If you are visually impaired or blind, you can visit the PDF version by Pressing CONTROL + ALT + 4
<br /> DERMATOLOGY<br /> ISSN 2054-6211 November 2014 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EADV 2014<br /> Amsterdam, the Netherlands<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 5<br /> CONGRESS REVIEW............................................................................................................................... 10<br /> • Review of the European Academy of Dermatology and Venereology Congress,<br /> held in Amsterdam, the Netherlands, 8th-12th October 2014<br /> SYMPOSIUM REVIEWS<br /> • Optimising the Patient Journey in Chronic Spontaneous Urticaria................................... 35<br /> • Revealing a Clear Path towards a New Era in the Management of Psoriasis<a title="EMJ Dermatology 2014 page 1" href="http://viewer.zmags.com/publication/33f0b1ec?page=1"> DERMATOLOGY ISSN 2054-6211 </a> <a title="EMJ Dermatology 2014 page 2" href="http://viewer.zmags.com/publication/33f0b1ec?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Dermatology 2014 page 3" href="http://viewer.zmags.com/publication/33f0b1ec?page=3"> DERMATOLOGY NEUTROPHILIC DERMATOSES REVISITED..</a> <a title="EMJ Dermatology 2014 page 4" href="http://viewer.zmags.com/publication/33f0b1ec?page=4"> </a> <a title="EMJ Dermatology 2014 page 5" href="http://viewer.zmags.com/publication/33f0b1ec?page=5"> Editorial Board Dermatology Editor-in-Chief: P</a> <a title="EMJ Dermatology 2014 page 6" href="http://viewer.zmags.com/publication/33f0b1ec?page=6"> Start W h Acna ac ® i G t oo t dbye </a> <a title="EMJ Dermatology 2014 page 7" href="http://viewer.zmags.com/publication/33f0b1ec?page=7"> Welcome Welcome to the new edition of the Europea</a> <a title="EMJ Dermatology 2014 page 8" href="http://viewer.zmags.com/publication/33f0b1ec?page=8"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjre</a> <a title="EMJ Dermatology 2014 page 9" href="http://viewer.zmags.com/publication/33f0b1ec?page=9"> Foreword Prof Robert Dellavalle Associate Profess</a> <a title="EMJ Dermatology 2014 page 10" href="http://viewer.zmags.com/publication/33f0b1ec?page=10"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 11" href="http://viewer.zmags.com/publication/33f0b1ec?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ Dermatology 2014 page 12" href="http://viewer.zmags.com/publication/33f0b1ec?page=12"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 13" href="http://viewer.zmags.com/publication/33f0b1ec?page=13"> support and stress management for patients. </a> <a title="EMJ Dermatology 2014 page 14" href="http://viewer.zmags.com/publication/33f0b1ec?page=14"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 15" href="http://viewer.zmags.com/publication/33f0b1ec?page=15"> Drugs to please inflammation; the IL-17 pathway is</a> <a title="EMJ Dermatology 2014 page 16" href="http://viewer.zmags.com/publication/33f0b1ec?page=16"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 17" href="http://viewer.zmags.com/publication/33f0b1ec?page=17"> Latest advances in hair transplantation INNOVATI</a> <a title="EMJ Dermatology 2014 page 18" href="http://viewer.zmags.com/publication/33f0b1ec?page=18"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 19" href="http://viewer.zmags.com/publication/33f0b1ec?page=19"> Melanoma treatment is a double-edged sword CATALO</a> <a title="EMJ Dermatology 2014 page 20" href="http://viewer.zmags.com/publication/33f0b1ec?page=20"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 21" href="http://viewer.zmags.com/publication/33f0b1ec?page=21"> Agenda makes managing eczema child’s play ACTION </a> <a title="EMJ Dermatology 2014 page 22" href="http://viewer.zmags.com/publication/33f0b1ec?page=22"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 23" href="http://viewer.zmags.com/publication/33f0b1ec?page=23"> Fighting for medical attention: major burns and t</a> <a title="EMJ Dermatology 2014 page 24" href="http://viewer.zmags.com/publication/33f0b1ec?page=24"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 25" href="http://viewer.zmags.com/publication/33f0b1ec?page=25"> A day in the life of a psoriasis patient PSYCHOLO</a> <a title="EMJ Dermatology 2014 page 26" href="http://viewer.zmags.com/publication/33f0b1ec?page=26"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 27" href="http://viewer.zmags.com/publication/33f0b1ec?page=27"> Sunflower seeds antiperspirant, including both </a> <a title="EMJ Dermatology 2014 page 28" href="http://viewer.zmags.com/publication/33f0b1ec?page=28"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 29" href="http://viewer.zmags.com/publication/33f0b1ec?page=29"> Exenatide injection: with new hope comes new dang</a> <a title="EMJ Dermatology 2014 page 30" href="http://viewer.zmags.com/publication/33f0b1ec?page=30"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 31" href="http://viewer.zmags.com/publication/33f0b1ec?page=31"> Laser-assisted drug delivery: the next frontier? </a> <a title="EMJ Dermatology 2014 page 32" href="http://viewer.zmags.com/publication/33f0b1ec?page=32"> EADV ANNUAL CONGRESS 2014 AMSTERDAM RAI CONVENTIO</a> <a title="EMJ Dermatology 2014 page 33" href="http://viewer.zmags.com/publication/33f0b1ec?page=33"> PicoWay proves that nothing lasts forever REVOLUT</a> <a title="EMJ Dermatology 2014 page 34" href="http://viewer.zmags.com/publication/33f0b1ec?page=34"> Would you like to write for the EMJ blog? Intera</a> <a title="EMJ Dermatology 2014 page 35" href="http://viewer.zmags.com/publication/33f0b1ec?page=35"> Introduction from the Chair Professor Marcus Maur</a> <a title="EMJ Dermatology 2014 page 36" href="http://viewer.zmags.com/publication/33f0b1ec?page=36"> CU patients. This was further confirmed by the aud</a> <a title="EMJ Dermatology 2014 page 37" href="http://viewer.zmags.com/publication/33f0b1ec?page=37"> Patients with inadequately controlled </a> <a title="EMJ Dermatology 2014 page 38" href="http://viewer.zmags.com/publication/33f0b1ec?page=38"> condition,27 whereas the DLQI is a dermatological</a> <a title="EMJ Dermatology 2014 page 39" href="http://viewer.zmags.com/publication/33f0b1ec?page=39"> Omalizumab and the Latest Data for </a> <a title="EMJ Dermatology 2014 page 40" href="http://viewer.zmags.com/publication/33f0b1ec?page=40"> REFERENCES 1. Zuberbier T et al. The EAACI/GA(2) </a> <a title="EMJ Dermatology 2014 page 41" href="http://viewer.zmags.com/publication/33f0b1ec?page=41"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjrevie</a> <a title="EMJ Dermatology 2014 page 42" href="http://viewer.zmags.com/publication/33f0b1ec?page=42"> REVEALING A CLEAR PATH TOWARDS A NEW ERA </a> <a title="EMJ Dermatology 2014 page 43" href="http://viewer.zmags.com/publication/33f0b1ec?page=43"> target in psoriasis has ushered in an exciting ne</a> <a title="EMJ Dermatology 2014 page 44" href="http://viewer.zmags.com/publication/33f0b1ec?page=44"> Secukinumab has a novel mechanism of action</a> <a title="EMJ Dermatology 2014 page 45" href="http://viewer.zmags.com/publication/33f0b1ec?page=45"> PASI response at Week 12 (etanercept and ustekinu</a> <a title="EMJ Dermatology 2014 page 46" href="http://viewer.zmags.com/publication/33f0b1ec?page=46"> Secukinumab has demonstrated a positive safety pr</a> <a title="EMJ Dermatology 2014 page 47" href="http://viewer.zmags.com/publication/33f0b1ec?page=47"> QoL and psychological outcomes need to be p</a> <a title="EMJ Dermatology 2014 page 48" href="http://viewer.zmags.com/publication/33f0b1ec?page=48"> psoriasis--results of two phase 3 trials. N Engl </a> <a title="EMJ Dermatology 2014 page 49" href="http://viewer.zmags.com/publication/33f0b1ec?page=49"> SUBSCRIBE FREE TO OUR YOUTUBE CHANNEL www.youtube</a> <a title="EMJ Dermatology 2014 page 50" href="http://viewer.zmags.com/publication/33f0b1ec?page=50"> THE RECENT RAPID DEVELOPMENT OF THE DIRECTED-</a> <a title="EMJ Dermatology 2014 page 51" href="http://viewer.zmags.com/publication/33f0b1ec?page=51"> HUD INDUSTRY HISTORY The announcement late la</a> <a title="EMJ Dermatology 2014 page 52" href="http://viewer.zmags.com/publication/33f0b1ec?page=52"> Rest of World Europe United States Asia </a> <a title="EMJ Dermatology 2014 page 53" href="http://viewer.zmags.com/publication/33f0b1ec?page=53"> Figure 3: Example home-use, non-ablat</a> <a title="EMJ Dermatology 2014 page 54" href="http://viewer.zmags.com/publication/33f0b1ec?page=54"> base as possible, and to avoid negative pr</a> <a title="EMJ Dermatology 2014 page 55" href="http://viewer.zmags.com/publication/33f0b1ec?page=55"> any type in the home-use area, although several m</a> <a title="EMJ Dermatology 2014 page 56" href="http://viewer.zmags.com/publication/33f0b1ec?page=56"> CURRENT CONCEPTS IN AESTHETIC LASER MEDICINE: </a> <a title="EMJ Dermatology 2014 page 57" href="http://viewer.zmags.com/publication/33f0b1ec?page=57"> draining lymph nodes by tissue macrophages. This </a> <a title="EMJ Dermatology 2014 page 58" href="http://viewer.zmags.com/publication/33f0b1ec?page=58"> ABC Figure 2: Treatment of a professiona</a> <a title="EMJ Dermatology 2014 page 59" href="http://viewer.zmags.com/publication/33f0b1ec?page=59"> The use of the QSRL can achieve excellent </a> <a title="EMJ Dermatology 2014 page 60" href="http://viewer.zmags.com/publication/33f0b1ec?page=60"> A B Figure 4: Treatment of solar l</a> <a title="EMJ Dermatology 2014 page 61" href="http://viewer.zmags.com/publication/33f0b1ec?page=61"> THE AETIOPATHOGENESIS OF PSORIASIS IN 2014: </a> <a title="EMJ Dermatology 2014 page 62" href="http://viewer.zmags.com/publication/33f0b1ec?page=62"> associated regions within individuals of European</a> <a title="EMJ Dermatology 2014 page 63" href="http://viewer.zmags.com/publication/33f0b1ec?page=63"> Table 1 continued. Chr Gene(s) Protein Fu</a> <a title="EMJ Dermatology 2014 page 64" href="http://viewer.zmags.com/publication/33f0b1ec?page=64"> Lastly, GWAS have mainly identified susceptibility</a> <a title="EMJ Dermatology 2014 page 65" href="http://viewer.zmags.com/publication/33f0b1ec?page=65"> more innate-like cells, such as γδ-T cells61,62 a</a> <a title="EMJ Dermatology 2014 page 66" href="http://viewer.zmags.com/publication/33f0b1ec?page=66"> Ustekinumab, a monoclonal antibody directed a</a> <a title="EMJ Dermatology 2014 page 67" href="http://viewer.zmags.com/publication/33f0b1ec?page=67"> active and to activate the inflammasome.87 Studies</a> <a title="EMJ Dermatology 2014 page 68" href="http://viewer.zmags.com/publication/33f0b1ec?page=68"> Acknowledgements We apologise to all the authors </a> <a title="EMJ Dermatology 2014 page 69" href="http://viewer.zmags.com/publication/33f0b1ec?page=69"> Pathol. 2012;7:385-422. 41. Nickoloff BJ. Crackin</a> <a title="EMJ Dermatology 2014 page 70" href="http://viewer.zmags.com/publication/33f0b1ec?page=70"> 2006;126:1338-47. 87. Walter A et al. Aldara acti</a> <a title="EMJ Dermatology 2014 page 71" href="http://viewer.zmags.com/publication/33f0b1ec?page=71"> PRIMARY CUTANEOUS NEUTROPHILIC DISORDERS </a> <a title="EMJ Dermatology 2014 page 72" href="http://viewer.zmags.com/publication/33f0b1ec?page=72"> SWEET’S SYNDROME SS (acute febrile ND) can be di</a> <a title="EMJ Dermatology 2014 page 73" href="http://viewer.zmags.com/publication/33f0b1ec?page=73"> Associated fever occurs in 40-80% of patien</a> <a title="EMJ Dermatology 2014 page 74" href="http://viewer.zmags.com/publication/33f0b1ec?page=74"> hepatitis, and Wegener’s granulomatosis. Othe</a> <a title="EMJ Dermatology 2014 page 75" href="http://viewer.zmags.com/publication/33f0b1ec?page=75"> High-dose systemic corticosteroids reducing with </a> <a title="EMJ Dermatology 2014 page 76" href="http://viewer.zmags.com/publication/33f0b1ec?page=76"> review. Pediatr Dermatol. 2009;26(4): 452-7. 1</a> <a title="EMJ Dermatology 2014 page 77" href="http://viewer.zmags.com/publication/33f0b1ec?page=77"> NEUTROPHILIC DERMATOSES REVISITED *Aristóteles R</a> <a title="EMJ Dermatology 2014 page 78" href="http://viewer.zmags.com/publication/33f0b1ec?page=78"> (GI) infection, pregnancy, and inflammatory bowel </a> <a title="EMJ Dermatology 2014 page 79" href="http://viewer.zmags.com/publication/33f0b1ec?page=79"> Table 2: Systemic diseases associated with Sweet’</a> <a title="EMJ Dermatology 2014 page 80" href="http://viewer.zmags.com/publication/33f0b1ec?page=80"> NEUTROPHILIC DERMATOSIS OF THE DORSAL HANDS (NDDH</a> <a title="EMJ Dermatology 2014 page 81" href="http://viewer.zmags.com/publication/33f0b1ec?page=81"> Diagnosis There are no specific tests for the diag</a> <a title="EMJ Dermatology 2014 page 82" href="http://viewer.zmags.com/publication/33f0b1ec?page=82"> recur after its suspension.25 Oral corticost</a> <a title="EMJ Dermatology 2014 page 83" href="http://viewer.zmags.com/publication/33f0b1ec?page=83"> NEUTROPHILIC ECCRINE HIDRADENITIS (NEH) NEH u</a> <a title="EMJ Dermatology 2014 page 84" href="http://viewer.zmags.com/publication/33f0b1ec?page=84"> ASEPTIC ABSCESSES (AAS) The AAS is a rar</a> <a title="EMJ Dermatology 2014 page 85" href="http://viewer.zmags.com/publication/33f0b1ec?page=85"> children. J Cutan Pathol. 1994;21:289-96. 41. Li</a> <a title="EMJ Dermatology 2014 page 86" href="http://viewer.zmags.com/publication/33f0b1ec?page=86"> SKIN pH IN THE ELDERLY AND APPROPRIATE </a> <a title="EMJ Dermatology 2014 page 87" href="http://viewer.zmags.com/publication/33f0b1ec?page=87"> normal pH of the interstitial space, indicating a</a> <a title="EMJ Dermatology 2014 page 88" href="http://viewer.zmags.com/publication/33f0b1ec?page=88"> which both exhibit highest activity at acidic pH.</a> <a title="EMJ Dermatology 2014 page 89" href="http://viewer.zmags.com/publication/33f0b1ec?page=89"> In particular, leave-on products (e.g. lotions an</a> <a title="EMJ Dermatology 2014 page 90" href="http://viewer.zmags.com/publication/33f0b1ec?page=90"> In addition, water-in-oil formulations are m</a> <a title="EMJ Dermatology 2014 page 91" href="http://viewer.zmags.com/publication/33f0b1ec?page=91"> 0.5 0.3 0.1 -0.1 -0.3 -0.5 -0.7 Mean pH me</a> <a title="EMJ Dermatology 2014 page 92" href="http://viewer.zmags.com/publication/33f0b1ec?page=92"> on our own clinical data, skin care products for </a> <a title="EMJ Dermatology 2014 page 93" href="http://viewer.zmags.com/publication/33f0b1ec?page=93"> lipids, skin barrier function and filaggrin mutati</a> <a title="EMJ Dermatology 2014 page 94" href="http://viewer.zmags.com/publication/33f0b1ec?page=94"> epidermal permeability barrier: basis for functio</a> <a title="EMJ Dermatology 2014 page 95" href="http://viewer.zmags.com/publication/33f0b1ec?page=95"> ISOTRETINOIN AND PSYCHIATRIC EFFECTS Zennure T</a> <a title="EMJ Dermatology 2014 page 96" href="http://viewer.zmags.com/publication/33f0b1ec?page=96"> psychological effects of isotretinoin.17 Accordin</a> <a title="EMJ Dermatology 2014 page 97" href="http://viewer.zmags.com/publication/33f0b1ec?page=97"> day. The authors’ conclusion of a causal associat</a> <a title="EMJ Dermatology 2014 page 98" href="http://viewer.zmags.com/publication/33f0b1ec?page=98"> of both OCD and bipolar disorder.58 There is a st</a> <a title="EMJ Dermatology 2014 page 99" href="http://viewer.zmags.com/publication/33f0b1ec?page=99"> REFERENCES 1. Orfanos CE et al. Current use and </a> <a title="EMJ Dermatology 2014 page 100" href="http://viewer.zmags.com/publication/33f0b1ec?page=100"> in acne vulgaris patients treated with isotr</a> <a title="EMJ Dermatology 2014 page 101" href="http://viewer.zmags.com/publication/33f0b1ec?page=101"> METHYLISOTHIAZOLINONE AND METH</a> <a title="EMJ Dermatology 2014 page 102" href="http://viewer.zmags.com/publication/33f0b1ec?page=102"> it has been estimated that BIT concentrations use</a> <a title="EMJ Dermatology 2014 page 103" href="http://viewer.zmags.com/publication/33f0b1ec?page=103"> mandatory regulations are carried out, the high p</a> <a title="EMJ Dermatology 2014 page 104" href="http://viewer.zmags.com/publication/33f0b1ec?page=104"> testing with MCI/MI but not MI separately could o</a> <a title="EMJ Dermatology 2014 page 105" href="http://viewer.zmags.com/publication/33f0b1ec?page=105"> Spain (2001). Actas Dermo-Sifiliográficas. 2004;95(</a> <a title="EMJ Dermatology 2014 page 106" href="http://viewer.zmags.com/publication/33f0b1ec?page=106"> GRAM-NEGATIVE BACTERIAL TOE WEB INTERTRIGO </a> <a title="EMJ Dermatology 2014 page 107" href="http://viewer.zmags.com/publication/33f0b1ec?page=107"> extensive use of closed shoes for professional an</a> <a title="EMJ Dermatology 2014 page 108" href="http://viewer.zmags.com/publication/33f0b1ec?page=108"> AETIOLOGY AND PATHOGENESIS Gram-negative bacteri</a> <a title="EMJ Dermatology 2014 page 109" href="http://viewer.zmags.com/publication/33f0b1ec?page=109"> Figure 1: A mild erythematous scaling form of int</a> <a title="EMJ Dermatology 2014 page 110" href="http://viewer.zmags.com/publication/33f0b1ec?page=110"> Figure 3: A severe Gram-negative toe web intertri</a> <a title="EMJ Dermatology 2014 page 111" href="http://viewer.zmags.com/publication/33f0b1ec?page=111"> although, in some cases, parenteral therapy </a> <a title="EMJ Dermatology 2014 page 112" href="http://viewer.zmags.com/publication/33f0b1ec?page=112"> WHAT’S NEW Photoacoustic microscopy can detect me</a> <a title="EMJ Dermatology 2014 page 113" href="http://viewer.zmags.com/publication/33f0b1ec?page=113"> DERMATOLOGY Skin cancer survey puts UK parents in</a> <a title="EMJ Dermatology 2014 page 114" href="http://viewer.zmags.com/publication/33f0b1ec?page=114"> WHAT’S NEW Figure-hugging sheet shuns bacterial b</a> <a title="EMJ Dermatology 2014 page 115" href="http://viewer.zmags.com/publication/33f0b1ec?page=115"> DERMATOLOGY Acute stress - the secret to skin hea</a> <a title="EMJ Dermatology 2014 page 116" href="http://viewer.zmags.com/publication/33f0b1ec?page=116"> WHAT’S NEW Text messaging serves as useful health</a> <a title="EMJ Dermatology 2014 page 117" href="http://viewer.zmags.com/publication/33f0b1ec?page=117"> DERMATOLOGY A two-gene test can differentiate bet</a> <a title="EMJ Dermatology 2014 page 118" href="http://viewer.zmags.com/publication/33f0b1ec?page=118"> WHAT’S NEW Climate change drives rise in Buruli u</a> <a title="EMJ Dermatology 2014 page 119" href="http://viewer.zmags.com/publication/33f0b1ec?page=119"> DERMATOLOGY Red wine grapes hold key to banishing</a> <a title="EMJ Dermatology 2014 page 120" href="http://viewer.zmags.com/publication/33f0b1ec?page=120"> WHAT’S NEW Smoking makes psoriatic arthritis drug</a> <a title="EMJ Dermatology 2014 page 121" href="http://viewer.zmags.com/publication/33f0b1ec?page=121"> If you are interested in submitting a paper to </a> <a title="EMJ Dermatology 2014 page 122" href="http://viewer.zmags.com/publication/33f0b1ec?page=122"> Featured Suppliers Dermatology Responsible for </a> <a title="EMJ Dermatology 2014 page 123" href="http://viewer.zmags.com/publication/33f0b1ec?page=123"> From a host of fifteen therapeutic areas, EUROPEAN</a> <a title="EMJ Dermatology 2014 page 124" href="http://viewer.zmags.com/publication/33f0b1ec?page=124"> Buyer’s Guide Exhibitors • 3 GEN / DERMLITE • </a> <a title="EMJ Dermatology 2014 page 125" href="http://viewer.zmags.com/publication/33f0b1ec?page=125"> Dermatology • JOHNSON & JOHNSON CONSUMER </a> <a title="EMJ Dermatology 2014 page 126" href="http://viewer.zmags.com/publication/33f0b1ec?page=126"> UPCOMING EVENTS European Dermatology Forum 22nd-</a> <a title="EMJ Dermatology 2014 page 127" href="http://viewer.zmags.com/publication/33f0b1ec?page=127"> DERMATOLOGY 41st Annual Meeting: Society for Ped</a> <a title="EMJ Dermatology 2014 page 128" href="http://viewer.zmags.com/publication/33f0b1ec?page=128"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS PUBLI</a>