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<br /> ARCHIVE<br /> 2<br /> VOLUME 112 NUMBER 1 JANUARY 2017<br /> www.nature.com/ajg<br /> official publication of the american college of gastroenterology<br /> LEADING ARTICLES OF THE MONTH<br /> Practice Guidelines<br /> 18 ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries CME<br /> Paul Y. Kwo, Stanley M. Cohen and Joseph K. Lim<br /> 37 Recommendations on Fecal Immunochemical Testing to Screen for<br /> Colorectal Neoplasia: A Consensus Statement by the US<br /> Multi-Society Task Force on Colorectal Cancer<br /> Douglas J. Robertson, Jeffrey K. Lee, C. Richard Boland, Jason A. Dominitz,<br /> Francis M. Giardiello, David A. Johnson, Tonya Kaltenbach,<br /> David Lieberman, Theodore R. Levin and Douglas K. Rex<br /> Clinical and Systematic Reviews<br /> 65 Screening for Celiac Disease in Irritable Bowel Syndrome:<br /> An Upd<a title="AJG_Vol.112.No5 page 1" href="http://viewer.zmags.com/publication/3622a8e8?page=1"> ARCHIVE 2 VOLUME 112 NUMBER 1 JANUARY 2017 www</a> <a title="AJG_Vol.112.No5 page 2" href="http://viewer.zmags.com/publication/3622a8e8?page=2"> VOLUME 112 NUMBER 5 MAY 2017 www.nature.com/ajg </a> <a title="AJG_Vol.112.No5 page 3" href="http://viewer.zmags.com/publication/3622a8e8?page=3"> For adult patients with moderately to severely ac</a> <a title="AJG_Vol.112.No5 page 4" href="http://viewer.zmags.com/publication/3622a8e8?page=4"> · Provides remission at 52 weeks for patients wit</a> <a title="AJG_Vol.112.No5 page 5" href="http://viewer.zmags.com/publication/3622a8e8?page=5"> BRIEF SUMMARY OF FULL PRESCRIBING INFORMATION ENT</a> <a title="AJG_Vol.112.No5 page 6" href="http://viewer.zmags.com/publication/3622a8e8?page=6"> Table 1. Adverse Reactions in ≥3% of ENTYVIO-trea</a> <a title="AJG_Vol.112.No5 page 7" href="http://viewer.zmags.com/publication/3622a8e8?page=7"> by several factors, including sample handling, ti</a> <a title="AJG_Vol.112.No5 page 8" href="http://viewer.zmags.com/publication/3622a8e8?page=8"> www.nature.com/ajg The American Journal o</a> <a title="AJG_Vol.112.No5 page 9" href="http://viewer.zmags.com/publication/3622a8e8?page=9"> official publication of the american college</a> <a title="AJG_Vol.112.No5 page 10" href="http://viewer.zmags.com/publication/3622a8e8?page=10"> * Test to uncover man</a> <a title="AJG_Vol.112.No5 page 11" href="http://viewer.zmags.com/publication/3622a8e8?page=11"> Call for Abstracts World Congress of Gastroenter</a> <a title="AJG_Vol.112.No5 page 12" href="http://viewer.zmags.com/publication/3622a8e8?page=12"> A CURE FOR EVERY TYPE TM Patients of any HCV gen</a> <a title="AJG_Vol.112.No5 page 13" href="http://viewer.zmags.com/publication/3622a8e8?page=13"> Albert Einstein used with permission of the HUJ/G</a> <a title="AJG_Vol.112.No5 page 14" href="http://viewer.zmags.com/publication/3622a8e8?page=14"> THE FIRST AND ONLY PAN-GENOTYPIC ONCE-DAILY SINGL</a> <a title="AJG_Vol.112.No5 page 15" href="http://viewer.zmags.com/publication/3622a8e8?page=15"> HARVONI® (ledipasvir 90 mg and sofosbuvir 400 mg)</a> <a title="AJG_Vol.112.No5 page 16" href="http://viewer.zmags.com/publication/3622a8e8?page=16"> Brief Summary (cont.) potential causal relationsh</a> <a title="AJG_Vol.112.No5 page 17" href="http://viewer.zmags.com/publication/3622a8e8?page=17"> EPCLUSA® (sofosbuvir 400 mg and velpatasvir 100 m</a> <a title="AJG_Vol.112.No5 page 18" href="http://viewer.zmags.com/publication/3622a8e8?page=18"> Brief Summary (cont.) assessed when amylase value</a> <a title="AJG_Vol.112.No5 page 19" href="http://viewer.zmags.com/publication/3622a8e8?page=19"> RECOMMEND THE BEST WITH NEXIUM® 24HR Nexium® 24HR</a> <a title="AJG_Vol.112.No5 page 20" href="http://viewer.zmags.com/publication/3622a8e8?page=20"> Endoscopic submucosal resection (EMR) with an EMR</a> <a title="AJG_Vol.112.No5 page 21" href="http://viewer.zmags.com/publication/3622a8e8?page=21"> CONTENTS C-arm Patient bed Attending/fe</a> <a title="AJG_Vol.112.No5 page 22" href="http://viewer.zmags.com/publication/3622a8e8?page=22"> www.nature.com/ajg </a> <a title="AJG_Vol.112.No5 page 23" href="http://viewer.zmags.com/publication/3622a8e8?page=23"> IMPORTANT SAFETY INFORMATION WARNING: RISK OF SE</a> <a title="AJG_Vol.112.No5 page 24" href="http://viewer.zmags.com/publication/3622a8e8?page=24"> </a> <a title="AJG_Vol.112.No5 page 25" href="http://viewer.zmags.com/publication/3622a8e8?page=25"> Trulance™ (plecanatide) tablets, for oral use Rx </a> <a title="AJG_Vol.112.No5 page 26" href="http://viewer.zmags.com/publication/3622a8e8?page=26"> Michael R. Charlton, MD The University of Chicago</a> <a title="AJG_Vol.112.No5 page 27" href="http://viewer.zmags.com/publication/3622a8e8?page=27"> Attend an ACG Regional Postgraduate Course close </a> <a title="AJG_Vol.112.No5 page 28" href="http://viewer.zmags.com/publication/3622a8e8?page=28"> FOR PATIENTS WITH ACTIVE, MILD TO MODERATE ULCERA</a> <a title="AJG_Vol.112.No5 page 29" href="http://viewer.zmags.com/publication/3622a8e8?page=29"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This bri</a> <a title="AJG_Vol.112.No5 page 30" href="http://viewer.zmags.com/publication/3622a8e8?page=30"> ADVERTISEMENT Persistent diarrhea: are there fast</a> <a title="AJG_Vol.112.No5 page 31" href="http://viewer.zmags.com/publication/3622a8e8?page=31"> American College of Gastroenterology & World Gast</a> <a title="AJG_Vol.112.No5 page 32" href="http://viewer.zmags.com/publication/3622a8e8?page=32"> THE RED SECTION 667 see related editorial</a> <a title="AJG_Vol.112.No5 page 33" href="http://viewer.zmags.com/publication/3622a8e8?page=33"> 668 THE RED SECTION HOW I APPROACH IT Table </a> <a title="AJG_Vol.112.No5 page 34" href="http://viewer.zmags.com/publication/3622a8e8?page=34"> favored over drug discontinuation or drug withhol</a> <a title="AJG_Vol.112.No5 page 35" href="http://viewer.zmags.com/publication/3622a8e8?page=35"> 670 THE RED SECTION POINT-COUNTERPOINT INTRO</a> <a title="AJG_Vol.112.No5 page 36" href="http://viewer.zmags.com/publication/3622a8e8?page=36"> Patient factors </a> <a title="AJG_Vol.112.No5 page 37" href="http://viewer.zmags.com/publication/3622a8e8?page=37"> 672 THE RED SECTION POINT-COUNTERPOINT 8. W</a> <a title="AJG_Vol.112.No5 page 38" href="http://viewer.zmags.com/publication/3622a8e8?page=38"> THE RED SECTION 673 see related editorial</a> <a title="AJG_Vol.112.No5 page 39" href="http://viewer.zmags.com/publication/3622a8e8?page=39"> 674 THE RED SECTION POINT-COUNTERPOINT Table</a> <a title="AJG_Vol.112.No5 page 40" href="http://viewer.zmags.com/publication/3622a8e8?page=40"> THE RED SECTION 675 Table 2. Anti-TNF drug c</a> <a title="AJG_Vol.112.No5 page 41" href="http://viewer.zmags.com/publication/3622a8e8?page=41"> 676 THE RED SECTION CONFLICT OF INTEREST </a> <a title="AJG_Vol.112.No5 page 42" href="http://viewer.zmags.com/publication/3622a8e8?page=42"> Springer Nature </a> <a title="AJG_Vol.112.No5 page 43" href="http://viewer.zmags.com/publication/3622a8e8?page=43"> 678 THE RED SECTION A Nipple Sign on an Ec</a> <a title="AJG_Vol.112.No5 page 44" href="http://viewer.zmags.com/publication/3622a8e8?page=44"> THE RED SECTION 679 Video of the Month End</a> <a title="AJG_Vol.112.No5 page 45" href="http://viewer.zmags.com/publication/3622a8e8?page=45"> 680 THE RED SECTION Video of the Month Ur</a> <a title="AJG_Vol.112.No5 page 46" href="http://viewer.zmags.com/publication/3622a8e8?page=46"> CLINICAL GUIDELINES 681 CME Continuing M</a> <a title="AJG_Vol.112.No5 page 47" href="http://viewer.zmags.com/publication/3622a8e8?page=47"> 682 CLINICAL GUIDELINES CME Recommendati</a> <a title="AJG_Vol.112.No5 page 48" href="http://viewer.zmags.com/publication/3622a8e8?page=48"> 683 Table 1. Estimated Penetrance and Age of O</a> <a title="AJG_Vol.112.No5 page 49" href="http://viewer.zmags.com/publication/3622a8e8?page=49"> 684 Durno et al. predisposition syndromes</a> <a title="AJG_Vol.112.No5 page 50" href="http://viewer.zmags.com/publication/3622a8e8?page=50"> 685 Table 3. Recommendations for Screening At-</a> <a title="AJG_Vol.112.No5 page 51" href="http://viewer.zmags.com/publication/3622a8e8?page=51"> 686 Durno et al. Because patients are l</a> <a title="AJG_Vol.112.No5 page 52" href="http://viewer.zmags.com/publication/3622a8e8?page=52"> Recommendation 5. In women with BMMRD, surveillan</a> <a title="AJG_Vol.112.No5 page 53" href="http://viewer.zmags.com/publication/3622a8e8?page=53"> 688 Durno et al. the high prevalence of m</a> <a title="AJG_Vol.112.No5 page 54" href="http://viewer.zmags.com/publication/3622a8e8?page=54"> Table 4. Knowledge Gaps Requiring Research in the</a> <a title="AJG_Vol.112.No5 page 55" href="http://viewer.zmags.com/publication/3622a8e8?page=55"> 690 Durno et al. 22. Wimmer K, Kratz CP. C</a> <a title="AJG_Vol.112.No5 page 56" href="http://viewer.zmags.com/publication/3622a8e8?page=56"> CLINICAL GUIDELINES 691 CME Continuing M</a> <a title="AJG_Vol.112.No5 page 57" href="http://viewer.zmags.com/publication/3622a8e8?page=57"> 692 CLINICAL AND SYSTEMATIC REVIEWS CME </a> <a title="AJG_Vol.112.No5 page 58" href="http://viewer.zmags.com/publication/3622a8e8?page=58"> CLINICAL AND SYSTEMATIC REVIEWS 693 CME C</a> <a title="AJG_Vol.112.No5 page 59" href="http://viewer.zmags.com/publication/3622a8e8?page=59"> 694 Sobin et al. REVIEW EVIDENCE FOR THE BE</a> <a title="AJG_Vol.112.No5 page 60" href="http://viewer.zmags.com/publication/3622a8e8?page=60"> Treating Functional GI Disorders: A Primer 695</a> <a title="AJG_Vol.112.No5 page 61" href="http://viewer.zmags.com/publication/3622a8e8?page=61"> 696 Sobin et al. REVIEW Table 2. Central ne</a> <a title="AJG_Vol.112.No5 page 62" href="http://viewer.zmags.com/publication/3622a8e8?page=62"> Treating Functional GI Disorders: A Primer 697</a> <a title="AJG_Vol.112.No5 page 63" href="http://viewer.zmags.com/publication/3622a8e8?page=63"> 698 Sobin et al. REVIEW venlafaxine, is dos</a> <a title="AJG_Vol.112.No5 page 64" href="http://viewer.zmags.com/publication/3622a8e8?page=64"> can be very effective in patients who have functi</a> <a title="AJG_Vol.112.No5 page 65" href="http://viewer.zmags.com/publication/3622a8e8?page=65"> 700 Sobin et al. alternative central neur</a> <a title="AJG_Vol.112.No5 page 66" href="http://viewer.zmags.com/publication/3622a8e8?page=66"> REFERENCES 1. Clouse RE, Lustman PJ. Use of psyc</a> <a title="AJG_Vol.112.No5 page 67" href="http://viewer.zmags.com/publication/3622a8e8?page=67"> 702 Sobin et al. APPENDIX - TREATMENT SCE</a> <a title="AJG_Vol.112.No5 page 68" href="http://viewer.zmags.com/publication/3622a8e8?page=68"> CLINICAL AND SYSTEMATIC REVIEWS 703 CME </a> <a title="AJG_Vol.112.No5 page 69" href="http://viewer.zmags.com/publication/3622a8e8?page=69"> 704 ORIGINAL CONTRIBUTIONS see related ed</a> <a title="AJG_Vol.112.No5 page 70" href="http://viewer.zmags.com/publication/3622a8e8?page=70"> Pepsinogen I (PGI), PGII, and gastrin-17 (G-17</a> <a title="AJG_Vol.112.No5 page 71" href="http://viewer.zmags.com/publication/3622a8e8?page=71"> 706 Tu et al. Zhuanghe County: 361 villag</a> <a title="AJG_Vol.112.No5 page 72" href="http://viewer.zmags.com/publication/3622a8e8?page=72"> Serological Biopsy and Gastric Cancer Risk Assess</a> <a title="AJG_Vol.112.No5 page 73" href="http://viewer.zmags.com/publication/3622a8e8?page=73"> 708 Tu et al. Table 2. Cross-sectional assoc</a> <a title="AJG_Vol.112.No5 page 74" href="http://viewer.zmags.com/publication/3622a8e8?page=74"> Serological Biopsy and Gastric Cancer Risk Assess</a> <a title="AJG_Vol.112.No5 page 75" href="http://viewer.zmags.com/publication/3622a8e8?page=75"> 710 Tu et al. a </a> <a title="AJG_Vol.112.No5 page 76" href="http://viewer.zmags.com/publication/3622a8e8?page=76"> Table 4. Multivariate odds ratios and risk points</a> <a title="AJG_Vol.112.No5 page 77" href="http://viewer.zmags.com/publication/3622a8e8?page=77"> 712 Tu et al. STOMACH Table 5. Measures of </a> <a title="AJG_Vol.112.No5 page 78" href="http://viewer.zmags.com/publication/3622a8e8?page=78"> the stomach fundus/body where acid-secreting glan</a> <a title="AJG_Vol.112.No5 page 79" href="http://viewer.zmags.com/publication/3622a8e8?page=79"> 714 Tu et al. STOMACH Study Highlights WHA</a> <a title="AJG_Vol.112.No5 page 80" href="http://viewer.zmags.com/publication/3622a8e8?page=80"> 41. Tindberg Y, Blennow M, Granstrom M. Clinical </a> <a title="AJG_Vol.112.No5 page 81" href="http://viewer.zmags.com/publication/3622a8e8?page=81"> 716 ORIGINAL CONTRIBUTIONS </a> <a title="AJG_Vol.112.No5 page 82" href="http://viewer.zmags.com/publication/3622a8e8?page=82"> Ocular Radiation Threshold Projection During ERCP</a> <a title="AJG_Vol.112.No5 page 83" href="http://viewer.zmags.com/publication/3622a8e8?page=83"> 718 Garg et al. ENDOSCOPY Table 1. Baseline</a> <a title="AJG_Vol.112.No5 page 84" href="http://viewer.zmags.com/publication/3622a8e8?page=84"> The remaining 187 cases were included in the stud</a> <a title="AJG_Vol.112.No5 page 85" href="http://viewer.zmags.com/publication/3622a8e8?page=85"> 720 Garg et al. Procedures performed 11 </a> <a title="AJG_Vol.112.No5 page 86" href="http://viewer.zmags.com/publication/3622a8e8?page=86"> REFERENCES 1. Chen MY, Van Swearingen FL, Mitche</a> <a title="AJG_Vol.112.No5 page 87" href="http://viewer.zmags.com/publication/3622a8e8?page=87"> 722 EDITORIAL see related article on pag</a> <a title="AJG_Vol.112.No5 page 88" href="http://viewer.zmags.com/publication/3622a8e8?page=88"> fluoroscopy-guided procedures. These measureme</a> <a title="AJG_Vol.112.No5 page 89" href="http://viewer.zmags.com/publication/3622a8e8?page=89"> 724 Mekaroonkamol and Keilin ENDOSCOPY 7. </a> <a title="AJG_Vol.112.No5 page 90" href="http://viewer.zmags.com/publication/3622a8e8?page=90"> ORIGINAL CONTRIBUTIONS 725 see related ed</a> <a title="AJG_Vol.112.No5 page 91" href="http://viewer.zmags.com/publication/3622a8e8?page=91"> 726 Abdelhafez et al. ENDOSCOPY Endoscopy r</a> <a title="AJG_Vol.112.No5 page 92" href="http://viewer.zmags.com/publication/3622a8e8?page=92"> Cap Assisted Endoscopy for Examination of Papilla</a> <a title="AJG_Vol.112.No5 page 93" href="http://viewer.zmags.com/publication/3622a8e8?page=93"> 728 Abdelhafez et al. abef ENDOSCOPY cdg</a> <a title="AJG_Vol.112.No5 page 94" href="http://viewer.zmags.com/publication/3622a8e8?page=94"> Cap Assisted Endoscopy for Examination of Papilla</a> <a title="AJG_Vol.112.No5 page 95" href="http://viewer.zmags.com/publication/3622a8e8?page=95"> 730 Abdelhafez et al. a1 </a> <a title="AJG_Vol.112.No5 page 96" href="http://viewer.zmags.com/publication/3622a8e8?page=96"> Table 3. Duration needed to localize the MDP and </a> <a title="AJG_Vol.112.No5 page 97" href="http://viewer.zmags.com/publication/3622a8e8?page=97"> 732 Abdelhafez et al. ENDOSCOPY Our study</a> <a title="AJG_Vol.112.No5 page 98" href="http://viewer.zmags.com/publication/3622a8e8?page=98"> 9. Vogt M, Jakobs R, Benz C et al. Endoscopic th</a> <a title="AJG_Vol.112.No5 page 99" href="http://viewer.zmags.com/publication/3622a8e8?page=99"> 734 ORIGINAL CONTRIBUTIONS see related e</a> <a title="AJG_Vol.112.No5 page 100" href="http://viewer.zmags.com/publication/3622a8e8?page=100"> with dabigatran was higher than that with warfari</a> <a title="AJG_Vol.112.No5 page 101" href="http://viewer.zmags.com/publication/3622a8e8?page=101"> 736 Cangemi et al. ENDOSCOPY DVT. Among the</a> <a title="AJG_Vol.112.No5 page 102" href="http://viewer.zmags.com/publication/3622a8e8?page=102"> Table 2. Continued Clinically significant GIB </a> <a title="AJG_Vol.112.No5 page 103" href="http://viewer.zmags.com/publication/3622a8e8?page=103"> 738 Cangemi et al. ENDOSCOPY Table 4. Secon</a> <a title="AJG_Vol.112.No5 page 104" href="http://viewer.zmags.com/publication/3622a8e8?page=104"> either of these may have impacted the rates of GI</a> <a title="AJG_Vol.112.No5 page 105" href="http://viewer.zmags.com/publication/3622a8e8?page=105"> 740 ORIGINAL CONTRIBUTIONS see related ed</a> <a title="AJG_Vol.112.No5 page 106" href="http://viewer.zmags.com/publication/3622a8e8?page=106"> result in cirrhosis, putting patients at risk of </a> <a title="AJG_Vol.112.No5 page 107" href="http://viewer.zmags.com/publication/3622a8e8?page=107"> 742 McPherson et al. LIVER EPoS/EASL Europe</a> <a title="AJG_Vol.112.No5 page 108" href="http://viewer.zmags.com/publication/3622a8e8?page=108"> Effect of Age on Non-Invasive Fibrosis Scores in </a> <a title="AJG_Vol.112.No5 page 109" href="http://viewer.zmags.com/publication/3622a8e8?page=109"> 744 McPherson et al. LIVER Table 3. Perform</a> <a title="AJG_Vol.112.No5 page 110" href="http://viewer.zmags.com/publication/3622a8e8?page=110"> a AST/ALT (5-year </a> <a title="AJG_Vol.112.No5 page 111" href="http://viewer.zmags.com/publication/3622a8e8?page=111"> 746 McPherson et al. a 150 125 100 L</a> <a title="AJG_Vol.112.No5 page 112" href="http://viewer.zmags.com/publication/3622a8e8?page=112"> a 150 Sensitivity/specificity (%) 100 50 </a> <a title="AJG_Vol.112.No5 page 113" href="http://viewer.zmags.com/publication/3622a8e8?page=113"> 748 McPherson et al. LIVER Table 4. Perform</a> <a title="AJG_Vol.112.No5 page 114" href="http://viewer.zmags.com/publication/3622a8e8?page=114"> Effect of Age on Non-Invasive Fibrosis Scores in </a> <a title="AJG_Vol.112.No5 page 115" href="http://viewer.zmags.com/publication/3622a8e8?page=115"> 750 McPherson et al. LIVER Study Highlights</a> <a title="AJG_Vol.112.No5 page 116" href="http://viewer.zmags.com/publication/3622a8e8?page=116"> 42. Fagan KJ, Pretorius CJ, Horsfall LU et al. EL</a> <a title="AJG_Vol.112.No5 page 117" href="http://viewer.zmags.com/publication/3622a8e8?page=117"> 752 EDITORIAL see related article on pag</a> <a title="AJG_Vol.112.No5 page 118" href="http://viewer.zmags.com/publication/3622a8e8?page=118"> Editorial 753 False positives Old </a> <a title="AJG_Vol.112.No5 page 119" href="http://viewer.zmags.com/publication/3622a8e8?page=119"> 754 Stine and Rinella LIVER CONFLICT OF INT</a> <a title="AJG_Vol.112.No5 page 120" href="http://viewer.zmags.com/publication/3622a8e8?page=120"> ORIGINAL CONTRIBUTIONS 755 see related ed</a> <a title="AJG_Vol.112.No5 page 121" href="http://viewer.zmags.com/publication/3622a8e8?page=121"> 756 Sarkar et al. LIVER and leading indicat</a> <a title="AJG_Vol.112.No5 page 122" href="http://viewer.zmags.com/publication/3622a8e8?page=122"> while levels remain relatively stable throughout </a> <a title="AJG_Vol.112.No5 page 123" href="http://viewer.zmags.com/publication/3622a8e8?page=123"> 758 Sarkar et al. LIVER approach employs re</a> <a title="AJG_Vol.112.No5 page 124" href="http://viewer.zmags.com/publication/3622a8e8?page=124"> protective effect of hormonal contraception on un</a> <a title="AJG_Vol.112.No5 page 125" href="http://viewer.zmags.com/publication/3622a8e8?page=125"> 760 Sarkar et al. LIVER Supplementary Table</a> <a title="AJG_Vol.112.No5 page 126" href="http://viewer.zmags.com/publication/3622a8e8?page=126"> sex-based models of care in NAFLD. Testosterone m</a> <a title="AJG_Vol.112.No5 page 127" href="http://viewer.zmags.com/publication/3622a8e8?page=127"> 762 Sarkar et al. LIVER 4. Wong RJ, Cheung</a> <a title="AJG_Vol.112.No5 page 128" href="http://viewer.zmags.com/publication/3622a8e8?page=128"> ORIGINAL CONTRIBUTIONS 763 see related edi</a> <a title="AJG_Vol.112.No5 page 129" href="http://viewer.zmags.com/publication/3622a8e8?page=129"> 764 Chey et al. FUNCTIONAL GI DISORDERS </a> <a title="AJG_Vol.112.No5 page 130" href="http://viewer.zmags.com/publication/3622a8e8?page=130"> before the screening visit were included in the s</a> <a title="AJG_Vol.112.No5 page 131" href="http://viewer.zmags.com/publication/3622a8e8?page=131"> 766 Chey et al. FUNCTIONAL GI DISORDERS bot</a> <a title="AJG_Vol.112.No5 page 132" href="http://viewer.zmags.com/publication/3622a8e8?page=132"> Phase 2 Efficacy and Safety Trial of Tenapanor in</a> <a title="AJG_Vol.112.No5 page 133" href="http://viewer.zmags.com/publication/3622a8e8?page=133"> 768 Chey et al. FUNCTIONAL GI DISORDERS Tab</a> <a title="AJG_Vol.112.No5 page 134" href="http://viewer.zmags.com/publication/3622a8e8?page=134"> Phase 2 Efficacy and Safety Trial of Tenapanor in</a> <a title="AJG_Vol.112.No5 page 135" href="http://viewer.zmags.com/publication/3622a8e8?page=135"> 770 Chey et al. 7 Mean average weekly </a> <a title="AJG_Vol.112.No5 page 136" href="http://viewer.zmags.com/publication/3622a8e8?page=136"> Phase 2 Efficacy and Safety Trial of Tenapanor in</a> <a title="AJG_Vol.112.No5 page 137" href="http://viewer.zmags.com/publication/3622a8e8?page=137"> 772 Chey et al. GI DISORDERS FUNCTIONAL Tab</a> <a title="AJG_Vol.112.No5 page 138" href="http://viewer.zmags.com/publication/3622a8e8?page=138"> sodium, but also of phosphate from the gut, it is</a> <a title="AJG_Vol.112.No5 page 139" href="http://viewer.zmags.com/publication/3622a8e8?page=139"> 774 Chey et al. FUNCTIONAL GI DISORDERS </a> <a title="AJG_Vol.112.No5 page 140" href="http://viewer.zmags.com/publication/3622a8e8?page=140"> ORIGINAL CONTRIBUTIONS 775 see related ed</a> <a title="AJG_Vol.112.No5 page 141" href="http://viewer.zmags.com/publication/3622a8e8?page=141"> 776 Rezaie et al. FUNCTIONAL GI DISORDERS o</a> <a title="AJG_Vol.112.No5 page 142" href="http://viewer.zmags.com/publication/3622a8e8?page=142"> Table 1. Preparation before breath testing Consen</a> <a title="AJG_Vol.112.No5 page 143" href="http://viewer.zmags.com/publication/3622a8e8?page=143"> 778 Rezaie et al. GI DISORDERS FUNCTIONAL T</a> <a title="AJG_Vol.112.No5 page 144" href="http://viewer.zmags.com/publication/3622a8e8?page=144"> breath gas levels and recurrence of reflux sympto</a> <a title="AJG_Vol.112.No5 page 145" href="http://viewer.zmags.com/publication/3622a8e8?page=145"> 780 Rezaie et al. FUNCTIONAL GI DISORDERS d</a> <a title="AJG_Vol.112.No5 page 146" href="http://viewer.zmags.com/publication/3622a8e8?page=146"> the colon and be metabolized. Rao et al. (67) rep</a> <a title="AJG_Vol.112.No5 page 147" href="http://viewer.zmags.com/publication/3622a8e8?page=147"> 782 Rezaie et al. FUNCTIONAL GI DISORDERS -</a> <a title="AJG_Vol.112.No5 page 148" href="http://viewer.zmags.com/publication/3622a8e8?page=148"> Study Highlights WHAT IS CURRENT KNOWLEDGE ✓ Bre</a> <a title="AJG_Vol.112.No5 page 149" href="http://viewer.zmags.com/publication/3622a8e8?page=149"> 784 Rezaie et al. FUNCTIONAL GI DISORDERS 4</a> <a title="AJG_Vol.112.No5 page 150" href="http://viewer.zmags.com/publication/3622a8e8?page=150"> ORIGINAL CONTRIBUTIONS 785 see related edi</a> <a title="AJG_Vol.112.No5 page 151" href="http://viewer.zmags.com/publication/3622a8e8?page=151"> 786 Backes et al. COLON/SMALL BOWEL INTRODU</a> <a title="AJG_Vol.112.No5 page 152" href="http://viewer.zmags.com/publication/3622a8e8?page=152"> the American Joint Committee on Cancer (AJCC) sta</a> <a title="AJG_Vol.112.No5 page 153" href="http://viewer.zmags.com/publication/3622a8e8?page=153"> 788 Backes et al. COLON/SMALL BOWEL Patient</a> <a title="AJG_Vol.112.No5 page 154" href="http://viewer.zmags.com/publication/3622a8e8?page=154"> Endoscopic Resection of T1 CRC 789 Table 1.</a> <a title="AJG_Vol.112.No5 page 155" href="http://viewer.zmags.com/publication/3622a8e8?page=155"> 790 Backes et al. COLON/SMALL BOWEL Table 1</a> <a title="AJG_Vol.112.No5 page 156" href="http://viewer.zmags.com/publication/3622a8e8?page=156"> Endoscopic Resection of T1 CRC 791 Table 2.</a> <a title="AJG_Vol.112.No5 page 157" href="http://viewer.zmags.com/publication/3622a8e8?page=157"> 792 Backes et al. COLON/SMALL BOWEL Table 3</a> <a title="AJG_Vol.112.No5 page 158" href="http://viewer.zmags.com/publication/3622a8e8?page=158"> Table 4. Multivariate analysis of clinical risk f</a> <a title="AJG_Vol.112.No5 page 159" href="http://viewer.zmags.com/publication/3622a8e8?page=159"> 794 Backes et al. COLON/SMALL BOWEL 19 18 </a> <a title="AJG_Vol.112.No5 page 160" href="http://viewer.zmags.com/publication/3622a8e8?page=160"> concept and design, acquisition of data, analysis</a> <a title="AJG_Vol.112.No5 page 161" href="http://viewer.zmags.com/publication/3622a8e8?page=161"> 796 Backes et al. COLON/SMALL BOWEL 36. Mos</a> <a title="AJG_Vol.112.No5 page 162" href="http://viewer.zmags.com/publication/3622a8e8?page=162"> ORIGINAL CONTRIBUTIONS 797 see related edi</a> <a title="AJG_Vol.112.No5 page 163" href="http://viewer.zmags.com/publication/3622a8e8?page=163"> 798 Buxbaum et al. PANCREAS AND BILIARY TRAC</a> <a title="AJG_Vol.112.No5 page 164" href="http://viewer.zmags.com/publication/3622a8e8?page=164"> regression analysis was used to adjust for the in</a> <a title="AJG_Vol.112.No5 page 165" href="http://viewer.zmags.com/publication/3622a8e8?page=165"> 800 Buxbaum et al. PANCREAS AND BILIARY TRAC</a> <a title="AJG_Vol.112.No5 page 166" href="http://viewer.zmags.com/publication/3622a8e8?page=166"> Standard Aggressive HR 1.98 (1.05–3.69) </a> <a title="AJG_Vol.112.No5 page 167" href="http://viewer.zmags.com/publication/3622a8e8?page=167"> 802 Buxbaum et al. PANCREAS AND BILIARY TRAC</a> <a title="AJG_Vol.112.No5 page 168" href="http://viewer.zmags.com/publication/3622a8e8?page=168"> 20. Sathiaraj E, Murthy S, Mansard MJ et al. 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