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<br /> Supplement to Nature Publishing Group Journals May 2013<br /> Epigenetics<br /> INTEGRATED BIOLOGY<br /> Produced with support from:<br /> Personalized TherBQFVUJDTt The Power of Epigenetics<br /> New Approaches to Personalized<br /> Cancer Treatment<br /> Each day we learn more about<br /> the biology of cancer and<br /> how genetic mutations in<br /> cancer cells cause them to<br /> grow and spread. This is the<br /> age of personalized therapeutics<br /> – medicines that hone in on<br /> The next frontier of personalized therapeutics – epigenetics<br /> Epizyme is at the forefront of drug discovery and development, leveraging discoveries to<br /> www.epizyme.com<br /> SPONSORED CONTENT<br /> Supplement to Nature Publishing Group Journals <a title="Nature Reprint Collection: Epigenetics May 2013 page 1" href="http://viewer.zmags.com/publication/617c50a3?page=1"> Supplement to Nature Publishing Group Journals </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 2" href="http://viewer.zmags.com/publication/617c50a3?page=2"> Personalized TherBQFVUJDTt The Power of Epigeneti</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 3" href="http://viewer.zmags.com/publication/617c50a3?page=3"> SPONSORED CONTENT Supplement to Nature</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 4" href="http://viewer.zmags.com/publication/617c50a3?page=4"> REVIEWS First published in Natur</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 5" href="http://viewer.zmags.com/publication/617c50a3?page=5"> REVIEWS </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 6" href="http://viewer.zmags.com/publication/617c50a3?page=6"> REVIEWS Table 1 | Epigenetic-enzyme inhibitors</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 7" href="http://viewer.zmags.com/publication/617c50a3?page=7"> REVIEWS Table 2 | Selected PKMTs and PRMTs tha</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 8" href="http://viewer.zmags.com/publication/617c50a3?page=8"> NH2 N N HO N N H O H </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 9" href="http://viewer.zmags.com/publication/617c50a3?page=9"> General base catalysis A mechanism that can occur</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 10" href="http://viewer.zmags.com/publication/617c50a3?page=10"> REVIEWS SAH and SAM, respectively27. Similarly</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 11" href="http://viewer.zmags.com/publication/617c50a3?page=11"> REVIEWS Structure–activity relationship The </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 12" href="http://viewer.zmags.com/publication/617c50a3?page=12"> REVIEWS 23. Jeong, S. J. et al. Coactivato</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 13" href="http://viewer.zmags.com/publication/617c50a3?page=13"> ARTICLE doi:10.1038/nature10351 First published </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 14" href="http://viewer.zmags.com/publication/617c50a3?page=14"> RESEARCH ARTICLE novel fusion transcripts (Supp</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 15" href="http://viewer.zmags.com/publication/617c50a3?page=15"> RESEARCH ARTICLE ARTICLE RESEARCH Table 1 | Ove</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 16" href="http://viewer.zmags.com/publication/617c50a3?page=16"> RESEARCH ARTICLE ABC GCB U FL AB</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 17" href="http://viewer.zmags.com/publication/617c50a3?page=17"> RESEARCH ARTICLE Discussion In our study of geno</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 18" href="http://viewer.zmags.com/publication/617c50a3?page=18"> RESEARCH ARTICLE 19. Greenman, C., Wooster, R.</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 19" href="http://viewer.zmags.com/publication/617c50a3?page=19"> ARTICLE PUBLISHED ONLINE: 10 JULY 2011 | DOI: 10</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 20" href="http://viewer.zmags.com/publication/617c50a3?page=20"> ANRATUIRCELCEHEMICAL BIOLOGY DOI: 10.1038/NCHEMBN</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 21" href="http://viewer.zmags.com/publication/617c50a3?page=21"> NATRUTRIECLHEMICAL BIOLOGY DOI: 10.1038/NCHEMBINO</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 22" href="http://viewer.zmags.com/publication/617c50a3?page=22"> ANRATUIRCELCEHEMICAL BIOLOGY DOI: 10.1038/NCHEMBN</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 23" href="http://viewer.zmags.com/publication/617c50a3?page=23"> NATRUTRIECLHEMICAL BIOLOGY DOI: 10.1038/NCHEMBNIO</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 24" href="http://viewer.zmags.com/publication/617c50a3?page=24"> ANRATUIRCELCEHEMICAL BIOLOGY DOI: 10.1038/NCHEMBN</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 25" href="http://viewer.zmags.com/publication/617c50a3?page=25"> NATRUTRIECLHEMICALBIOLOGYDOI:10.1038/NCHEMBINO.A5</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 26" href="http://viewer.zmags.com/publication/617c50a3?page=26"> ANRATUIRCELCEHEMICAL BIOLOGY DOI: 10.1038/NCHEMBN</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 27" href="http://viewer.zmags.com/publication/617c50a3?page=27"> NATRUTRIECLHEMICAL BIOLOGY DOI: 10.1038/NCHEMBINO</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 28" href="http://viewer.zmags.com/publication/617c50a3?page=28"> LETTER doi:10.1038/nature10953 First published i</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 29" href="http://viewer.zmags.com/publication/617c50a3?page=29"> a </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 30" href="http://viewer.zmags.com/publication/617c50a3?page=30"> 5.0 4.5 n=3 * 4.0 3.5 3.0 2.5 2.0 1.5 1.</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 31" href="http://viewer.zmags.com/publication/617c50a3?page=31"> a ESCs H3K79me2 Fib Fib_OSKM Fib_iDot1L </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 32" href="http://viewer.zmags.com/publication/617c50a3?page=32"> RESEARCH LETTER inhibition on these two pluripo</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 33" href="http://viewer.zmags.com/publication/617c50a3?page=33"> LETTER doi:10.1038/nature11606 First published i</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 34" href="http://viewer.zmags.com/publication/617c50a3?page=34"> SC-1 WSU-NHL NU-DUL-1 MC116 RI-1 MINO U-698-M MHH</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 35" href="http://viewer.zmags.com/publication/617c50a3?page=35"> characterization will be required to fully elucid</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 36" href="http://viewer.zmags.com/publication/617c50a3?page=36"> RESEARCH LETTER Toledo cells, a cell line with w</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 37" href="http://viewer.zmags.com/publication/617c50a3?page=37"> Although we do not expect GSK126 to be effective </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 38" href="http://viewer.zmags.com/publication/617c50a3?page=38"> ARTICLE doi:10.1038/nature11213 First published </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 39" href="http://viewer.zmags.com/publication/617c50a3?page=39"> RESEARCH ARTICLE Age and sex Histology </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 40" href="http://viewer.zmags.com/publication/617c50a3?page=40"> RESEARCH ARTICLE one unclassified medulloblasto</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 41" href="http://viewer.zmags.com/publication/617c50a3?page=41"> RESEARCH ARTICLE also showed a mutation in CTNNB</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 42" href="http://viewer.zmags.com/publication/617c50a3?page=42"> RESEARCH ARTICLE ,50% more labelled cells at P1</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 43" href="http://viewer.zmags.com/publication/617c50a3?page=43"> RESEARCH ARTICLE as previously described50. Det</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 44" href="http://viewer.zmags.com/publication/617c50a3?page=44"> ARTICLE PUBLISHED ONLINE: 30 SEPTEMBER 2012 | DO</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 45" href="http://viewer.zmags.com/publication/617c50a3?page=45"> NATURE CHEMICAL BIOLOGY DOI: 10.1038/NCHEMBIO.108</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 46" href="http://viewer.zmags.com/publication/617c50a3?page=46"> ARTICLE NATUR</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 47" href="http://viewer.zmags.com/publication/617c50a3?page=47"> NATURE CHEMICAL BIOLOGY DOI: 10.1038/NCHEMBIO.108</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 48" href="http://viewer.zmags.com/publication/617c50a3?page=48"> ARTICLE NATUR</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 49" href="http://viewer.zmags.com/publication/617c50a3?page=49"> NATURE CHEMICAL BIOLOGY DOI: 10.1038/NCHEMBIO.108</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 50" href="http://viewer.zmags.com/publication/617c50a3?page=50"> ARTICLE NATUR</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 51" href="http://viewer.zmags.com/publication/617c50a3?page=51"> Oncogene (2013) 32, 939–946 & 2013 Macmillan Publ</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 52" href="http://viewer.zmags.com/publication/617c50a3?page=52"> Targeting genetic alterations in protein methyltr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 53" href="http://viewer.zmags.com/publication/617c50a3?page=53"> Targeting genetic alterations in protein methyltr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 54" href="http://viewer.zmags.com/publication/617c50a3?page=54"> Targeting genetic alterations in protein methyltr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 55" href="http://viewer.zmags.com/publication/617c50a3?page=55"> Targeting genetic alterations in protein methyltr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 56" href="http://viewer.zmags.com/publication/617c50a3?page=56"> Targeting genetic alterations in protein methyltr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 57" href="http://viewer.zmags.com/publication/617c50a3?page=57"> Targeting genetic alterations in protein methyltr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 58" href="http://viewer.zmags.com/publication/617c50a3?page=58"> Targeting genetic alterations in protein methyltr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 59" href="http://viewer.zmags.com/publication/617c50a3?page=59"> Finding the right antibody for the right applicat</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 60" href="http://viewer.zmags.com/publication/617c50a3?page=60"> 3HUVRQDOL]HG7KHUDSHXWLFV‡7KH3RZHURI(SLJHQHWLFV </a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 61" href="http://viewer.zmags.com/publication/617c50a3?page=61"> (SL]\PHPDSSHGWKH+07RPHDWKHUDSHXWLFDOO\LPSRUWDQWFO</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 62" href="http://viewer.zmags.com/publication/617c50a3?page=62"> Seeking Solvers Plastic with pr</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 63" href="http://viewer.zmags.com/publication/617c50a3?page=63"> Supplement to Nature Publishing Group Journals P</a> <a title="Nature Reprint Collection: Epigenetics May 2013 page 64" href="http://viewer.zmags.com/publication/617c50a3?page=64"> www.nature.com/reprintcollections/epigenetics</a>