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<br /> SUBSCRIBE<br /> TO RECEIVE<br /> THE LATEST<br /> CATIONS <br /> PUBLI<br /> & UPDATES<br /> FROM A HOST OF FIFTEEN <br /> ETTERS <br /> NEWSL<br /> THERAPEUTIC AREAS<br /> If you are interested in submitting a paper<br /> to EMJ, contact editor@emjreviews.com<br /> Follow us:<br /> www.emjreviews.com<br /> <br /> <br /> RHEUMATOLOGY<br /> ISSN 2056-6395 July 2014 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EULAR 2014<br /> Paris, France<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................... 5<br /> CONGRESS REVIEW................................................................................................................................. 10<br /> • Review of the Annual European Congress of Rheumatol<a title="EMJ Rheumatology 2014 page 1" href="http://viewer.zmags.com/publication/23b0a329?page=1"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS PUBLI</a> <a title="EMJ Rheumatology 2014 page 2" href="http://viewer.zmags.com/publication/23b0a329?page=2"> RHEUMATOLOGY ISSN 2056-6395 </a> <a title="EMJ Rheumatology 2014 page 3" href="http://viewer.zmags.com/publication/23b0a329?page=3"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Rheumatology 2014 page 4" href="http://viewer.zmags.com/publication/23b0a329?page=4"> RHEUMATOLOGY UPDATE ON GENETIC SUSCEPTIBILITY </a> <a title="EMJ Rheumatology 2014 page 5" href="http://viewer.zmags.com/publication/23b0a329?page=5"> ACHIEVE BALANCE FROM YOUR RA* BIOLOGIC THERAPY1,2</a> <a title="EMJ Rheumatology 2014 page 6" href="http://viewer.zmags.com/publication/23b0a329?page=6"> Editorial Board Rheumatology Editor-in-Chief: </a> <a title="EMJ Rheumatology 2014 page 7" href="http://viewer.zmags.com/publication/23b0a329?page=7"> A Swiss pharmaceutical company with a focus on re</a> <a title="EMJ Rheumatology 2014 page 8" href="http://viewer.zmags.com/publication/23b0a329?page=8"> Welcome It is with great anticipation that I unve</a> <a title="EMJ Rheumatology 2014 page 9" href="http://viewer.zmags.com/publication/23b0a329?page=9"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjre</a> <a title="EMJ Rheumatology 2014 page 10" href="http://viewer.zmags.com/publication/23b0a329?page=10"> Foreword Dr Ian Chikanza Consultant/Senior Lectur</a> <a title="EMJ Rheumatology 2014 page 11" href="http://viewer.zmags.com/publication/23b0a329?page=11"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 12" href="http://viewer.zmags.com/publication/23b0a329?page=12"> Welcome to the European Medical Journal review of</a> <a title="EMJ Rheumatology 2014 page 13" href="http://viewer.zmags.com/publication/23b0a329?page=13"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 14" href="http://viewer.zmags.com/publication/23b0a329?page=14"> with the Commission in Brussels,” said Prof</a> <a title="EMJ Rheumatology 2014 page 15" href="http://viewer.zmags.com/publication/23b0a329?page=15"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 16" href="http://viewer.zmags.com/publication/23b0a329?page=16"> Could Sjögren’s syndrome cause a heart attack? HE</a> <a title="EMJ Rheumatology 2014 page 17" href="http://viewer.zmags.com/publication/23b0a329?page=17"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 18" href="http://viewer.zmags.com/publication/23b0a329?page=18"> Exercise proved to trample rheumatic disease LOC</a> <a title="EMJ Rheumatology 2014 page 19" href="http://viewer.zmags.com/publication/23b0a329?page=19"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 20" href="http://viewer.zmags.com/publication/23b0a329?page=20"> First biomarkers indicative of osteoarthritis hav</a> <a title="EMJ Rheumatology 2014 page 21" href="http://viewer.zmags.com/publication/23b0a329?page=21"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 22" href="http://viewer.zmags.com/publication/23b0a329?page=22"> One-third of psoriatic arthritis patients miss ou</a> <a title="EMJ Rheumatology 2014 page 23" href="http://viewer.zmags.com/publication/23b0a329?page=23"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 24" href="http://viewer.zmags.com/publication/23b0a329?page=24"> Rheumatoid arthritis patients have a friend in va</a> <a title="EMJ Rheumatology 2014 page 25" href="http://viewer.zmags.com/publication/23b0a329?page=25"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 26" href="http://viewer.zmags.com/publication/23b0a329?page=26"> The costly burden of musculoskeletal conditions </a> <a title="EMJ Rheumatology 2014 page 27" href="http://viewer.zmags.com/publication/23b0a329?page=27"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 28" href="http://viewer.zmags.com/publication/23b0a329?page=28"> Giant cell arteritis, a pain in the head CRANIAL </a> <a title="EMJ Rheumatology 2014 page 29" href="http://viewer.zmags.com/publication/23b0a329?page=29"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 30" href="http://viewer.zmags.com/publication/23b0a329?page=30"> New drug shows significant increase in bone densit</a> <a title="EMJ Rheumatology 2014 page 31" href="http://viewer.zmags.com/publication/23b0a329?page=31"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 32" href="http://viewer.zmags.com/publication/23b0a329?page=32"> CT-P13 shows unparalleled efficacy for biosimilar</a> <a title="EMJ Rheumatology 2014 page 33" href="http://viewer.zmags.com/publication/23b0a329?page=33"> ANNUAL EUROPEAN CONGRESS OF RHEUMATOLOGY 2014 LE </a> <a title="EMJ Rheumatology 2014 page 34" href="http://viewer.zmags.com/publication/23b0a329?page=34"> OSTEOARTHRITIS: THE CHALLENGE OF ESTABLISHI</a> <a title="EMJ Rheumatology 2014 page 35" href="http://viewer.zmags.com/publication/23b0a329?page=35"> Metabolic Syndrome-Associated OA: A New Phenoty</a> <a title="EMJ Rheumatology 2014 page 36" href="http://viewer.zmags.com/publication/23b0a329?page=36"> Obesity conveys a variable risk of OA depending o</a> <a title="EMJ Rheumatology 2014 page 37" href="http://viewer.zmags.com/publication/23b0a329?page=37"> the age of 60. The main symptom is pain, with joi</a> <a title="EMJ Rheumatology 2014 page 38" href="http://viewer.zmags.com/publication/23b0a329?page=38"> meta-analyses that also noted a therapeutic carry</a> <a title="EMJ Rheumatology 2014 page 39" href="http://viewer.zmags.com/publication/23b0a329?page=39"> 1994, there has been one documented case of acute</a> <a title="EMJ Rheumatology 2014 page 40" href="http://viewer.zmags.com/publication/23b0a329?page=40"> Epidemiol. 1992;45:187–95. 17. Rahme E et al.</a> <a title="EMJ Rheumatology 2014 page 41" href="http://viewer.zmags.com/publication/23b0a329?page=41"> INNATE IMMUNITY IN SYSTEMIC SCLEROSIS - ROLE OF T</a> <a title="EMJ Rheumatology 2014 page 42" href="http://viewer.zmags.com/publication/23b0a329?page=42"> Table 1: Toll-like receptor localisation and liga</a> <a title="EMJ Rheumatology 2014 page 43" href="http://viewer.zmags.com/publication/23b0a329?page=43"> regulates DC differentiation, maturation, </a> <a title="EMJ Rheumatology 2014 page 44" href="http://viewer.zmags.com/publication/23b0a329?page=44"> of chemokines.25 Cathelicidins appear </a> <a title="EMJ Rheumatology 2014 page 45" href="http://viewer.zmags.com/publication/23b0a329?page=45"> healthy controls. CCL18 and IL-10 were secreted b</a> <a title="EMJ Rheumatology 2014 page 46" href="http://viewer.zmags.com/publication/23b0a329?page=46"> of DCs, to decrease important inflammato</a> <a title="EMJ Rheumatology 2014 page 47" href="http://viewer.zmags.com/publication/23b0a329?page=47"> development of dendritic cells. Immunol Rev. 2010</a> <a title="EMJ Rheumatology 2014 page 48" href="http://viewer.zmags.com/publication/23b0a329?page=48"> autoantibodies to topoisomerase I: associat</a> <a title="EMJ Rheumatology 2014 page 49" href="http://viewer.zmags.com/publication/23b0a329?page=49"> IDIOPATHIC SCOLIOSIS *Jens Ivar Br</a> <a title="EMJ Rheumatology 2014 page 50" href="http://viewer.zmags.com/publication/23b0a329?page=50"> 36% in dizygotic twins. Despite a number o</a> <a title="EMJ Rheumatology 2014 page 51" href="http://viewer.zmags.com/publication/23b0a329?page=51"> suggest that patients and their parents pre</a> <a title="EMJ Rheumatology 2014 page 52" href="http://viewer.zmags.com/publication/23b0a329?page=52"> Figure 2: Radiographs showing a right convex prim</a> <a title="EMJ Rheumatology 2014 page 53" href="http://viewer.zmags.com/publication/23b0a329?page=53"> Figure 3: Radiographs show juvenile idiopathic sc</a> <a title="EMJ Rheumatology 2014 page 54" href="http://viewer.zmags.com/publication/23b0a329?page=54"> Figure 4: Radiographs that show idiopathic scolio</a> <a title="EMJ Rheumatology 2014 page 55" href="http://viewer.zmags.com/publication/23b0a329?page=55"> scoliosis-specific HRQoL in scoliosis patients</a> <a title="EMJ Rheumatology 2014 page 56" href="http://viewer.zmags.com/publication/23b0a329?page=56"> Med. 2014;50(1):93-110. 35. Negrini S et al. Brac</a> <a title="EMJ Rheumatology 2014 page 57" href="http://viewer.zmags.com/publication/23b0a329?page=57"> OSTEOPOROSIS-RELATED MORTALITY: TIME-TRENDS </a> <a title="EMJ Rheumatology 2014 page 58" href="http://viewer.zmags.com/publication/23b0a329?page=58"> focused on potential risk factors associated with</a> <a title="EMJ Rheumatology 2014 page 59" href="http://viewer.zmags.com/publication/23b0a329?page=59"> pelvis, shoulder). Fractures at the forearm were </a> <a title="EMJ Rheumatology 2014 page 60" href="http://viewer.zmags.com/publication/23b0a329?page=60"> Table 1: Summary of studies addressing mortality </a> <a title="EMJ Rheumatology 2014 page 61" href="http://viewer.zmags.com/publication/23b0a329?page=61"> Table 1 continued. Year Population Follow-up </a> <a title="EMJ Rheumatology 2014 page 62" href="http://viewer.zmags.com/publication/23b0a329?page=62"> Table 2: Summary of studies addressing mortality </a> <a title="EMJ Rheumatology 2014 page 63" href="http://viewer.zmags.com/publication/23b0a329?page=63"> Table 3: Summary of studies addressing mortality </a> <a title="EMJ Rheumatology 2014 page 64" href="http://viewer.zmags.com/publication/23b0a329?page=64"> REFERENCES 1. Johnell O et al. The burden </a> <a title="EMJ Rheumatology 2014 page 65" href="http://viewer.zmags.com/publication/23b0a329?page=65"> 48. Cooper C et al. Population-based study of sur</a> <a title="EMJ Rheumatology 2014 page 66" href="http://viewer.zmags.com/publication/23b0a329?page=66"> USE OF ULTRASOUND FOR DIAGNOSIS AND </a> <a title="EMJ Rheumatology 2014 page 67" href="http://viewer.zmags.com/publication/23b0a329?page=67"> American College of Rheumatology/European L</a> <a title="EMJ Rheumatology 2014 page 68" href="http://viewer.zmags.com/publication/23b0a329?page=68"> A B C p F</a> <a title="EMJ Rheumatology 2014 page 69" href="http://viewer.zmags.com/publication/23b0a329?page=69"> In patients with psoriatic onychopathy, US reveal</a> <a title="EMJ Rheumatology 2014 page 70" href="http://viewer.zmags.com/publication/23b0a329?page=70"> patients’ pain, and global assessment, as well as</a> <a title="EMJ Rheumatology 2014 page 71" href="http://viewer.zmags.com/publication/23b0a329?page=71"> We therefore need a new US composite score</a> <a title="EMJ Rheumatology 2014 page 72" href="http://viewer.zmags.com/publication/23b0a329?page=72"> resonance imaging in the assessment of metacarpop</a> <a title="EMJ Rheumatology 2014 page 73" href="http://viewer.zmags.com/publication/23b0a329?page=73"> on high-frequency ultrasound evaluation of the sk</a> <a title="EMJ Rheumatology 2014 page 74" href="http://viewer.zmags.com/publication/23b0a329?page=74"> UPDATE ON GENETIC SUSCEPTIBILITY AND PAT</a> <a title="EMJ Rheumatology 2014 page 75" href="http://viewer.zmags.com/publication/23b0a329?page=75"> regarding JIA subtypes.6-9 A study using the Utah</a> <a title="EMJ Rheumatology 2014 page 76" href="http://viewer.zmags.com/publication/23b0a329?page=76"> But in the past 5 years, with the use of genome- </a> <a title="EMJ Rheumatology 2014 page 77" href="http://viewer.zmags.com/publication/23b0a329?page=77"> In 2013, the results from the largest gene</a> <a title="EMJ Rheumatology 2014 page 78" href="http://viewer.zmags.com/publication/23b0a329?page=78"> This idea is also supported by the findings</a> <a title="EMJ Rheumatology 2014 page 79" href="http://viewer.zmags.com/publication/23b0a329?page=79"> Table 2 continued. Association Gene region </a> <a title="EMJ Rheumatology 2014 page 80" href="http://viewer.zmags.com/publication/23b0a329?page=80"> Table 3: Genetic variations associated with speci</a> <a title="EMJ Rheumatology 2014 page 81" href="http://viewer.zmags.com/publication/23b0a329?page=81"> To utilise future GWASs, investigating </a> <a title="EMJ Rheumatology 2014 page 82" href="http://viewer.zmags.com/publication/23b0a329?page=82"> trait. Arthritis Rheum. 1999;42(11):2261-8. 6. R</a> <a title="EMJ Rheumatology 2014 page 83" href="http://viewer.zmags.com/publication/23b0a329?page=83"> juvenile idiopathic arthritis susceptibility loci</a> <a title="EMJ Rheumatology 2014 page 84" href="http://viewer.zmags.com/publication/23b0a329?page=84"> efficacy of methotrexate in patients with juvenil</a> <a title="EMJ Rheumatology 2014 page 85" href="http://viewer.zmags.com/publication/23b0a329?page=85"> THE IMPORTANCE OF THE MTOR REGULATORY NETW</a> <a title="EMJ Rheumatology 2014 page 86" href="http://viewer.zmags.com/publication/23b0a329?page=86"> Previous studies have demonstrated that the </a> <a title="EMJ Rheumatology 2014 page 87" href="http://viewer.zmags.com/publication/23b0a329?page=87"> Hypoxia Amino Growth Cell </a> <a title="EMJ Rheumatology 2014 page 88" href="http://viewer.zmags.com/publication/23b0a329?page=88"> decreased A Disintegrin, and Metalloproteinas</a> <a title="EMJ Rheumatology 2014 page 89" href="http://viewer.zmags.com/publication/23b0a329?page=89"> Table 1: Effects of mTOR signalling on chondrocyt</a> <a title="EMJ Rheumatology 2014 page 90" href="http://viewer.zmags.com/publication/23b0a329?page=90"> Table 1 continued. Condition or treatment mTO</a> <a title="EMJ Rheumatology 2014 page 91" href="http://viewer.zmags.com/publication/23b0a329?page=91"> However, proteomic studies in human OA </a> <a title="EMJ Rheumatology 2014 page 92" href="http://viewer.zmags.com/publication/23b0a329?page=92"> Glucosamine is an amino sugar widely used t</a> <a title="EMJ Rheumatology 2014 page 93" href="http://viewer.zmags.com/publication/23b0a329?page=93"> CONCLUSION The importance of mTOR regulation in </a> <a title="EMJ Rheumatology 2014 page 94" href="http://viewer.zmags.com/publication/23b0a329?page=94"> 26. Marcu KB et al. NF-κB signaling: multip</a> <a title="EMJ Rheumatology 2014 page 95" href="http://viewer.zmags.com/publication/23b0a329?page=95"> anabolic and catabolic responses. Am </a> <a title="EMJ Rheumatology 2014 page 96" href="http://viewer.zmags.com/publication/23b0a329?page=96"> 111. Gkretsi V et al. Lipid metabolism and </a> <a title="EMJ Rheumatology 2014 page 97" href="http://viewer.zmags.com/publication/23b0a329?page=97"> WHY BASIC CALCIUM PHOSPHATE CRYSTALS SHOULD BE T</a> <a title="EMJ Rheumatology 2014 page 98" href="http://viewer.zmags.com/publication/23b0a329?page=98"> the clinical and structural characteristics of OA</a> <a title="EMJ Rheumatology 2014 page 99" href="http://viewer.zmags.com/publication/23b0a329?page=99"> this method is difficult to interpret and also st</a> <a title="EMJ Rheumatology 2014 page 100" href="http://viewer.zmags.com/publication/23b0a329?page=100"> in advanced, but also in mild and moderate OA.21 </a> <a title="EMJ Rheumatology 2014 page 101" href="http://viewer.zmags.com/publication/23b0a329?page=101"> of metalloproteinases (TIMP).31-33 BCP crystals </a> <a title="EMJ Rheumatology 2014 page 102" href="http://viewer.zmags.com/publication/23b0a329?page=102"> REFERENCES 1. Murphy LB et al. One in four peopl</a> <a title="EMJ Rheumatology 2014 page 103" href="http://viewer.zmags.com/publication/23b0a329?page=103"> mitogen-activated protein kinase cascade block</a> <a title="EMJ Rheumatology 2014 page 104" href="http://viewer.zmags.com/publication/23b0a329?page=104"> EXTRA-ARTICULAR MANIFESTATIONS OF RHEUM</a> <a title="EMJ Rheumatology 2014 page 105" href="http://viewer.zmags.com/publication/23b0a329?page=105"> studied in numerous RA cohorts. This partly justi</a> <a title="EMJ Rheumatology 2014 page 106" href="http://viewer.zmags.com/publication/23b0a329?page=106"> Table 1: Extra-articular manifestations in rheuma</a> <a title="EMJ Rheumatology 2014 page 107" href="http://viewer.zmags.com/publication/23b0a329?page=107"> This condition is often painless and can evolve t</a> <a title="EMJ Rheumatology 2014 page 108" href="http://viewer.zmags.com/publication/23b0a329?page=108"> or meningitis. Stroke also occurs with increased </a> <a title="EMJ Rheumatology 2014 page 109" href="http://viewer.zmags.com/publication/23b0a329?page=109"> associated with an increased risk of malign</a> <a title="EMJ Rheumatology 2014 page 110" href="http://viewer.zmags.com/publication/23b0a329?page=110"> Although there is some evidence that CV risk in R</a> <a title="EMJ Rheumatology 2014 page 111" href="http://viewer.zmags.com/publication/23b0a329?page=111"> Standard treatment for AA amyloidosis has been ba</a> <a title="EMJ Rheumatology 2014 page 112" href="http://viewer.zmags.com/publication/23b0a329?page=112"> 2010;9:849–52. 29. Nicola PJ et al. The risk of c</a> <a title="EMJ Rheumatology 2014 page 113" href="http://viewer.zmags.com/publication/23b0a329?page=113"> by DMARDS and biologic agents in rheumatoid </a> <a title="EMJ Rheumatology 2014 page 114" href="http://viewer.zmags.com/publication/23b0a329?page=114"> ANTIPHOSPHOLIPID SYNDROME NOVEL THERAPIES </a> <a title="EMJ Rheumatology 2014 page 115" href="http://viewer.zmags.com/publication/23b0a329?page=115"> to phosphatidylserine surfaces; this shield inhib</a> <a title="EMJ Rheumatology 2014 page 116" href="http://viewer.zmags.com/publication/23b0a329?page=116"> SNAPS involve several other antigens th</a> <a title="EMJ Rheumatology 2014 page 117" href="http://viewer.zmags.com/publication/23b0a329?page=117"> MANAGEMENT The management of APS thrombosis cons</a> <a title="EMJ Rheumatology 2014 page 118" href="http://viewer.zmags.com/publication/23b0a329?page=118"> Patients with concomitant autoimmune diseases</a> <a title="EMJ Rheumatology 2014 page 119" href="http://viewer.zmags.com/publication/23b0a329?page=119"> aPL-mediated thrombosis in mice by restoring the </a> <a title="EMJ Rheumatology 2014 page 120" href="http://viewer.zmags.com/publication/23b0a329?page=120"> REFERENCES 1. Harris EN. Syndrome of the black s</a> <a title="EMJ Rheumatology 2014 page 121" href="http://viewer.zmags.com/publication/23b0a329?page=121"> recommendations for the prevention and long-term </a> <a title="EMJ Rheumatology 2014 page 122" href="http://viewer.zmags.com/publication/23b0a329?page=122"> 1996;94(7):1746-51. 82. Asherson RA, Cervera R. 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