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<br /> RESPIRATORY<br /> ISSN 2054-3166 Vol 5.1 • October 2017 • europeanmedical-journal.com<br /> INSIDE<br /> Review of<br /> ERS 2017<br /> Milan, Italy<br /> CONTENTS<br /> EDITORIAL BOARD...................................................................................................................................... 4<br /> CONGRESS REVIEW..................................................................................................................................... 10<br /> • Review of the European Respiratory Society (ERS) International Congress, held in Milan,<br /> Italy, 9th–13th September 2017<br /> INTERVIEWS WITH EMJ RESPIRATORY EDITORIAL BOARD............................................................. 25<br /> SYMPOSIUM REVIEWS<br /> • TRANSITIONING CLINICAL DATA INTO PATIENT CARE: RECENT REAL-LIFE<br /> EXPERIENCES WITH ALPHA 1.......................................................<a title="EMJ Respiratory 5.1 2017 page 1" href="http://viewer.zmags.com/publication/64224be3?page=1"> RESPIRATORY ISSN 2054-3166 </a> <a title="EMJ Respiratory 5.1 2017 page 2" href="http://viewer.zmags.com/publication/64224be3?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Respiratory 5.1 2017 page 3" href="http://viewer.zmags.com/publication/64224be3?page=3"> RESPIRATORY • ‘NO STENT LEFT BEHIND’: A REVIEW </a> <a title="EMJ Respiratory 5.1 2017 page 4" href="http://viewer.zmags.com/publication/64224be3?page=4"> EDITORIAL BOARD EDITOR-IN-CHIEF Dr Antonio Ross</a> <a title="EMJ Respiratory 5.1 2017 page 5" href="http://viewer.zmags.com/publication/64224be3?page=5"> RESPIRATORY AIMS AND SCOPE • The European </a> <a title="EMJ Respiratory 5.1 2017 page 6" href="http://viewer.zmags.com/publication/64224be3?page=6"> RESPIRATORY 5.1 OCTOBER 2017 Director Spencer G</a> <a title="EMJ Respiratory 5.1 2017 page 7" href="http://viewer.zmags.com/publication/64224be3?page=7"> Welcome A very warm welcome to the 2017 editio</a> <a title="EMJ Respiratory 5.1 2017 page 8" href="http://viewer.zmags.com/publication/64224be3?page=8"> ALPHA 1 ANTITRYPSIN DEFICIENCY (AATD) THERAPIES. </a> <a title="EMJ Respiratory 5.1 2017 page 9" href="http://viewer.zmags.com/publication/64224be3?page=9"> Foreword Dr Antonio Rossi IR</a> <a title="EMJ Respiratory 5.1 2017 page 10" href="http://viewer.zmags.com/publication/64224be3?page=10"> </a> <a title="EMJ Respiratory 5.1 2017 page 11" href="http://viewer.zmags.com/publication/64224be3?page=11"> ERS ANNUAL CONGRESS 2017 MICO, </a> <a title="EMJ Respiratory 5.1 2017 page 12" href="http://viewer.zmags.com/publication/64224be3?page=12"> Next, the ERS Gold Medal was given to thr</a> <a title="EMJ Respiratory 5.1 2017 page 13" href="http://viewer.zmags.com/publication/64224be3?page=13"> Asthma Symptoms Potentially Reduced by Park Acces</a> <a title="EMJ Respiratory 5.1 2017 page 14" href="http://viewer.zmags.com/publication/64224be3?page=14"> The researchers hoped that their research wo</a> <a title="EMJ Respiratory 5.1 2017 page 15" href="http://viewer.zmags.com/publication/64224be3?page=15"> worsened lung function, with lower FVC, FEV1</a> <a title="EMJ Respiratory 5.1 2017 page 16" href="http://viewer.zmags.com/publication/64224be3?page=16"> ...we saw that, in children with asthma, most of </a> <a title="EMJ Respiratory 5.1 2017 page 17" href="http://viewer.zmags.com/publication/64224be3?page=17"> ...our research concerns a very large population </a> <a title="EMJ Respiratory 5.1 2017 page 18" href="http://viewer.zmags.com/publication/64224be3?page=18"> usage was combined with the smoking of conv</a> <a title="EMJ Respiratory 5.1 2017 page 19" href="http://viewer.zmags.com/publication/64224be3?page=19"> The breakdown of results showed that 11% of</a> <a title="EMJ Respiratory 5.1 2017 page 20" href="http://viewer.zmags.com/publication/64224be3?page=20"> A survey including >55,000 people from withi</a> <a title="EMJ Respiratory 5.1 2017 page 21" href="http://viewer.zmags.com/publication/64224be3?page=21"> with COPD risk, including glutaraldehyde </a> <a title="EMJ Respiratory 5.1 2017 page 22" href="http://viewer.zmags.com/publication/64224be3?page=22"> Following this, offspring were exposed to an oval</a> <a title="EMJ Respiratory 5.1 2017 page 23" href="http://viewer.zmags.com/publication/64224be3?page=23"> approximately one-in-ten individuals in the W</a> <a title="EMJ Respiratory 5.1 2017 page 24" href="http://viewer.zmags.com/publication/64224be3?page=24"> VALUE OF VISUALIZATION Benefits of point-of-care u</a> <a title="EMJ Respiratory 5.1 2017 page 25" href="http://viewer.zmags.com/publication/64224be3?page=25"> Peter Barnes Professor of Thoracic Medicine and </a> <a title="EMJ Respiratory 5.1 2017 page 26" href="http://viewer.zmags.com/publication/64224be3?page=26"> In addition to asthma, Prof Barnes has als</a> <a title="EMJ Respiratory 5.1 2017 page 27" href="http://viewer.zmags.com/publication/64224be3?page=27"> I think a problem that is still ongoing is the po</a> <a title="EMJ Respiratory 5.1 2017 page 28" href="http://viewer.zmags.com/publication/64224be3?page=28"> research funding, so the charities that sup</a> <a title="EMJ Respiratory 5.1 2017 page 29" href="http://viewer.zmags.com/publication/64224be3?page=29"> The problem is exactly the same that it was 20 ye</a> <a title="EMJ Respiratory 5.1 2017 page 30" href="http://viewer.zmags.com/publication/64224be3?page=30"> Q: Is there a specific factor that you believe is </a> <a title="EMJ Respiratory 5.1 2017 page 31" href="http://viewer.zmags.com/publication/64224be3?page=31"> SUBSCRIBE FREE TO OUR YOUTUBE CHANNEL www.youtube</a> <a title="EMJ Respiratory 5.1 2017 page 32" href="http://viewer.zmags.com/publication/64224be3?page=32"> TRANSITIONING CLINICAL DATA INTO PATIENT CARE: </a> <a title="EMJ Respiratory 5.1 2017 page 33" href="http://viewer.zmags.com/publication/64224be3?page=33"> Welcome and Introduction Doctor Jan</a> <a title="EMJ Respiratory 5.1 2017 page 34" href="http://viewer.zmags.com/publication/64224be3?page=34"> However, some questions still remain, including h</a> <a title="EMJ Respiratory 5.1 2017 page 35" href="http://viewer.zmags.com/publication/64224be3?page=35"> bronchial tethering, which secures patency o</a> <a title="EMJ Respiratory 5.1 2017 page 36" href="http://viewer.zmags.com/publication/64224be3?page=36"> Using change in lung density as a primary </a> <a title="EMJ Respiratory 5.1 2017 page 37" href="http://viewer.zmags.com/publication/64224be3?page=37"> function, outcomes, therapies, visit type, and vi</a> <a title="EMJ Respiratory 5.1 2017 page 38" href="http://viewer.zmags.com/publication/64224be3?page=38"> versus 12 mL/year for treated patients. Thi</a> <a title="EMJ Respiratory 5.1 2017 page 39" href="http://viewer.zmags.com/publication/64224be3?page=39"> A: Regarding healthcare payer data, Prof Strange </a> <a title="EMJ Respiratory 5.1 2017 page 40" href="http://viewer.zmags.com/publication/64224be3?page=40"> impact of alpha 1-antitrypsin deficiency: 876-8</a> <a title="EMJ Respiratory 5.1 2017 page 41" href="http://viewer.zmags.com/publication/64224be3?page=41"> NONTUBERCULOUS MYCOBACTERIAL LUNG DISEASE: CURREN</a> <a title="EMJ Respiratory 5.1 2017 page 42" href="http://viewer.zmags.com/publication/64224be3?page=42"> MEETING SUMMARY The main objectives of the two s</a> <a title="EMJ Respiratory 5.1 2017 page 43" href="http://viewer.zmags.com/publication/64224be3?page=43"> Annual % change Primary immunodeficienc</a> <a title="EMJ Respiratory 5.1 2017 page 44" href="http://viewer.zmags.com/publication/64224be3?page=44"> find the causative NTM and meet the microbiologica</a> <a title="EMJ Respiratory 5.1 2017 page 45" href="http://viewer.zmags.com/publication/64224be3?page=45"> Sputum Culture for Mycobacteria in Bronchiectasis</a> <a title="EMJ Respiratory 5.1 2017 page 46" href="http://viewer.zmags.com/publication/64224be3?page=46"> advised. Other options are to delay NTM treatment</a> <a title="EMJ Respiratory 5.1 2017 page 47" href="http://viewer.zmags.com/publication/64224be3?page=47"> consequences. Macrolides and amikacin treatment s</a> <a title="EMJ Respiratory 5.1 2017 page 48" href="http://viewer.zmags.com/publication/64224be3?page=48"> The Nontuberculous Mycobacterium Lung Disease Dru</a> <a title="EMJ Respiratory 5.1 2017 page 49" href="http://viewer.zmags.com/publication/64224be3?page=49"> Clofazimine-containing regimens have bee</a> <a title="EMJ Respiratory 5.1 2017 page 50" href="http://viewer.zmags.com/publication/64224be3?page=50"> Mycobacterium Avium Complex Lung Disease and Myco</a> <a title="EMJ Respiratory 5.1 2017 page 51" href="http://viewer.zmags.com/publication/64224be3?page=51"> REFERENCES 1. Hoefsloot W et al. The geogr</a> <a title="EMJ Respiratory 5.1 2017 page 52" href="http://viewer.zmags.com/publication/64224be3?page=52"> 41. Griffith DE et al. Clinical and molecular ana</a> <a title="EMJ Respiratory 5.1 2017 page 53" href="http://viewer.zmags.com/publication/64224be3?page=53"> europeanmedical-journal.com EUROPEAN UNION Invest</a> <a title="EMJ Respiratory 5.1 2017 page 54" href="http://viewer.zmags.com/publication/64224be3?page=54"> Abstract Reviews CELLULAR STRUCTURE OF THE IN</a> <a title="EMJ Respiratory 5.1 2017 page 55" href="http://viewer.zmags.com/publication/64224be3?page=55"> ERS 2017 bronchial obstruction. The increase of </a> <a title="EMJ Respiratory 5.1 2017 page 56" href="http://viewer.zmags.com/publication/64224be3?page=56"> Abstract Reviews of the proteoglycans biglyca</a> <a title="EMJ Respiratory 5.1 2017 page 57" href="http://viewer.zmags.com/publication/64224be3?page=57"> ERS 2017 Patient and public involvement (PPI</a> <a title="EMJ Respiratory 5.1 2017 page 58" href="http://viewer.zmags.com/publication/64224be3?page=58"> Abstract Reviews 8. Hogg L et al. Effectiveness,</a> <a title="EMJ Respiratory 5.1 2017 page 59" href="http://viewer.zmags.com/publication/64224be3?page=59"> ERS 2017 RELATIONSHIP BETWEEN VITAMIN D AND SEVER</a> <a title="EMJ Respiratory 5.1 2017 page 60" href="http://viewer.zmags.com/publication/64224be3?page=60"> Abstract Reviews Reduced vitamin D levels ma</a> <a title="EMJ Respiratory 5.1 2017 page 61" href="http://viewer.zmags.com/publication/64224be3?page=61"> ERS 2017 Table 1: Risk factors for developing act</a> <a title="EMJ Respiratory 5.1 2017 page 62" href="http://viewer.zmags.com/publication/64224be3?page=62"> Abstract Reviews REFERENCES 1. Venturini E et al</a> <a title="EMJ Respiratory 5.1 2017 page 63" href="http://viewer.zmags.com/publication/64224be3?page=63"> ESC 2017 during azithromycin therapy (decr</a> <a title="EMJ Respiratory 5.1 2017 page 64" href="http://viewer.zmags.com/publication/64224be3?page=64"> Abstract Reviews SILICOMYCOBACTERIOSIS: DIAGNOSIS</a> <a title="EMJ Respiratory 5.1 2017 page 65" href="http://viewer.zmags.com/publication/64224be3?page=65"> ERS 2017 81% of cases; it was also reported as a</a> <a title="EMJ Respiratory 5.1 2017 page 66" href="http://viewer.zmags.com/publication/64224be3?page=66"> Abstract Reviews BACKGROUND The chronic obst</a> <a title="EMJ Respiratory 5.1 2017 page 67" href="http://viewer.zmags.com/publication/64224be3?page=67"> ERS 2017 2. Gulart AA et al. Does the COPD asses</a> <a title="EMJ Respiratory 5.1 2017 page 68" href="http://viewer.zmags.com/publication/64224be3?page=68"> Abstract Reviews less cumulative dose (to reduce</a> <a title="EMJ Respiratory 5.1 2017 page 69" href="http://viewer.zmags.com/publication/64224be3?page=69"> ERS 2017 Interact. owever, im roblemati</a> <a title="EMJ Respiratory 5.1 2017 page 70" href="http://viewer.zmags.com/publication/64224be3?page=70"> EDITOR’S PICK Over the years, the st</a> <a title="EMJ Respiratory 5.1 2017 page 71" href="http://viewer.zmags.com/publication/64224be3?page=71"> INTRODUCTION Asthma is a common chronic respirat</a> <a title="EMJ Respiratory 5.1 2017 page 72" href="http://viewer.zmags.com/publication/64224be3?page=72"> LAR, usually as changes in maximal decrease in </a> <a title="EMJ Respiratory 5.1 2017 page 73" href="http://viewer.zmags.com/publication/64224be3?page=73"> Despite standard use in pharmaceutical research, </a> <a title="EMJ Respiratory 5.1 2017 page 74" href="http://viewer.zmags.com/publication/64224be3?page=74"> Grainge and Howarth18 investigated a repeate</a> <a title="EMJ Respiratory 5.1 2017 page 75" href="http://viewer.zmags.com/publication/64224be3?page=75"> developed an EAR and 47% developed an LAR. Overal</a> <a title="EMJ Respiratory 5.1 2017 page 76" href="http://viewer.zmags.com/publication/64224be3?page=76"> percentage fall only happens once, others require</a> <a title="EMJ Respiratory 5.1 2017 page 77" href="http://viewer.zmags.com/publication/64224be3?page=77"> 16. Schulze J et al. Airway responses and inflamma</a> <a title="EMJ Respiratory 5.1 2017 page 78" href="http://viewer.zmags.com/publication/64224be3?page=78"> ‘NO STENT LEFT BEHIND’: A REVIEW OF STENT RE</a> <a title="EMJ Respiratory 5.1 2017 page 79" href="http://viewer.zmags.com/publication/64224be3?page=79"> total cost per stent removal in the same study wa</a> <a title="EMJ Respiratory 5.1 2017 page 80" href="http://viewer.zmags.com/publication/64224be3?page=80"> A B Figure 2: Silicone stent. A) The silicone s</a> <a title="EMJ Respiratory 5.1 2017 page 81" href="http://viewer.zmags.com/publication/64224be3?page=81"> Figure 4: A bronchoscopic image demonstrating a m</a> <a title="EMJ Respiratory 5.1 2017 page 82" href="http://viewer.zmags.com/publication/64224be3?page=82"> Most of the complications encountered in the seri</a> <a title="EMJ Respiratory 5.1 2017 page 83" href="http://viewer.zmags.com/publication/64224be3?page=83"> places the patient under undue risk. We have not </a> <a title="EMJ Respiratory 5.1 2017 page 84" href="http://viewer.zmags.com/publication/64224be3?page=84"> REFERENCES 1. Doyle DJ et al. Anesthesia and air</a> <a title="EMJ Respiratory 5.1 2017 page 85" href="http://viewer.zmags.com/publication/64224be3?page=85"> MANAGING EXTUBATION AND THE POST EXTUBATION </a> <a title="EMJ Respiratory 5.1 2017 page 86" href="http://viewer.zmags.com/publication/64224be3?page=86"> risk of failure following extubation. This articl</a> <a title="EMJ Respiratory 5.1 2017 page 87" href="http://viewer.zmags.com/publication/64224be3?page=87"> 1) Treatme nt of ARF 3) Assessing readiness to we</a> <a title="EMJ Respiratory 5.1 2017 page 88" href="http://viewer.zmags.com/publication/64224be3?page=88"> for reintubation in this study. Although th</a> <a title="EMJ Respiratory 5.1 2017 page 89" href="http://viewer.zmags.com/publication/64224be3?page=89"> in several randomised controlled trials and meta-</a> <a title="EMJ Respiratory 5.1 2017 page 90" href="http://viewer.zmags.com/publication/64224be3?page=90"> A more recent study,56 terminated early due to re</a> <a title="EMJ Respiratory 5.1 2017 page 91" href="http://viewer.zmags.com/publication/64224be3?page=91"> more than 15 days. Am J Respir Critical Care Med.</a> <a title="EMJ Respiratory 5.1 2017 page 92" href="http://viewer.zmags.com/publication/64224be3?page=92"> A PATIENT PERSPECTIVE: IDENTIFYING AND </a> <a title="EMJ Respiratory 5.1 2017 page 93" href="http://viewer.zmags.com/publication/64224be3?page=93"> THE PROBLEM: CONSEQUENCES OF A LATE DIAGNOSIS De</a> <a title="EMJ Respiratory 5.1 2017 page 94" href="http://viewer.zmags.com/publication/64224be3?page=94"> patients (of whom 21 were current or forme</a> <a title="EMJ Respiratory 5.1 2017 page 95" href="http://viewer.zmags.com/publication/64224be3?page=95"> to fully comprehend the connection between s</a> <a title="EMJ Respiratory 5.1 2017 page 96" href="http://viewer.zmags.com/publication/64224be3?page=96"> associated feelings of humiliation and self-blame</a> <a title="EMJ Respiratory 5.1 2017 page 97" href="http://viewer.zmags.com/publication/64224be3?page=97"> to ascertain more about the reasons of delayed </a> <a title="EMJ Respiratory 5.1 2017 page 98" href="http://viewer.zmags.com/publication/64224be3?page=98"> BMC Public Health. 2016;16(1):508-19. 40. Cataldo</a> <a title="EMJ Respiratory 5.1 2017 page 99" href="http://viewer.zmags.com/publication/64224be3?page=99"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Respiratory 5.1 2017 page 100" href="http://viewer.zmags.com/publication/64224be3?page=100"> THYMOMAS AND THYMIC CARCINOMAS: A RE</a> <a title="EMJ Respiratory 5.1 2017 page 101" href="http://viewer.zmags.com/publication/64224be3?page=101"> Table 1: Refined diagnostic criteria of thym</a> <a title="EMJ Respiratory 5.1 2017 page 102" href="http://viewer.zmags.com/publication/64224be3?page=102"> undifferentiated carcinoma. These cancers nee</a> <a title="EMJ Respiratory 5.1 2017 page 103" href="http://viewer.zmags.com/publication/64224be3?page=103"> CT scans play a role in characterisation of the t</a> <a title="EMJ Respiratory 5.1 2017 page 104" href="http://viewer.zmags.com/publication/64224be3?page=104"> following R0–1 resection.12,25-30 Multiple studie</a> <a title="EMJ Respiratory 5.1 2017 page 105" href="http://viewer.zmags.com/publication/64224be3?page=105"> For patients with unresectable metastatic disease</a> <a title="EMJ Respiratory 5.1 2017 page 106" href="http://viewer.zmags.com/publication/64224be3?page=106"> REFERENCES 1. Detterbeck FC, Parsons AM. Thymic </a> <a title="EMJ Respiratory 5.1 2017 page 107" href="http://viewer.zmags.com/publication/64224be3?page=107"> 40. Lemma GL et al. Phase II study of carboplatin</a> <a title="EMJ Respiratory 5.1 2017 page 108" href="http://viewer.zmags.com/publication/64224be3?page=108"> ELECTRONIC CIGARETTE USE AMONG EMERGING </a> <a title="EMJ Respiratory 5.1 2017 page 109" href="http://viewer.zmags.com/publication/64224be3?page=109"> as tobacco cigarettes, while the heated vap</a> <a title="EMJ Respiratory 5.1 2017 page 110" href="http://viewer.zmags.com/publication/64224be3?page=110"> in their lifetime but had not smoked in the </a> <a title="EMJ Respiratory 5.1 2017 page 111" href="http://viewer.zmags.com/publication/64224be3?page=111"> Table 2: Univariate analysis of base charac</a> <a title="EMJ Respiratory 5.1 2017 page 112" href="http://viewer.zmags.com/publication/64224be3?page=112"> However, those who knew that e-cigarettes contain</a> <a title="EMJ Respiratory 5.1 2017 page 113" href="http://viewer.zmags.com/publication/64224be3?page=113"> Young adults aged 18–25 years and included in thi</a> <a title="EMJ Respiratory 5.1 2017 page 114" href="http://viewer.zmags.com/publication/64224be3?page=114"> without the harmful effects associated </a> <a title="EMJ Respiratory 5.1 2017 page 115" href="http://viewer.zmags.com/publication/64224be3?page=115"> 17. Filippidis FT et al. Two-year trends and pred</a> <a title="EMJ Respiratory 5.1 2017 page 116" href="http://viewer.zmags.com/publication/64224be3?page=116"> UPCOMING EVENTS British Thoracic Society Winter M</a> <a title="EMJ Respiratory 5.1 2017 page 117" href="http://viewer.zmags.com/publication/64224be3?page=117"> RESPIRATORY German Respiratory Society 59th Annua</a> <a title="EMJ Respiratory 5.1 2017 page 118" href="http://viewer.zmags.com/publication/64224be3?page=118"> Buyer’s Guide • 3D SYSTEMS HEALTHCARE • ACTEL</a> <a title="EMJ Respiratory 5.1 2017 page 119" href="http://viewer.zmags.com/publication/64224be3?page=119"> Respiratory • MEDICINE EVALUATION UNIT • MEDI</a> <a title="EMJ Respiratory 5.1 2017 page 120" href="http://viewer.zmags.com/publication/64224be3?page=120"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS, NEW</a>