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<br /> CARDIOLOGY<br /> ISSN 2054-3174 Vol 4.1 • October 2016 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ESC 2016<br /> Rome, Italy<br /> CONTENTS<br /> EDITORIAL BOARD...................................................................................................................................... 4<br /> CONGRESS REVIEW..................................................................................................................................... 10<br /> • Review of the Annual Meeting of the European Society of Cardiology (ESC), held in<br /> Rome, Italy, 27th–31st August 2016<br /> INTERVIEWS WITH EMJ CARDIOLOGY EDITORIAL BOARD............................................................. 28<br /> SYMPOSIUM REVIEWS<br /> • INTERPRETING FINDINGS WITH NON-VITAMIN K ANTAGONIST ORAL<br /> ANTICOAGULANTS IN ATRIAL FIBRILLATION: COLLECTIVE VIEWS ON DATA FROM<br /<a title="EMJ Cardiology 4.1 2016 page 1" href="http://viewer.zmags.com/publication/49205362?page=1"> CARDIOLOGY ISSN 2054-3174 </a> <a title="EMJ Cardiology 4.1 2016 page 2" href="http://viewer.zmags.com/publication/49205362?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Cardiology 4.1 2016 page 3" href="http://viewer.zmags.com/publication/49205362?page=3"> CARDIOLOGY • ARTERIAL STIFFNESS AND CORONARY </a> <a title="EMJ Cardiology 4.1 2016 page 4" href="http://viewer.zmags.com/publication/49205362?page=4"> Editorial Board Editor-in-Chief: Dr Fernando Al</a> <a title="EMJ Cardiology 4.1 2016 page 5" href="http://viewer.zmags.com/publication/49205362?page=5"> Cardiology Dr Carl J. Lavie, Medical Dir</a> <a title="EMJ Cardiology 4.1 2016 page 6" href="http://viewer.zmags.com/publication/49205362?page=6"> CARDIOLOGY 4.1 OCTOBER 2016 Director Spencer Go</a> <a title="EMJ Cardiology 4.1 2016 page 7" href="http://viewer.zmags.com/publication/49205362?page=7"> Welcome Welcome to this year’s edition of EMJ </a> <a title="EMJ Cardiology 4.1 2016 page 8" href="http://viewer.zmags.com/publication/49205362?page=8"> EMJ EUROPEAN MEDICAL </a> <a title="EMJ Cardiology 4.1 2016 page 9" href="http://viewer.zmags.com/publication/49205362?page=9"> Foreword </a> <a title="EMJ Cardiology 4.1 2016 page 10" href="http://viewer.zmags.com/publication/49205362?page=10"> 10 CARDIOLOGY • October 2016 </a> <a title="EMJ Cardiology 4.1 2016 page 11" href="http://viewer.zmags.com/publication/49205362?page=11"> CARDIOLOGY • October 2016 </a> <a title="EMJ Cardiology 4.1 2016 page 12" href="http://viewer.zmags.com/publication/49205362?page=12"> 12 CARDIOLOGY • October 2016 </a> <a title="EMJ Cardiology 4.1 2016 page 13" href="http://viewer.zmags.com/publication/49205362?page=13"> Congress Highlights Invasive Imaging</a> <a title="EMJ Cardiology 4.1 2016 page 14" href="http://viewer.zmags.com/publication/49205362?page=14"> The improvement in functional outcomes could tran</a> <a title="EMJ Cardiology 4.1 2016 page 15" href="http://viewer.zmags.com/publication/49205362?page=15"> Prof Chang also argued that the significant reduct</a> <a title="EMJ Cardiology 4.1 2016 page 16" href="http://viewer.zmags.com/publication/49205362?page=16"> Cardiology experts from over 140 countries HF </a> <a title="EMJ Cardiology 4.1 2016 page 17" href="http://viewer.zmags.com/publication/49205362?page=17"> Although the results from our study were negative</a> <a title="EMJ Cardiology 4.1 2016 page 18" href="http://viewer.zmags.com/publication/49205362?page=18"> term exposure to the combination of both lo</a> <a title="EMJ Cardiology 4.1 2016 page 19" href="http://viewer.zmags.com/publication/49205362?page=19"> The Hot Line study randomised 1,230 patients to </a> <a title="EMJ Cardiology 4.1 2016 page 20" href="http://viewer.zmags.com/publication/49205362?page=20"> Potential New Treatment Option for Refractory Ang</a> <a title="EMJ Cardiology 4.1 2016 page 21" href="http://viewer.zmags.com/publication/49205362?page=21"> The results will definitely spark further research</a> <a title="EMJ Cardiology 4.1 2016 page 22" href="http://viewer.zmags.com/publication/49205362?page=22"> The advantage of the YEARS algorithm over existin</a> <a title="EMJ Cardiology 4.1 2016 page 23" href="http://viewer.zmags.com/publication/49205362?page=23"> Rome  Patients treated with infused itMSCs </a> <a title="EMJ Cardiology 4.1 2016 page 24" href="http://viewer.zmags.com/publication/49205362?page=24"> Effective Antidote for Anticoagulant Bleeding Dis</a> <a title="EMJ Cardiology 4.1 2016 page 25" href="http://viewer.zmags.com/publication/49205362?page=25"> women were at a low risk of recurrence after an u</a> <a title="EMJ Cardiology 4.1 2016 page 26" href="http://viewer.zmags.com/publication/49205362?page=26"> 6 months, or acute coronary syndrome in the past </a> <a title="EMJ Cardiology 4.1 2016 page 27" href="http://viewer.zmags.com/publication/49205362?page=27"> Confidence from Evidence and Real World Experienc</a> <a title="EMJ Cardiology 4.1 2016 page 28" href="http://viewer.zmags.com/publication/49205362?page=28"> Giuseppe Biondi Zoccai Assistant Professor, Depa</a> <a title="EMJ Cardiology 4.1 2016 page 29" href="http://viewer.zmags.com/publication/49205362?page=29"> A: The combination of biometric data, big data fr</a> <a title="EMJ Cardiology 4.1 2016 page 30" href="http://viewer.zmags.com/publication/49205362?page=30"> without significant side effects, particularly</a> <a title="EMJ Cardiology 4.1 2016 page 31" href="http://viewer.zmags.com/publication/49205362?page=31"> prognosis. As in most people, especially CVD, fitn</a> <a title="EMJ Cardiology 4.1 2016 page 32" href="http://viewer.zmags.com/publication/49205362?page=32"> is called ‘Meetbaar Beter’, (roughly translated a</a> <a title="EMJ Cardiology 4.1 2016 page 33" href="http://viewer.zmags.com/publication/49205362?page=33"> by the radial approach. Second, in cases of patie</a> <a title="EMJ Cardiology 4.1 2016 page 34" href="http://viewer.zmags.com/publication/49205362?page=34"> INTERPRETING FINDINGS WITH NON-VITAMIN K </a> <a title="EMJ Cardiology 4.1 2016 page 35" href="http://viewer.zmags.com/publication/49205362?page=35"> From Large-Scale Study to Larger-Scale Practice</a> <a title="EMJ Cardiology 4.1 2016 page 36" href="http://viewer.zmags.com/publication/49205362?page=36"> Pooled Pooled </a> <a title="EMJ Cardiology 4.1 2016 page 37" href="http://viewer.zmags.com/publication/49205362?page=37"> Day-to-Day Management of Patients with Atrial </a> <a title="EMJ Cardiology 4.1 2016 page 38" href="http://viewer.zmags.com/publication/49205362?page=38"> and no patients received recombinant factor VII.3</a> <a title="EMJ Cardiology 4.1 2016 page 39" href="http://viewer.zmags.com/publication/49205362?page=39"> Studying the real-world use of NOACs provides imp</a> <a title="EMJ Cardiology 4.1 2016 page 40" href="http://viewer.zmags.com/publication/49205362?page=40"> Professor Jafna L. Cox Most clinical trials test </a> <a title="EMJ Cardiology 4.1 2016 page 41" href="http://viewer.zmags.com/publication/49205362?page=41"> ESCEndorsed by the European Stroke Organisati</a> <a title="EMJ Cardiology 4.1 2016 page 42" href="http://viewer.zmags.com/publication/49205362?page=42"> DEVELOPING REAL-WORLD PATIENT PATHWAYS </a> <a title="EMJ Cardiology 4.1 2016 page 43" href="http://viewer.zmags.com/publication/49205362?page=43"> Opening and Introduction Professor Stavros V.</a> <a title="EMJ Cardiology 4.1 2016 page 44" href="http://viewer.zmags.com/publication/49205362?page=44"> guidelines1 advise that patients with a low risk </a> <a title="EMJ Cardiology 4.1 2016 page 45" href="http://viewer.zmags.com/publication/49205362?page=45"> p=0.011 6 5 4 3 Major bleeding (%) 2 </a> <a title="EMJ Cardiology 4.1 2016 page 46" href="http://viewer.zmags.com/publication/49205362?page=46"> Primary estimators • Recent surgery provokin</a> <a title="EMJ Cardiology 4.1 2016 page 47" href="http://viewer.zmags.com/publication/49205362?page=47"> The primary endpoints are symptomatic recurrent V</a> <a title="EMJ Cardiology 4.1 2016 page 48" href="http://viewer.zmags.com/publication/49205362?page=48"> The Importance of Patient Preference One audience</a> <a title="EMJ Cardiology 4.1 2016 page 49" href="http://viewer.zmags.com/publication/49205362?page=49"> Extended Oral Anticoagulation After a First Episo</a> <a title="EMJ Cardiology 4.1 2016 page 50" href="http://viewer.zmags.com/publication/49205362?page=50"> IDENTIFYING FABRY DISEASE PATIENTS THROUGH CARDI</a> <a title="EMJ Cardiology 4.1 2016 page 51" href="http://viewer.zmags.com/publication/49205362?page=51"> Introduction Professor Aleš Linhart Diagnosing th</a> <a title="EMJ Cardiology 4.1 2016 page 52" href="http://viewer.zmags.com/publication/49205362?page=52"> Consequently, the underlying cause of increased L</a> <a title="EMJ Cardiology 4.1 2016 page 53" href="http://viewer.zmags.com/publication/49205362?page=53"> As a syndrome, classical multi-organ disease may </a> <a title="EMJ Cardiology 4.1 2016 page 54" href="http://viewer.zmags.com/publication/49205362?page=54"> (p=0.0061) (Figure 2).19 Cardiac and renal functi</a> <a title="EMJ Cardiology 4.1 2016 page 55" href="http://viewer.zmags.com/publication/49205362?page=55"> What is the Value in Screening Programme</a> <a title="EMJ Cardiology 4.1 2016 page 56" href="http://viewer.zmags.com/publication/49205362?page=56"> Prof Linhart replied that registry data indicate </a> <a title="EMJ Cardiology 4.1 2016 page 57" href="http://viewer.zmags.com/publication/49205362?page=57"> basis of inherited disease, 8th edition (2001). </a> <a title="EMJ Cardiology 4.1 2016 page 58" href="http://viewer.zmags.com/publication/49205362?page=58"> Abstract Reviews IMPACT OF CARDIAC RESYNCHRO</a> <a title="EMJ Cardiology 4.1 2016 page 59" href="http://viewer.zmags.com/publication/49205362?page=59"> ESC 2016 (95% CI: €5,337.0–€5,828.4) in the year</a> <a title="EMJ Cardiology 4.1 2016 page 60" href="http://viewer.zmags.com/publication/49205362?page=60"> Abstract Reviews in vitro into a 90–95% pure cul</a> <a title="EMJ Cardiology 4.1 2016 page 61" href="http://viewer.zmags.com/publication/49205362?page=61"> ESC 2016 impact on the development of both </a> <a title="EMJ Cardiology 4.1 2016 page 62" href="http://viewer.zmags.com/publication/49205362?page=62"> Abstract Reviews mortality risk only in thos</a> <a title="EMJ Cardiology 4.1 2016 page 63" href="http://viewer.zmags.com/publication/49205362?page=63"> ESC 2016 in G1 patients (86±25 versus 77±19 bpm;</a> <a title="EMJ Cardiology 4.1 2016 page 64" href="http://viewer.zmags.com/publication/49205362?page=64"> Abstract Reviews needed to return to work sooner</a> <a title="EMJ Cardiology 4.1 2016 page 65" href="http://viewer.zmags.com/publication/49205362?page=65"> ESC 2016 Self-assessment of health and wellb</a> <a title="EMJ Cardiology 4.1 2016 page 66" href="http://viewer.zmags.com/publication/49205362?page=66"> Abstract Reviews A </a> <a title="EMJ Cardiology 4.1 2016 page 67" href="http://viewer.zmags.com/publication/49205362?page=67"> ESC 2016 A </a> <a title="EMJ Cardiology 4.1 2016 page 68" href="http://viewer.zmags.com/publication/49205362?page=68"> Abstract Reviews MRI was both effective and effi</a> <a title="EMJ Cardiology 4.1 2016 page 69" href="http://viewer.zmags.com/publication/49205362?page=69"> ESC 2016 Table 1: Baseline characteristics. Param</a> <a title="EMJ Cardiology 4.1 2016 page 70" href="http://viewer.zmags.com/publication/49205362?page=70"> Abstract Reviews MIDREGIONAL PROADRENOMEDULLIN </a> <a title="EMJ Cardiology 4.1 2016 page 71" href="http://viewer.zmags.com/publication/49205362?page=71"> ESC 2016 AIMS Obesity is a risk factor for heart</a> <a title="EMJ Cardiology 4.1 2016 page 72" href="http://viewer.zmags.com/publication/49205362?page=72"> Abstract Reviews if the drug-carrying nanopar</a> <a title="EMJ Cardiology 4.1 2016 page 73" href="http://viewer.zmags.com/publication/49205362?page=73"> ESC 2016 ATRIAL FIBRILLATION IN THE SETTING OF A</a> <a title="EMJ Cardiology 4.1 2016 page 74" href="http://viewer.zmags.com/publication/49205362?page=74"> Abstract Reviews of patients with ACS and AF dif</a> <a title="EMJ Cardiology 4.1 2016 page 75" href="http://viewer.zmags.com/publication/49205362?page=75"> ESC 2016 antioxidant and protein-disulfide </a> <a title="EMJ Cardiology 4.1 2016 page 76" href="http://viewer.zmags.com/publication/49205362?page=76"> EDITOR’S PICK In o</a> <a title="EMJ Cardiology 4.1 2016 page 77" href="http://viewer.zmags.com/publication/49205362?page=77"> A B C Figure 1: Different types of </a> <a title="EMJ Cardiology 4.1 2016 page 78" href="http://viewer.zmags.com/publication/49205362?page=78"> of choice at many centres and has been th</a> <a title="EMJ Cardiology 4.1 2016 page 79" href="http://viewer.zmags.com/publication/49205362?page=79"> were able to successfully complete a pregnancy wi</a> <a title="EMJ Cardiology 4.1 2016 page 80" href="http://viewer.zmags.com/publication/49205362?page=80"> aspirin or warfarin was used. There was also no s</a> <a title="EMJ Cardiology 4.1 2016 page 81" href="http://viewer.zmags.com/publication/49205362?page=81"> cavopulmonary connection which today would be</a> <a title="EMJ Cardiology 4.1 2016 page 82" href="http://viewer.zmags.com/publication/49205362?page=82"> for Fontan’s procedure,” Anderson R, Shine</a> <a title="EMJ Cardiology 4.1 2016 page 83" href="http://viewer.zmags.com/publication/49205362?page=83"> 2065-72. 51. Carey JA et al. Orthotopic cardiac t</a> <a title="EMJ Cardiology 4.1 2016 page 84" href="http://viewer.zmags.com/publication/49205362?page=84"> ARTERIAL STIFFNESS AND CORONARY ARTERY DISEASE</a> <a title="EMJ Cardiology 4.1 2016 page 85" href="http://viewer.zmags.com/publication/49205362?page=85"> linking within arterial walls.10 Emerging evidenc</a> <a title="EMJ Cardiology 4.1 2016 page 86" href="http://viewer.zmags.com/publication/49205362?page=86"> during invasive coronary angiography (ICA), have </a> <a title="EMJ Cardiology 4.1 2016 page 87" href="http://viewer.zmags.com/publication/49205362?page=87"> clinical follow-up.32 The value of aortic PWV in </a> <a title="EMJ Cardiology 4.1 2016 page 88" href="http://viewer.zmags.com/publication/49205362?page=88"> such subclinical changes in routine med</a> <a title="EMJ Cardiology 4.1 2016 page 89" href="http://viewer.zmags.com/publication/49205362?page=89"> Guidelines for the Management of Arterial Hyperte</a> <a title="EMJ Cardiology 4.1 2016 page 90" href="http://viewer.zmags.com/publication/49205362?page=90"> RECURRENT CORONARY PERFORATIONS IN AN ANEURYSMA</a> <a title="EMJ Cardiology 4.1 2016 page 91" href="http://viewer.zmags.com/publication/49205362?page=91"> to the emergency department following 2 days of i</a> <a title="EMJ Cardiology 4.1 2016 page 92" href="http://viewer.zmags.com/publication/49205362?page=92"> The patient was later transferred to the intensiv</a> <a title="EMJ Cardiology 4.1 2016 page 93" href="http://viewer.zmags.com/publication/49205362?page=93"> Histopathologic findings of autopsies have reveale</a> <a title="EMJ Cardiology 4.1 2016 page 94" href="http://viewer.zmags.com/publication/49205362?page=94"> guidewire-related perforations, to emergenc</a> <a title="EMJ Cardiology 4.1 2016 page 95" href="http://viewer.zmags.com/publication/49205362?page=95"> Exclusive Interviews from the European Societ</a> <a title="EMJ Cardiology 4.1 2016 page 96" href="http://viewer.zmags.com/publication/49205362?page=96"> CURRENT CONCEPTS IN CORONARY ARTERY SPASM </a> <a title="EMJ Cardiology 4.1 2016 page 97" href="http://viewer.zmags.com/publication/49205362?page=97"> testing in the cardiac catheterisation laboratory</a> <a title="EMJ Cardiology 4.1 2016 page 98" href="http://viewer.zmags.com/publication/49205362?page=98"> the use of acetylcholine provocation testing can </a> <a title="EMJ Cardiology 4.1 2016 page 99" href="http://viewer.zmags.com/publication/49205362?page=99"> Other animal models have suggested a number of pa</a> <a title="EMJ Cardiology 4.1 2016 page 100" href="http://viewer.zmags.com/publication/49205362?page=100"> major adverse cardiovascular events rates between</a> <a title="EMJ Cardiology 4.1 2016 page 101" href="http://viewer.zmags.com/publication/49205362?page=101"> CONCLUSION CAS is caused by abnormal coronary ar</a> <a title="EMJ Cardiology 4.1 2016 page 102" href="http://viewer.zmags.com/publication/49205362?page=102"> 32. Okumura K et al. Multivessel coronary spasm i</a> <a title="EMJ Cardiology 4.1 2016 page 103" href="http://viewer.zmags.com/publication/49205362?page=103"> VALVULAR HEART DISEASE AND RISK SCORE </a> <a title="EMJ Cardiology 4.1 2016 page 104" href="http://viewer.zmags.com/publication/49205362?page=104"> with lower prevalence of RHD and different patien</a> <a title="EMJ Cardiology 4.1 2016 page 105" href="http://viewer.zmags.com/publication/49205362?page=105"> To implement those models, statistical analy</a> <a title="EMJ Cardiology 4.1 2016 page 106" href="http://viewer.zmags.com/publication/49205362?page=106"> REFERENCES 1. Ambler G et al. Generic simple ris</a> <a title="EMJ Cardiology 4.1 2016 page 107" href="http://viewer.zmags.com/publication/49205362?page=107"> CARDIAC ARREST IN PREGNANCY: END-TIDAL CO </a> <a title="EMJ Cardiology 4.1 2016 page 108" href="http://viewer.zmags.com/publication/49205362?page=108"> pregnant population.2 We present a case fro</a> <a title="EMJ Cardiology 4.1 2016 page 109" href="http://viewer.zmags.com/publication/49205362?page=109"> obstruction to the circulation like pulmonary or </a> <a title="EMJ Cardiology 4.1 2016 page 110" href="http://viewer.zmags.com/publication/49205362?page=110"> REFERENCES 1. Jeejeebhoy F et al. Cardiac </a> <a title="EMJ Cardiology 4.1 2016 page 111" href="http://viewer.zmags.com/publication/49205362?page=111"> Available Now EMJ Int</a> <a title="EMJ Cardiology 4.1 2016 page 112" href="http://viewer.zmags.com/publication/49205362?page=112"> CLINICAL TRIALS FOR THE DIAGNOSIS AND</a> <a title="EMJ Cardiology 4.1 2016 page 113" href="http://viewer.zmags.com/publication/49205362?page=113"> Table 1: Sensitivity and specificity of non-invasi</a> <a title="EMJ Cardiology 4.1 2016 page 114" href="http://viewer.zmags.com/publication/49205362?page=114"> The ideal non-invasive diagnostic test would</a> <a title="EMJ Cardiology 4.1 2016 page 115" href="http://viewer.zmags.com/publication/49205362?page=115"> A B C D E Figure 1: Computed tomography of a SC</a> <a title="EMJ Cardiology 4.1 2016 page 116" href="http://viewer.zmags.com/publication/49205362?page=116"> cardiovascular event (MACE) at 1 and 3 years, and</a> <a title="EMJ Cardiology 4.1 2016 page 117" href="http://viewer.zmags.com/publication/49205362?page=117"> revascularisation. It is hypothesised that C</a> <a title="EMJ Cardiology 4.1 2016 page 118" href="http://viewer.zmags.com/publication/49205362?page=118"> A Cine B Rest perfusion C Stress perfusion </a> <a title="EMJ Cardiology 4.1 2016 page 119" href="http://viewer.zmags.com/publication/49205362?page=119"> the absence of flow-limiting epicardial CAD. In th</a> <a title="EMJ Cardiology 4.1 2016 page 120" href="http://viewer.zmags.com/publication/49205362?page=120"> Acknowledgements Dr Corcoran is funded by a Briti</a> <a title="EMJ Cardiology 4.1 2016 page 121" href="http://viewer.zmags.com/publication/49205362?page=121"> Last accessed: 9 September 2016. 27. Seoul Nati</a> <a title="EMJ Cardiology 4.1 2016 page 122" href="http://viewer.zmags.com/publication/49205362?page=122"> Buyer’s Guide • ABBOTT VASCULAR INTERNAT</a> <a title="EMJ Cardiology 4.1 2016 page 123" href="http://viewer.zmags.com/publication/49205362?page=123"> Cardiology • LE-COR CO., LTD. • LITTMAN •</a> <a title="EMJ Cardiology 4.1 2016 page 124" href="http://viewer.zmags.com/publication/49205362?page=124"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS, NE</a>