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DERMATOLOGY
ISSN 2054-6211 Vol 6.1 • October 2018 • europeanmedical-journal.com
INSIDE
Review of
EADV 2018
Paris, France
Bring balance to your
psoriasis patients
Skilarence®
dimethyl fumarate
Skilarence® is an oral treatment option for moderate-to-severe plaque psoriasis in adults in need of
systemic therapy.1
A cost-effective choice over apremilast that improves quality of life vs. placebo2,3*
Flexible dosing that allows for a balance between ef cacy and tolerability1
A higher drug survival rate with FAEs compared to methotrexate4†
Skilarence 30 mg & 120 mg gastro-resistant tablets Active
Ingredient: Skilarence 30 mg Each gastro-resistant tablet contains
30 mg dimethyl fumarate. Also contains 34.2 mg lactose (as
monohydrate). Skilarence 120 mg Each gastro
DERMATOLOGY ISSN 2054-6211
Bring balance to your psoriasis patients Skil
The only FAE for adults with moderate- t
Contents EDITORIAL BOARD
"A ve
Editorial Board Editor-in-Chief Prof Lawrence F.
Aims and Scope The European Medical Journal (EMJ)
EMJ Dermatol. Chief Executive Officer Spencer Gor
Welcome A very warm welcome to EMJ Dermatology 6.
® The 3D imaging solution for FACE, BREAST, and
Foreword Dear colleagues, Welcome to the latest e
Confidence starts with clearance b oda umab s n
What does PASI 100 mean to Simon? Kyntheum® is a
ME TRO
Congress Review Review of the European
on Saturday, Dr Elisabeth Grice, Philadelphia, Pe
Improving Social Acceptance for Psoriasis Patient
of sun exposure, independent of skin type.
The EADV argues that current regulations do not g
Basilica of the Sacré-Coeur Landma
"The health authorities do not seem to have
M TRO E
The next milestone in the history of the Hôpital
Quality of Life and Psychosocial Issue in Skin Di
Bridging the Gap Nevertheless, Dr Sampogna does b
It is hoped these kinds of initiatives can help p
See the evidence of long-term CONTROL Rapid an
Interviews Delve into the minds of our dermatol
scientific advances cannot be applied to
You recently published a paper on pemphigoid gest
Dr Simone Ribero University of Turin, Italy As
"Sunbed use has been reported to increase
of course. I will quote here Patrice Morel
What do you make of the Australian ‘Slip, Slop, S
How important do you feel congress (JD
PASI 90/100, DLQI 0/1, and IL-17
patients’ perspective on the value of treatment.
83% (lower limbs).6 This reflects what is seen in
These T cells respond to autoantigens that
IL-17A/F heterodimers (and IL-17A homodimers) sig
Interestingly, IL-17C protein levels are ~100-fol
are ambitious enough to help patients achieve thi
as the anchoring variable, it was achieved for ~8
with psoriasis: Results from BE 38.
Navigating the Road to Psoriasis Control in Women
Prof Augustin discussed the significant impac
cycles and natural menopause (multivariate ha
The amount of time physicians spend listening to
Current therapies include topical treatments
first invited to share their experience regarding
Research has been conducted recently on the level
outpatient clinic: Cohort study. BMJ. 2002;325(73
Is Complete Skin Clearance in Psoriasis the Answe
Prof Reich and Prof Bachelez presented key clinic
p40
the p40 subunit and inhibits both IL-12 an
Take Home Message Discussion of the pathogenes
Tildrakizumab Tildrakizumab targets the p19 subun
PASI 90
therapy experience. In patients receiving
(CHAMPION). Br J Dermatol. 2008;158(3):558-66. 7.
IL-23 Inhibition in Psoriasis: Changing the
provide further patient benefit, with focus on the
patients who are affected by psoriasis in d
Modern treatment options provide the
that showed significantly greater ACR 20
IL-23-mediated Th17 pathway.47 In contrast, the
Notably, at the end of the 1-year study, almost h
WATCH THE FULL SYMPOSIUM ONLINE https:/www.youtub
human/003729/WC500183129.pdf. Last accessed: 20 S
From Evolution to Revolution: IL-23 in the Treat
with a maintenance of response in patients with p
allow for the characterisation of a drug’s
by producing IL-22 for as long as 6 years
Finally, in immune surveillance, IL-12 acts
changes in the levels of various members of the
about any long-term effects on these cells,
[IL-23p19/Epstein–Barr virus-induced 3 (Ebi3)] in
Emerging Insights in the Treatment of Psoriasis
Clinical Response After Guselkumab Trea
In VOYAGE 1, 334 patients were initia
To further explore the impact of switching from a
patients in the withdrawal group had PASI 9
work.9 This poster describes the results from a r
guselkumab. Neutropenia was reported in f
Table 1: Gastrointestinal signs and symptoms amon
4. Reich K et al. Efficacy and safety of
Efficacy, Sustainability, and Patient-Reported
Drug Survival is Superior Among Patients Treated
the association between changes in patient-
Absenteeism and presenteeism data through to
using a manually-operated, patient-controlled,
Mean SIAQ scores for ‘feeling abou
Abstract Reviews Learn from the researchers the
This novel procedure may improve the early
The Influence of Itch and Pain on Sleep in Atopic
inflammatory dermatoses such as AD.8 Results sugge
approach is based on treating the underlying mali
Polymorphic Eruption of Pregnancy with Post
The diagnosis of PEP is mostly clinical, based on
age of the female patients was 38.4±13.3 years an
References 1. Zerbinati N et al. Topical imm
lymphocytes around and within the infundibula of
The recognition of EPDS is of utmost importance t
Figure 1: A 27-year-old secundigravid female, 13
A 1,000 Anti-alpha gal IgE Ab levels (UA/mL) 10
METHODS A total of 56 patients who presented at S
Beneath the Skin: The Relationship Between
and altered expression of various chemical signal
CAUSING INFLAMMATION PSYCHOLOGICAL DISTRESS Ther
rely on lower-affinity GR to regulate the HPA axi
depressive symptoms correlates significantly wi
who were exposed to IFN and/or IL-2 showed signifi
Systemic inflammation can cause an activation of
psoriatic population leads to the persistence of
35. Quevedo ME et al. Pleiotropic effects
Psychiatry. 2011;35(3):702-21. 8
A Systematic Review on the Efficacy of Topical
INTRODUCTION Herpes labialis is primarily caused
Articles identified through database searches (N=1
Assessment for Risk of Bias The reviewers evalu
Jensen et al.36 performed a review of oral
30 August 2018. 8. RxList. Denavir. 2013. Avai
Predicting Response to Omalizumab in Chronic Urti
in patients between the ages of 20 and 40 years;
use and work as an objective follow-up tool for p
The ASST is also associated with autoimmune CU
and induces degranulation of mast cells, while eo
levels of clusterin might be useful in predicting
Arch Allergy Immunol. 2017;172(1): 33. 4
Lingual Pustular Psoriasis and Acrodermatitis Co
BACKGROUND Psoriasis is a well-described derm
A B Figure 1: Psoriatic tongue (A) and
Table 1a: Classification of oral psoriasis.13 Cat
often parallels the clinical course of cutaneous
oral lesions that parallel the clinical course of
Systemic use of the immunomodulator m
pustular psoriasis was achieved, with added
Clinical, histopathological, immunohistochemical
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