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<br /> NEPHROLOGY<br /> ISSN 2053-4248 Vol 3.1 • July 2015 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ERA-EDTA 2015<br /> London, UK<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 4<br /> CONGRESS REVIEW........................................................................................................................................ 12<br /> • Review of the European Renal Association - European Dialysis and Transplant<br /> Association Congress held in London, UK, 28th-31st May 2015<br /> BEST ABSTRACT AWARD WINNERS AT ERA-EDTA 2015..................................................................... 27<br /> INTERVIEWS WITH EMJ NEPHROLOGY EDITORIAL BOARD............................................................... 30<br /> SYMPOSIUM REVIEWS<br <a title="EMJ Nephrology 3.1 2015 page 1" href="http://viewer.zmags.com/publication/49607ba2?page=1"> NEPHROLOGY ISSN 2053-4248 </a> <a title="EMJ Nephrology 3.1 2015 page 2" href="http://viewer.zmags.com/publication/49607ba2?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Nephrology 3.1 2015 page 3" href="http://viewer.zmags.com/publication/49607ba2?page=3"> NEPHROLOGY • ACUTE KIDNEY INJURY - AN UPDATE.</a> <a title="EMJ Nephrology 3.1 2015 page 4" href="http://viewer.zmags.com/publication/49607ba2?page=4"> Editorial Board Editor-in-Chief: Prof Norbert L</a> <a title="EMJ Nephrology 3.1 2015 page 5" href="http://viewer.zmags.com/publication/49607ba2?page=5"> Nephrology Dr Ron T. Gansevoort, Associat</a> <a title="EMJ Nephrology 3.1 2015 page 6" href="http://viewer.zmags.com/publication/49607ba2?page=6"> As individual as your patients PD therapy tailore</a> <a title="EMJ Nephrology 3.1 2015 page 7" href="http://viewer.zmags.com/publication/49607ba2?page=7"> European Medical Journal EMJ Nephrology Vol 3.1</a> <a title="EMJ Nephrology 3.1 2015 page 8" href="http://viewer.zmags.com/publication/49607ba2?page=8"> “big enough to cope, small enough to care”  </a> <a title="EMJ Nephrology 3.1 2015 page 9" href="http://viewer.zmags.com/publication/49607ba2?page=9"> Welcome Hello and a very warm welcome to the 2</a> <a title="EMJ Nephrology 3.1 2015 page 10" href="http://viewer.zmags.com/publication/49607ba2?page=10"> World leader in medical devices for ABO-inco</a> <a title="EMJ Nephrology 3.1 2015 page 11" href="http://viewer.zmags.com/publication/49607ba2?page=11"> Foreword </a> <a title="EMJ Nephrology 3.1 2015 page 12" href="http://viewer.zmags.com/publication/49607ba2?page=12"> ERA-EDTA ANNUAL CONGRESS 2015 EXCEL LONDON EXHIB</a> <a title="EMJ Nephrology 3.1 2015 page 13" href="http://viewer.zmags.com/publication/49607ba2?page=13"> Welcome to the European Medical Journal revi</a> <a title="EMJ Nephrology 3.1 2015 page 14" href="http://viewer.zmags.com/publication/49607ba2?page=14"> ERA-EDTA ANNUAL CONGRESS 2015 150 exhibitors, ov</a> <a title="EMJ Nephrology 3.1 2015 page 15" href="http://viewer.zmags.com/publication/49607ba2?page=15"> H IGHLIGHTS Genetic Risk Factors Impl</a> <a title="EMJ Nephrology 3.1 2015 page 16" href="http://viewer.zmags.com/publication/49607ba2?page=16"> ERA-EDTA ANNUAL CONGRESS 2015 and observed an es</a> <a title="EMJ Nephrology 3.1 2015 page 17" href="http://viewer.zmags.com/publication/49607ba2?page=17"> Combined Therapy Produces Promising Results for A</a> <a title="EMJ Nephrology 3.1 2015 page 18" href="http://viewer.zmags.com/publication/49607ba2?page=18"> ERA-EDTA ANNUAL CONGRESS 2015 “Several AGT crysta</a> <a title="EMJ Nephrology 3.1 2015 page 19" href="http://viewer.zmags.com/publication/49607ba2?page=19"> synthesised interference RNA (RNAi) are encouragi</a> <a title="EMJ Nephrology 3.1 2015 page 20" href="http://viewer.zmags.com/publication/49607ba2?page=20"> ERA-EDTA ANNUAL CONGRESS 2015 Potential Bone Biom</a> <a title="EMJ Nephrology 3.1 2015 page 21" href="http://viewer.zmags.com/publication/49607ba2?page=21"> In spite of the World Health Organizati</a> <a title="EMJ Nephrology 3.1 2015 page 22" href="http://viewer.zmags.com/publication/49607ba2?page=22"> ERA-EDTA ANNUAL CONGRESS 2015 Ethn</a> <a title="EMJ Nephrology 3.1 2015 page 23" href="http://viewer.zmags.com/publication/49607ba2?page=23"> global issue. The team therefore urges furth</a> <a title="EMJ Nephrology 3.1 2015 page 24" href="http://viewer.zmags.com/publication/49607ba2?page=24"> ERA-EDTA ANNUAL CONGRESS 2015 CRP Levels May Help</a> <a title="EMJ Nephrology 3.1 2015 page 25" href="http://viewer.zmags.com/publication/49607ba2?page=25"> and magnitude of inflammation in dialysis pati</a> <a title="EMJ Nephrology 3.1 2015 page 26" href="http://viewer.zmags.com/publication/49607ba2?page=26"> ERA-EDTA ANNUAL CONGRESS 2015 “These data suggest</a> <a title="EMJ Nephrology 3.1 2015 page 27" href="http://viewer.zmags.com/publication/49607ba2?page=27"> BEST ABSTRACT AWARD WINNERS AT ERA-EDTA 20</a> <a title="EMJ Nephrology 3.1 2015 page 28" href="http://viewer.zmags.com/publication/49607ba2?page=28"> ERA-EDTA ANNUAL CONGRESS 2015 patien</a> <a title="EMJ Nephrology 3.1 2015 page 29" href="http://viewer.zmags.com/publication/49607ba2?page=29"> ethnicity, and a history of pre- transp</a> <a title="EMJ Nephrology 3.1 2015 page 30" href="http://viewer.zmags.com/publication/49607ba2?page=30"> EDITORIAL BOARD INTERVIEWS Vladimir Tesar P</a> <a title="EMJ Nephrology 3.1 2015 page 31" href="http://viewer.zmags.com/publication/49607ba2?page=31"> complications of CKD), as well as a limited chanc</a> <a title="EMJ Nephrology 3.1 2015 page 32" href="http://viewer.zmags.com/publication/49607ba2?page=32"> EDITORIAL BOARD INTERVIEWS To sustain the lives </a> <a title="EMJ Nephrology 3.1 2015 page 33" href="http://viewer.zmags.com/publication/49607ba2?page=33"> A: Hopefully this highlights the harm ketamine ca</a> <a title="EMJ Nephrology 3.1 2015 page 34" href="http://viewer.zmags.com/publication/49607ba2?page=34"> EDITORIAL BOARD INTERVIEWS the key therapy, RRT,</a> <a title="EMJ Nephrology 3.1 2015 page 35" href="http://viewer.zmags.com/publication/49607ba2?page=35"> Rosanna Coppo Director of Nephrolo</a> <a title="EMJ Nephrology 3.1 2015 page 36" href="http://viewer.zmags.com/publication/49607ba2?page=36"> EDITORIAL BOARD INTERVIEWS Q: How do the standar</a> <a title="EMJ Nephrology 3.1 2015 page 37" href="http://viewer.zmags.com/publication/49607ba2?page=37"> 53rd Congress ViennaERA-EDTA Austria Held joint</a> <a title="EMJ Nephrology 3.1 2015 page 38" href="http://viewer.zmags.com/publication/49607ba2?page=38"> SUPPORTING CKD PATIENTS AT HOME Summary of presen</a> <a title="EMJ Nephrology 3.1 2015 page 39" href="http://viewer.zmags.com/publication/49607ba2?page=39"> some face-to-face contact with HCPs. Remote </a> <a title="EMJ Nephrology 3.1 2015 page 40" href="http://viewer.zmags.com/publication/49607ba2?page=40"> thousands of patients with HF and an implanted pa</a> <a title="EMJ Nephrology 3.1 2015 page 41" href="http://viewer.zmags.com/publication/49607ba2?page=41"> in patients who choose PD upon availability of th</a> <a title="EMJ Nephrology 3.1 2015 page 42" href="http://viewer.zmags.com/publication/49607ba2?page=42"> 12 Relevant data </a> <a title="EMJ Nephrology 3.1 2015 page 43" href="http://viewer.zmags.com/publication/49607ba2?page=43"> within the remote monitoring tool by the patient </a> <a title="EMJ Nephrology 3.1 2015 page 44" href="http://viewer.zmags.com/publication/49607ba2?page=44"> monitored in implantable devices for identify</a> <a title="EMJ Nephrology 3.1 2015 page 45" href="http://viewer.zmags.com/publication/49607ba2?page=45"> GET CONNECTED TO PATIENTS ON HOME DIALYSIS. A. R</a> <a title="EMJ Nephrology 3.1 2015 page 46" href="http://viewer.zmags.com/publication/49607ba2?page=46"> THE ONGOING MANAGEMENT OF HYPERKALAEMIA </a> <a title="EMJ Nephrology 3.1 2015 page 47" href="http://viewer.zmags.com/publication/49607ba2?page=47"> practice is to discontinue or reduce the use of R</a> <a title="EMJ Nephrology 3.1 2015 page 48" href="http://viewer.zmags.com/publication/49607ba2?page=48"> and in cases of undercurrent clinical problems (e</a> <a title="EMJ Nephrology 3.1 2015 page 49" href="http://viewer.zmags.com/publication/49607ba2?page=49"> Diabetic patients In patients with diabetic nephr</a> <a title="EMJ Nephrology 3.1 2015 page 50" href="http://viewer.zmags.com/publication/49607ba2?page=50"> Patients with kidney transplantation According to</a> <a title="EMJ Nephrology 3.1 2015 page 51" href="http://viewer.zmags.com/publication/49607ba2?page=51"> How about novel strategies? Aldosterone antagonis</a> <a title="EMJ Nephrology 3.1 2015 page 52" href="http://viewer.zmags.com/publication/49607ba2?page=52"> Table 2: An acute versus chronic case of hyperkal</a> <a title="EMJ Nephrology 3.1 2015 page 53" href="http://viewer.zmags.com/publication/49607ba2?page=53"> The results showed that patiromer is effective in</a> <a title="EMJ Nephrology 3.1 2015 page 54" href="http://viewer.zmags.com/publication/49607ba2?page=54"> 5.4 5.2 5.0 4.8 4.6 4.4 Mean serum potassiu</a> <a title="EMJ Nephrology 3.1 2015 page 55" href="http://viewer.zmags.com/publication/49607ba2?page=55"> EmphasisItems/Electrolytefluidbalance. html. Last</a> <a title="EMJ Nephrology 3.1 2015 page 56" href="http://viewer.zmags.com/publication/49607ba2?page=56"> RENAL TRANSPLANTATION IN AUTOSOMAL DOMINANT POL</a> <a title="EMJ Nephrology 3.1 2015 page 57" href="http://viewer.zmags.com/publication/49607ba2?page=57"> implantation of the transplant. In effect, only 2</a> <a title="EMJ Nephrology 3.1 2015 page 58" href="http://viewer.zmags.com/publication/49607ba2?page=58"> Liver Polycystic liver disease (PLD) is obse</a> <a title="EMJ Nephrology 3.1 2015 page 59" href="http://viewer.zmags.com/publication/49607ba2?page=59"> Cardiovascular System Research results contra</a> <a title="EMJ Nephrology 3.1 2015 page 60" href="http://viewer.zmags.com/publication/49607ba2?page=60"> of Caillard et al.,62 ADPKD is associated with ri</a> <a title="EMJ Nephrology 3.1 2015 page 61" href="http://viewer.zmags.com/publication/49607ba2?page=61"> REFERENCES 1. Chang MY, Ong AC. Autoso</a> <a title="EMJ Nephrology 3.1 2015 page 62" href="http://viewer.zmags.com/publication/49607ba2?page=62"> in the recipient with autosomal dominant polycyst</a> <a title="EMJ Nephrology 3.1 2015 page 63" href="http://viewer.zmags.com/publication/49607ba2?page=63"> COMPLEMENT INVOLVEMENT IN </a> <a title="EMJ Nephrology 3.1 2015 page 64" href="http://viewer.zmags.com/publication/49607ba2?page=64"> Alternative pathway Lectin pathway Spontaneous an</a> <a title="EMJ Nephrology 3.1 2015 page 65" href="http://viewer.zmags.com/publication/49607ba2?page=65"> Table 1: Anti-complement agents in clinical trial</a> <a title="EMJ Nephrology 3.1 2015 page 66" href="http://viewer.zmags.com/publication/49607ba2?page=66"> Sacks et al.28 and is currently the subjec</a> <a title="EMJ Nephrology 3.1 2015 page 67" href="http://viewer.zmags.com/publication/49607ba2?page=67"> with DSAs but without C4d have been reported.49 C</a> <a title="EMJ Nephrology 3.1 2015 page 68" href="http://viewer.zmags.com/publication/49607ba2?page=68"> REFERENCES 1. Walport MJ. Complement. First </a> <a title="EMJ Nephrology 3.1 2015 page 69" href="http://viewer.zmags.com/publication/49607ba2?page=69"> ahead of print]. 45. Ponticelli C. The mechanisms</a> <a title="EMJ Nephrology 3.1 2015 page 70" href="http://viewer.zmags.com/publication/49607ba2?page=70"> RETROGRADE INTRARENAL SURGERY FOR COMPLEX STONE</a> <a title="EMJ Nephrology 3.1 2015 page 71" href="http://viewer.zmags.com/publication/49607ba2?page=71"> limited fluoroscopy time. Regardless of </a> <a title="EMJ Nephrology 3.1 2015 page 72" href="http://viewer.zmags.com/publication/49607ba2?page=72"> Figure 2: A duplicated collecting system on the </a> <a title="EMJ Nephrology 3.1 2015 page 73" href="http://viewer.zmags.com/publication/49607ba2?page=73"> Figure 3: The retrograde pyelogram revealed high</a> <a title="EMJ Nephrology 3.1 2015 page 74" href="http://viewer.zmags.com/publication/49607ba2?page=74"> surgery monotherapy versus shock 12. Sch</a> <a title="EMJ Nephrology 3.1 2015 page 75" href="http://viewer.zmags.com/publication/49607ba2?page=75"> ACUTE KIDNEY INJURY - AN UPDATE Matt Varrier, Ric</a> <a title="EMJ Nephrology 3.1 2015 page 76" href="http://viewer.zmags.com/publication/49607ba2?page=76"> also shown that some patients have a slow but per</a> <a title="EMJ Nephrology 3.1 2015 page 77" href="http://viewer.zmags.com/publication/49607ba2?page=77"> variations in perfusion and oxygen consumption, i</a> <a title="EMJ Nephrology 3.1 2015 page 78" href="http://viewer.zmags.com/publication/49607ba2?page=78"> Table 2: Summary of guidelines for treatment of a</a> <a title="EMJ Nephrology 3.1 2015 page 79" href="http://viewer.zmags.com/publication/49607ba2?page=79"> recovery and an increased mortality.39 </a> <a title="EMJ Nephrology 3.1 2015 page 80" href="http://viewer.zmags.com/publication/49607ba2?page=80"> to repair processes following AKI. A single-centr</a> <a title="EMJ Nephrology 3.1 2015 page 81" href="http://viewer.zmags.com/publication/49607ba2?page=81"> The most-studied biomarkers are neutrophi</a> <a title="EMJ Nephrology 3.1 2015 page 82" href="http://viewer.zmags.com/publication/49607ba2?page=82"> Hypertens. 2013;22(6):637-42. 20. Wilson FP </a> <a title="EMJ Nephrology 3.1 2015 page 83" href="http://viewer.zmags.com/publication/49607ba2?page=83"> MANAGEMENT OF REFRACTORY LUPUS NEPHRITIS </a> <a title="EMJ Nephrology 3.1 2015 page 84" href="http://viewer.zmags.com/publication/49607ba2?page=84"> filtration rate (GFR) (i.e. within 10% of n</a> <a title="EMJ Nephrology 3.1 2015 page 85" href="http://viewer.zmags.com/publication/49607ba2?page=85"> increase in chronic, irreversible glo</a> <a title="EMJ Nephrology 3.1 2015 page 86" href="http://viewer.zmags.com/publication/49607ba2?page=86"> (UPr: 4.0-4.4 g/24 h, preserved renal function), </a> <a title="EMJ Nephrology 3.1 2015 page 87" href="http://viewer.zmags.com/publication/49607ba2?page=87"> Two RCTs were recently published comparing c</a> <a title="EMJ Nephrology 3.1 2015 page 88" href="http://viewer.zmags.com/publication/49607ba2?page=88"> In the study by Rivera et al.26 that test</a> <a title="EMJ Nephrology 3.1 2015 page 89" href="http://viewer.zmags.com/publication/49607ba2?page=89"> Transplant. 2013;28:3014-23. 16. Alsuwaida A e</a> <a title="EMJ Nephrology 3.1 2015 page 90" href="http://viewer.zmags.com/publication/49607ba2?page=90"> ACUTE KIDNEY INJURY: EPIDEMIOLOGY, DIAGNOSIS, </a> <a title="EMJ Nephrology 3.1 2015 page 91" href="http://viewer.zmags.com/publication/49607ba2?page=91"> as has the incidence of dialysis-requiring </a> <a title="EMJ Nephrology 3.1 2015 page 92" href="http://viewer.zmags.com/publication/49607ba2?page=92"> without renal dysfunction,8-12,17-30 namely l</a> <a title="EMJ Nephrology 3.1 2015 page 93" href="http://viewer.zmags.com/publication/49607ba2?page=93"> Table 2: Acute Kidney Injury Network (AKIN)3 and </a> <a title="EMJ Nephrology 3.1 2015 page 94" href="http://viewer.zmags.com/publication/49607ba2?page=94"> pathways and immune activation play an active and</a> <a title="EMJ Nephrology 3.1 2015 page 95" href="http://viewer.zmags.com/publication/49607ba2?page=95"> of defining acute kidney injury. QJM. 2011;10</a> <a title="EMJ Nephrology 3.1 2015 page 96" href="http://viewer.zmags.com/publication/49607ba2?page=96"> 64. Gomez H et al. A unified theory of </a> <a title="EMJ Nephrology 3.1 2015 page 97" href="http://viewer.zmags.com/publication/49607ba2?page=97"> IgA NEPHROPATHY: NEW ASPECTS IN</a> <a title="EMJ Nephrology 3.1 2015 page 98" href="http://viewer.zmags.com/publication/49607ba2?page=98"> dialysis/death. We demonstrated that these three </a> <a title="EMJ Nephrology 3.1 2015 page 99" href="http://viewer.zmags.com/publication/49607ba2?page=99"> O-Glycosylated lateral chains: complete or trunca</a> <a title="EMJ Nephrology 3.1 2015 page 100" href="http://viewer.zmags.com/publication/49607ba2?page=100"> an association with a particular </a> <a title="EMJ Nephrology 3.1 2015 page 101" href="http://viewer.zmags.com/publication/49607ba2?page=101"> Gd-IgA1 Mesangial Deposition and Creation of Rena</a> <a title="EMJ Nephrology 3.1 2015 page 102" href="http://viewer.zmags.com/publication/49607ba2?page=102"> In any case, the initiation of the disease</a> <a title="EMJ Nephrology 3.1 2015 page 103" href="http://viewer.zmags.com/publication/49607ba2?page=103"> Nephrol. 2008;28(1):78-87. 29. Yanagawa H et </a> <a title="EMJ Nephrology 3.1 2015 page 104" href="http://viewer.zmags.com/publication/49607ba2?page=104"> PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS: W</a> <a title="EMJ Nephrology 3.1 2015 page 105" href="http://viewer.zmags.com/publication/49607ba2?page=105"> THE COMPLEX DEFINITION OF PRIMARY FOCAL SEGMENTAL</a> <a title="EMJ Nephrology 3.1 2015 page 106" href="http://viewer.zmags.com/publication/49607ba2?page=106"> primary acquired variant apparently caused b</a> <a title="EMJ Nephrology 3.1 2015 page 107" href="http://viewer.zmags.com/publication/49607ba2?page=107"> inhibitory properties on adhesion and uPAR- </a> <a title="EMJ Nephrology 3.1 2015 page 108" href="http://viewer.zmags.com/publication/49607ba2?page=108"> podocytopathy have been reported; however, the fa</a> <a title="EMJ Nephrology 3.1 2015 page 109" href="http://viewer.zmags.com/publication/49607ba2?page=109"> 2014;doi:10.1093/ndt/gfu035. [Epub ahead o</a> <a title="EMJ Nephrology 3.1 2015 page 110" href="http://viewer.zmags.com/publication/49607ba2?page=110"> 52. Keir ME et al. PD-1 and its ligands in toler</a> <a title="EMJ Nephrology 3.1 2015 page 111" href="http://viewer.zmags.com/publication/49607ba2?page=111"> CHRONIC KIDNEY DISEASE AND ENDOTHELIUM *Da</a> <a title="EMJ Nephrology 3.1 2015 page 112" href="http://viewer.zmags.com/publication/49607ba2?page=112"> reflect a decreased bioavailability of n</a> <a title="EMJ Nephrology 3.1 2015 page 113" href="http://viewer.zmags.com/publication/49607ba2?page=113"> direct cause of vascular injury. Pro-inflammatory </a> <a title="EMJ Nephrology 3.1 2015 page 114" href="http://viewer.zmags.com/publication/49607ba2?page=114"> TNF-α in dialysis patients, but also </a> <a title="EMJ Nephrology 3.1 2015 page 115" href="http://viewer.zmags.com/publication/49607ba2?page=115"> permselectivity and microalbuminuria, where</a> <a title="EMJ Nephrology 3.1 2015 page 116" href="http://viewer.zmags.com/publication/49607ba2?page=116"> to both the CV system and the kidney.52 However, </a> <a title="EMJ Nephrology 3.1 2015 page 117" href="http://viewer.zmags.com/publication/49607ba2?page=117"> chronic hemodialysis patients with overt cardiova</a> <a title="EMJ Nephrology 3.1 2015 page 118" href="http://viewer.zmags.com/publication/49607ba2?page=118"> Buyer’s Guide • ABBVIE • ACTUAL WAY • AKEBI</a> <a title="EMJ Nephrology 3.1 2015 page 119" href="http://viewer.zmags.com/publication/49607ba2?page=119"> Nephrology • JIANGXI SANXIN MEDTEC • JIHUA M</a> <a title="EMJ Nephrology 3.1 2015 page 120" href="http://viewer.zmags.com/publication/49607ba2?page=120"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS, PUBL</a>