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SPONSORED CONTENT<br />
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Produced by Nature Publishing Group December 2011<br />
Physical Sciences in Oncology<br />
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Sponsored by<br />
Physical Sciences-Oncology Centers (PS-OCs) Network<br />
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Northwestern University Cornell University<br />
Physical Sciences-Oncology Center Physical Sciences-Oncology Center<br />
Principal Investigator: Principal Investigator:<br />
Thomas V. O'Halloran, Ph.D. Michael L. Shuler, Ph.D.<br />
Senior Co-Investigator: Senior Co-Investigator:<br />
Jonathan D. Licht, M.D. <a title="Nature Reprint Collection - Physical Sciences in Oncology page 1" href="http://viewer.zmags.com/publication/2e03b128?page=1">SPONSORED CONTENTProduced by Nature Publis</a> SPONSORED CONTENTProduced by Nature Publis<a title="Nature Reprint Collection - Physical Sciences in Oncology page 2" href="http://viewer.zmags.com/publication/2e03b128?page=2">Physical Sciences-Oncology Centers (PS-OCs) Netwo</a> Physical Sciences-Oncology Centers (PS-OCs) Netwo<a title="Nature Reprint Collection - Physical Sciences in Oncology page 3" href="http://viewer.zmags.com/publication/2e03b128?page=3">cover design: alex wingIMAGES FROM SCIENCE PHOT</a> cover design: alex wingIMAGES FROM SCIENCE PHOT<a title="Nature Reprint Collection - Physical Sciences in Oncology page 4" href="http://viewer.zmags.com/publication/2e03b128?page=4">CoMMentThe evolutionary dynamics of cancerpre</a> CoMMentThe evolutionary dynamics of cancerpre<a title="Nature Reprint Collection - Physical Sciences in Oncology page 5" href="http://viewer.zmags.com/publication/2e03b128?page=5">abDifferentiatedcellsTransientamplif</a> abDifferentiatedcellsTransientamplif<a title="Nature Reprint Collection - Physical Sciences in Oncology page 6" href="http://viewer.zmags.com/publication/2e03b128?page=6">ANALYSISDNA secondary structures and epigenet</a> ANALYSISDNA secondary structures and epigenet<a title="Nature Reprint Collection - Physical Sciences in Oncology page 7" href="http://viewer.zmags.com/publication/2e03b128?page=7">A N A LY S I Sa </a> A N A LY S I Sa <a title="Nature Reprint Collection - Physical Sciences in Oncology page 8" href="http://viewer.zmags.com/publication/2e03b128?page=8">A N A LY S I SFigure 2 Association between G-qu</a> A N A LY S I SFigure 2 Association between G-qu<a title="Nature Reprint Collection - Physical Sciences in Oncology page 9" href="http://viewer.zmags.com/publication/2e03b128?page=9">A N A LY S I SFigure 3 Role of G-quadruplex str</a> A N A LY S I SFigure 3 Role of G-quadruplex str<a title="Nature Reprint Collection - Physical Sciences in Oncology page 10" href="http://viewer.zmags.com/publication/2e03b128?page=10">A N A LY S I SFigure 4 A mechanistic hypothesi</a> A N A LY S I SFigure 4 A mechanistic hypothesi<a title="Nature Reprint Collection - Physical Sciences in Oncology page 11" href="http://viewer.zmags.com/publication/2e03b128?page=11">A N A LY S I S16. Maizels, N. Dynamic roles fo</a> A N A LY S I S16. Maizels, N. Dynamic roles fo<a title="Nature Reprint Collection - Physical Sciences in Oncology page 12" href="http://viewer.zmags.com/publication/2e03b128?page=12">PERSPECTIVESOPINIONThe physics of cancer: </a> PERSPECTIVESOPINIONThe physics of cancer: <a title="Nature Reprint Collection - Physical Sciences in Oncology page 13" href="http://viewer.zmags.com/publication/2e03b128?page=13">2D substrates15. In turn, many features that are</a> 2D substrates15. In turn, many features that are<a title="Nature Reprint Collection - Physical Sciences in Oncology page 14" href="http://viewer.zmags.com/publication/2e03b128?page=14">PERSPECTIVESculture, a lamellipodium actively </a> PERSPECTIVESculture, a lamellipodium actively <a title="Nature Reprint Collection - Physical Sciences in Oncology page 15" href="http://viewer.zmags.com/publication/2e03b128?page=15">Box 1 | The extracellular matrixThe extracellula</a> Box 1 | The extracellular matrixThe extracellula<a title="Nature Reprint Collection - Physical Sciences in Oncology page 16" href="http://viewer.zmags.com/publication/2e03b128?page=16">PERSPECTIVESTable 1 | Tools for the study of </a> PERSPECTIVESTable 1 | Tools for the study of <a title="Nature Reprint Collection - Physical Sciences in Oncology page 17" href="http://viewer.zmags.com/publication/2e03b128?page=17">likely to preserve this phenotype over severalge</a> likely to preserve this phenotype over severalge<a title="Nature Reprint Collection - Physical Sciences in Oncology page 18" href="http://viewer.zmags.com/publication/2e03b128?page=18">PERSPECTIVES A cell moving along a vessel wal</a> PERSPECTIVES A cell moving along a vessel wal<a title="Nature Reprint Collection - Physical Sciences in Oncology page 19" href="http://viewer.zmags.com/publication/2e03b128?page=19">PERSPECTIVESCD44 variant isoforms, carcinoembr</a> PERSPECTIVESCD44 variant isoforms, carcinoembr<a title="Nature Reprint Collection - Physical Sciences in Oncology page 20" href="http://viewer.zmags.com/publication/2e03b128?page=20">PERSPECTIVESmechanical hypothesis and the seed</a> PERSPECTIVESmechanical hypothesis and the seed<a title="Nature Reprint Collection - Physical Sciences in Oncology page 21" href="http://viewer.zmags.com/publication/2e03b128?page=21">41. Sahai, E. & Marshall, C. J. Differing modes </a> 41. Sahai, E. & Marshall, C. J. Differing modes <a title="Nature Reprint Collection - Physical Sciences in Oncology page 22" href="http://viewer.zmags.com/publication/2e03b128?page=22">PERSPECTIVES114. Chang, S. F. et al. Tumor c</a> PERSPECTIVES114. Chang, S. F. et al. Tumor c<a title="Nature Reprint Collection - Physical Sciences in Oncology page 23" href="http://viewer.zmags.com/publication/2e03b128?page=23">PERSPECTIVEST H E R A P E U T I C R E S I S TA </a> PERSPECTIVEST H E R A P E U T I C R E S I S TA <a title="Nature Reprint Collection - Physical Sciences in Oncology page 24" href="http://viewer.zmags.com/publication/2e03b128?page=24">PERSPECTIVESaTimeb </a> PERSPECTIVESaTimeb <a title="Nature Reprint Collection - Physical Sciences in Oncology page 25" href="http://viewer.zmags.com/publication/2e03b128?page=25">PERSPECTIVESbeneficial to the population as a </a> PERSPECTIVESbeneficial to the population as a <a title="Nature Reprint Collection - Physical Sciences in Oncology page 26" href="http://viewer.zmags.com/publication/2e03b128?page=26">PERSPECTIVESBox 2 | Bacterial cell communitie</a> PERSPECTIVESBox 2 | Bacterial cell communitie<a title="Nature Reprint Collection - Physical Sciences in Oncology page 27" href="http://viewer.zmags.com/publication/2e03b128?page=27">ab TumourMore </a> ab TumourMore <a title="Nature Reprint Collection - Physical Sciences in Oncology page 28" href="http://viewer.zmags.com/publication/2e03b128?page=28">Reactivated GFPPERSPECTIVESaBiofilmmicro</a> Reactivated GFPPERSPECTIVESaBiofilmmicro<a title="Nature Reprint Collection - Physical Sciences in Oncology page 29" href="http://viewer.zmags.com/publication/2e03b128?page=29">Model limitations and concluding remarks 6.Al</a> Model limitations and concluding remarks 6.Al<a title="Nature Reprint Collection - Physical Sciences in Oncology page 30" href="http://viewer.zmags.com/publication/2e03b128?page=30">PERSPECTIVES60. Conibear, T. C. R., Collins</a> PERSPECTIVES60. Conibear, T. C. R., Collins<a title="Nature Reprint Collection - Physical Sciences in Oncology page 31" href="http://viewer.zmags.com/publication/2e03b128?page=31">Recommend to your librarianW</a> Recommend to your librarianW<a title="Nature Reprint Collection - Physical Sciences in Oncology page 32" href="http://viewer.zmags.com/publication/2e03b128?page=32">The Journal of Cancer Gene and Cellular Therapies</a> The Journal of Cancer Gene and Cellular Therapies<a title="Nature Reprint Collection - Physical Sciences in Oncology page 33" href="http://viewer.zmags.com/publication/2e03b128?page=33">REVIEWSWhat does physics have to dowith </a> REVIEWSWhat does physics have to dowith <a title="Nature Reprint Collection - Physical Sciences in Oncology page 34" href="http://viewer.zmags.com/publication/2e03b128?page=34">REVIEWSAt a glance• Approaches from the phys</a> REVIEWSAt a glance• Approaches from the phys<a title="Nature Reprint Collection - Physical Sciences in Oncology page 35" href="http://viewer.zmags.com/publication/2e03b128?page=35">acNormal AbnormalbMembrane elast</a> acNormal AbnormalbMembrane elast<a title="Nature Reprint Collection - Physical Sciences in Oncology page 36" href="http://viewer.zmags.com/publication/2e03b128?page=36">REVIEWSCancer cellBloodEndotheli</a> REVIEWSCancer cellBloodEndotheli<a title="Nature Reprint Collection - Physical Sciences in Oncology page 37" href="http://viewer.zmags.com/publication/2e03b128?page=37">be regarded as collections of cells that accumula</a> be regarded as collections of cells that accumula<a title="Nature Reprint Collection - Physical Sciences in Oncology page 38" href="http://viewer.zmags.com/publication/2e03b128?page=38">REVIEWSPopulation geneticsThe mathematical </a> REVIEWSPopulation geneticsThe mathematical <a title="Nature Reprint Collection - Physical Sciences in Oncology page 39" href="http://viewer.zmags.com/publication/2e03b128?page=39">alterations were identified using Genomic Identif</a> alterations were identified using Genomic Identif<a title="Nature Reprint Collection - Physical Sciences in Oncology page 40" href="http://viewer.zmags.com/publication/2e03b128?page=40">REVIEWSMesoscopicA subdiscipline of condens</a> REVIEWSMesoscopicA subdiscipline of condens<a title="Nature Reprint Collection - Physical Sciences in Oncology page 41" href="http://viewer.zmags.com/publication/2e03b128?page=41">DNA binding proteins, each seeking to bind to fav</a> DNA binding proteins, each seeking to bind to fav<a title="Nature Reprint Collection - Physical Sciences in Oncology page 42" href="http://viewer.zmags.com/publication/2e03b128?page=42">REVIEWSa </a> REVIEWSa <a title="Nature Reprint Collection - Physical Sciences in Oncology page 43" href="http://viewer.zmags.com/publication/2e03b128?page=43">Tumour cellBlood vesselmechanics, in com</a> Tumour cellBlood vesselmechanics, in com<a title="Nature Reprint Collection - Physical Sciences in Oncology page 44" href="http://viewer.zmags.com/publication/2e03b128?page=44">REVIEWSProbesNanoparticles ormacromolecule</a> REVIEWSProbesNanoparticles ormacromolecule<a title="Nature Reprint Collection - Physical Sciences in Oncology page 45" href="http://viewer.zmags.com/publication/2e03b128?page=45">31. Haeno, H., Levine, R. L., Gilliland, D. G. &</a> 31. Haeno, H., Levine, R. L., Gilliland, D. G. &<a title="Nature Reprint Collection - Physical Sciences in Oncology page 46" href="http://viewer.zmags.com/publication/2e03b128?page=46">REVIEWS108. Segal, E. & Widom, J. From DNA s</a> REVIEWS108. Segal, E. & Widom, J. From DNA s<a title="Nature Reprint Collection - Physical Sciences in Oncology page 47" href="http://viewer.zmags.com/publication/2e03b128?page=47">ARTICLES </a> ARTICLES <a title="Nature Reprint Collection - Physical Sciences in Oncology page 48" href="http://viewer.zmags.com/publication/2e03b128?page=48">ARTICLES </a> ARTICLES <a title="Nature Reprint Collection - Physical Sciences in Oncology page 49" href="http://viewer.zmags.com/publication/2e03b128?page=49">ARTICLES </a> ARTICLES <a title="Nature Reprint Collection - Physical Sciences in Oncology page 50" href="http://viewer.zmags.com/publication/2e03b128?page=50">ARTICLES </a> ARTICLES <a title="Nature Reprint Collection - Physical Sciences in Oncology page 51" href="http://viewer.zmags.com/publication/2e03b128?page=51">ARTICLES </a> ARTICLES <a title="Nature Reprint Collection - Physical Sciences in Oncology page 52" href="http://viewer.zmags.com/publication/2e03b128?page=52">ARTICLES </a> ARTICLES <a title="Nature Reprint Collection - Physical Sciences in Oncology page 53" href="http://viewer.zmags.com/publication/2e03b128?page=53">Impact Factor30.306 *Submit online today!Nat</a> Impact Factor30.306 *Submit online today!Nat<a title="Nature Reprint Collection - Physical Sciences in Oncology page 54" href="http://viewer.zmags.com/publication/2e03b128?page=54">Sponsor FeatureSPONSORFEATURENational Cancer </a> Sponsor FeatureSPONSORFEATURENational Cancer <a title="Nature Reprint Collection - Physical Sciences in Oncology page 55" href="http://viewer.zmags.com/publication/2e03b128?page=55">Sponsor FeatureMASSACHUSETTS INSTITUTE OF TECH</a> Sponsor FeatureMASSACHUSETTS INSTITUTE OF TECH<a title="Nature Reprint Collection - Physical Sciences in Oncology page 56" href="http://viewer.zmags.com/publication/2e03b128?page=56">http:/viewer.zmags.com/publication/2e03b128</a> http:/viewer.zmags.com/publication/2e03b128