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<br /> SUBSCRIBE<br /> TO RECEIVE<br /> THE LATEST<br /> PUBLICATIONS<br /> NEWSLETTERS<br /> & UPDATES<br /> FROM A HOST OF 14<br /> THERAPEUTIC AREAS<br /> www.emjreviews.com<br /> If you are interested in submitting a paper<br /> to EMJ, contact editor@emjreviews.com<br /> GASTROENTEROLOGY<br /> ISSN 2054-6203 December 2013 • emjreviews.com<br /> INSIDE<br /> Review of<br /> UEG Week 2013<br /> Berlin, Germany<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 4<br /> CONGRESS REVIEW............................................................................................................................... 8<br /> • Review of the 21st United European Gastroenterology Con<a title="EMJ - Gastroenterology page 1" href="http://viewer.zmags.com/publication/25af39a6?page=1"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS NEW</a> <a title="EMJ - Gastroenterology page 2" href="http://viewer.zmags.com/publication/25af39a6?page=2"> GASTROENTEROLOGY ISSN 2054-6203 </a> <a title="EMJ - Gastroenterology page 3" href="http://viewer.zmags.com/publication/25af39a6?page=3"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ - Gastroenterology page 4" href="http://viewer.zmags.com/publication/25af39a6?page=4"> GASTROENTEROLOGY EFFECTS OF ANTIBIOTIC USE ON T</a> <a title="EMJ - Gastroenterology page 5" href="http://viewer.zmags.com/publication/25af39a6?page=5"> European Medical Journal Gastroenterology</a> <a title="EMJ - Gastroenterology page 6" href="http://viewer.zmags.com/publication/25af39a6?page=6"> Prof Chadli Dziri Head of Medical Staff, </a> <a title="EMJ - Gastroenterology page 7" href="http://viewer.zmags.com/publication/25af39a6?page=7"> Robust protection against recurrent episodes of h</a> <a title="EMJ - Gastroenterology page 8" href="http://viewer.zmags.com/publication/25af39a6?page=8"> Welcome Kelly-Ann Lazarus Editor, European Medica</a> <a title="EMJ - Gastroenterology page 9" href="http://viewer.zmags.com/publication/25af39a6?page=9"> UEG CONGRESS 2013 THE INTERNATIONALES CONGRESS CE</a> <a title="EMJ - Gastroenterology page 10" href="http://viewer.zmags.com/publication/25af39a6?page=10"> Welcome to the European Medical Journal r</a> <a title="EMJ - Gastroenterology page 11" href="http://viewer.zmags.com/publication/25af39a6?page=11"> UEG CONGRESS 2013 THE INTERNATIONALES CONGRESS CE</a> <a title="EMJ - Gastroenterology page 12" href="http://viewer.zmags.com/publication/25af39a6?page=12"> panel discussions and ‘Chat with </a> <a title="EMJ - Gastroenterology page 13" href="http://viewer.zmags.com/publication/25af39a6?page=13"> UEG CONGRESS 2013 THE INTERNATIONALES CONGRESS CE</a> <a title="EMJ - Gastroenterology page 14" href="http://viewer.zmags.com/publication/25af39a6?page=14"> Critical analysis in the diagnosis of alcoholic l</a> <a title="EMJ - Gastroenterology page 15" href="http://viewer.zmags.com/publication/25af39a6?page=15"> UEG CONGRESS 2013 THE INTERNATIONALES CONGRESS CE</a> <a title="EMJ - Gastroenterology page 16" href="http://viewer.zmags.com/publication/25af39a6?page=16"> Cell count can reduce complications after pancrea</a> <a title="EMJ - Gastroenterology page 17" href="http://viewer.zmags.com/publication/25af39a6?page=17"> UEG CONGRESS 2013 THE INTERNATIONALES CONGRESS CE</a> <a title="EMJ - Gastroenterology page 18" href="http://viewer.zmags.com/publication/25af39a6?page=18"> New syndrome non-coeliac gluten sensitivity requi</a> <a title="EMJ - Gastroenterology page 19" href="http://viewer.zmags.com/publication/25af39a6?page=19"> UEG CONGRESS 2013 THE INTERNATIONALES CONGRESS CE</a> <a title="EMJ - Gastroenterology page 20" href="http://viewer.zmags.com/publication/25af39a6?page=20"> Do immunosuppressants increase the risk of skin c</a> <a title="EMJ - Gastroenterology page 21" href="http://viewer.zmags.com/publication/25af39a6?page=21"> TREATMENT OF HEPATIC ENCEPHALOPATHY: TARGETIN</a> <a title="EMJ - Gastroenterology page 22" href="http://viewer.zmags.com/publication/25af39a6?page=22"> Liver injury Hepatic fibrosis Gut dysbiosis Al</a> <a title="EMJ - Gastroenterology page 23" href="http://viewer.zmags.com/publication/25af39a6?page=23"> the result of damage at different levels of the i</a> <a title="EMJ - Gastroenterology page 24" href="http://viewer.zmags.com/publication/25af39a6?page=24"> Impaired bile flow/composition Impaired synth</a> <a title="EMJ - Gastroenterology page 25" href="http://viewer.zmags.com/publication/25af39a6?page=25"> other complications of cirrhosis. However, t</a> <a title="EMJ - Gastroenterology page 26" href="http://viewer.zmags.com/publication/25af39a6?page=26"> Table 1. Systemic haemodynamics, endogenous vasoa</a> <a title="EMJ - Gastroenterology page 27" href="http://viewer.zmags.com/publication/25af39a6?page=27"> Reduce portal H</a> <a title="EMJ - Gastroenterology page 28" href="http://viewer.zmags.com/publication/25af39a6?page=28"> hepatosplenomegaly, no ascites and no peripheral </a> <a title="EMJ - Gastroenterology page 29" href="http://viewer.zmags.com/publication/25af39a6?page=29"> 100 Rifaximin 80 Placebo Patients (%) 60 4</a> <a title="EMJ - Gastroenterology page 30" href="http://viewer.zmags.com/publication/25af39a6?page=30"> not be sufficient to eradicate the bacteria and o</a> <a title="EMJ - Gastroenterology page 31" href="http://viewer.zmags.com/publication/25af39a6?page=31"> STATE-OF-THE-ART TREATMENT OF IRRITABLE BOWEL </a> <a title="EMJ - Gastroenterology page 32" href="http://viewer.zmags.com/publication/25af39a6?page=32"> Table 1. ROME III diagnostic criteria and subtype</a> <a title="EMJ - Gastroenterology page 33" href="http://viewer.zmags.com/publication/25af39a6?page=33"> successfully with loperamide (see below), but has</a> <a title="EMJ - Gastroenterology page 34" href="http://viewer.zmags.com/publication/25af39a6?page=34"> has also been found to be effective for patients </a> <a title="EMJ - Gastroenterology page 35" href="http://viewer.zmags.com/publication/25af39a6?page=35"> Table 3: Primary endpoints specified by the Europe</a> <a title="EMJ - Gastroenterology page 36" href="http://viewer.zmags.com/publication/25af39a6?page=36"> is a nonabsorbable antibiotic that demonstrates n</a> <a title="EMJ - Gastroenterology page 37" href="http://viewer.zmags.com/publication/25af39a6?page=37"> acute pain attacks in patients with irritable bow</a> <a title="EMJ - Gastroenterology page 38" href="http://viewer.zmags.com/publication/25af39a6?page=38"> htm. Accessed 11 November 2011. 47. Tack J et al.</a> <a title="EMJ - Gastroenterology page 39" href="http://viewer.zmags.com/publication/25af39a6?page=39"> 85. van Nood E et al. Fecal microbiota transplant</a> <a title="EMJ - Gastroenterology page 40" href="http://viewer.zmags.com/publication/25af39a6?page=40"> CALL FOR PAPERS IF YOU ARE INTERESTED IN SUBMITT</a> <a title="EMJ - Gastroenterology page 41" href="http://viewer.zmags.com/publication/25af39a6?page=41"> UNDERSTANDING THE PATHOPHYSIOLOGY OF IBS Giovanni</a> <a title="EMJ - Gastroenterology page 42" href="http://viewer.zmags.com/publication/25af39a6?page=42"> history of emotional, physical, and sexual abuse)</a> <a title="EMJ - Gastroenterology page 43" href="http://viewer.zmags.com/publication/25af39a6?page=43"> There is no evidence that bloating is caused by a</a> <a title="EMJ - Gastroenterology page 44" href="http://viewer.zmags.com/publication/25af39a6?page=44"> compared with controls. Increased permeabilit</a> <a title="EMJ - Gastroenterology page 45" href="http://viewer.zmags.com/publication/25af39a6?page=45"> of the gastrointestinal tract acting on receptors</a> <a title="EMJ - Gastroenterology page 46" href="http://viewer.zmags.com/publication/25af39a6?page=46"> motility in irritable bowel syndrome: is IBS a mo</a> <a title="EMJ - Gastroenterology page 47" href="http://viewer.zmags.com/publication/25af39a6?page=47"> gastroenteritis. Gastroenterology. 2010</a> <a title="EMJ - Gastroenterology page 48" href="http://viewer.zmags.com/publication/25af39a6?page=48"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjrevie</a> <a title="EMJ - Gastroenterology page 49" href="http://viewer.zmags.com/publication/25af39a6?page=49"> PRACTICAL EVALUATION AND HANDLING OF PATIENTS </a> <a title="EMJ - Gastroenterology page 50" href="http://viewer.zmags.com/publication/25af39a6?page=50"> When patients are presenting themselves at </a> <a title="EMJ - Gastroenterology page 51" href="http://viewer.zmags.com/publication/25af39a6?page=51"> Patient ID ______________________________________</a> <a title="EMJ - Gastroenterology page 52" href="http://viewer.zmags.com/publication/25af39a6?page=52"> symptom development.24,25,29 This may be </a> <a title="EMJ - Gastroenterology page 53" href="http://viewer.zmags.com/publication/25af39a6?page=53"> facilitate this treatment, which demands a great </a> <a title="EMJ - Gastroenterology page 54" href="http://viewer.zmags.com/publication/25af39a6?page=54"> J Gastroenterol. 2013;48:27-34. 35. Halpert A, Go</a> <a title="EMJ - Gastroenterology page 55" href="http://viewer.zmags.com/publication/25af39a6?page=55"> ENDOSCOPIC OPTICAL ENHANCEMENT TE</a> <a title="EMJ - Gastroenterology page 56" href="http://viewer.zmags.com/publication/25af39a6?page=56"> Consistently, growing efforts have </a> <a title="EMJ - Gastroenterology page 57" href="http://viewer.zmags.com/publication/25af39a6?page=57"> Consistently, several studies have re</a> <a title="EMJ - Gastroenterology page 58" href="http://viewer.zmags.com/publication/25af39a6?page=58"> could detect 4.75-fold more neoplastic lesio</a> <a title="EMJ - Gastroenterology page 59" href="http://viewer.zmags.com/publication/25af39a6?page=59"> with chronic inflammation seen on CLE showed acute</a> <a title="EMJ - Gastroenterology page 60" href="http://viewer.zmags.com/publication/25af39a6?page=60"> for real-time in vivo histology during ongo</a> <a title="EMJ - Gastroenterology page 61" href="http://viewer.zmags.com/publication/25af39a6?page=61"> surveillance in ulcerative colitis. Expert Rev Ga</a> <a title="EMJ - Gastroenterology page 62" href="http://viewer.zmags.com/publication/25af39a6?page=62"> 2012;18(12):2261-9. 73. Kiesslich R et al. L</a> <a title="EMJ - Gastroenterology page 63" href="http://viewer.zmags.com/publication/25af39a6?page=63"> ADHESION MOLECULES AS A THERAPEUTIC </a> <a title="EMJ - Gastroenterology page 64" href="http://viewer.zmags.com/publication/25af39a6?page=64"> signalling molecules participate in media</a> <a title="EMJ - Gastroenterology page 65" href="http://viewer.zmags.com/publication/25af39a6?page=65"> Table 1. Integrins and their receptors. Adhesion </a> <a title="EMJ - Gastroenterology page 66" href="http://viewer.zmags.com/publication/25af39a6?page=66"> adhesion molecules, which are characterised </a> <a title="EMJ - Gastroenterology page 67" href="http://viewer.zmags.com/publication/25af39a6?page=67"> Table 2. Clinical trials involving drugs targetin</a> <a title="EMJ - Gastroenterology page 68" href="http://viewer.zmags.com/publication/25af39a6?page=68"> NCT number; status Completed Completed NC</a> <a title="EMJ - Gastroenterology page 69" href="http://viewer.zmags.com/publication/25af39a6?page=69"> Table 3. Clinical trials involving drugs targetin</a> <a title="EMJ - Gastroenterology page 70" href="http://viewer.zmags.com/publication/25af39a6?page=70"> Completed Completed Completed NCT009286</a> <a title="EMJ - Gastroenterology page 71" href="http://viewer.zmags.com/publication/25af39a6?page=71"> Natalizumab Several placebo-controlled stud</a> <a title="EMJ - Gastroenterology page 72" href="http://viewer.zmags.com/publication/25af39a6?page=72"> a more favourable safety profile; e.g. a blockade </a> <a title="EMJ - Gastroenterology page 73" href="http://viewer.zmags.com/publication/25af39a6?page=73"> 1, ISIS 3082, has been shown to be active</a> <a title="EMJ - Gastroenterology page 74" href="http://viewer.zmags.com/publication/25af39a6?page=74"> 11. Cellier C et al. In-situ endothelial cell adh</a> <a title="EMJ - Gastroenterology page 75" href="http://viewer.zmags.com/publication/25af39a6?page=75"> EFFECTS OF ANTIBIOTIC USE ON THE MICROBIOTA OF </a> <a title="EMJ - Gastroenterology page 76" href="http://viewer.zmags.com/publication/25af39a6?page=76"> composition of the gut microbiota. These studies </a> <a title="EMJ - Gastroenterology page 77" href="http://viewer.zmags.com/publication/25af39a6?page=77"> Importantly, C. difficile can cause a varyi</a> <a title="EMJ - Gastroenterology page 78" href="http://viewer.zmags.com/publication/25af39a6?page=78"> allergies.40,44-46 Furthermore, some relations</a> <a title="EMJ - Gastroenterology page 79" href="http://viewer.zmags.com/publication/25af39a6?page=79"> EFFECTS ON METABOLIC HEALTH The gut microbiota</a> <a title="EMJ - Gastroenterology page 80" href="http://viewer.zmags.com/publication/25af39a6?page=80"> Acknowledgements This work was supported the Span</a> <a title="EMJ - Gastroenterology page 81" href="http://viewer.zmags.com/publication/25af39a6?page=81"> 38. Kuvaeva IB et al. Microecology of the </a> <a title="EMJ - Gastroenterology page 82" href="http://viewer.zmags.com/publication/25af39a6?page=82"> From a host of fourteen therapeutical areas, EURO</a> <a title="EMJ - Gastroenterology page 83" href="http://viewer.zmags.com/publication/25af39a6?page=83"> MANAGING ULCERATIVE COLITIS: THE GUIDELINES AND</a> <a title="EMJ - Gastroenterology page 84" href="http://viewer.zmags.com/publication/25af39a6?page=84"> Left-Sided Disease A combination of oral and </a> <a title="EMJ - Gastroenterology page 85" href="http://viewer.zmags.com/publication/25af39a6?page=85"> Specific treatment New diagnosis Infection? CMV;</a> <a title="EMJ - Gastroenterology page 86" href="http://viewer.zmags.com/publication/25af39a6?page=86"> regarding infliximab contain only a few subjects w</a> <a title="EMJ - Gastroenterology page 87" href="http://viewer.zmags.com/publication/25af39a6?page=87"> However there is little published data that study</a> <a title="EMJ - Gastroenterology page 88" href="http://viewer.zmags.com/publication/25af39a6?page=88"> We strongly recommend that all the above drug tre</a> <a title="EMJ - Gastroenterology page 89" href="http://viewer.zmags.com/publication/25af39a6?page=89"> failed previous glucocorticoid, immunosuppressive</a> <a title="EMJ - Gastroenterology page 90" href="http://viewer.zmags.com/publication/25af39a6?page=90"> 7. Sninsky CA et al. Oral mesalamine (Asaco</a> <a title="EMJ - Gastroenterology page 91" href="http://viewer.zmags.com/publication/25af39a6?page=91"> long-term follow-up of a single-centre cohort. </a> <a title="EMJ - Gastroenterology page 92" href="http://viewer.zmags.com/publication/25af39a6?page=92"> ranging study. Inflamm Bowel Dis. Bowel</a> <a title="EMJ - Gastroenterology page 93" href="http://viewer.zmags.com/publication/25af39a6?page=93"> NON-SURGICAL THERAPY FOR UNRESECTABLE HILAR CHOLA</a> <a title="EMJ - Gastroenterology page 94" href="http://viewer.zmags.com/publication/25af39a6?page=94"> Table 1. The Bismuth-Corlette classification for m</a> <a title="EMJ - Gastroenterology page 95" href="http://viewer.zmags.com/publication/25af39a6?page=95"> PERCUTANEOUS TRANSHEPATIC DRAINAGE VERSUS ENDOTHE</a> <a title="EMJ - Gastroenterology page 96" href="http://viewer.zmags.com/publication/25af39a6?page=96"> mm theoretically offer the optimal condition</a> <a title="EMJ - Gastroenterology page 97" href="http://viewer.zmags.com/publication/25af39a6?page=97"> was not available. Furthermore, patient subgroup </a> <a title="EMJ - Gastroenterology page 98" href="http://viewer.zmags.com/publication/25af39a6?page=98"> Figure 2. Bilateral stenting in a side by </a> <a title="EMJ - Gastroenterology page 99" href="http://viewer.zmags.com/publication/25af39a6?page=99"> Table 3. Studies comparing unilateral placement v</a> <a title="EMJ - Gastroenterology page 100" href="http://viewer.zmags.com/publication/25af39a6?page=100"> REFERENCES 1. Larghi A et al. Management of hila</a> <a title="EMJ - Gastroenterology page 101" href="http://viewer.zmags.com/publication/25af39a6?page=101"> of malignant hilar strictures: the role of liver </a> <a title="EMJ - Gastroenterology page 102" href="http://viewer.zmags.com/publication/25af39a6?page=102"> CALL FOR PAPERS IF YOU ARE INTERESTED IN SUBMITT</a> <a title="EMJ - Gastroenterology page 103" href="http://viewer.zmags.com/publication/25af39a6?page=103"> ENDOSCOPIC NECROSECTOMY AS TREATMENT FOR </a> <a title="EMJ - Gastroenterology page 104" href="http://viewer.zmags.com/publication/25af39a6?page=104"> ENDOSCOPIC NECROSECTOMY Growing Acceptance The i</a> <a title="EMJ - Gastroenterology page 105" href="http://viewer.zmags.com/publication/25af39a6?page=105"> Figure 3. Internal endoscopic aspect of the cavit</a> <a title="EMJ - Gastroenterology page 106" href="http://viewer.zmags.com/publication/25af39a6?page=106"> • cholecystectomy after biliary pancreati</a> <a title="EMJ - Gastroenterology page 107" href="http://viewer.zmags.com/publication/25af39a6?page=107"> THE VERSATILE ROLE OF THE VAGUS NERVE IN THE </a> <a title="EMJ - Gastroenterology page 108" href="http://viewer.zmags.com/publication/25af39a6?page=108"> vagus, respectively.1,5,6 However, one has to kee</a> <a title="EMJ - Gastroenterology page 109" href="http://viewer.zmags.com/publication/25af39a6?page=109"> Electrophysiological studies have confirm</a> <a title="EMJ - Gastroenterology page 110" href="http://viewer.zmags.com/publication/25af39a6?page=110"> Indeed, the administration of specific CCK-A </a> <a title="EMJ - Gastroenterology page 111" href="http://viewer.zmags.com/publication/25af39a6?page=111"> circumventricular organs [CVO]) that are devoid o</a> <a title="EMJ - Gastroenterology page 112" href="http://viewer.zmags.com/publication/25af39a6?page=112"> REFERENCES 1. Drake RL et al. Gray’s atlas of an</a> <a title="EMJ - Gastroenterology page 113" href="http://viewer.zmags.com/publication/25af39a6?page=113"> 46. Berthoud HR et al. Vagal afferent innervation</a> <a title="EMJ - Gastroenterology page 114" href="http://viewer.zmags.com/publication/25af39a6?page=114"> Trauma. 2011;70(5):1168-75; discussion 75- 6. 91.</a> <a title="EMJ - Gastroenterology page 115" href="http://viewer.zmags.com/publication/25af39a6?page=115"> J Clin Invest. 2008;118(6):2209-18. 133. Rosas-B</a> <a title="EMJ - Gastroenterology page 116" href="http://viewer.zmags.com/publication/25af39a6?page=116"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjrevie</a> <a title="EMJ - Gastroenterology page 117" href="http://viewer.zmags.com/publication/25af39a6?page=117"> A REVIEW OF CROHN’S DISEASE Phi</a> <a title="EMJ - Gastroenterology page 118" href="http://viewer.zmags.com/publication/25af39a6?page=118"> of their Crohn’s disease.3,4 Rates in the </a> <a title="EMJ - Gastroenterology page 119" href="http://viewer.zmags.com/publication/25af39a6?page=119"> Microbiome The microbiome consists of </a> <a title="EMJ - Gastroenterology page 120" href="http://viewer.zmags.com/publication/25af39a6?page=120"> (azathioprine is known to increase the risk</a> <a title="EMJ - Gastroenterology page 121" href="http://viewer.zmags.com/publication/25af39a6?page=121"> Standard abdominal radiography is useful for</a> <a title="EMJ - Gastroenterology page 122" href="http://viewer.zmags.com/publication/25af39a6?page=122"> Table 2. Clinical, endoscopic, and laboratory pre</a> <a title="EMJ - Gastroenterology page 123" href="http://viewer.zmags.com/publication/25af39a6?page=123"> an anti-metabolite, is used in Crohn’s dise</a> <a title="EMJ - Gastroenterology page 124" href="http://viewer.zmags.com/publication/25af39a6?page=124"> 5. Ahuja V, Tandon RK. Inflammatory bowel dis</a> <a title="EMJ - Gastroenterology page 125" href="http://viewer.zmags.com/publication/25af39a6?page=125"> WHAT’S NEW EUROPEAN CHMP SUPPORTS APPROVAL OF GIL</a> <a title="EMJ - Gastroenterology page 126" href="http://viewer.zmags.com/publication/25af39a6?page=126"> GASTROENTEROLOGY based on t</a> <a title="EMJ - Gastroenterology page 127" href="http://viewer.zmags.com/publication/25af39a6?page=127"> WHAT’S NEW A coffee a day keeps liver cancer away</a> <a title="EMJ - Gastroenterology page 128" href="http://viewer.zmags.com/publication/25af39a6?page=128"> GASTROENTEROLOGY Surgery not always the solution</a> <a title="EMJ - Gastroenterology page 129" href="http://viewer.zmags.com/publication/25af39a6?page=129"> WHAT’S NEW The key to intestinal health - HDAC3 </a> <a title="EMJ - Gastroenterology page 130" href="http://viewer.zmags.com/publication/25af39a6?page=130"> GASTROENTEROLOGY Butyrate: a positive influence f</a> <a title="EMJ - Gastroenterology page 131" href="http://viewer.zmags.com/publication/25af39a6?page=131"> WHAT’S NEW Specialists could save the lives of bo</a> <a title="EMJ - Gastroenterology page 132" href="http://viewer.zmags.com/publication/25af39a6?page=132"> GASTROENTEROLOGY Is there a link between autism a</a> <a title="EMJ - Gastroenterology page 133" href="http://viewer.zmags.com/publication/25af39a6?page=133"> WHAT’S NEW Is screening to detect coeliac disease</a> <a title="EMJ - Gastroenterology page 134" href="http://viewer.zmags.com/publication/25af39a6?page=134"> GASTROENTEROLOGY Colon cancer linked with gut ba</a> <a title="EMJ - Gastroenterology page 135" href="http://viewer.zmags.com/publication/25af39a6?page=135"> Abbott Products Operations AG Abbvie ACTIAL FARMA</a> <a title="EMJ - Gastroenterology page 136" href="http://viewer.zmags.com/publication/25af39a6?page=136"> Leufen Medical GmbH Life Partners Europe M.I. 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