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<br /> HEPATOLOGY<br /> ISSN 2053-4221 Vol 3.2 • June 2015 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ILC 2015<br /> Vienna, Austria<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 4<br /> CONGRESS REVIEW........................................................................................................................................ 12<br /> • Review of the International Liver Congress™ held in Vienna, Austria,<br /> 22nd-26th April 2015<br /> INTERVIEWS WITH EMJ HEPATOLOGY EDITORIAL BOARD............................................... 28<br /> • Dhiraj Tripathi<br /> • Daniele Prati<br /> • Jean-Francois Dufour<br /> • Cecília Rodrigues<br /> • Helen Reeves<br /> • Marina Berenguer<br /> 2<br /> HEPATOLOGY • June 2015 <a title="EMJ Hepatology 3.2 2015 page 1" href="http://viewer.zmags.com/publication/27f0f068?page=1"> HEPATOLOGY ISSN 2053-4221 </a> <a title="EMJ Hepatology 3.2 2015 page 2" href="http://viewer.zmags.com/publication/27f0f068?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Hepatology 3.2 2015 page 3" href="http://viewer.zmags.com/publication/27f0f068?page=3"> HEPATOLOGY SYMPOSIUM REVIEWS • CONQUERING C — </a> <a title="EMJ Hepatology 3.2 2015 page 4" href="http://viewer.zmags.com/publication/27f0f068?page=4"> Editorial Board Editor-in-Chief: Prof Dr M</a> <a title="EMJ Hepatology 3.2 2015 page 5" href="http://viewer.zmags.com/publication/27f0f068?page=5"> Hepatology Prof Jean-Francois Dufour, Clinic </a> <a title="EMJ Hepatology 3.2 2015 page 6" href="http://viewer.zmags.com/publication/27f0f068?page=6"> European Medical Journal EMJ Hepatology Vol 3.2</a> <a title="EMJ Hepatology 3.2 2015 page 7" href="http://viewer.zmags.com/publication/27f0f068?page=7"> Welcome Hello and welcome to this year’s secon</a> <a title="EMJ Hepatology 3.2 2015 page 8" href="http://viewer.zmags.com/publication/27f0f068?page=8"> Vital Therapies® Seeks Subjects for ELAD® Clinica</a> <a title="EMJ Hepatology 3.2 2015 page 9" href="http://viewer.zmags.com/publication/27f0f068?page=9"> Foreword Prof Markus Peck-Radosavljevic </a> <a title="EMJ Hepatology 3.2 2015 page 10" href="http://viewer.zmags.com/publication/27f0f068?page=10"> Available Now EMJ Hepatology 3.1 20</a> <a title="EMJ Hepatology 3.2 2015 page 11" href="http://viewer.zmags.com/publication/27f0f068?page=11"> Editor's Pick: Non-Alcoholic Fatty Liver Disease </a> <a title="EMJ Hepatology 3.2 2015 page 12" href="http://viewer.zmags.com/publication/27f0f068?page=12"> ILC ANNUAL CONGRESS 2015 MESSE CONFERENCE CENTRE</a> <a title="EMJ Hepatology 3.2 2015 page 13" href="http://viewer.zmags.com/publication/27f0f068?page=13"> Welcome to the European Medical Journal re</a> <a title="EMJ Hepatology 3.2 2015 page 14" href="http://viewer.zmags.com/publication/27f0f068?page=14"> ILC ANNUAL CONGRESS 2015 “EASL was founded 50 ye</a> <a title="EMJ Hepatology 3.2 2015 page 15" href="http://viewer.zmags.com/publication/27f0f068?page=15"> H IGHLIGHTS who had already been </a> <a title="EMJ Hepatology 3.2 2015 page 16" href="http://viewer.zmags.com/publication/27f0f068?page=16"> ILC ANNUAL CONGRESS 2015 HCV Patients at Higher R</a> <a title="EMJ Hepatology 3.2 2015 page 17" href="http://viewer.zmags.com/publication/27f0f068?page=17"> “These results show that AUDs are a much more acc</a> <a title="EMJ Hepatology 3.2 2015 page 18" href="http://viewer.zmags.com/publication/27f0f068?page=18"> ILC ANNUAL CONGRESS 2015 The resu</a> <a title="EMJ Hepatology 3.2 2015 page 19" href="http://viewer.zmags.com/publication/27f0f068?page=19"> RBV was 100% and 96.6% after 12 and 24 weeks, </a> <a title="EMJ Hepatology 3.2 2015 page 20" href="http://viewer.zmags.com/publication/27f0f068?page=20"> ILC ANNUAL CONGRESS 2015 According to prel</a> <a title="EMJ Hepatology 3.2 2015 page 21" href="http://viewer.zmags.com/publication/27f0f068?page=21"> recorded in treatment-experienced GT2 patients</a> <a title="EMJ Hepatology 3.2 2015 page 22" href="http://viewer.zmags.com/publication/27f0f068?page=22"> ILC ANNUAL CONGRESS 2015 Liraglutide Successful i</a> <a title="EMJ Hepatology 3.2 2015 page 23" href="http://viewer.zmags.com/publication/27f0f068?page=23"> “Not only are people dealing with the illness, it</a> <a title="EMJ Hepatology 3.2 2015 page 24" href="http://viewer.zmags.com/publication/27f0f068?page=24"> ILC ANNUAL CONGRESS 2015 EASL is celebrating the</a> <a title="EMJ Hepatology 3.2 2015 page 25" href="http://viewer.zmags.com/publication/27f0f068?page=25"> with HCC once the cancer is at an advanced stage</a> <a title="EMJ Hepatology 3.2 2015 page 26" href="http://viewer.zmags.com/publication/27f0f068?page=26"> ILC ANNUAL CONGRESS 2015 “The weight of alcohol b</a> <a title="EMJ Hepatology 3.2 2015 page 27" href="http://viewer.zmags.com/publication/27f0f068?page=27"> 18th ECCO - 40th ESMO E</a> <a title="EMJ Hepatology 3.2 2015 page 28" href="http://viewer.zmags.com/publication/27f0f068?page=28"> EDITORIAL BOARD INTERVIEWS </a> <a title="EMJ Hepatology 3.2 2015 page 29" href="http://viewer.zmags.com/publication/27f0f068?page=29"> The greatest success has been the STOPAH NI</a> <a title="EMJ Hepatology 3.2 2015 page 30" href="http://viewer.zmags.com/publication/27f0f068?page=30"> EDITORIAL BOARD INTERVIEWS been published in Gut</a> <a title="EMJ Hepatology 3.2 2015 page 31" href="http://viewer.zmags.com/publication/27f0f068?page=31"> Q: With so much migration to and within Europe in</a> <a title="EMJ Hepatology 3.2 2015 page 32" href="http://viewer.zmags.com/publication/27f0f068?page=32"> EDITORIAL BOARD INTERVIEWS Q: Are there any othe</a> <a title="EMJ Hepatology 3.2 2015 page 33" href="http://viewer.zmags.com/publication/27f0f068?page=33"> A: Certainly! The Milan criteria have been </a> <a title="EMJ Hepatology 3.2 2015 page 34" href="http://viewer.zmags.com/publication/27f0f068?page=34"> EDITORIAL BOARD INTERVIEWS political bodies. P</a> <a title="EMJ Hepatology 3.2 2015 page 35" href="http://viewer.zmags.com/publication/27f0f068?page=35"> Q: You recently co-authored an article showing ho</a> <a title="EMJ Hepatology 3.2 2015 page 36" href="http://viewer.zmags.com/publication/27f0f068?page=36"> EDITORIAL BOARD INTERVIEWS Q: How important </a> <a title="EMJ Hepatology 3.2 2015 page 37" href="http://viewer.zmags.com/publication/27f0f068?page=37"> United States as a postdoctoral scientist, and wa</a> <a title="EMJ Hepatology 3.2 2015 page 38" href="http://viewer.zmags.com/publication/27f0f068?page=38"> EDITORIAL BOARD INTERVIEWS “I want to deliver nov</a> <a title="EMJ Hepatology 3.2 2015 page 39" href="http://viewer.zmags.com/publication/27f0f068?page=39"> efficiency and trying to communicate effectively.</a> <a title="EMJ Hepatology 3.2 2015 page 40" href="http://viewer.zmags.com/publication/27f0f068?page=40"> EDITORIAL BOARD INTERVIEWS Q: Would you like to </a> <a title="EMJ Hepatology 3.2 2015 page 41" href="http://viewer.zmags.com/publication/27f0f068?page=41"> </a> <a title="EMJ Hepatology 3.2 2015 page 42" href="http://viewer.zmags.com/publication/27f0f068?page=42"> CONQUERING C – GOING BEYOND CURE Summary of prese</a> <a title="EMJ Hepatology 3.2 2015 page 43" href="http://viewer.zmags.com/publication/27f0f068?page=43"> a patient population that can have heterogeneous </a> <a title="EMJ Hepatology 3.2 2015 page 44" href="http://viewer.zmags.com/publication/27f0f068?page=44"> Table 1: Treatment prioritisation of patients wit</a> <a title="EMJ Hepatology 3.2 2015 page 45" href="http://viewer.zmags.com/publication/27f0f068?page=45"> 1a) both with and without cirrhosis, with studies</a> <a title="EMJ Hepatology 3.2 2015 page 46" href="http://viewer.zmags.com/publication/27f0f068?page=46"> with SVR was also shown in cirrhotic GT1 patients</a> <a title="EMJ Hepatology 3.2 2015 page 47" href="http://viewer.zmags.com/publication/27f0f068?page=47"> Table 2: A summary of the possible drug–dr</a> <a title="EMJ Hepatology 3.2 2015 page 48" href="http://viewer.zmags.com/publication/27f0f068?page=48"> treated with LDV/SOF with or without RBV, as well</a> <a title="EMJ Hepatology 3.2 2015 page 49" href="http://viewer.zmags.com/publication/27f0f068?page=49"> a heterogenous population of patients c</a> <a title="EMJ Hepatology 3.2 2015 page 50" href="http://viewer.zmags.com/publication/27f0f068?page=50"> www.australianprescriber.com/maga- zine/23/6/114/</a> <a title="EMJ Hepatology 3.2 2015 page 51" href="http://viewer.zmags.com/publication/27f0f068?page=51"> of hepatitis C. J Hepatol. 2008;49(4): 528–36. 44</a> <a title="EMJ Hepatology 3.2 2015 page 52" href="http://viewer.zmags.com/publication/27f0f068?page=52"> ANSWERING PIVOTAL QUESTIONS IN THE DIAGNOSIS AN</a> <a title="EMJ Hepatology 3.2 2015 page 53" href="http://viewer.zmags.com/publication/27f0f068?page=53"> affecting 6% of the population.1 Chronic disease </a> <a title="EMJ Hepatology 3.2 2015 page 54" href="http://viewer.zmags.com/publication/27f0f068?page=54"> Patients Responding* (%) 100 90 80 70 60 50 40 3</a> <a title="EMJ Hepatology 3.2 2015 page 55" href="http://viewer.zmags.com/publication/27f0f068?page=55"> Discontinuation due to pruritus (itch) was an iss</a> <a title="EMJ Hepatology 3.2 2015 page 56" href="http://viewer.zmags.com/publication/27f0f068?page=56"> 60 50 40 30 Patients (%)* 20 10 0 45 Pl</a> <a title="EMJ Hepatology 3.2 2015 page 57" href="http://viewer.zmags.com/publication/27f0f068?page=57"> either with active disease or progression r</a> <a title="EMJ Hepatology 3.2 2015 page 58" href="http://viewer.zmags.com/publication/27f0f068?page=58"> REFERENCES 1. EASL. Many ways one aim... The con</a> <a title="EMJ Hepatology 3.2 2015 page 59" href="http://viewer.zmags.com/publication/27f0f068?page=59"> delta agonist, GFT505, in rodent models of nona</a> <a title="EMJ Hepatology 3.2 2015 page 60" href="http://viewer.zmags.com/publication/27f0f068?page=60"> WOULD YOU FIGURE IT OUT? DIFFERENTIAL </a> <a title="EMJ Hepatology 3.2 2015 page 61" href="http://viewer.zmags.com/publication/27f0f068?page=61"> Overview of Lysosomal Acid </a> <a title="EMJ Hepatology 3.2 2015 page 62" href="http://viewer.zmags.com/publication/27f0f068?page=62"> Figure 2: Liver biopsy with haematoxylin/van Gies</a> <a title="EMJ Hepatology 3.2 2015 page 63" href="http://viewer.zmags.com/publication/27f0f068?page=63"> Wilson’s disease (WD). There was also villo</a> <a title="EMJ Hepatology 3.2 2015 page 64" href="http://viewer.zmags.com/publication/27f0f068?page=64"> non-alcoholic fatty liver disease/non-alcoh</a> <a title="EMJ Hepatology 3.2 2015 page 65" href="http://viewer.zmags.com/publication/27f0f068?page=65"> ABC 20 µm </a> <a title="EMJ Hepatology 3.2 2015 page 66" href="http://viewer.zmags.com/publication/27f0f068?page=66"> long-term safety of SA in adults with LAL </a> <a title="EMJ Hepatology 3.2 2015 page 67" href="http://viewer.zmags.com/publication/27f0f068?page=67"> and treatment monitoring by magnetic resonance. J</a> <a title="EMJ Hepatology 3.2 2015 page 68" href="http://viewer.zmags.com/publication/27f0f068?page=68"> ABSTRACT REVIEWS PROVIDING HEPATITIS- T</a> <a title="EMJ Hepatology 3.2 2015 page 69" href="http://viewer.zmags.com/publication/27f0f068?page=69"> ILC Table 1: Prevalence of HIV—HCV and HIV—HBV co</a> <a title="EMJ Hepatology 3.2 2015 page 70" href="http://viewer.zmags.com/publication/27f0f068?page=70"> ABSTRACT REVIEWS practical for certain key a</a> <a title="EMJ Hepatology 3.2 2015 page 71" href="http://viewer.zmags.com/publication/27f0f068?page=71"> ILC A key barrier for the implementati</a> <a title="EMJ Hepatology 3.2 2015 page 72" href="http://viewer.zmags.com/publication/27f0f068?page=72"> ABSTRACT REVIEWS rate was slightly lower in blac</a> <a title="EMJ Hepatology 3.2 2015 page 73" href="http://viewer.zmags.com/publication/27f0f068?page=73"> ILC and biological therapy. One question at the </a> <a title="EMJ Hepatology 3.2 2015 page 74" href="http://viewer.zmags.com/publication/27f0f068?page=74"> ABSTRACT REVIEWS In conclusion, we demonstrate t</a> <a title="EMJ Hepatology 3.2 2015 page 75" href="http://viewer.zmags.com/publication/27f0f068?page=75"> ILC The third study considered whether or not th</a> <a title="EMJ Hepatology 3.2 2015 page 76" href="http://viewer.zmags.com/publication/27f0f068?page=76"> ABSTRACT REVIEWS FACS-isolated, single SOX9+ </a> <a title="EMJ Hepatology 3.2 2015 page 77" href="http://viewer.zmags.com/publication/27f0f068?page=77"> ILC in patients who have resolved acut</a> <a title="EMJ Hepatology 3.2 2015 page 78" href="http://viewer.zmags.com/publication/27f0f068?page=78"> ABSTRACT REVIEWS HEPATITIS C VIRUS </a> <a title="EMJ Hepatology 3.2 2015 page 79" href="http://viewer.zmags.com/publication/27f0f068?page=79"> ILC wt FL-N/</a> <a title="EMJ Hepatology 3.2 2015 page 80" href="http://viewer.zmags.com/publication/27f0f068?page=80"> ABSTRACT REVIEWS EARLY CLINICAL FEATURE</a> <a title="EMJ Hepatology 3.2 2015 page 81" href="http://viewer.zmags.com/publication/27f0f068?page=81"> ILC 2 years post-diagnosis, ALP >1.5×ULN and >2×</a> <a title="EMJ Hepatology 3.2 2015 page 82" href="http://viewer.zmags.com/publication/27f0f068?page=82"> ABSTRACT REVIEWS sequencing. Differentially ex</a> <a title="EMJ Hepatology 3.2 2015 page 83" href="http://viewer.zmags.com/publication/27f0f068?page=83"> ILC 7. Liver Unit, Barts and the Lo</a> <a title="EMJ Hepatology 3.2 2015 page 84" href="http://viewer.zmags.com/publication/27f0f068?page=84"> ABSTRACT REVIEWS improvement compared with </a> <a title="EMJ Hepatology 3.2 2015 page 85" href="http://viewer.zmags.com/publication/27f0f068?page=85"> ILC REFERENCES 1. Flora K et al. Milk thistle (S</a> <a title="EMJ Hepatology 3.2 2015 page 86" href="http://viewer.zmags.com/publication/27f0f068?page=86"> ABSTRACT REVIEWS International Classification </a> <a title="EMJ Hepatology 3.2 2015 page 87" href="http://viewer.zmags.com/publication/27f0f068?page=87"> ILC • The overall frequency of further tests n</a> <a title="EMJ Hepatology 3.2 2015 page 88" href="http://viewer.zmags.com/publication/27f0f068?page=88"> ABSTRACT REVIEWS well as acceptor splice sites. </a> <a title="EMJ Hepatology 3.2 2015 page 89" href="http://viewer.zmags.com/publication/27f0f068?page=89"> ILC complications occurred in 9/58 patients, but</a> <a title="EMJ Hepatology 3.2 2015 page 90" href="http://viewer.zmags.com/publication/27f0f068?page=90"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Hepatology 3.2 2015 page 91" href="http://viewer.zmags.com/publication/27f0f068?page=91"> Buyer’s Guide • ABBVIE • ALFA WASSERMANN SPA</a> <a title="EMJ Hepatology 3.2 2015 page 92" href="http://viewer.zmags.com/publication/27f0f068?page=92"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS, PUBL</a>