If you are visually impaired or blind, you can visit the PDF version by Pressing CONTROL + ALT + 4
<br /> European Edition<br /> Vol. 5.1 March 2020<br /> + VACCINES<br /> FOR COVID-19:<br /> PERSPECTIVES,<br /> PROSPECTS AND<br /> CHALLENGES<br /> + FEATURE<br /> The People versus COVID-19<br /> + EDITOR’S PICK<br /> Chronic Spontaneous Urticaria: A Review of<br /> Pathological Mechanisms, Diagnosis, Clinical<br /> Management, and Treatment<br /> emjreviews.com<br /> Contents<br /> + EDITORIAL BOARD 4<br /> + WELCOME 7<br /> + FOREWORD 9<br /> + FEATURES<br /> Vaccines for COVID-19: Perspectives, Prospects, and Challenges Based 12<br /> on Candidate SARS and MERS and Animal Coronavirus Vaccines<br /> Linda J. Saif<br /> The Peop<a title="EMJ 5.1 2020 page 1" href="http://viewer.zmags.com/publication/3b0fa0ac?page=1"> European Edition Vol. 5.1 March 2020 + </a> <a title="EMJ 5.1 2020 page 2" href="http://viewer.zmags.com/publication/3b0fa0ac?page=2"> Contents + EDITORIAL BOARD </a> <a title="EMJ 5.1 2020 page 3" href="http://viewer.zmags.com/publication/3b0fa0ac?page=3"> “Along with other exciting healthcare innovatio</a> <a title="EMJ 5.1 2020 page 4" href="http://viewer.zmags.com/publication/3b0fa0ac?page=4"> Editorial Board Editor-in-Chief Prof Markus Peck-</a> <a title="EMJ 5.1 2020 page 5" href="http://viewer.zmags.com/publication/3b0fa0ac?page=5"> Aims and Scope EMJ is an online only, peer-review</a> <a title="EMJ 5.1 2020 page 6" href="http://viewer.zmags.com/publication/3b0fa0ac?page=6"> EMJ 5.1. Chief Executive Officer Spencer Gore Sen</a> <a title="EMJ 5.1 2020 page 7" href="http://viewer.zmags.com/publication/3b0fa0ac?page=7"> Welcome It is with great delight that I welcome r</a> <a title="EMJ 5.1 2020 page 8" href="http://viewer.zmags.com/publication/3b0fa0ac?page=8"> IN YOUR PATIENTS WITH SEVERE UNCONTROLLED ASTHMA </a> <a title="EMJ 5.1 2020 page 9" href="http://viewer.zmags.com/publication/3b0fa0ac?page=9"> Foreword Dear friends and colleagues, It is with</a> <a title="EMJ 5.1 2020 page 10" href="http://viewer.zmags.com/publication/3b0fa0ac?page=10"> ERLEADA® ABBREVIATED PRESCRIBING INFORMATION BASE</a> <a title="EMJ 5.1 2020 page 11" href="http://viewer.zmags.com/publication/3b0fa0ac?page=11"> PUSH BACK EARLY. EXTEND LIFE. ERLEADA® NOW APPRO</a> <a title="EMJ 5.1 2020 page 12" href="http://viewer.zmags.com/publication/3b0fa0ac?page=12"> Vaccines for COVID-19: Perspectives, Prospects, a</a> <a title="EMJ 5.1 2020 page 13" href="http://viewer.zmags.com/publication/3b0fa0ac?page=13"> forthcoming more rapidly than before but unf</a> <a title="EMJ 5.1 2020 page 14" href="http://viewer.zmags.com/publication/3b0fa0ac?page=14"> anticipated development of a portable mRNA 'print</a> <a title="EMJ 5.1 2020 page 15" href="http://viewer.zmags.com/publication/3b0fa0ac?page=15"> a subunit S or RBD protein, may be effective as </a> <a title="EMJ 5.1 2020 page 16" href="http://viewer.zmags.com/publication/3b0fa0ac?page=16"> SARS-CoV-2 which causes atypical pneumonia, IBV </a> <a title="EMJ 5.1 2020 page 17" href="http://viewer.zmags.com/publication/3b0fa0ac?page=17"> The elderly and those with chronic conditions or </a> <a title="EMJ 5.1 2020 page 18" href="http://viewer.zmags.com/publication/3b0fa0ac?page=18"> to pig. Emerg Infect Dis 2005;11:446- </a> <a title="EMJ 5.1 2020 page 19" href="http://viewer.zmags.com/publication/3b0fa0ac?page=19"> MEDICATION ALONE IS NOT ENOUGH TO HELP ALL HEART </a> <a title="EMJ 5.1 2020 page 20" href="http://viewer.zmags.com/publication/3b0fa0ac?page=20"> The People Versus COVID-19 Katherine Colvin Edit</a> <a title="EMJ 5.1 2020 page 21" href="http://viewer.zmags.com/publication/3b0fa0ac?page=21"> Transmissibility of a virus can be describe</a> <a title="EMJ 5.1 2020 page 22" href="http://viewer.zmags.com/publication/3b0fa0ac?page=22"> "The COVID-19 challenge has allowed us </a> <a title="EMJ 5.1 2020 page 23" href="http://viewer.zmags.com/publication/3b0fa0ac?page=23"> due to original recognition of DNA structure in t</a> <a title="EMJ 5.1 2020 page 24" href="http://viewer.zmags.com/publication/3b0fa0ac?page=24"> Preparing Patients for Intervention: Inte</a> <a title="EMJ 5.1 2020 page 25" href="http://viewer.zmags.com/publication/3b0fa0ac?page=25"> of possible shortcomings. In thrombocytopenic pat</a> <a title="EMJ 5.1 2020 page 26" href="http://viewer.zmags.com/publication/3b0fa0ac?page=26"> needed before a procedure that carries the </a> <a title="EMJ 5.1 2020 page 27" href="http://viewer.zmags.com/publication/3b0fa0ac?page=27"> and this may have an impact on both the IR and cl</a> <a title="EMJ 5.1 2020 page 28" href="http://viewer.zmags.com/publication/3b0fa0ac?page=28"> among the various specialists involved in the pro</a> <a title="EMJ 5.1 2020 page 29" href="http://viewer.zmags.com/publication/3b0fa0ac?page=29"> Chronic Spontaneous Urticaria: A Review of Pathol</a> <a title="EMJ 5.1 2020 page 30" href="http://viewer.zmags.com/publication/3b0fa0ac?page=30"> ≥6 weeks). Chronic urticaria can be further class</a> <a title="EMJ 5.1 2020 page 31" href="http://viewer.zmags.com/publication/3b0fa0ac?page=31"> A B C D F E Figure 1: (</a> <a title="EMJ 5.1 2020 page 32" href="http://viewer.zmags.com/publication/3b0fa0ac?page=32"> It has also been suggested that autoimmunity coul</a> <a title="EMJ 5.1 2020 page 33" href="http://viewer.zmags.com/publication/3b0fa0ac?page=33"> Several biomarkers have been investigated in asso</a> <a title="EMJ 5.1 2020 page 34" href="http://viewer.zmags.com/publication/3b0fa0ac?page=34"> to the first-generation antihistamines, these </a> <a title="EMJ 5.1 2020 page 35" href="http://viewer.zmags.com/publication/3b0fa0ac?page=35"> a 90-day post-treatment observation period, b</a> <a title="EMJ 5.1 2020 page 36" href="http://viewer.zmags.com/publication/3b0fa0ac?page=36"> Table 1: Other therapeutic options in chronic spo</a> <a title="EMJ 5.1 2020 page 37" href="http://viewer.zmags.com/publication/3b0fa0ac?page=37"> Another humanised IgG1 monoclonal antibody is qui</a> <a title="EMJ 5.1 2020 page 38" href="http://viewer.zmags.com/publication/3b0fa0ac?page=38"> clinical characteristics of chronic spontaneous u</a> <a title="EMJ 5.1 2020 page 39" href="http://viewer.zmags.com/publication/3b0fa0ac?page=39"> 51. Bishnoi A et al. Phototherapy using</a> <a title="EMJ 5.1 2020 page 40" href="http://viewer.zmags.com/publication/3b0fa0ac?page=40"> FOR ADULT AND PAEDIATRIC PATIENTS WITH NTRK GENE </a> <a title="EMJ 5.1 2020 page 41" href="http://viewer.zmags.com/publication/3b0fa0ac?page=41"> Pulmonary Rehabilitation is Improved by In-Shoe </a> <a title="EMJ 5.1 2020 page 42" href="http://viewer.zmags.com/publication/3b0fa0ac?page=42"> INTRODUCTION Pulmonary rehabilitation (PR) is cu</a> <a title="EMJ 5.1 2020 page 43" href="http://viewer.zmags.com/publication/3b0fa0ac?page=43"> A 6MWT distance (m) 480 460 440 420 400 380 360</a> <a title="EMJ 5.1 2020 page 44" href="http://viewer.zmags.com/publication/3b0fa0ac?page=44"> 250 2) 200 CoP surface (mm 150 100 250 2</a> <a title="EMJ 5.1 2020 page 45" href="http://viewer.zmags.com/publication/3b0fa0ac?page=45"> Statistical Analyses Based on mean and standard </a> <a title="EMJ 5.1 2020 page 46" href="http://viewer.zmags.com/publication/3b0fa0ac?page=46"> Foot Orthoses Intervention and Bodily Fatigue Sen</a> <a title="EMJ 5.1 2020 page 47" href="http://viewer.zmags.com/publication/3b0fa0ac?page=47"> also result from an increased mechanosensitivity </a> <a title="EMJ 5.1 2020 page 48" href="http://viewer.zmags.com/publication/3b0fa0ac?page=48"> Epigenetics of Diabetic Nephropathy: From </a> <a title="EMJ 5.1 2020 page 49" href="http://viewer.zmags.com/publication/3b0fa0ac?page=49"> extracellular matrix proteins, and podocytopenia </a> <a title="EMJ 5.1 2020 page 50" href="http://viewer.zmags.com/publication/3b0fa0ac?page=50"> Table 1: Classification of diabetic nephropathy. </a> <a title="EMJ 5.1 2020 page 51" href="http://viewer.zmags.com/publication/3b0fa0ac?page=51"> Disease promoting gene Healthy Unmethylated</a> <a title="EMJ 5.1 2020 page 52" href="http://viewer.zmags.com/publication/3b0fa0ac?page=52"> on follow-up.27 These results imply that genetic </a> <a title="EMJ 5.1 2020 page 53" href="http://viewer.zmags.com/publication/3b0fa0ac?page=53"> profiles of whole blood from the cases versus cont</a> <a title="EMJ 5.1 2020 page 54" href="http://viewer.zmags.com/publication/3b0fa0ac?page=54"> are understudied; therefore, a focus on histone m</a> <a title="EMJ 5.1 2020 page 55" href="http://viewer.zmags.com/publication/3b0fa0ac?page=55"> cells utilising four transcription factors: Emx2,</a> <a title="EMJ 5.1 2020 page 56" href="http://viewer.zmags.com/publication/3b0fa0ac?page=56"> 2009;23(7):781-3. 16. Keating ST et al. Epigene</a> <a title="EMJ 5.1 2020 page 57" href="http://viewer.zmags.com/publication/3b0fa0ac?page=57"> reprogramming of fibroblasts into 63. re</a> <a title="EMJ 5.1 2020 page 58" href="http://viewer.zmags.com/publication/3b0fa0ac?page=58"> Managing Heart Disease in Pregnancy Authors: </a> <a title="EMJ 5.1 2020 page 59" href="http://viewer.zmags.com/publication/3b0fa0ac?page=59"> In this review the management of pregnant p</a> <a title="EMJ 5.1 2020 page 60" href="http://viewer.zmags.com/publication/3b0fa0ac?page=60"> > Discussion about maternal life expectancy and </a> <a title="EMJ 5.1 2020 page 61" href="http://viewer.zmags.com/publication/3b0fa0ac?page=61"> Box 1: Modified World Health Organization (WHO) cl</a> <a title="EMJ 5.1 2020 page 62" href="http://viewer.zmags.com/publication/3b0fa0ac?page=62"> SYNDROME MANAGEMENT OF ACUTE CORONARY Acute co</a> <a title="EMJ 5.1 2020 page 63" href="http://viewer.zmags.com/publication/3b0fa0ac?page=63"> severe mitral regurgitation, valve repair should </a> <a title="EMJ 5.1 2020 page 64" href="http://viewer.zmags.com/publication/3b0fa0ac?page=64"> Dilated Cardiomyopathy Dilated cardiomyopathy </a> <a title="EMJ 5.1 2020 page 65" href="http://viewer.zmags.com/publication/3b0fa0ac?page=65"> hypertension because they have reduce the rate of</a> <a title="EMJ 5.1 2020 page 66" href="http://viewer.zmags.com/publication/3b0fa0ac?page=66"> 15. Robson C et al. Cardiac output duri</a> <a title="EMJ 5.1 2020 page 67" href="http://viewer.zmags.com/publication/3b0fa0ac?page=67"> Personalising Exercise and Nutrition Behaviours i</a> <a title="EMJ 5.1 2020 page 68" href="http://viewer.zmags.com/publication/3b0fa0ac?page=68"> (e.g., structured and unstructured exerci</a> <a title="EMJ 5.1 2020 page 69" href="http://viewer.zmags.com/publication/3b0fa0ac?page=69"> However, it is important to consider that early- </a> <a title="EMJ 5.1 2020 page 70" href="http://viewer.zmags.com/publication/3b0fa0ac?page=70"> Table 1: Common micronutrient supplementation, po</a> <a title="EMJ 5.1 2020 page 71" href="http://viewer.zmags.com/publication/3b0fa0ac?page=71"> Meta-analysis of 23 lifestyle interventions that </a> <a title="EMJ 5.1 2020 page 72" href="http://viewer.zmags.com/publication/3b0fa0ac?page=72"> groups such as overweight women, who followed a H</a> <a title="EMJ 5.1 2020 page 73" href="http://viewer.zmags.com/publication/3b0fa0ac?page=73"> improvement in T2DM outcomes and related qua</a> <a title="EMJ 5.1 2020 page 74" href="http://viewer.zmags.com/publication/3b0fa0ac?page=74"> Table 2: Recommendations for physical activity an</a> <a title="EMJ 5.1 2020 page 75" href="http://viewer.zmags.com/publication/3b0fa0ac?page=75"> A 10-week intervention involving 158 students rel</a> <a title="EMJ 5.1 2020 page 76" href="http://viewer.zmags.com/publication/3b0fa0ac?page=76"> Prevention Study. Physical activity in 24. </a> <a title="EMJ 5.1 2020 page 77" href="http://viewer.zmags.com/publication/3b0fa0ac?page=77"> risk factors in people with Type 2 56.</a> <a title="EMJ 5.1 2020 page 78" href="http://viewer.zmags.com/publication/3b0fa0ac?page=78"> Second AACR International Meeting ADVANCES IN MA</a> <a title="EMJ 5.1 2020 page 79" href="http://viewer.zmags.com/publication/3b0fa0ac?page=79"> Clinical Profile of Patients with Psoriasis and th</a> <a title="EMJ 5.1 2020 page 80" href="http://viewer.zmags.com/publication/3b0fa0ac?page=80"> unsatisfactory. Patients with psoriasis direc</a> <a title="EMJ 5.1 2020 page 81" href="http://viewer.zmags.com/publication/3b0fa0ac?page=81"> Table 1: The clinical profile of the subjects. Var</a> <a title="EMJ 5.1 2020 page 82" href="http://viewer.zmags.com/publication/3b0fa0ac?page=82"> Table 3: Item-wise responses for psoriasis attitu</a> <a title="EMJ 5.1 2020 page 83" href="http://viewer.zmags.com/publication/3b0fa0ac?page=83"> Furthermore, the findings showed that 90 (45.</a> <a title="EMJ 5.1 2020 page 84" href="http://viewer.zmags.com/publication/3b0fa0ac?page=84"> psoriasis.17 This present study indicated that 90</a> <a title="EMJ 5.1 2020 page 85" href="http://viewer.zmags.com/publication/3b0fa0ac?page=85"> 4. Ginsburg IH, Link BG. Feelings of </a> <a title="EMJ 5.1 2020 page 86" href="http://viewer.zmags.com/publication/3b0fa0ac?page=86"> Attitudes and Perceptions of General Practitioner</a> <a title="EMJ 5.1 2020 page 87" href="http://viewer.zmags.com/publication/3b0fa0ac?page=87"> overall care for the patient and improved quality</a> <a title="EMJ 5.1 2020 page 88" href="http://viewer.zmags.com/publication/3b0fa0ac?page=88"> this, uptake has been slow, with an estimated 27%</a> <a title="EMJ 5.1 2020 page 89" href="http://viewer.zmags.com/publication/3b0fa0ac?page=89"> Sample Size Sample size was based on the assumed</a> <a title="EMJ 5.1 2020 page 90" href="http://viewer.zmags.com/publication/3b0fa0ac?page=90"> Table 1: Summary of results regarding demographic</a> <a title="EMJ 5.1 2020 page 91" href="http://viewer.zmags.com/publication/3b0fa0ac?page=91"> Table 2 continued. Q9 Adequate support - </a> <a title="EMJ 5.1 2020 page 92" href="http://viewer.zmags.com/publication/3b0fa0ac?page=92"> review and upload onto NEHR, results similar to m</a> <a title="EMJ 5.1 2020 page 93" href="http://viewer.zmags.com/publication/3b0fa0ac?page=93"> record system (SEPAS). Archives of 25. Med</a> <a title="EMJ 5.1 2020 page 94" href="http://viewer.zmags.com/publication/3b0fa0ac?page=94"> Diabetic Amyotrophy: From the Basics to </a> <a title="EMJ 5.1 2020 page 95" href="http://viewer.zmags.com/publication/3b0fa0ac?page=95"> as diabetic amyotrophy. Other terms exist in prac</a> <a title="EMJ 5.1 2020 page 96" href="http://viewer.zmags.com/publication/3b0fa0ac?page=96"> Table 1: Characteristics of 115 cases of diabetic</a> <a title="EMJ 5.1 2020 page 97" href="http://viewer.zmags.com/publication/3b0fa0ac?page=97"> Table 1 continued. Characteristics Number of case</a> <a title="EMJ 5.1 2020 page 98" href="http://viewer.zmags.com/publication/3b0fa0ac?page=98"> Table 1 continued. Characteristics Number of case</a> <a title="EMJ 5.1 2020 page 99" href="http://viewer.zmags.com/publication/3b0fa0ac?page=99"> The differential diagnosis for a lumbosacral</a> <a title="EMJ 5.1 2020 page 100" href="http://viewer.zmags.com/publication/3b0fa0ac?page=100"> electromyography (EMG) is also a beneficial test </a> <a title="EMJ 5.1 2020 page 101" href="http://viewer.zmags.com/publication/3b0fa0ac?page=101"> underwent plasma exchange, three who received int</a> <a title="EMJ 5.1 2020 page 102" href="http://viewer.zmags.com/publication/3b0fa0ac?page=102"> patients requiring a wheelchair for ambulation de</a> <a title="EMJ 5.1 2020 page 103" href="http://viewer.zmags.com/publication/3b0fa0ac?page=103"> amyotrophy: a follow-up study. Br Med J. 1972;1(5</a> <a title="EMJ 5.1 2020 page 104" href="http://viewer.zmags.com/publication/3b0fa0ac?page=104"> From Traditional Histology to Next-Generation Pa</a> <a title="EMJ 5.1 2020 page 105" href="http://viewer.zmags.com/publication/3b0fa0ac?page=105"> therapy is the treatment of choice in NSCLC with </a> <a title="EMJ 5.1 2020 page 106" href="http://viewer.zmags.com/publication/3b0fa0ac?page=106"> Nucleic acids Quantity Quality Surgical resecti</a> <a title="EMJ 5.1 2020 page 107" href="http://viewer.zmags.com/publication/3b0fa0ac?page=107"> p<0.01 for lesions ≤10 mm).43 For CNB sampling, t</a> <a title="EMJ 5.1 2020 page 108" href="http://viewer.zmags.com/publication/3b0fa0ac?page=108"> rate, tumour samples considered positive in IHC s</a> <a title="EMJ 5.1 2020 page 109" href="http://viewer.zmags.com/publication/3b0fa0ac?page=109"> technique allows the feasibility of molecula</a> <a title="EMJ 5.1 2020 page 110" href="http://viewer.zmags.com/publication/3b0fa0ac?page=110"> (LUX-Lung 3), ctDNA was extracted from serum. The</a> <a title="EMJ 5.1 2020 page 111" href="http://viewer.zmags.com/publication/3b0fa0ac?page=111"> histological diagnosis. Definitive therapy for</a> <a title="EMJ 5.1 2020 page 112" href="http://viewer.zmags.com/publication/3b0fa0ac?page=112"> 33. Aguiar PN Jr et al. PD-L1 expression </a> <a title="EMJ 5.1 2020 page 113" href="http://viewer.zmags.com/publication/3b0fa0ac?page=113"> testing. J Clin Pathol. 2017;70(10):819- 26. 75. </a> <a title="EMJ 5.1 2020 page 114" href="http://viewer.zmags.com/publication/3b0fa0ac?page=114"> What's New Preventing Antioxidant Response Suppr</a> <a title="EMJ 5.1 2020 page 115" href="http://viewer.zmags.com/publication/3b0fa0ac?page=115"> What's New Combination Approach Demonstrates Bet</a> <a title="EMJ 5.1 2020 page 116" href="http://viewer.zmags.com/publication/3b0fa0ac?page=116"> Never miss an update again. J</a>