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<br /> RESPIRATORY<br /> ISSN 2054-3166 Vol 3.2 • November 2015 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ERS 2015<br /> Amsterdam, Netherlands<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 4<br /> CONGRESS REVIEW........................................................................................................................................ 10<br /> • Review of the European Respiratory Society International Congress 2015, held in<br /> Amsterdam, Netherlands, 26th–30th September 2015<br /> INTERVIEWS WITH EMJ RESPIRATORY EDITORIAL BOARD.....................………………….… 31<br /> SYMPOSIUM REVIEWS<br /> • TREATING INADEQUATELY CONTROLLED ASTHMA: EXPLORING THE<br /> POTENTIAL OF PHENOTYPE-TARGETED THERAPY…………………………………………......... 42<br /> • INHALER <a title="EMJ Respiratory 3.2 2015 page 1" href="http://viewer.zmags.com/publication/5603a828?page=1"> RESPIRATORY ISSN 2054-3166 </a> <a title="EMJ Respiratory 3.2 2015 page 2" href="http://viewer.zmags.com/publication/5603a828?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Respiratory 3.2 2015 page 3" href="http://viewer.zmags.com/publication/5603a828?page=3"> RESPIRATORY • Emerging Regulation and Functions</a> <a title="EMJ Respiratory 3.2 2015 page 4" href="http://viewer.zmags.com/publication/5603a828?page=4"> Editorial Board Editor-in-Chief: Prof Nikolaos</a> <a title="EMJ Respiratory 3.2 2015 page 5" href="http://viewer.zmags.com/publication/5603a828?page=5"> Respiratory Prof Dr Oliver Eickelberg, Chairm</a> <a title="EMJ Respiratory 3.2 2015 page 6" href="http://viewer.zmags.com/publication/5603a828?page=6"> European Medical Journal EMJ Respiratory Vol 3.</a> <a title="EMJ Respiratory 3.2 2015 page 7" href="http://viewer.zmags.com/publication/5603a828?page=7"> Welcome Hello and a very warm welcome to</a> <a title="EMJ Respiratory 3.2 2015 page 8" href="http://viewer.zmags.com/publication/5603a828?page=8"> Proof changes everything In the treatment of </a> <a title="EMJ Respiratory 3.2 2015 page 9" href="http://viewer.zmags.com/publication/5603a828?page=9"> Foreword Pro</a> <a title="EMJ Respiratory 3.2 2015 page 10" href="http://viewer.zmags.com/publication/5603a828?page=10"> ERS ANNUAL CONGRESS 2015 AMSTERDAM RAI EXHIBITIO</a> <a title="EMJ Respiratory 3.2 2015 page 11" href="http://viewer.zmags.com/publication/5603a828?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ Respiratory 3.2 2015 page 12" href="http://viewer.zmags.com/publication/5603a828?page=12"> ERS ANNUAL CONGRESS 2015 “the last year,” showin</a> <a title="EMJ Respiratory 3.2 2015 page 13" href="http://viewer.zmags.com/publication/5603a828?page=13"> H IGHLIGHTS Novel Method May Identif</a> <a title="EMJ Respiratory 3.2 2015 page 14" href="http://viewer.zmags.com/publication/5603a828?page=14"> ERS ANNUAL CONGRESS 2015 New Combinati</a> <a title="EMJ Respiratory 3.2 2015 page 15" href="http://viewer.zmags.com/publication/5603a828?page=15"> Pharmacology and Respiratory Medicine</a> <a title="EMJ Respiratory 3.2 2015 page 16" href="http://viewer.zmags.com/publication/5603a828?page=16"> ERS ANNUAL CONGRESS 2015 from any cause in patie</a> <a title="EMJ Respiratory 3.2 2015 page 17" href="http://viewer.zmags.com/publication/5603a828?page=17"> different and complementary piece of information </a> <a title="EMJ Respiratory 3.2 2015 page 18" href="http://viewer.zmags.com/publication/5603a828?page=18"> ERS ANNUAL CONGRESS 2015 smoked whilst pregnan</a> <a title="EMJ Respiratory 3.2 2015 page 19" href="http://viewer.zmags.com/publication/5603a828?page=19"> Successful Use of Pirfenidone in Idiopathic Pulmo</a> <a title="EMJ Respiratory 3.2 2015 page 20" href="http://viewer.zmags.com/publication/5603a828?page=20"> ERS ANNUAL CONGRESS 2015 The results of the ASCEN</a> <a title="EMJ Respiratory 3.2 2015 page 21" href="http://viewer.zmags.com/publication/5603a828?page=21"> The non-smoking group were often diagnosed a</a> <a title="EMJ Respiratory 3.2 2015 page 22" href="http://viewer.zmags.com/publication/5603a828?page=22"> ERS ANNUAL CONGRESS 2015 Live endoscopy </a> <a title="EMJ Respiratory 3.2 2015 page 23" href="http://viewer.zmags.com/publication/5603a828?page=23"> success and a major breakthrough 10 years aft</a> <a title="EMJ Respiratory 3.2 2015 page 24" href="http://viewer.zmags.com/publication/5603a828?page=24"> ERS ANNUAL CONGRESS 2015 WHO/ER</a> <a title="EMJ Respiratory 3.2 2015 page 25" href="http://viewer.zmags.com/publication/5603a828?page=25"> Furthermore, a therapy management application </a> <a title="EMJ Respiratory 3.2 2015 page 26" href="http://viewer.zmags.com/publication/5603a828?page=26"> ERS ANNUAL CONGRESS 2015 microbiota in early </a> <a title="EMJ Respiratory 3.2 2015 page 27" href="http://viewer.zmags.com/publication/5603a828?page=27"> Prevention, Morgantown, West Virginia, USA, in an</a> <a title="EMJ Respiratory 3.2 2015 page 28" href="http://viewer.zmags.com/publication/5603a828?page=28"> ERS ANNUAL CONGRESS 2015 Air Pollutio</a> <a title="EMJ Respiratory 3.2 2015 page 29" href="http://viewer.zmags.com/publication/5603a828?page=29"> these patients’ survival and lower their risk of </a> <a title="EMJ Respiratory 3.2 2015 page 30" href="http://viewer.zmags.com/publication/5603a828?page=30"> Invacare produces truly portable oxygen system</a> <a title="EMJ Respiratory 3.2 2015 page 31" href="http://viewer.zmags.com/publication/5603a828?page=31"> EDITORIAL BOARD INTERVIEWS Nicholas Hill Professo</a> <a title="EMJ Respiratory 3.2 2015 page 32" href="http://viewer.zmags.com/publication/5603a828?page=32"> EDITORIAL BOARD INTERVIEWS patients are being de</a> <a title="EMJ Respiratory 3.2 2015 page 33" href="http://viewer.zmags.com/publication/5603a828?page=33"> Q: What are the main differences that you </a> <a title="EMJ Respiratory 3.2 2015 page 34" href="http://viewer.zmags.com/publication/5603a828?page=34"> EDITORIAL BOARD INTERVIEWS </a> <a title="EMJ Respiratory 3.2 2015 page 35" href="http://viewer.zmags.com/publication/5603a828?page=35"> By contrast, in countries where the epidemic onse</a> <a title="EMJ Respiratory 3.2 2015 page 36" href="http://viewer.zmags.com/publication/5603a828?page=36"> EDITORIAL BOARD INTERVIEWS Q: Which aspect of yo</a> <a title="EMJ Respiratory 3.2 2015 page 37" href="http://viewer.zmags.com/publication/5603a828?page=37"> Q: How well integrated are the medical services o</a> <a title="EMJ Respiratory 3.2 2015 page 38" href="http://viewer.zmags.com/publication/5603a828?page=38"> EDITORIAL BOARD INTERVIEWS large European congre</a> <a title="EMJ Respiratory 3.2 2015 page 39" href="http://viewer.zmags.com/publication/5603a828?page=39"> trend in the number of people smoking tobacco. Th</a> <a title="EMJ Respiratory 3.2 2015 page 40" href="http://viewer.zmags.com/publication/5603a828?page=40"> EDITORIAL BOARD INTERVIEWS different forms of br</a> <a title="EMJ Respiratory 3.2 2015 page 41" href="http://viewer.zmags.com/publication/5603a828?page=41"> Endobronchial Coil Treatment for Severe Emphysema</a> <a title="EMJ Respiratory 3.2 2015 page 42" href="http://viewer.zmags.com/publication/5603a828?page=42"> TREATING INADEQUATELY CONTROLLED ASTHMA: EXPLORIN</a> <a title="EMJ Respiratory 3.2 2015 page 43" href="http://viewer.zmags.com/publication/5603a828?page=43"> with Th2-high genotype expression had a higher nu</a> <a title="EMJ Respiratory 3.2 2015 page 44" href="http://viewer.zmags.com/publication/5603a828?page=44"> Mass spectrometry was used to analyse proteins in</a> <a title="EMJ Respiratory 3.2 2015 page 45" href="http://viewer.zmags.com/publication/5603a828?page=45"> In the last 10–15 years, evidence has emer</a> <a title="EMJ Respiratory 3.2 2015 page 46" href="http://viewer.zmags.com/publication/5603a828?page=46"> lowered blood and sputum eosinophilic counts</a> <a title="EMJ Respiratory 3.2 2015 page 47" href="http://viewer.zmags.com/publication/5603a828?page=47"> blood eosinophils ≥300 cells/µL treated with</a> <a title="EMJ Respiratory 3.2 2015 page 48" href="http://viewer.zmags.com/publication/5603a828?page=48"> files/docs/guidelines/asthgdln.pdf. Last accesse</a> <a title="EMJ Respiratory 3.2 2015 page 49" href="http://viewer.zmags.com/publication/5603a828?page=49"> INHALER DEVICES: THE PAST, THE PRESENT, AND TH</a> <a title="EMJ Respiratory 3.2 2015 page 50" href="http://viewer.zmags.com/publication/5603a828?page=50"> Are Inhalers Failing Our Patients? </a> <a title="EMJ Respiratory 3.2 2015 page 51" href="http://viewer.zmags.com/publication/5603a828?page=51"> patients about the necessity of treatme</a> <a title="EMJ Respiratory 3.2 2015 page 52" href="http://viewer.zmags.com/publication/5603a828?page=52"> Table 1: Problems with inhaler use. Aspect of inh</a> <a title="EMJ Respiratory 3.2 2015 page 53" href="http://viewer.zmags.com/publication/5603a828?page=53"> preparing a dose, which results in the dose not b</a> <a title="EMJ Respiratory 3.2 2015 page 54" href="http://viewer.zmags.com/publication/5603a828?page=54"> REFERENCES 1. Global Initiative for Asthma (GINA</a> <a title="EMJ Respiratory 3.2 2015 page 55" href="http://viewer.zmags.com/publication/5603a828?page=55"> THERAPY FOR ALPHA-1 ANTITRYPSIN DEFICIENCY: </a> <a title="EMJ Respiratory 3.2 2015 page 56" href="http://viewer.zmags.com/publication/5603a828?page=56"> endpoint of lung density for α1-PI augmentation t</a> <a title="EMJ Respiratory 3.2 2015 page 57" href="http://viewer.zmags.com/publication/5603a828?page=57"> The Relevance of CT Lung Density for Assess</a> <a title="EMJ Respiratory 3.2 2015 page 58" href="http://viewer.zmags.com/publication/5603a828?page=58"> Efficacy of α1-PI Augmentation Therapy </a> <a title="EMJ Respiratory 3.2 2015 page 59" href="http://viewer.zmags.com/publication/5603a828?page=59"> (DLCO), statistically significant cross-sect</a> <a title="EMJ Respiratory 3.2 2015 page 60" href="http://viewer.zmags.com/publication/5603a828?page=60"> 0 -1 -2 -3 -4 -5 Decline in adjusted lung </a> <a title="EMJ Respiratory 3.2 2015 page 61" href="http://viewer.zmags.com/publication/5603a828?page=61"> How close did you get to a normal non-alpha rate </a> <a title="EMJ Respiratory 3.2 2015 page 62" href="http://viewer.zmags.com/publication/5603a828?page=62"> tomography-based biomarker provides monitori</a> <a title="EMJ Respiratory 3.2 2015 page 63" href="http://viewer.zmags.com/publication/5603a828?page=63"> ADVANCES IN AMBULATORY OXYGEN WORKSHOP AND LONG-T</a> <a title="EMJ Respiratory 3.2 2015 page 64" href="http://viewer.zmags.com/publication/5603a828?page=64"> PRACTICAL WORKSHOP Advances in Ambulatory Oxygen </a> <a title="EMJ Respiratory 3.2 2015 page 65" href="http://viewer.zmags.com/publication/5603a828?page=65"> Figure 1 removed due to copyright expiration. </a> <a title="EMJ Respiratory 3.2 2015 page 66" href="http://viewer.zmags.com/publication/5603a828?page=66"> Pulsed-dose devices have varying characteristics,</a> <a title="EMJ Respiratory 3.2 2015 page 67" href="http://viewer.zmags.com/publication/5603a828?page=67"> MINI SYMPOSIUM Long-Term Oxygen Therapy in Real-L</a> <a title="EMJ Respiratory 3.2 2015 page 68" href="http://viewer.zmags.com/publication/5603a828?page=68"> Long-Term Oxygen Therapy During Exerci</a> <a title="EMJ Respiratory 3.2 2015 page 69" href="http://viewer.zmags.com/publication/5603a828?page=69"> to benefit patients by providing an accurate</a> <a title="EMJ Respiratory 3.2 2015 page 70" href="http://viewer.zmags.com/publication/5603a828?page=70"> Rapport d’evaluation]. 2011. Available at: </a> <a title="EMJ Respiratory 3.2 2015 page 71" href="http://viewer.zmags.com/publication/5603a828?page=71"> LONG-TERM NIV IN COPD – WHO AND WHEN? This sympos</a> <a title="EMJ Respiratory 3.2 2015 page 72" href="http://viewer.zmags.com/publication/5603a828?page=72"> Society for Pneumology (DGP) published guidelines</a> <a title="EMJ Respiratory 3.2 2015 page 73" href="http://viewer.zmags.com/publication/5603a828?page=73"> 352 assessed for eligibility 195 rand omised 15</a> <a title="EMJ Respiratory 3.2 2015 page 74" href="http://viewer.zmags.com/publication/5603a828?page=74"> In the NIV group, the mean inspiratory and</a> <a title="EMJ Respiratory 3.2 2015 page 75" href="http://viewer.zmags.com/publication/5603a828?page=75"> Exacerbation is a major cause of death in COPD an</a> <a title="EMJ Respiratory 3.2 2015 page 76" href="http://viewer.zmags.com/publication/5603a828?page=76"> International Practice of HMV for COPD </a> <a title="EMJ Respiratory 3.2 2015 page 77" href="http://viewer.zmags.com/publication/5603a828?page=77"> with stable COPD receiving controlled noninvasive</a> <a title="EMJ Respiratory 3.2 2015 page 78" href="http://viewer.zmags.com/publication/5603a828?page=78"> BEST ABSTRACT AWARD WINNERS AWARD WINNERS AT </a> <a title="EMJ Respiratory 3.2 2015 page 79" href="http://viewer.zmags.com/publication/5603a828?page=79"> abstract describing the use of regional fiss</a> <a title="EMJ Respiratory 3.2 2015 page 80" href="http://viewer.zmags.com/publication/5603a828?page=80"> BEST ABSTRACT AWARD WINNERS ...the new model coul</a> <a title="EMJ Respiratory 3.2 2015 page 81" href="http://viewer.zmags.com/publication/5603a828?page=81"> the Developmental Behaviour Checklist for Adults)</a> <a title="EMJ Respiratory 3.2 2015 page 82" href="http://viewer.zmags.com/publication/5603a828?page=82"> BEST ABSTRACT AWARD WINNERS For </a> <a title="EMJ Respiratory 3.2 2015 page 83" href="http://viewer.zmags.com/publication/5603a828?page=83"> of critical illness following discharge from an I</a> <a title="EMJ Respiratory 3.2 2015 page 84" href="http://viewer.zmags.com/publication/5603a828?page=84"> ABSTRACT REVIEWS ASTHMA BEYOND THE BRONCHUS *Min</a> <a title="EMJ Respiratory 3.2 2015 page 85" href="http://viewer.zmags.com/publication/5603a828?page=85"> ERS REFERENCES 1. Centers for Medicare and Medic</a> <a title="EMJ Respiratory 3.2 2015 page 86" href="http://viewer.zmags.com/publication/5603a828?page=86"> ABSTRACT REVIEWS with irreversible airway obstru</a> <a title="EMJ Respiratory 3.2 2015 page 87" href="http://viewer.zmags.com/publication/5603a828?page=87"> ERS thrombocytopaenic patients. A high c</a> <a title="EMJ Respiratory 3.2 2015 page 88" href="http://viewer.zmags.com/publication/5603a828?page=88"> ABSTRACT REVIEWS clearance prevents the eliminat</a> <a title="EMJ Respiratory 3.2 2015 page 89" href="http://viewer.zmags.com/publication/5603a828?page=89"> ERS INFLAMMATORY PATHWAY ACTIVATION BY INTERMITT</a> <a title="EMJ Respiratory 3.2 2015 page 90" href="http://viewer.zmags.com/publication/5603a828?page=90"> ABSTRACT REVIEWS Step 1: Recognise the child at </a> <a title="EMJ Respiratory 3.2 2015 page 91" href="http://viewer.zmags.com/publication/5603a828?page=91"> ERS CAN CATABOLISM AND IMMUNE RESPONSES B</a> <a title="EMJ Respiratory 3.2 2015 page 92" href="http://viewer.zmags.com/publication/5603a828?page=92"> ABSTRACT REVIEWS with no (negative) impact o</a> <a title="EMJ Respiratory 3.2 2015 page 93" href="http://viewer.zmags.com/publication/5603a828?page=93"> ERS In paediatrics, two randomised clini</a> <a title="EMJ Respiratory 3.2 2015 page 94" href="http://viewer.zmags.com/publication/5603a828?page=94"> ABSTRACT REVIEWS Rigshospitalet, Copenhagen, Den</a> <a title="EMJ Respiratory 3.2 2015 page 95" href="http://viewer.zmags.com/publication/5603a828?page=95"> ERS In conclusion, trainees must practis</a> <a title="EMJ Respiratory 3.2 2015 page 96" href="http://viewer.zmags.com/publication/5603a828?page=96"> ABSTRACT REVIEWS and partially thrombosed, and t</a> <a title="EMJ Respiratory 3.2 2015 page 97" href="http://viewer.zmags.com/publication/5603a828?page=97"> Available Now EMJ Respiratory 3.1 2</a> <a title="EMJ Respiratory 3.2 2015 page 98" href="http://viewer.zmags.com/publication/5603a828?page=98"> CHALLENGES OF INHALER USE IN THE TREATMENT OF AS</a> <a title="EMJ Respiratory 3.2 2015 page 99" href="http://viewer.zmags.com/publication/5603a828?page=99"> 300 million people worldwide, and is responsible </a> <a title="EMJ Respiratory 3.2 2015 page 100" href="http://viewer.zmags.com/publication/5603a828?page=100"> PRESSURISED METERED DOSE INHALERS Introduced in </a> <a title="EMJ Respiratory 3.2 2015 page 101" href="http://viewer.zmags.com/publication/5603a828?page=101"> Therefore, it is simplistic to attempt to </a> <a title="EMJ Respiratory 3.2 2015 page 102" href="http://viewer.zmags.com/publication/5603a828?page=102"> having an overall adequate technique when using p</a> <a title="EMJ Respiratory 3.2 2015 page 103" href="http://viewer.zmags.com/publication/5603a828?page=103"> Independent Vitalograph’s Clement </a> <a title="EMJ Respiratory 3.2 2015 page 104" href="http://viewer.zmags.com/publication/5603a828?page=104"> patient’s specific difficulties should be made. In</a> <a title="EMJ Respiratory 3.2 2015 page 105" href="http://viewer.zmags.com/publication/5603a828?page=105"> 13. Nikander K et al. The evolution of spacers an</a> <a title="EMJ Respiratory 3.2 2015 page 106" href="http://viewer.zmags.com/publication/5603a828?page=106"> LATEST NEWS · CONGRE </a> <a title="EMJ Respiratory 3.2 2015 page 107" href="http://viewer.zmags.com/publication/5603a828?page=107"> POSITIVE PRESSURE THERAPIES </a> <a title="EMJ Respiratory 3.2 2015 page 108" href="http://viewer.zmags.com/publication/5603a828?page=108"> Postoperative RF may occur following a wide range</a> <a title="EMJ Respiratory 3.2 2015 page 109" href="http://viewer.zmags.com/publication/5603a828?page=109"> mechanism of delivery also allows warming and hum</a> <a title="EMJ Respiratory 3.2 2015 page 110" href="http://viewer.zmags.com/publication/5603a828?page=110"> a vital respiratory support therapy for the effec</a> <a title="EMJ Respiratory 3.2 2015 page 111" href="http://viewer.zmags.com/publication/5603a828?page=111"> Positive Pressure Physiotherapy Techniques Positi</a> <a title="EMJ Respiratory 3.2 2015 page 112" href="http://viewer.zmags.com/publication/5603a828?page=112"> therapy with PEP devices, which would add </a> <a title="EMJ Respiratory 3.2 2015 page 113" href="http://viewer.zmags.com/publication/5603a828?page=113"> ventilation (NIV) in the perioperative period</a> <a title="EMJ Respiratory 3.2 2015 page 114" href="http://viewer.zmags.com/publication/5603a828?page=114"> Buyer’s Guide • 3D SYSTEMS, SIMBIONIX PRODUCT</a> <a title="EMJ Respiratory 3.2 2015 page 115" href="http://viewer.zmags.com/publication/5603a828?page=115"> Respiratory • MCROBERTS • MEDICAL DEVELOPMEN</a> <a title="EMJ Respiratory 3.2 2015 page 116" href="http://viewer.zmags.com/publication/5603a828?page=116"> UPCOMING EVENTS British Thoracic Society Winter M</a> <a title="EMJ Respiratory 3.2 2015 page 117" href="http://viewer.zmags.com/publication/5603a828?page=117"> RESPIRATORY X World Congress on Asthma, COPD & Im</a> <a title="EMJ Respiratory 3.2 2015 page 118" href="http://viewer.zmags.com/publication/5603a828?page=118"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS, & UPDA</a>