692ad?page=58"> Fibrates reduce hepatic synthesis of VLDL by</a> <a title="EMJ Diabetes 6.1 2018 page 59" href="http://viewer.zmags.com/publication/1f8692ad?page=59"> Table 2: Effects of antidiabetics on lipid levels</a> <a title="EMJ Diabetes 6.1 2018 page 60" href="http://viewer.zmags.com/publication/1f8692ad?page=60"> total cholesterol levels appear to be </a> <a title="EMJ Diabetes 6.1 2018 page 61" href="http://viewer.zmags.com/publication/1f8692ad?page=61"> BMJ. 2002;324(7343):939-42. 20. Wannamethee SG e</a> <a title="EMJ Diabetes 6.1 2018 page 62" href="http://viewer.zmags.com/publication/1f8692ad?page=62"> Efficacy of Wearable Devices to Measure and P</a> <a title="EMJ Diabetes 6.1 2018 page 63" href="http://viewer.zmags.com/publication/1f8692ad?page=63"> of obesity and non-communicable diseases, suc</a> <a title="EMJ Diabetes 6.1 2018 page 64" href="http://viewer.zmags.com/publication/1f8692ad?page=64"> measured sedentary time was unfavourably asso</a> <a title="EMJ Diabetes 6.1 2018 page 65" href="http://viewer.zmags.com/publication/1f8692ad?page=65"> Plotnikoff et al.28 assessed the efficacy of an i</a> <a title="EMJ Diabetes 6.1 2018 page 66" href="http://viewer.zmags.com/publication/1f8692ad?page=66"> was maintained at Week 12 (-24.6 mmHg versus -15.</a> <a title="EMJ Diabetes 6.1 2018 page 67" href="http://viewer.zmags.com/publication/1f8692ad?page=67"> tolerance test; however, the secondary outcome in</a> <a title="EMJ Diabetes 6.1 2018 page 68" href="http://viewer.zmags.com/publication/1f8692ad?page=68"> References 1. Howe KB et al. Gotta catch'em </a> <a title="EMJ Diabetes 6.1 2018 page 69" href="http://viewer.zmags.com/publication/1f8692ad?page=69"> for a randomised controlled trial. BMJ Open. 2017</a> <a title="EMJ Diabetes 6.1 2018 page 70" href="http://viewer.zmags.com/publication/1f8692ad?page=70"> Low-Carbohydrate Diets and Glycaemic Control</a> <a title="EMJ Diabetes 6.1 2018 page 71" href="http://viewer.zmags.com/publication/1f8692ad?page=71"> The latter was hazardous, and patients often succ</a> <a title="EMJ Diabetes 6.1 2018 page 72" href="http://viewer.zmags.com/publication/1f8692ad?page=72"> 2-week crossover trial. Their findings revealed si</a> <a title="EMJ Diabetes 6.1 2018 page 73" href="http://viewer.zmags.com/publication/1f8692ad?page=73"> They found significant reductions in HbA1c (5</a> <a title="EMJ Diabetes 6.1 2018 page 74" href="http://viewer.zmags.com/publication/1f8692ad?page=74"> in low-GI diets compared with carbohydrate e</a> <a title="EMJ Diabetes 6.1 2018 page 75" href="http://viewer.zmags.com/publication/1f8692ad?page=75"> constitute from 45–65% of the total daily c</a> <a title="EMJ Diabetes 6.1 2018 page 76" href="http://viewer.zmags.com/publication/1f8692ad?page=76"> overcorrection when titrating insulin resulti</a> <a title="EMJ Diabetes 6.1 2018 page 77" href="http://viewer.zmags.com/publication/1f8692ad?page=77"> 13. Nielsen JV et al. Low carbohydrate </a> <a title="EMJ Diabetes 6.1 2018 page 78" href="http://viewer.zmags.com/publication/1f8692ad?page=78"> Growth Hormone and Metabolic Homeostasis Author</a> <a title="EMJ Diabetes 6.1 2018 page 79" href="http://viewer.zmags.com/publication/1f8692ad?page=79"> characterised by altered hormone levels, such as </a> <a title="EMJ Diabetes 6.1 2018 page 80" href="http://viewer.zmags.com/publication/1f8692ad?page=80"> which is independent of GHRH and somatostatin. It</a> <a title="EMJ Diabetes 6.1 2018 page 81" href="http://viewer.zmags.com/publication/1f8692ad?page=81"> GH FAK IRSp130Cas CrkllGRB2 SOS SHC</a> <a title="EMJ Diabetes 6.1 2018 page 82" href="http://viewer.zmags.com/publication/1f8692ad?page=82"> family, which includes SOCS-1–7, and cytokine- in</a> <a title="EMJ Diabetes 6.1 2018 page 83" href="http://viewer.zmags.com/publication/1f8692ad?page=83"> glycogenolysis.37 GH induces gluconeogenesis a</a> <a title="EMJ Diabetes 6.1 2018 page 84" href="http://viewer.zmags.com/publication/1f8692ad?page=84"> Insulin resistance is one of the clin</a> <a title="EMJ Diabetes 6.1 2018 page 85" href="http://viewer.zmags.com/publication/1f8692ad?page=85"> patients with poorly controlled diabetes, Press e</a> <a title="EMJ Diabetes 6.1 2018 page 86" href="http://viewer.zmags.com/publication/1f8692ad?page=86"> SUMMARY To summarise, GH plays a complex role in </a> <a title="EMJ Diabetes 6.1 2018 page 87" href="http://viewer.zmags.com/publication/1f8692ad?page=87"> 24. Richardson FG, Young FG. Histology o</a> <a title="EMJ Diabetes 6.1 2018 page 88" href="http://viewer.zmags.com/publication/1f8692ad?page=88"> Proprotein Convertase Subtilisin/Kexin Type 9 In</a> <a title="EMJ Diabetes 6.1 2018 page 89" href="http://viewer.zmags.com/publication/1f8692ad?page=89"> (as a chaperone rather than a catalytic enzyme) a</a> <a title="EMJ Diabetes 6.1 2018 page 90" href="http://viewer.zmags.com/publication/1f8692ad?page=90"> Evolocumab reduced LDL-C by approximately 30% in </a> <a title="EMJ Diabetes 6.1 2018 page 91" href="http://viewer.zmags.com/publication/1f8692ad?page=91"> OVERVIEW OF CLINICAL TRIALS OF PROPROTEIN CONVERT</a> <a title="EMJ Diabetes 6.1 2018 page 92" href="http://viewer.zmags.com/publication/1f8692ad?page=92"> Table 2: Comparison of four meta-analyses on prop</a> <a title="EMJ Diabetes 6.1 2018 page 93" href="http://viewer.zmags.com/publication/1f8692ad?page=93"> Table 3: Safety of anti-proprotein convertase sub</a> <a title="EMJ Diabetes 6.1 2018 page 94" href="http://viewer.zmags.com/publication/1f8692ad?page=94"> had essentially identical side effect profile</a> <a title="EMJ Diabetes 6.1 2018 page 95" href="http://viewer.zmags.com/publication/1f8692ad?page=95"> PCSK9 inhibition has been suggested to have a del</a> <a title="EMJ Diabetes 6.1 2018 page 96" href="http://viewer.zmags.com/publication/1f8692ad?page=96"> References 1. Seidah NG et al. The secretory</a> <a title="EMJ Diabetes 6.1 2018 page 97" href="http://viewer.zmags.com/publication/1f8692ad?page=97"> antibody reduces LDL-cholesterol on top of a stat</a> <a title="EMJ Diabetes 6.1 2018 page 98" href="http://viewer.zmags.com/publication/1f8692ad?page=98"> Never miss an update again. J</a>