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<br /> RESPIRATORY<br /> ISSN 2054-3166 Vol 4.1 • October 2016 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ERS 2016<br /> London, UK<br /> CONTENTS<br /> EDITORIAL BOARD...................................................................................................................................... 4<br /> CONGRESS REVIEW.................................................................................................................................... 10<br /> • Review of the Annual Meeting of the European Respiratory Society (ERS) International<br /> Congress, held in London, UK, 3rd–7th September 2016<br /> INTERVIEWS WITH EMJ RESPIRATORY EDITORIAL BOARD............................................................ 27<br /> SYMPOSIUM REVIEWS<br /> • MODIFYING ALPHA-1 ANTITRYPSIN DEFICIENCY-RELATED EMPHYSEMA:<br /> FROM EVIDENCE TO PRACTICE................................<a title="EMJ Respiratory 4.1 2016 page 1" href="http://viewer.zmags.com/publication/2c343926?page=1"> RESPIRATORY ISSN 2054-3166 </a> <a title="EMJ Respiratory 4.1 2016 page 2" href="http://viewer.zmags.com/publication/2c343926?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Respiratory 4.1 2016 page 3" href="http://viewer.zmags.com/publication/2c343926?page=3"> RESPIRATORY • A CONFOUNDING CASE: PNEUMOCOCCA</a> <a title="EMJ Respiratory 4.1 2016 page 4" href="http://viewer.zmags.com/publication/2c343926?page=4"> Editorial Board Editor-in-Chief: Dr Antonio Ros</a> <a title="EMJ Respiratory 4.1 2016 page 5" href="http://viewer.zmags.com/publication/2c343926?page=5"> Respiratory Dr Ravi Kalhan, Associate Profess</a> <a title="EMJ Respiratory 4.1 2016 page 6" href="http://viewer.zmags.com/publication/2c343926?page=6"> RESPIRATORY 4.1 OCTOBER 2016 Director Spencer G</a> <a title="EMJ Respiratory 4.1 2016 page 7" href="http://viewer.zmags.com/publication/2c343926?page=7"> Welcome Welcome to EMJ Respiratory 4.1. As eve</a> <a title="EMJ Respiratory 4.1 2016 page 8" href="http://viewer.zmags.com/publication/2c343926?page=8"> gehealthcare.com Solutions to he</a> <a title="EMJ Respiratory 4.1 2016 page 9" href="http://viewer.zmags.com/publication/2c343926?page=9"> Foreword </a> <a title="EMJ Respiratory 4.1 2016 page 10" href="http://viewer.zmags.com/publication/2c343926?page=10"> 10 RESPIRATORY • October 2016 </a> <a title="EMJ Respiratory 4.1 2016 page 11" href="http://viewer.zmags.com/publication/2c343926?page=11"> RESPIRATORY • October 2016 </a> <a title="EMJ Respiratory 4.1 2016 page 12" href="http://viewer.zmags.com/publication/2c343926?page=12"> 12 RESPIRATORY • October 2016 </a> <a title="EMJ Respiratory 4.1 2016 page 13" href="http://viewer.zmags.com/publication/2c343926?page=13"> Congress Highlights Diagnosis of Lon</a> <a title="EMJ Respiratory 4.1 2016 page 14" href="http://viewer.zmags.com/publication/2c343926?page=14"> An attractive quality of artificial intelligence i</a> <a title="EMJ Respiratory 4.1 2016 page 15" href="http://viewer.zmags.com/publication/2c343926?page=15"> 4,100 abstracts submitted Smaller Fetal Size Incr</a> <a title="EMJ Respiratory 4.1 2016 page 16" href="http://viewer.zmags.com/publication/2c343926?page=16"> Early life exposure to antibiotics is related to </a> <a title="EMJ Respiratory 4.1 2016 page 17" href="http://viewer.zmags.com/publication/2c343926?page=17"> The author of the study, Dr Priya Daniel, </a> <a title="EMJ Respiratory 4.1 2016 page 18" href="http://viewer.zmags.com/publication/2c343926?page=18"> Possible Link Between Menopause and Decreased Lun</a> <a title="EMJ Respiratory 4.1 2016 page 19" href="http://viewer.zmags.com/publication/2c343926?page=19"> Vitamin D Can Significantly Reduce Asthma Attacks </a> <a title="EMJ Respiratory 4.1 2016 page 20" href="http://viewer.zmags.com/publication/2c343926?page=20"> The first of the studies looked at childhood expos</a> <a title="EMJ Respiratory 4.1 2016 page 21" href="http://viewer.zmags.com/publication/2c343926?page=21"> Reducing Anxiety and Depression in Patients with </a> <a title="EMJ Respiratory 4.1 2016 page 22" href="http://viewer.zmags.com/publication/2c343926?page=22"> We hope that our findings can aid clinicians ident</a> <a title="EMJ Respiratory 4.1 2016 page 23" href="http://viewer.zmags.com/publication/2c343926?page=23"> Results showed an acute dip in dietary intake (15</a> <a title="EMJ Respiratory 4.1 2016 page 24" href="http://viewer.zmags.com/publication/2c343926?page=24"> Exposure to traffic should be taken into account </a> <a title="EMJ Respiratory 4.1 2016 page 25" href="http://viewer.zmags.com/publication/2c343926?page=25"> Various data were collected from patients, i</a> <a title="EMJ Respiratory 4.1 2016 page 26" href="http://viewer.zmags.com/publication/2c343926?page=26"> In asthma and COPD </a> <a title="EMJ Respiratory 4.1 2016 page 27" href="http://viewer.zmags.com/publication/2c343926?page=27"> Enrico Clini Associate Professor of Respiratory </a> <a title="EMJ Respiratory 4.1 2016 page 28" href="http://viewer.zmags.com/publication/2c343926?page=28"> Q: Do you expect an increased adoption of </a> <a title="EMJ Respiratory 4.1 2016 page 29" href="http://viewer.zmags.com/publication/2c343926?page=29"> of inhaled corticosteroids (ICS) and long-ac</a> <a title="EMJ Respiratory 4.1 2016 page 30" href="http://viewer.zmags.com/publication/2c343926?page=30"> collaborative relationship, ideally in both acade</a> <a title="EMJ Respiratory 4.1 2016 page 31" href="http://viewer.zmags.com/publication/2c343926?page=31"> becoming a handicap not being able to handle sick</a> <a title="EMJ Respiratory 4.1 2016 page 32" href="http://viewer.zmags.com/publication/2c343926?page=32"> than treatment escalated. However, it is al</a> <a title="EMJ Respiratory 4.1 2016 page 33" href="http://viewer.zmags.com/publication/2c343926?page=33"> A: What I would like to see and believe we are on</a> <a title="EMJ Respiratory 4.1 2016 page 34" href="http://viewer.zmags.com/publication/2c343926?page=34"> α1 ANTITRYPSIN DEFICIENCY (AATD) THERAPIES. THEY </a> <a title="EMJ Respiratory 4.1 2016 page 35" href="http://viewer.zmags.com/publication/2c343926?page=35"> MODIFYING ALPHA-1 ANTITRYPSIN DEFICIENCY- R</a> <a title="EMJ Respiratory 4.1 2016 page 36" href="http://viewer.zmags.com/publication/2c343926?page=36"> disease-modifying effect. Prof Koczulla closed th</a> <a title="EMJ Respiratory 4.1 2016 page 37" href="http://viewer.zmags.com/publication/2c343926?page=37"> As the causative process has been identified</a> <a title="EMJ Respiratory 4.1 2016 page 38" href="http://viewer.zmags.com/publication/2c343926?page=38"> Placebo Resp</a> <a title="EMJ Respiratory 4.1 2016 page 39" href="http://viewer.zmags.com/publication/2c343926?page=39"> A B Annually Medical history </a> <a title="EMJ Respiratory 4.1 2016 page 40" href="http://viewer.zmags.com/publication/2c343926?page=40"> crucial to measure baseline severity of dis</a> <a title="EMJ Respiratory 4.1 2016 page 41" href="http://viewer.zmags.com/publication/2c343926?page=41"> delays in treatment initiation, and that a </a> <a title="EMJ Respiratory 4.1 2016 page 42" href="http://viewer.zmags.com/publication/2c343926?page=42"> 13. McElvaney NG et al. Increased propo</a> <a title="EMJ Respiratory 4.1 2016 page 43" href="http://viewer.zmags.com/publication/2c343926?page=43"> DEVICE MATTERS: LOOKING BEYOND THE DRUG This sate</a> <a title="EMJ Respiratory 4.1 2016 page 44" href="http://viewer.zmags.com/publication/2c343926?page=44"> The meeting objectives were to look beyond drugs </a> <a title="EMJ Respiratory 4.1 2016 page 45" href="http://viewer.zmags.com/publication/2c343926?page=45"> By tailoring treatment according to this phenotyp</a> <a title="EMJ Respiratory 4.1 2016 page 46" href="http://viewer.zmags.com/publication/2c343926?page=46"> 12 months.18,19 Therefore, while there is a need </a> <a title="EMJ Respiratory 4.1 2016 page 47" href="http://viewer.zmags.com/publication/2c343926?page=47"> Spiromax® 100 100 80 90th percentile </a> <a title="EMJ Respiratory 4.1 2016 page 48" href="http://viewer.zmags.com/publication/2c343926?page=48"> Table 1: Opportunities to demonstrate proper inha</a> <a title="EMJ Respiratory 4.1 2016 page 49" href="http://viewer.zmags.com/publication/2c343926?page=49"> Although both HCPs and patients can be taught the</a> <a title="EMJ Respiratory 4.1 2016 page 50" href="http://viewer.zmags.com/publication/2c343926?page=50"> with fixed-combination budesonide/ formotero</a> <a title="EMJ Respiratory 4.1 2016 page 51" href="http://viewer.zmags.com/publication/2c343926?page=51"> WHY, WHEN, AND HOW? OPTIMISING THE MANAGEMENT OF </a> <a title="EMJ Respiratory 4.1 2016 page 52" href="http://viewer.zmags.com/publication/2c343926?page=52"> A New Era for Patients with Uncontrolled Severe A</a> <a title="EMJ Respiratory 4.1 2016 page 53" href="http://viewer.zmags.com/publication/2c343926?page=53"> cells (ILC-2) produce IL-4, IL-5, and IL-13 at hi</a> <a title="EMJ Respiratory 4.1 2016 page 54" href="http://viewer.zmags.com/publication/2c343926?page=54"> In Prof Buhl’s opinion, typical patients with sev</a> <a title="EMJ Respiratory 4.1 2016 page 55" href="http://viewer.zmags.com/publication/2c343926?page=55"> some associations and treatments have not been ev</a> <a title="EMJ Respiratory 4.1 2016 page 56" href="http://viewer.zmags.com/publication/2c343926?page=56"> -0.1 placebo, p=0.012) compared with those with n</a> <a title="EMJ Respiratory 4.1 2016 page 57" href="http://viewer.zmags.com/publication/2c343926?page=57"> 2.50 2.00 1.50 1.00 Annual exacerbation rate*</a> <a title="EMJ Respiratory 4.1 2016 page 58" href="http://viewer.zmags.com/publication/2c343926?page=58"> Footnotes Benralizumab was not approved at the ti</a> <a title="EMJ Respiratory 4.1 2016 page 59" href="http://viewer.zmags.com/publication/2c343926?page=59"> to-high-dose inhaled corticosteroids plus a long-</a> <a title="EMJ Respiratory 4.1 2016 page 60" href="http://viewer.zmags.com/publication/2c343926?page=60"> Abstract Reviews DOES ANAESTHESIA TYPE INFLUENCE</a> <a title="EMJ Respiratory 4.1 2016 page 61" href="http://viewer.zmags.com/publication/2c343926?page=61"> ERS 2016 of obtaining a good smear, and as</a> <a title="EMJ Respiratory 4.1 2016 page 62" href="http://viewer.zmags.com/publication/2c343926?page=62"> Abstract Reviews hospitalised patients to unders</a> <a title="EMJ Respiratory 4.1 2016 page 63" href="http://viewer.zmags.com/publication/2c343926?page=63"> ERS 2016 chromogens. The percentage of immun</a> <a title="EMJ Respiratory 4.1 2016 page 64" href="http://viewer.zmags.com/publication/2c343926?page=64"> Abstract Reviews METHOD Data from the Southam</a> <a title="EMJ Respiratory 4.1 2016 page 65" href="http://viewer.zmags.com/publication/2c343926?page=65"> ERS 2016 SUMMARY OF GLOBAL LUNG FUNCTION</a> <a title="EMJ Respiratory 4.1 2016 page 66" href="http://viewer.zmags.com/publication/2c343926?page=66"> Abstract Reviews includes children that never</a> <a title="EMJ Respiratory 4.1 2016 page 67" href="http://viewer.zmags.com/publication/2c343926?page=67"> ERS 2016 (40 ppm) at the time of diagnosis</a> <a title="EMJ Respiratory 4.1 2016 page 68" href="http://viewer.zmags.com/publication/2c343926?page=68"> Abstract Reviews to sulphur hexafluoride (SF )</a> <a title="EMJ Respiratory 4.1 2016 page 69" href="http://viewer.zmags.com/publication/2c343926?page=69"> ERS 2016 RESULTS Among our patients, 65% had rec</a> <a title="EMJ Respiratory 4.1 2016 page 70" href="http://viewer.zmags.com/publication/2c343926?page=70"> Abstract Reviews (%) FEV 1 Change in 25 20 15 10</a> <a title="EMJ Respiratory 4.1 2016 page 71" href="http://viewer.zmags.com/publication/2c343926?page=71"> ERS 2016 NURSES’ KNOWLEDGE AND ABIL</a> <a title="EMJ Respiratory 4.1 2016 page 72" href="http://viewer.zmags.com/publication/2c343926?page=72"> EDITOR’S PICK My c</a> <a title="EMJ Respiratory 4.1 2016 page 73" href="http://viewer.zmags.com/publication/2c343926?page=73"> Keywords: Respiratory symptoms, farming, lung fun</a> <a title="EMJ Respiratory 4.1 2016 page 74" href="http://viewer.zmags.com/publication/2c343926?page=74"> use of mechanised equipment, irrigation, and</a> <a title="EMJ Respiratory 4.1 2016 page 75" href="http://viewer.zmags.com/publication/2c343926?page=75"> Classification of smoking status was determined ac</a> <a title="EMJ Respiratory 4.1 2016 page 76" href="http://viewer.zmags.com/publication/2c343926?page=76"> Table 3: Risk of developing asthma and chronic ob</a> <a title="EMJ Respiratory 4.1 2016 page 77" href="http://viewer.zmags.com/publication/2c343926?page=77"> European Association of Schools of Occupational M</a> <a title="EMJ Respiratory 4.1 2016 page 78" href="http://viewer.zmags.com/publication/2c343926?page=78"> lung function impairment, and chronic obstructive</a> <a title="EMJ Respiratory 4.1 2016 page 79" href="http://viewer.zmags.com/publication/2c343926?page=79"> The prevalence of COPD in the present study is no</a> <a title="EMJ Respiratory 4.1 2016 page 80" href="http://viewer.zmags.com/publication/2c343926?page=80"> Health Survey (ECRHS). Eur Respir J. 1996;9(</a> <a title="EMJ Respiratory 4.1 2016 page 81" href="http://viewer.zmags.com/publication/2c343926?page=81"> </a> <a title="EMJ Respiratory 4.1 2016 page 82" href="http://viewer.zmags.com/publication/2c343926?page=82"> A CONFOUNDING CASE: PNEUMOCOCCAL PNEUMONIA </a> <a title="EMJ Respiratory 4.1 2016 page 83" href="http://viewer.zmags.com/publication/2c343926?page=83"> per minute with use of accessory muscles, and oxy</a> <a title="EMJ Respiratory 4.1 2016 page 84" href="http://viewer.zmags.com/publication/2c343926?page=84"> Figure 2: Chest radiograph showing resolution of </a> <a title="EMJ Respiratory 4.1 2016 page 85" href="http://viewer.zmags.com/publication/2c343926?page=85"> This is a novel case, in which the patient had an</a> <a title="EMJ Respiratory 4.1 2016 page 86" href="http://viewer.zmags.com/publication/2c343926?page=86"> SMOKING CESSATION WITH LUNG CANCER: NOT TO</a> <a title="EMJ Respiratory 4.1 2016 page 87" href="http://viewer.zmags.com/publication/2c343926?page=87"> suppressing the body’s defenses.14 TS affects the</a> <a title="EMJ Respiratory 4.1 2016 page 88" href="http://viewer.zmags.com/publication/2c343926?page=88"> of diarrhoea and skin toxicity, compared wi</a> <a title="EMJ Respiratory 4.1 2016 page 89" href="http://viewer.zmags.com/publication/2c343926?page=89"> Benefit of Smoking Cessation in all Patients with </a> <a title="EMJ Respiratory 4.1 2016 page 90" href="http://viewer.zmags.com/publication/2c343926?page=90"> is working with those who have been diagnosed i</a> <a title="EMJ Respiratory 4.1 2016 page 91" href="http://viewer.zmags.com/publication/2c343926?page=91"> status on survival following radiation therap</a> <a title="EMJ Respiratory 4.1 2016 page 92" href="http://viewer.zmags.com/publication/2c343926?page=92"> THORACIC SURGERY AND TRANSPLANTATION </a> <a title="EMJ Respiratory 4.1 2016 page 93" href="http://viewer.zmags.com/publication/2c343926?page=93"> (‘fast-track’) after thoracic surgery and anaesth</a> <a title="EMJ Respiratory 4.1 2016 page 94" href="http://viewer.zmags.com/publication/2c343926?page=94"> MOBILE TECHNOLOGY AND THORACIC SURGERY The use </a> <a title="EMJ Respiratory 4.1 2016 page 95" href="http://viewer.zmags.com/publication/2c343926?page=95"> port, and robotic-assisted), and after train</a> <a title="EMJ Respiratory 4.1 2016 page 96" href="http://viewer.zmags.com/publication/2c343926?page=96"> 32. Sugarbaker DJ et al. Hyperthermic intraoperat</a> <a title="EMJ Respiratory 4.1 2016 page 97" href="http://viewer.zmags.com/publication/2c343926?page=97"> BreathCaring Simplicity. prisma VENT. brilliant </a> <a title="EMJ Respiratory 4.1 2016 page 98" href="http://viewer.zmags.com/publication/2c343926?page=98"> THERAPEUTIC EFFECT OF WHOLE LUNG LAVAGE </a> <a title="EMJ Respiratory 4.1 2016 page 99" href="http://viewer.zmags.com/publication/2c343926?page=99"> poor disease resistance and can ultimately lose t</a> <a title="EMJ Respiratory 4.1 2016 page 100" href="http://viewer.zmags.com/publication/2c343926?page=100"> • Heart, liver, kidney function, and relevant t</a> <a title="EMJ Respiratory 4.1 2016 page 101" href="http://viewer.zmags.com/publication/2c343926?page=101"> This study adopted a high-frequency jet ventilati</a> <a title="EMJ Respiratory 4.1 2016 page 102" href="http://viewer.zmags.com/publication/2c343926?page=102"> dyspnoea in 502 patients. The improvement rate of</a> <a title="EMJ Respiratory 4.1 2016 page 103" href="http://viewer.zmags.com/publication/2c343926?page=103"> lung lavage was strictly selected. The anaesthesi</a> <a title="EMJ Respiratory 4.1 2016 page 104" href="http://viewer.zmags.com/publication/2c343926?page=104"> NON-INTUBATED VIDEO-ASSISTED THORACIC SURGER</a> <a title="EMJ Respiratory 4.1 2016 page 105" href="http://viewer.zmags.com/publication/2c343926?page=105"> procedures such as carinal resection, bronch</a> <a title="EMJ Respiratory 4.1 2016 page 106" href="http://viewer.zmags.com/publication/2c343926?page=106"> base’. The other two ports were placed at the ‘fir</a> <a title="EMJ Respiratory 4.1 2016 page 107" href="http://viewer.zmags.com/publication/2c343926?page=107"> Table 1: Awake Thoracic Surgery Research Group at</a> <a title="EMJ Respiratory 4.1 2016 page 108" href="http://viewer.zmags.com/publication/2c343926?page=108"> A B C D E F Figure 1: Surgical steps in non-r</a> <a title="EMJ Respiratory 4.1 2016 page 109" href="http://viewer.zmags.com/publication/2c343926?page=109"> RESECTION OF NODULES In 2004 Dr Mineo began </a> <a title="EMJ Respiratory 4.1 2016 page 110" href="http://viewer.zmags.com/publication/2c343926?page=110"> When compared with conventional surgery, both lym</a> <a title="EMJ Respiratory 4.1 2016 page 111" href="http://viewer.zmags.com/publication/2c343926?page=111"> Footnotes More recently, data from the Official A</a> <a title="EMJ Respiratory 4.1 2016 page 112" href="http://viewer.zmags.com/publication/2c343926?page=112"> 40. Pompeo E et al. The role of awake video-assis</a> <a title="EMJ Respiratory 4.1 2016 page 113" href="http://viewer.zmags.com/publication/2c343926?page=113"> RespiCare®, the first therapy chair to improve th</a> <a title="EMJ Respiratory 4.1 2016 page 114" href="http://viewer.zmags.com/publication/2c343926?page=114"> CHRONIC OBSTRUCTIVE PULMONARY DISEASE </a> <a title="EMJ Respiratory 4.1 2016 page 115" href="http://viewer.zmags.com/publication/2c343926?page=115"> such as carotid intima media thickness, endotheli</a> <a title="EMJ Respiratory 4.1 2016 page 116" href="http://viewer.zmags.com/publication/2c343926?page=116"> AIx measures the augmentation of BP during the sy</a> <a title="EMJ Respiratory 4.1 2016 page 117" href="http://viewer.zmags.com/publication/2c343926?page=117"> deposition. Arterial stiffness is also increased </a> <a title="EMJ Respiratory 4.1 2016 page 118" href="http://viewer.zmags.com/publication/2c343926?page=118"> albumin-derived AGEs. Kemeny et al.49 simila</a> <a title="EMJ Respiratory 4.1 2016 page 119" href="http://viewer.zmags.com/publication/2c343926?page=119"> primarily a marker of vascular elastin degradatio</a> <a title="EMJ Respiratory 4.1 2016 page 120" href="http://viewer.zmags.com/publication/2c343926?page=120"> systematic analysis for the Global Burden of Dis</a> <a title="EMJ Respiratory 4.1 2016 page 121" href="http://viewer.zmags.com/publication/2c343926?page=121"> albumin-derived advanced glycosylation end produ</a> <a title="EMJ Respiratory 4.1 2016 page 122" href="http://viewer.zmags.com/publication/2c343926?page=122"> UPCOMING EVENTS 24th Annual Meeting of the German</a> <a title="EMJ Respiratory 4.1 2016 page 123" href="http://viewer.zmags.com/publication/2c343926?page=123"> RESPIRATORY Asthma: From Pathway Biology to Preci</a> <a title="EMJ Respiratory 4.1 2016 page 124" href="http://viewer.zmags.com/publication/2c343926?page=124"> Buyer’s Guide • 3D SYSTEMS HEALTHCARE • ACTEL</a> <a title="EMJ Respiratory 4.1 2016 page 125" href="http://viewer.zmags.com/publication/2c343926?page=125"> Respiratory • MEDCHIP SOLUTIONS • MEDICAL DEV</a> <a title="EMJ Respiratory 4.1 2016 page 126" href="http://viewer.zmags.com/publication/2c343926?page=126"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS, NE</a>