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<br /> RESPIRATORY<br /> EMJ Respir. 2020 Suppl 1 • emjreviews.com<br /> INSIDE<br /> Integrating Type 2 Biologics in the<br /> Management of Uncontrolled Severe<br /> Asthma: The Importance of Lung<br /> Function in Disease Control<br /> Integrating Type 2 Biologics in the Management of<br /> Uncontrolled Severe Asthma: The Importance of<br /> Lung Function in Disease Control<br /> This symposium took place on 30th September 2019, as part of the 29th<br /> European Respiratory Society (ERS) Congress in Madrid, Spain<br /> Chairpeople: Klaus F. Rabe1,2<br /> Speakers: Marc Humbert,3 Michael Wechsler4<br /> 1. Lung Clinic Großhansdorf, Großhansdorf, Germany<br /> 2. University of Kiel, Kiel, Germany<br /> 3. South Paris University, Paris, France<br /> 4. National Jewish Health, Denver, Colorado, USA<br /> Disclosure: Prof Rabe received speaker’s honoraria from AstraZeneca, Be<a title="EMJ Respiratory. 2020 Suppl 1 page 1" href="http://viewer.zmags.com/publication/4c4042a2?page=1"> RESPIRATORY EMJ Respir. 2020 Suppl 1 • emjreviews</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 2" href="http://viewer.zmags.com/publication/4c4042a2?page=2"> Integrating Type 2 Biologics in the Management of</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 3" href="http://viewer.zmags.com/publication/4c4042a2?page=3"> recommend considering add-on of Type 2-targeted b</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 4" href="http://viewer.zmags.com/publication/4c4042a2?page=4"> those with normal FEV at baseline (≥80%), those </a> <a title="EMJ Respiratory. 2020 Suppl 1 page 5" href="http://viewer.zmags.com/publication/4c4042a2?page=5"> IL-4, IL-13, and IL-5 Are Key Cytokineis</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 6" href="http://viewer.zmags.com/publication/4c4042a2?page=6"> Key Type 2 Cytokines IL-4, IL-13, and IL-5 in the</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 7" href="http://viewer.zmags.com/publication/4c4042a2?page=7"> and airway hyper-responsiveness. Clinically, this</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 8" href="http://viewer.zmags.com/publication/4c4042a2?page=8"> In patients with inadequately control</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 9" href="http://viewer.zmags.com/publication/4c4042a2?page=9"> Dupilumab: Effect on OCS Use, Lung Function, and </a> <a title="EMJ Respiratory. 2020 Suppl 1 page 10" href="http://viewer.zmags.com/publication/4c4042a2?page=10"> 1% with placebo), and the same for eosinophilia (</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 11" href="http://viewer.zmags.com/publication/4c4042a2?page=11"> accelerated decline in lung function in adult-ons</a> <a title="EMJ Respiratory. 2020 Suppl 1 page 12" href="http://viewer.zmags.com/publication/4c4042a2?page=12"> subgroups in the Phase 3 LIBERTY 74. ASTH</a>