If you are visually impaired or blind, you can visit the PDF version by Pressing CONTROL + ALT + 4
&lt;br /&gt; Supplement to Nature Publishing Group December 2011&lt;br /&gt; Technology Features&lt;br /&gt; INTEGRATED BIOLOGY&lt;br /&gt; 5-Hydroxymethylcytosine&lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; OH NH&lt;br /&gt; 2&lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; N&lt;br /&gt; &lt;br /&gt; 5-hmC&lt;br /&gt; &lt;br /&gt; N&lt;br /&gt; O&lt;br /&gt; H&lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; decode the mystery of the sixth base&lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt; &lt;br /&gt<a title="Nature Reprint Collection - Technology Features page 1" href="http://viewer.zmags.com/publication/370fd028?page=1">Supplement to Nature Publishing Group </a> Supplement to Nature Publishing Group <a title="Nature Reprint Collection - Technology Features page 2" href="http://viewer.zmags.com/publication/370fd028?page=2">The Most Comprehensive Reagents &amp; Servicesfor Yo</a> The Most Comprehensive Reagents &amp; Servicesfor Yo<a title="Nature Reprint Collection - Technology Features page 3" href="http://viewer.zmags.com/publication/370fd028?page=3">Supplement to Nature Publishing Group </a> Supplement to Nature Publishing Group <a title="Nature Reprint Collection - Technology Features page 4" href="http://viewer.zmags.com/publication/370fd028?page=4">&#9632;&#9632;&#9632;&#9632;&#9632;Your miss</a> &#9632;&#9632;&#9632;&#9632;&#9632;Your miss<a title="Nature Reprint Collection - Technology Features page 5" href="http://viewer.zmags.com/publication/370fd028?page=5">Nature Reprint Collectioneditor-in-chief, Nature</a> Nature Reprint Collectioneditor-in-chief, Nature<a title="Nature Reprint Collection - Technology Features page 6" href="http://viewer.zmags.com/publication/370fd028?page=6">C:LL:7H&gt;I:K&gt;H&gt;IDJGlll#VXi^kZbdi^[#Xdb6Xi^kZ</a> C:LL:7H&gt;I:K&gt;H&gt;IDJGlll#VXi^kZbdi^[#Xdb6Xi^kZ<a title="Nature Reprint Collection - Technology Features page 7" href="http://viewer.zmags.com/publication/370fd028?page=7">TECHNOLOGY FEATUREGENOMES IN THREEDIMENSIONSA</a> TECHNOLOGY FEATUREGENOMES IN THREEDIMENSIONSA<a title="Nature Reprint Collection - Technology Features page 8" href="http://viewer.zmags.com/publication/370fd028?page=8">TECHNOLOGYGENOMICSeach other in the nucleus,&rdquo;</a> TECHNOLOGYGENOMICSeach other in the nucleus,&rdquo;<a title="Nature Reprint Collection - Technology Features page 9" href="http://viewer.zmags.com/publication/370fd028?page=9">GENOMICSTECHNOLOGYINVESTIGATING THE ARCHITECTU</a> GENOMICSTECHNOLOGYINVESTIGATING THE ARCHITECTU<a title="Nature Reprint Collection - Technology Features page 10" href="http://viewer.zmags.com/publication/370fd028?page=10">TECHNOLOGYGENOMICSREF. 10reading. No one bel</a> TECHNOLOGYGENOMICSREF. 10reading. No one bel<a title="Nature Reprint Collection - Technology Features page 11" href="http://viewer.zmags.com/publication/370fd028?page=11">GENOMICSTECHNOLOGYY. MARKAKI/T. CREMER LAB.S</a> GENOMICSTECHNOLOGYY. MARKAKI/T. CREMER LAB.S<a title="Nature Reprint Collection - Technology Features page 12" href="http://viewer.zmags.com/publication/370fd028?page=12">MiSeq. </a> MiSeq. <a title="Nature Reprint Collection - Technology Features page 13" href="http://viewer.zmags.com/publication/370fd028?page=13"></a> <a title="Nature Reprint Collection - Technology Features page 14" href="http://viewer.zmags.com/publication/370fd028?page=14">Luciferase Assay SystemA complete reporter assay</a> Luciferase Assay SystemA complete reporter assay<a title="Nature Reprint Collection - Technology Features page 15" href="http://viewer.zmags.com/publication/370fd028?page=15">TECHNOLOGY FEATURETHE NEXT STEP FOR THESYNTHET</a> TECHNOLOGY FEATURETHE NEXT STEP FOR THESYNTHET<a title="Nature Reprint Collection - Technology Features page 16" href="http://viewer.zmags.com/publication/370fd028?page=16">TECHNOLOGYSYNTHETIC GENOMES &ldquo;We frankly</a> TECHNOLOGYSYNTHETIC GENOMES &ldquo;We frankly<a title="Nature Reprint Collection - Technology Features page 17" href="http://viewer.zmags.com/publication/370fd028?page=17">SOURCE: R. CARLSON/WWW.SYNTHESIS.CCMaking DNA o</a> SOURCE: R. CARLSON/WWW.SYNTHESIS.CCMaking DNA o<a title="Nature Reprint Collection - Technology Features page 18" href="http://viewer.zmags.com/publication/370fd028?page=18">TECHNOLOGYSYNTHETIC GENOMESbe assembled in pa</a> TECHNOLOGYSYNTHETIC GENOMESbe assembled in pa<a title="Nature Reprint Collection - Technology Features page 19" href="http://viewer.zmags.com/publication/370fd028?page=19">SYNTHETIC GENOMESTECHNOLOGYGINGKO BIOWORKSTh</a> SYNTHETIC GENOMESTECHNOLOGYGINGKO BIOWORKSTh<a title="Nature Reprint Collection - Technology Features page 20" href="http://viewer.zmags.com/publication/370fd028?page=20"></a> <a title="Nature Reprint Collection - Technology Features page 21" href="http://viewer.zmags.com/publication/370fd028?page=21">TECHNOLOGY FEATURETime to apply </a> TECHNOLOGY FEATURETime to apply <a title="Nature Reprint Collection - Technology Features page 22" href="http://viewer.zmags.com/publication/370fd028?page=22">TECHNOLOGY FEATURE </a> TECHNOLOGY FEATURE <a title="Nature Reprint Collection - Technology Features page 23" href="http://viewer.zmags.com/publication/370fd028?page=23"> In a different </a> In a different <a title="Nature Reprint Collection - Technology Features page 24" href="http://viewer.zmags.com/publication/370fd028?page=24">TECHNOLOGY FEATURE Metabolomics' beginning</a> TECHNOLOGY FEATURE Metabolomics' beginning<a title="Nature Reprint Collection - Technology Features page 25" href="http://viewer.zmags.com/publication/370fd028?page=25">TECHNOLOGY FEATURETool box </a> TECHNOLOGY FEATURETool box <a title="Nature Reprint Collection - Technology Features page 26" href="http://viewer.zmags.com/publication/370fd028?page=26">TECHNOLOGY FEATUREBOX 1 LONG NONCODING RNAs</a> TECHNOLOGY FEATUREBOX 1 LONG NONCODING RNAs<a title="Nature Reprint Collection - Technology Features page 27" href="http://viewer.zmags.com/publication/370fd028?page=27">TECHNOLOGY FEATURE </a> TECHNOLOGY FEATURE <a title="Nature Reprint Collection - Technology Features page 28" href="http://viewer.zmags.com/publication/370fd028?page=28">TECHNOLOGY FEATUREASH1-E1 </a> TECHNOLOGY FEATUREASH1-E1 <a title="Nature Reprint Collection - Technology Features page 29" href="http://viewer.zmags.com/publication/370fd028?page=29">AMPLIFICATION // SsoADVANCED SUPERMIXRobust, </a> AMPLIFICATION // SsoADVANCED SUPERMIXRobust, <a title="Nature Reprint Collection - Technology Features page 30" href="http://viewer.zmags.com/publication/370fd028?page=30"></a> <a title="Nature Reprint Collection - Technology Features page 31" href="http://viewer.zmags.com/publication/370fd028?page=31">Microarrays, megasynthesisMonya BakerMicroar</a> Microarrays, megasynthesisMonya BakerMicroar<a title="Nature Reprint Collection - Technology Features page 32" href="http://viewer.zmags.com/publication/370fd028?page=32">TECHNOLOGY FEATUREBOX 1 BUILDING OLIGOSDavi</a> TECHNOLOGY FEATUREBOX 1 BUILDING OLIGOSDavi<a title="Nature Reprint Collection - Technology Features page 33" href="http://viewer.zmags.com/publication/370fd028?page=33">&ldquo;Microarraystraditionally havebeen used for ana</a> &ldquo;Microarraystraditionally havebeen used for ana<a title="Nature Reprint Collection - Technology Features page 34" href="http://viewer.zmags.com/publication/370fd028?page=34">TECHNOLOGY FEATUREsynthesis, oligonucleotides </a> TECHNOLOGY FEATUREsynthesis, oligonucleotides <a title="Nature Reprint Collection - Technology Features page 35" href="http://viewer.zmags.com/publication/370fd028?page=35"></a> <a title="Nature Reprint Collection - Technology Features page 36" href="http://viewer.zmags.com/publication/370fd028?page=36">The moment technology provides youwith a result </a> The moment technology provides youwith a result <a title="Nature Reprint Collection - Technology Features page 37" href="http://viewer.zmags.com/publication/370fd028?page=37">TECHNOLOGY FEATUREA LIVING SYSTEMON A CHIPFor</a> TECHNOLOGY FEATUREA LIVING SYSTEMON A CHIPFor<a title="Nature Reprint Collection - Technology Features page 38" href="http://viewer.zmags.com/publication/370fd028?page=38">TECHNOLOGYTISSUE MODELSN. DOUVILLE/Y. TUNG/S. </a> TECHNOLOGYTISSUE MODELSN. DOUVILLE/Y. TUNG/S. <a title="Nature Reprint Collection - Technology Features page 39" href="http://viewer.zmags.com/publication/370fd028?page=39">brain and bone marrow. A third team, led byKiich</a> brain and bone marrow. A third team, led byKiich<a title="Nature Reprint Collection - Technology Features page 40" href="http://viewer.zmags.com/publication/370fd028?page=40">TECHNOLOGYTISSUE MODELSJ. H. SUNG/SHULER LAB, </a> TECHNOLOGYTISSUE MODELSJ. H. SUNG/SHULER LAB, <a title="Nature Reprint Collection - Technology Features page 41" href="http://viewer.zmags.com/publication/370fd028?page=41">TECHNOLOGY FEATURESurface jobs </a> TECHNOLOGY FEATURESurface jobs <a title="Nature Reprint Collection - Technology Features page 42" href="http://viewer.zmags.com/publication/370fd028?page=42">TECHNOLOGY FEATURE </a> TECHNOLOGY FEATURE <a title="Nature Reprint Collection - Technology Features page 43" href="http://viewer.zmags.com/publication/370fd028?page=43">TECHNOLOGY FEATUREBOX 1 ASSESSING CULTURE EF</a> TECHNOLOGY FEATUREBOX 1 ASSESSING CULTURE EF<a title="Nature Reprint Collection - Technology Features page 44" href="http://viewer.zmags.com/publication/370fd028?page=44">TECHNOLOGY FEATUREBD BiosciencesPhase-contras</a> TECHNOLOGY FEATUREBD BiosciencesPhase-contras<a title="Nature Reprint Collection - Technology Features page 45" href="http://viewer.zmags.com/publication/370fd028?page=45">BD Matrigel MatrixThe original, trusted extracel</a> BD Matrigel MatrixThe original, trusted extracel<a title="Nature Reprint Collection - Technology Features page 46" href="http://viewer.zmags.com/publication/370fd028?page=46">Is your HCS system giving you the whole picture?</a> Is your HCS system giving you the whole picture?<a title="Nature Reprint Collection - Technology Features page 47" href="http://viewer.zmags.com/publication/370fd028?page=47">TECHNOLOGY FEATUREInterpreting images </a> TECHNOLOGY FEATUREInterpreting images <a title="Nature Reprint Collection - Technology Features page 48" href="http://viewer.zmags.com/publication/370fd028?page=48">TECHNOLOGY FEATURE </a> TECHNOLOGY FEATURE <a title="Nature Reprint Collection - Technology Features page 49" href="http://viewer.zmags.com/publication/370fd028?page=49">Zebrafish larvae are placed in a 96-well plate fo</a> Zebrafish larvae are placed in a 96-well plate fo<a title="Nature Reprint Collection - Technology Features page 50" href="http://viewer.zmags.com/publication/370fd028?page=50">TECHNOLOGY FEATURESigrid HartMicrofluidics sy</a> TECHNOLOGY FEATURESigrid HartMicrofluidics sy<a title="Nature Reprint Collection - Technology Features page 51" href="http://viewer.zmags.com/publication/370fd028?page=51"> Mouse suppliers agree:...not all mice are </a> Mouse suppliers agree:...not all mice are <a title="Nature Reprint Collection - Technology Features page 52" href="http://viewer.zmags.com/publication/370fd028?page=52">CLASSIC TALESAs the basi</a> CLASSIC TALESAs the basi<a title="Nature Reprint Collection - Technology Features page 53" href="http://viewer.zmags.com/publication/370fd028?page=53">TECHNOLOGY FEATUREINSIDE THE MINDSOF MICE AND </a> TECHNOLOGY FEATUREINSIDE THE MINDSOF MICE AND <a title="Nature Reprint Collection - Technology Features page 54" href="http://viewer.zmags.com/publication/370fd028?page=54">TECHNOLOGYANIMAL MODELSC. TOUMA/MAX PLANCK INS</a> TECHNOLOGYANIMAL MODELSC. TOUMA/MAX PLANCK INS<a title="Nature Reprint Collection - Technology Features page 55" href="http://viewer.zmags.com/publication/370fd028?page=55">nervous animals avoid exposed areas. For both,ps</a> nervous animals avoid exposed areas. For both,ps<a title="Nature Reprint Collection - Technology Features page 56" href="http://viewer.zmags.com/publication/370fd028?page=56">TECHNOLOGYANIMAL MODELSCLEVER SYSVideo-track</a> TECHNOLOGYANIMAL MODELSCLEVER SYSVideo-track<a title="Nature Reprint Collection - Technology Features page 57" href="http://viewer.zmags.com/publication/370fd028?page=57">Assessing the assaysResearchers evaluating ani</a> Assessing the assaysResearchers evaluating ani<a title="Nature Reprint Collection - Technology Features page 58" href="http://viewer.zmags.com/publication/370fd028?page=58">you know usbetter than you thinkLook cl</a> you know usbetter than you thinkLook cl<a title="Nature Reprint Collection - Technology Features page 59" href="http://viewer.zmags.com/publication/370fd028?page=59">TECHNOLOGY FEATURECookbook algorithms </a> TECHNOLOGY FEATURECookbook algorithms <a title="Nature Reprint Collection - Technology Features page 60" href="http://viewer.zmags.com/publication/370fd028?page=60">TECHNOLOGY FEATUREBOX 1 ADVICE FROM THE PRO</a> TECHNOLOGY FEATUREBOX 1 ADVICE FROM THE PRO<a title="Nature Reprint Collection - Technology Features page 61" href="http://viewer.zmags.com/publication/370fd028?page=61">TECHNOLOGY FEATUREfree ImageJ package let rese</a> TECHNOLOGY FEATUREfree ImageJ package let rese<a title="Nature Reprint Collection - Technology Features page 62" href="http://viewer.zmags.com/publication/370fd028?page=62">ENDNOTE X5. AN INTELLIGENT ADDITIONTO YOUR RESEA</a> ENDNOTE X5. AN INTELLIGENT ADDITIONTO YOUR RESEA<a title="Nature Reprint Collection - Technology Features page 63" href="http://viewer.zmags.com/publication/370fd028?page=63">strontium doped lanthanum III-IV nitride mat</a> strontium doped lanthanum III-IV nitride mat<a title="Nature Reprint Collection - Technology Features page 64" href="http://viewer.zmags.com/publication/370fd028?page=64">more samples, more speedYour centrifuge is esse</a> more samples, more speedYour centrifuge is esse