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<br /> DIABETES<br /> ISSN 2054-6181 Vol 4.1 • October 2016 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EASD 2016<br /> Munich, Germany<br /> CONTENTS<br /> EDITORIAL BOARD...................................................................................................................................... 4<br /> CONGRESS REVIEW.................................................................................................................................... 12<br /> • Review of the 52nd European Association for the Study of Diabetes (EASD)<br /> Annual Meeting, held in Munich, Germany, 12th–16th September 2016<br /> INTERVIEWS WITH EMJ DIABETES EDITORIAL BOARD.................................................................... 29<br /> SYMPOSIUM REVIEW<br /> • TYPE 2 DIABETES MELLITUS: BEYOND THE BETA CELL...............................................<a title="EMJ Diabetes 4.1 2016 page 1" href="http://viewer.zmags.com/publication/513d7363?page=1"> DIABETES ISSN 2054-6181 </a> <a title="EMJ Diabetes 4.1 2016 page 2" href="http://viewer.zmags.com/publication/513d7363?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Diabetes 4.1 2016 page 3" href="http://viewer.zmags.com/publication/513d7363?page=3"> DIABETES • TREATMENT OF TYPE 2 DIABETES WITH BI</a> <a title="EMJ Diabetes 4.1 2016 page 4" href="http://viewer.zmags.com/publication/513d7363?page=4"> Editorial Board Editor-in-Chief: Prof Jörg Hube</a> <a title="EMJ Diabetes 4.1 2016 page 5" href="http://viewer.zmags.com/publication/513d7363?page=5"> Diabetes Mrs Deirdre Kyne-Grzebalski, Treasur</a> <a title="EMJ Diabetes 4.1 2016 page 6" href="http://viewer.zmags.com/publication/513d7363?page=6"> DIABETES 4.1 OCTOBER 2016 Director Spencer Gore</a> <a title="EMJ Diabetes 4.1 2016 page 7" href="http://viewer.zmags.com/publication/513d7363?page=7"> Welcome Welcome to the 2016 publication of EMJ</a> <a title="EMJ Diabetes 4.1 2016 page 8" href="http://viewer.zmags.com/publication/513d7363?page=8"> Atherogenic Dyslipidaemia is a major cause of mor</a> <a title="EMJ Diabetes 4.1 2016 page 9" href="http://viewer.zmags.com/publication/513d7363?page=9"> Foreword </a> <a title="EMJ Diabetes 4.1 2016 page 10" href="http://viewer.zmags.com/publication/513d7363?page=10"> SUBSCRIBE FREE TO OUR YOUTUBE CHANNEL www.youtube</a> <a title="EMJ Diabetes 4.1 2016 page 11" href="http://viewer.zmags.com/publication/513d7363?page=11"> x E clusive Interviews from the European</a> <a title="EMJ Diabetes 4.1 2016 page 12" href="http://viewer.zmags.com/publication/513d7363?page=12"> 12 DIABETES • October 2016 </a> <a title="EMJ Diabetes 4.1 2016 page 13" href="http://viewer.zmags.com/publication/513d7363?page=13"> DIABETES • October 2016 </a> <a title="EMJ Diabetes 4.1 2016 page 14" href="http://viewer.zmags.com/publication/513d7363?page=14"> EASD 2016 for this year was the introductio</a> <a title="EMJ Diabetes 4.1 2016 page 15" href="http://viewer.zmags.com/publication/513d7363?page=15"> Congress Highlights Interactions Bet</a> <a title="EMJ Diabetes 4.1 2016 page 16" href="http://viewer.zmags.com/publication/513d7363?page=16"> premature to suggest public health measures shoul</a> <a title="EMJ Diabetes 4.1 2016 page 17" href="http://viewer.zmags.com/publication/513d7363?page=17"> These findings suggest that social supportive care</a> <a title="EMJ Diabetes 4.1 2016 page 18" href="http://viewer.zmags.com/publication/513d7363?page=18"> and thus reduce compliance with this dieting stra</a> <a title="EMJ Diabetes 4.1 2016 page 19" href="http://viewer.zmags.com/publication/513d7363?page=19"> We would not necessarily recommend cutting these </a> <a title="EMJ Diabetes 4.1 2016 page 20" href="http://viewer.zmags.com/publication/513d7363?page=20">  Compared with the standard diet, the HFHS di</a> <a title="EMJ Diabetes 4.1 2016 page 21" href="http://viewer.zmags.com/publication/513d7363?page=21"> Although VAT volume was higher in the AAS subgrou</a> <a title="EMJ Diabetes 4.1 2016 page 22" href="http://viewer.zmags.com/publication/513d7363?page=22"> Preconception and Gestational Diabetes Both Linke</a> <a title="EMJ Diabetes 4.1 2016 page 23" href="http://viewer.zmags.com/publication/513d7363?page=23"> Our findings suggest seasonal variations in the 2-</a> <a title="EMJ Diabetes 4.1 2016 page 24" href="http://viewer.zmags.com/publication/513d7363?page=24"> showed a J-shaped relationship between the length</a> <a title="EMJ Diabetes 4.1 2016 page 25" href="http://viewer.zmags.com/publication/513d7363?page=25"> Commenting on their study, the authors stated: “I</a> <a title="EMJ Diabetes 4.1 2016 page 26" href="http://viewer.zmags.com/publication/513d7363?page=26"> These simulated outcomes provide patients and cli</a> <a title="EMJ Diabetes 4.1 2016 page 27" href="http://viewer.zmags.com/publication/513d7363?page=27"> The authors of the study, led by Dr Pavel Škrha, </a> <a title="EMJ Diabetes 4.1 2016 page 28" href="http://viewer.zmags.com/publication/513d7363?page=28"> FORXIGA®: A highly selective SGLT2 inhibitor </a> <a title="EMJ Diabetes 4.1 2016 page 29" href="http://viewer.zmags.com/publication/513d7363?page=29"> Jörg Huber Professor of Health Sciences and Depu</a> <a title="EMJ Diabetes 4.1 2016 page 30" href="http://viewer.zmags.com/publication/513d7363?page=30"> diabetes and other long-term conditio</a> <a title="EMJ Diabetes 4.1 2016 page 31" href="http://viewer.zmags.com/publication/513d7363?page=31"> Henning Beck-Nielsen Professor and Chief Physici</a> <a title="EMJ Diabetes 4.1 2016 page 32" href="http://viewer.zmags.com/publication/513d7363?page=32"> on insulin resistance in skeletal muscles. </a> <a title="EMJ Diabetes 4.1 2016 page 33" href="http://viewer.zmags.com/publication/513d7363?page=33"> Q: Have you noticed any trends in the prevalence </a> <a title="EMJ Diabetes 4.1 2016 page 34" href="http://viewer.zmags.com/publication/513d7363?page=34"> the tantalising question of what the environmenta</a> <a title="EMJ Diabetes 4.1 2016 page 35" href="http://viewer.zmags.com/publication/513d7363?page=35"> hence also more targeted treatment. The</a> <a title="EMJ Diabetes 4.1 2016 page 36" href="http://viewer.zmags.com/publication/513d7363?page=36"> TYPE 2 DIABETES MELLITUS: BEYOND THE BETA CELL T</a> <a title="EMJ Diabetes 4.1 2016 page 37" href="http://viewer.zmags.com/publication/513d7363?page=37"> tissue into brown fat, mimicking physiological ef</a> <a title="EMJ Diabetes 4.1 2016 page 38" href="http://viewer.zmags.com/publication/513d7363?page=38"> disease of chronic hyperglycaemia; a high glucose</a> <a title="EMJ Diabetes 4.1 2016 page 39" href="http://viewer.zmags.com/publication/513d7363?page=39"> Event rates for macrovascular complications </a> <a title="EMJ Diabetes 4.1 2016 page 40" href="http://viewer.zmags.com/publication/513d7363?page=40"> with T2DM. The EMPA-REG outcome study d</a> <a title="EMJ Diabetes 4.1 2016 page 41" href="http://viewer.zmags.com/publication/513d7363?page=41"> Combination Therapy in Type 2 Diabetes Mellitus: </a> <a title="EMJ Diabetes 4.1 2016 page 42" href="http://viewer.zmags.com/publication/513d7363?page=42"> development of personalised approaches for the tr</a> <a title="EMJ Diabetes 4.1 2016 page 43" href="http://viewer.zmags.com/publication/513d7363?page=43"> Decreased incretin effect GLP-1 RA, AGI Impaired </a> <a title="EMJ Diabetes 4.1 2016 page 44" href="http://viewer.zmags.com/publication/513d7363?page=44"> the audience responded that pancreatitis was a ma</a> <a title="EMJ Diabetes 4.1 2016 page 45" href="http://viewer.zmags.com/publication/513d7363?page=45"> With the range of therapies now on offer and the </a> <a title="EMJ Diabetes 4.1 2016 page 46" href="http://viewer.zmags.com/publication/513d7363?page=46"> trial. Expert Opin Pharmacother. 2013; 14(18)</a> <a title="EMJ Diabetes 4.1 2016 page 47" href="http://viewer.zmags.com/publication/513d7363?page=47"> Click here to view the AWARD WINNERS at the 5</a> <a title="EMJ Diabetes 4.1 2016 page 48" href="http://viewer.zmags.com/publication/513d7363?page=48"> Abstract Reviews AEROBIC PLUS RESIST</a> <a title="EMJ Diabetes 4.1 2016 page 49" href="http://viewer.zmags.com/publication/513d7363?page=49"> EASD 2016 6. Tock L et al. Nonalcoholic fatty li</a> <a title="EMJ Diabetes 4.1 2016 page 50" href="http://viewer.zmags.com/publication/513d7363?page=50"> Abstract Reviews evaluated for fasting blo</a> <a title="EMJ Diabetes 4.1 2016 page 51" href="http://viewer.zmags.com/publication/513d7363?page=51"> EASD 2016 myocardial infarction (MI) and stroke.</a> <a title="EMJ Diabetes 4.1 2016 page 52" href="http://viewer.zmags.com/publication/513d7363?page=52"> Abstract Reviews Hence, the potential to reduce </a> <a title="EMJ Diabetes 4.1 2016 page 53" href="http://viewer.zmags.com/publication/513d7363?page=53"> EASD 2016 expression levels of many cytokines in</a> <a title="EMJ Diabetes 4.1 2016 page 54" href="http://viewer.zmags.com/publication/513d7363?page=54"> Abstract Reviews obesity-induced secretory dysfu</a> <a title="EMJ Diabetes 4.1 2016 page 55" href="http://viewer.zmags.com/publication/513d7363?page=55"> EASD 2016 higher N-terminal pro b-type natriuret</a> <a title="EMJ Diabetes 4.1 2016 page 56" href="http://viewer.zmags.com/publication/513d7363?page=56"> Abstract Reviews and markedly inhibits str</a> <a title="EMJ Diabetes 4.1 2016 page 57" href="http://viewer.zmags.com/publication/513d7363?page=57"> EASD 2016 Blood Glucose Gluconeogenesis Pyruvat</a> <a title="EMJ Diabetes 4.1 2016 page 58" href="http://viewer.zmags.com/publication/513d7363?page=58"> Abstract Reviews was abrogated in Hep-Glud1-/</a> <a title="EMJ Diabetes 4.1 2016 page 59" href="http://viewer.zmags.com/publication/513d7363?page=59"> EASD 2016 obese group. In both groups, the incre</a> <a title="EMJ Diabetes 4.1 2016 page 60" href="http://viewer.zmags.com/publication/513d7363?page=60"> Abstract Reviews observed that ERK7 expression i</a> <a title="EMJ Diabetes 4.1 2016 page 61" href="http://viewer.zmags.com/publication/513d7363?page=61"> EASD 2016 singular validated adherence rating of</a> <a title="EMJ Diabetes 4.1 2016 page 62" href="http://viewer.zmags.com/publication/513d7363?page=62"> Abstract Reviews the study were 372 patients wit</a> <a title="EMJ Diabetes 4.1 2016 page 63" href="http://viewer.zmags.com/publication/513d7363?page=63"> EASD 2016 Annual Meeting, 12-16 September, 2016.</a> <a title="EMJ Diabetes 4.1 2016 page 64" href="http://viewer.zmags.com/publication/513d7363?page=64"> Abstract Reviews Table 1: Change in weight, glyca</a> <a title="EMJ Diabetes 4.1 2016 page 65" href="http://viewer.zmags.com/publication/513d7363?page=65"> EASD 2016 NEWLY DIAGNOSED AND PREVALENT T</a> <a title="EMJ Diabetes 4.1 2016 page 66" href="http://viewer.zmags.com/publication/513d7363?page=66"> EDITOR’S PICK Dr B</a> <a title="EMJ Diabetes 4.1 2016 page 67" href="http://viewer.zmags.com/publication/513d7363?page=67"> and wrist,2 and this association was found to be </a> <a title="EMJ Diabetes 4.1 2016 page 68" href="http://viewer.zmags.com/publication/513d7363?page=68"> a receptor independent of the ‘classic’ cAM</a> <a title="EMJ Diabetes 4.1 2016 page 69" href="http://viewer.zmags.com/publication/513d7363?page=69"> Table 1: Newest three classes of anti-hyperglycae</a> <a title="EMJ Diabetes 4.1 2016 page 70" href="http://viewer.zmags.com/publication/513d7363?page=70"> SODIUM-GLUCOSE COTRANSPORTER TYPE 2 INHIBITORS C</a> <a title="EMJ Diabetes 4.1 2016 page 71" href="http://viewer.zmags.com/publication/513d7363?page=71"> (1,25-[OH] D) cannot be predicted a priori, becau</a> <a title="EMJ Diabetes 4.1 2016 page 72" href="http://viewer.zmags.com/publication/513d7363?page=72"> metabolism and bone density in patients with type</a> <a title="EMJ Diabetes 4.1 2016 page 73" href="http://viewer.zmags.com/publication/513d7363?page=73"> 57. List JF et al. Sodium-glucose Di</a> <a title="EMJ Diabetes 4.1 2016 page 74" href="http://viewer.zmags.com/publication/513d7363?page=74"> TREATMENT OF TYPE 2 DIABETES WITH BIPHASI</a> <a title="EMJ Diabetes 4.1 2016 page 75" href="http://viewer.zmags.com/publication/513d7363?page=75"> long-acting insulin is added to OAD agents which </a> <a title="EMJ Diabetes 4.1 2016 page 76" href="http://viewer.zmags.com/publication/513d7363?page=76"> A 12 10 Glucose infusion rate (mg/kg/min) 30/7</a> <a title="EMJ Diabetes 4.1 2016 page 77" href="http://viewer.zmags.com/publication/513d7363?page=77"> using BIA and provides both basal and prandial co</a> <a title="EMJ Diabetes 4.1 2016 page 78" href="http://viewer.zmags.com/publication/513d7363?page=78"> relatively low.34 Clinical and economic outcomes </a> <a title="EMJ Diabetes 4.1 2016 page 79" href="http://viewer.zmags.com/publication/513d7363?page=79"> Table 1: Data from selected clinical trials invol</a> <a title="EMJ Diabetes 4.1 2016 page 80" href="http://viewer.zmags.com/publication/513d7363?page=80"> and individualisation is therefore essential for </a> <a title="EMJ Diabetes 4.1 2016 page 81" href="http://viewer.zmags.com/publication/513d7363?page=81"> The enhanced flexibility and convenience improves </a> <a title="EMJ Diabetes 4.1 2016 page 82" href="http://viewer.zmags.com/publication/513d7363?page=82"> Pract. 2006;12(Suppl 1):63-6. 13. Monnier L, Cole</a> <a title="EMJ Diabetes 4.1 2016 page 83" href="http://viewer.zmags.com/publication/513d7363?page=83"> diabetes mellitus. Diabetes Technol Ther. 2003;5(</a> <a title="EMJ Diabetes 4.1 2016 page 84" href="http://viewer.zmags.com/publication/513d7363?page=84"> UTILITY OF GLYCATED HAEMOGLOBIN IN GESTATIONAL </a> <a title="EMJ Diabetes 4.1 2016 page 85" href="http://viewer.zmags.com/publication/513d7363?page=85"> there is no uniform or best way to diagnose GDM t</a> <a title="EMJ Diabetes 4.1 2016 page 86" href="http://viewer.zmags.com/publication/513d7363?page=86"> groups of the proteins through the non-enzymatic </a> <a title="EMJ Diabetes 4.1 2016 page 87" href="http://viewer.zmags.com/publication/513d7363?page=87"> recommendations of its utility in the diagn</a> <a title="EMJ Diabetes 4.1 2016 page 88" href="http://viewer.zmags.com/publication/513d7363?page=88"> In our study of 607 patients in 2012, the values </a> <a title="EMJ Diabetes 4.1 2016 page 89" href="http://viewer.zmags.com/publication/513d7363?page=89"> 6.2% for HbA1c levels <5% to 18.3% for HbA1c leve</a> <a title="EMJ Diabetes 4.1 2016 page 90" href="http://viewer.zmags.com/publication/513d7363?page=90"> the diagnosis and classification of hyperg</a> <a title="EMJ Diabetes 4.1 2016 page 91" href="http://viewer.zmags.com/publication/513d7363?page=91"> TREATMENT STRATEGIES FOR CHORIORETINAL VASC</a> <a title="EMJ Diabetes 4.1 2016 page 92" href="http://viewer.zmags.com/publication/513d7363?page=92"> retinal ischaemia causes profound vision los</a> <a title="EMJ Diabetes 4.1 2016 page 93" href="http://viewer.zmags.com/publication/513d7363?page=93"> Examination, treatment, diagnosis YesEligible for</a> <a title="EMJ Diabetes 4.1 2016 page 94" href="http://viewer.zmags.com/publication/513d7363?page=94"> -0.8 letters (mean number of injections: afliberce</a> <a title="EMJ Diabetes 4.1 2016 page 95" href="http://viewer.zmags.com/publication/513d7363?page=95"> oedema. Based on a pre-planned sub-analysis,</a> <a title="EMJ Diabetes 4.1 2016 page 96" href="http://viewer.zmags.com/publication/513d7363?page=96"> This has reassured surgeons and encouraged the us</a> <a title="EMJ Diabetes 4.1 2016 page 97" href="http://viewer.zmags.com/publication/513d7363?page=97"> are lengthened, their central retinal thickn</a> <a title="EMJ Diabetes 4.1 2016 page 98" href="http://viewer.zmags.com/publication/513d7363?page=98"> label extension trial of ranibizumab for choroida</a> <a title="EMJ Diabetes 4.1 2016 page 99" href="http://viewer.zmags.com/publication/513d7363?page=99"> ANTI-HYPERGLYCAEMIC AND LIPID PROFILE REGU</a> <a title="EMJ Diabetes 4.1 2016 page 100" href="http://viewer.zmags.com/publication/513d7363?page=100"> It is known that the treatment of these diseases </a> <a title="EMJ Diabetes 4.1 2016 page 101" href="http://viewer.zmags.com/publication/513d7363?page=101"> Table 1: Changes in the levels of fasting blood g</a> <a title="EMJ Diabetes 4.1 2016 page 102" href="http://viewer.zmags.com/publication/513d7363?page=102"> Table 2: Percentage changes in the biochemical pa</a> <a title="EMJ Diabetes 4.1 2016 page 103" href="http://viewer.zmags.com/publication/513d7363?page=103"> FBG HbA1c TG TC LDLc HDLc 60 </a> <a title="EMJ Diabetes 4.1 2016 page 104" href="http://viewer.zmags.com/publication/513d7363?page=104"> After the basic dietary incorporation, the levels</a> <a title="EMJ Diabetes 4.1 2016 page 105" href="http://viewer.zmags.com/publication/513d7363?page=105"> supplementation of MOLP have positive blood </a> <a title="EMJ Diabetes 4.1 2016 page 106" href="http://viewer.zmags.com/publication/513d7363?page=106"> UPCOMING EVENTS Swiss Society of Endocrinology an</a> <a title="EMJ Diabetes 4.1 2016 page 107" href="http://viewer.zmags.com/publication/513d7363?page=107"> DIABETES Diabetes UK Professional Conference 2017</a> <a title="EMJ Diabetes 4.1 2016 page 108" href="http://viewer.zmags.com/publication/513d7363?page=108"> EUROPEAN MEDICAL JOURNAL provides influential ar</a> <a title="EMJ Diabetes 4.1 2016 page 109" href="http://viewer.zmags.com/publication/513d7363?page=109"> Buyer’s Guide • A. 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