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<br /> HEPATOLOGY<br /> ISSN 2053-4221 May 2013 • emjreviews.com<br /> INSIDE<br /> Review of The International<br /> Liver Congress™ 2013:<br /> the 48th Annual Meeting of EASL<br /> Amsterdam, The Netherlands<br /> HEPATOLOGY<br /> Contents<br /> EDITORIAL PANEL........................................................................................................................................................4<br /> CONGRESS REVIEW......................................................................................................................................................8<br /> • Review of The International Liver CongressTM, the 48th Annual Meeting of the European<br /> Association for the Study of the Liver, held in Amsterdam, The Netherlands, 24th-28th April 2013<br /> HEPATIC ENCEPHALOPATHY: A PARADIGM SHIFT.........................<a title="EMJ - Hepatology page 1" href="http://viewer.zmags.com/publication/683d5226?page=1"> HEPATOLOGY ISSN 2053-4221 </a> <a title="EMJ - Hepatology page 2" href="http://viewer.zmags.com/publication/683d5226?page=2"> HEPATOLOGY Contents EDITORIAL PANEL............</a> <a title="EMJ - Hepatology page 3" href="http://viewer.zmags.com/publication/683d5226?page=3"> IL28B POLYMORPHISMS IN INTERFERON-TREATED PATIEN</a> <a title="EMJ - Hepatology page 4" href="http://viewer.zmags.com/publication/683d5226?page=4"> HEPATOLOGY Editorial Panel Prof. Paolo Angeli A</a> <a title="EMJ - Hepatology page 5" href="http://viewer.zmags.com/publication/683d5226?page=5"> HEPATOLOGY Publisher Claire Gore Editorial Di</a> <a title="EMJ - Hepatology page 6" href="http://viewer.zmags.com/publication/683d5226?page=6"> Robust protection against recurrent episodes of h</a> <a title="EMJ - Hepatology page 7" href="http://viewer.zmags.com/publication/683d5226?page=7"> Foreword Prof. Dr. Markus Peck-Radosavljevic </a> <a title="EMJ - Hepatology page 8" href="http://viewer.zmags.com/publication/683d5226?page=8"> EASL ANNUAL MEETING 2013 THE INTERNATIONAL LIVER </a> <a title="EMJ - Hepatology page 9" href="http://viewer.zmags.com/publication/683d5226?page=9"> Welcome to the European Medical Journal review of</a> <a title="EMJ - Hepatology page 10" href="http://viewer.zmags.com/publication/683d5226?page=10"> EASL ANNUAL MEETING 2013 THE INTERNATIONAL LIVER </a> <a title="EMJ - Hepatology page 11" href="http://viewer.zmags.com/publication/683d5226?page=11"> URNAL REVIEW OF EASL’S 48TH ANNUAL IVER CONGRES</a> <a title="EMJ - Hepatology page 12" href="http://viewer.zmags.com/publication/683d5226?page=12"> EASL ANNUAL MEETING 2013 THE INTERNATIONAL LIVER </a> <a title="EMJ - Hepatology page 13" href="http://viewer.zmags.com/publication/683d5226?page=13"> THE EUROPEAN ASSOCIATION FOR THE STUDY OF THE LIV</a> <a title="EMJ - Hepatology page 14" href="http://viewer.zmags.com/publication/683d5226?page=14"> EASL ANNUAL MEETING 2013 THE INTERNATIONAL LIVER </a> <a title="EMJ - Hepatology page 15" href="http://viewer.zmags.com/publication/683d5226?page=15"> L, WEIGHT AND LIVER DISEASE SHOWS OPE, THE HARDES</a> <a title="EMJ - Hepatology page 16" href="http://viewer.zmags.com/publication/683d5226?page=16"> EASL ANNUAL MEETING 2013 THE INTERNATIONAL LIVER </a> <a title="EMJ - Hepatology page 17" href="http://viewer.zmags.com/publication/683d5226?page=17"> LIVERTREETM TO BE ONE-STOP WEBSITE FOLLOWING the</a> <a title="EMJ - Hepatology page 18" href="http://viewer.zmags.com/publication/683d5226?page=18"> EASL ANNUAL MEETING 2013 THE INTERNATIONAL LIVER </a> <a title="EMJ - Hepatology page 19" href="http://viewer.zmags.com/publication/683d5226?page=19"> CARDIO AIDS POTENTIAL CANCER CURE REGULAR </a> <a title="EMJ - Hepatology page 20" href="http://viewer.zmags.com/publication/683d5226?page=20"> HEPATIC ENCEPHALOPATHY: A PARADIGM SHIFT Summary</a> <a title="EMJ - Hepatology page 21" href="http://viewer.zmags.com/publication/683d5226?page=21"> Liver cirrhosis Control HE no H</a> <a title="EMJ - Hepatology page 22" href="http://viewer.zmags.com/publication/683d5226?page=22"> Survival 1.0 0.8 0.6 0.4 0.2 0.0 0 Survi</a> <a title="EMJ - Hepatology page 23" href="http://viewer.zmags.com/publication/683d5226?page=23"> 30 Compensated (N=114)</a> <a title="EMJ - Hepatology page 24" href="http://viewer.zmags.com/publication/683d5226?page=24"> syndrome that is referred to as acute or chronic </a> <a title="EMJ - Hepatology page 25" href="http://viewer.zmags.com/publication/683d5226?page=25"> Patient with possible overt HE Not HE: Alt</a> <a title="EMJ - Hepatology page 26" href="http://viewer.zmags.com/publication/683d5226?page=26"> Rifaximin is used for secondary prophylaxis, and </a> <a title="EMJ - Hepatology page 27" href="http://viewer.zmags.com/publication/683d5226?page=27"> showed that overall antibiotics produced a positi</a> <a title="EMJ - Hepatology page 28" href="http://viewer.zmags.com/publication/683d5226?page=28"> Placebo Xifaxan® 550mg Overall </a> <a title="EMJ - Hepatology page 29" href="http://viewer.zmags.com/publication/683d5226?page=29"> REFERENCES 1. Häussinger D. Low grade cereb</a> <a title="EMJ - Hepatology page 30" href="http://viewer.zmags.com/publication/683d5226?page=30"> induced ototoxicity. Curr Pharm Des. 2007;13(</a> <a title="EMJ - Hepatology page 31" href="http://viewer.zmags.com/publication/683d5226?page=31"> The revolution continues At Philips, we strive f</a> <a title="EMJ - Hepatology page 32" href="http://viewer.zmags.com/publication/683d5226?page=32"> ADRENAL INSUFFICIENCY (AI) IN CIRRHOSIS Julia O’</a> <a title="EMJ - Hepatology page 33" href="http://viewer.zmags.com/publication/683d5226?page=33"> plasma cortisol is measured, which is a surrogate</a> <a title="EMJ - Hepatology page 34" href="http://viewer.zmags.com/publication/683d5226?page=34"> diseases such as alcoholic liver disease, primary</a> <a title="EMJ - Hepatology page 35" href="http://viewer.zmags.com/publication/683d5226?page=35"> and free cortisol concentrations. Over the last y</a> <a title="EMJ - Hepatology page 36" href="http://viewer.zmags.com/publication/683d5226?page=36"> with steroid sparing regimen31 and after steroid </a> <a title="EMJ - Hepatology page 37" href="http://viewer.zmags.com/publication/683d5226?page=37"> of serum-free and salivary cortisol. Liver Intern</a> <a title="EMJ - Hepatology page 38" href="http://viewer.zmags.com/publication/683d5226?page=38"> ACUTE-ON-CHRONIC LIVER FAILURE: APPLYING THE </a> <a title="EMJ - Hepatology page 39" href="http://viewer.zmags.com/publication/683d5226?page=39"> • Male gender • Higher bilirubin level • Lo</a> <a title="EMJ - Hepatology page 40" href="http://viewer.zmags.com/publication/683d5226?page=40"> generate an adequate immune response due to a dys</a> <a title="EMJ - Hepatology page 41" href="http://viewer.zmags.com/publication/683d5226?page=41"> The PIRO concept of acute on chronic liver failur</a> <a title="EMJ - Hepatology page 42" href="http://viewer.zmags.com/publication/683d5226?page=42"> REFERENCES 1. Sen S, Williams R, Jalan R. </a> <a title="EMJ - Hepatology page 43" href="http://viewer.zmags.com/publication/683d5226?page=43"> F, Neff G, Leevy CB, Sigal S, et al. Rifaximin tr</a> <a title="EMJ - Hepatology page 44" href="http://viewer.zmags.com/publication/683d5226?page=44"> CELLULAR CONSEQUENCES OF Z ALPHA-1 ANTITRYPS</a> <a title="EMJ - Hepatology page 45" href="http://viewer.zmags.com/publication/683d5226?page=45"> Figure 1. Polymerisation of Z-alpha-1 antitrypsin</a> <a title="EMJ - Hepatology page 46" href="http://viewer.zmags.com/publication/683d5226?page=46"> Lung Disease in Z α -Antitrypsin Deficiency </a> <a title="EMJ - Hepatology page 47" href="http://viewer.zmags.com/publication/683d5226?page=47"> Activation of the ER-Overload Response in Severe </a> <a title="EMJ - Hepatology page 48" href="http://viewer.zmags.com/publication/683d5226?page=48"> Figure 4A. 4M dissociates intracellular Z-AT poly</a> <a title="EMJ - Hepatology page 49" href="http://viewer.zmags.com/publication/683d5226?page=49"> between pathogenesis of liver and lung disease in</a> <a title="EMJ - Hepatology page 50" href="http://viewer.zmags.com/publication/683d5226?page=50"> REFERENCES 1. Stoller J K, Aboussouan L S. A rev</a> <a title="EMJ - Hepatology page 51" href="http://viewer.zmags.com/publication/683d5226?page=51"> secretion impaired glycoprotein into distin</a> <a title="EMJ - Hepatology page 52" href="http://viewer.zmags.com/publication/683d5226?page=52"> IL28B POLYMORPHISMS IN INTERFERON-TREATED </a> <a title="EMJ - Hepatology page 53" href="http://viewer.zmags.com/publication/683d5226?page=53"> 100 80 60 40 % Patients with HBeAg seroconver</a> <a title="EMJ - Hepatology page 54" href="http://viewer.zmags.com/publication/683d5226?page=54"> p<0.001). IL28B genotypes were also independently</a> <a title="EMJ - Hepatology page 55" href="http://viewer.zmags.com/publication/683d5226?page=55"> TT patients. The 42 rs12979860 CT patients with t</a> <a title="EMJ - Hepatology page 56" href="http://viewer.zmags.com/publication/683d5226?page=56"> REFERENCES 1. EASL Clinical Practice Guideli</a> <a title="EMJ - Hepatology page 57" href="http://viewer.zmags.com/publication/683d5226?page=57"> discover Now the… </a> <a title="EMJ - Hepatology page 58" href="http://viewer.zmags.com/publication/683d5226?page=58"> MANAGEMENT OF HEPATITIS B VIRUS INFECTION IN </a> <a title="EMJ - Hepatology page 59" href="http://viewer.zmags.com/publication/683d5226?page=59"> i. Resistance/mutation to oral antiviral dru</a> <a title="EMJ - Hepatology page 60" href="http://viewer.zmags.com/publication/683d5226?page=60"> 3 of 651 (0.5%) recipients when donors were anti-</a> <a title="EMJ - Hepatology page 61" href="http://viewer.zmags.com/publication/683d5226?page=61"> Adefovir (10mg/day or 5mg/day in presence of rena</a> <a title="EMJ - Hepatology page 62" href="http://viewer.zmags.com/publication/683d5226?page=62"> Hepatitis B Immunoglobulin Nucleoside/Nucleotid</a> <a title="EMJ - Hepatology page 63" href="http://viewer.zmags.com/publication/683d5226?page=63"> (iv) Alternatives to standard HBIG dose This incl</a> <a title="EMJ - Hepatology page 64" href="http://viewer.zmags.com/publication/683d5226?page=64"> body weight of <75Kg & >75Kg respectively) of HBI</a> <a title="EMJ - Hepatology page 65" href="http://viewer.zmags.com/publication/683d5226?page=65"> Y, Livni N, Tur-Kaspa R. Sanctuary of hepatitis B</a> <a title="EMJ - Hepatology page 66" href="http://viewer.zmags.com/publication/683d5226?page=66"> Proc. 2007;39(5):1533-6. 48. Xiong X, Flores C, Y</a> <a title="EMJ - Hepatology page 67" href="http://viewer.zmags.com/publication/683d5226?page=67"> 83. Yi NJ, Choi JY, Suh KS, et al. Post- transpla</a> <a title="EMJ - Hepatology page 68" href="http://viewer.zmags.com/publication/683d5226?page=68"> VIRAL PROTEINS MEDIATE UPREGULATION OF </a> <a title="EMJ - Hepatology page 69" href="http://viewer.zmags.com/publication/683d5226?page=69"> 1 Positive for anti-HCV antibodies 2 Nega</a> <a title="EMJ - Hepatology page 70" href="http://viewer.zmags.com/publication/683d5226?page=70"> (A) (B) </a> <a title="EMJ - Hepatology page 71" href="http://viewer.zmags.com/publication/683d5226?page=71"> evaluated by analysis of dot plots or histograms </a> <a title="EMJ - Hepatology page 72" href="http://viewer.zmags.com/publication/683d5226?page=72"> *** 3 2 Fold increase in MFI 1 0 HC CH</a> <a title="EMJ - Hepatology page 73" href="http://viewer.zmags.com/publication/683d5226?page=73"> (A) </a> <a title="EMJ - Hepatology page 74" href="http://viewer.zmags.com/publication/683d5226?page=74"> This has brought in a state of ambiguity to the s</a> <a title="EMJ - Hepatology page 75" href="http://viewer.zmags.com/publication/683d5226?page=75"> might be related to up-regulation of SOCS3.39 The</a> <a title="EMJ - Hepatology page 76" href="http://viewer.zmags.com/publication/683d5226?page=76"> MaWhinney S, Wilson CC. Influence of plasma viremi</a> <a title="EMJ - Hepatology page 77" href="http://viewer.zmags.com/publication/683d5226?page=77"> The revolution continues At Philips, we strive f</a> <a title="EMJ - Hepatology page 78" href="http://viewer.zmags.com/publication/683d5226?page=78"> TOWARDS A STANDARDISED METHOD TO ACQUIRE AND STO</a> <a title="EMJ - Hepatology page 79" href="http://viewer.zmags.com/publication/683d5226?page=79"> to acceptance and implementation in the sci</a> <a title="EMJ - Hepatology page 80" href="http://viewer.zmags.com/publication/683d5226?page=80"> MATERIAL AND METHODS A PubMed search was perform</a> <a title="EMJ - Hepatology page 81" href="http://viewer.zmags.com/publication/683d5226?page=81"> Best Variation </a> <a title="EMJ - Hepatology page 82" href="http://viewer.zmags.com/publication/683d5226?page=82"> data will be much more reliable, and since refere</a> <a title="EMJ - Hepatology page 83" href="http://viewer.zmags.com/publication/683d5226?page=83"> 2012;56:869-76. 18. Nault J C, Fabre M, Couchy G,</a> <a title="EMJ - Hepatology page 84" href="http://viewer.zmags.com/publication/683d5226?page=84"> Hepatol. 2007;46:151-9. 56. Omenetti A, Bass L M,</a> <a title="EMJ - Hepatology page 85" href="http://viewer.zmags.com/publication/683d5226?page=85"> Robust protection against recurrent episodes of h</a> <a title="EMJ - Hepatology page 86" href="http://viewer.zmags.com/publication/683d5226?page=86"> WHAT’S NEW NEW DRUG STIMULATES IMMUNE SYSTEM TO K</a> <a title="EMJ - Hepatology page 87" href="http://viewer.zmags.com/publication/683d5226?page=87"> HEPATOLOGY 19-YEAR-OLD WOMAN NEARING FULL PREGNAN</a> <a title="EMJ - Hepatology page 88" href="http://viewer.zmags.com/publication/683d5226?page=88"> WHAT’S NEW “GAME-CHANGING” HEPATITIS C VIRUS DRUG</a> <a title="EMJ - Hepatology page 89" href="http://viewer.zmags.com/publication/683d5226?page=89"> HEPATOLOGY LIFETIME COPIOUS COFFEE CONSUMPTION NO</a> <a title="EMJ - Hepatology page 90" href="http://viewer.zmags.com/publication/683d5226?page=90"> FEATUREDSUPPLIERS FEATURED SUPPLIERS Norgine is</a> <a title="EMJ - Hepatology page 91" href="http://viewer.zmags.com/publication/683d5226?page=91"> HEPATOLOGY BUYER’S GUIDE ABBOTT </a> <a title="EMJ - Hepatology page 92" href="http://viewer.zmags.com/publication/683d5226?page=92"> UPCOMING EVENTS & COURSES EVENTS APASL Liver Wee</a> <a title="EMJ - Hepatology page 93" href="http://viewer.zmags.com/publication/683d5226?page=93"> HEPATOLOGY COURSES EASLClinicalSchoolofHepatolog</a> <a title="EMJ - Hepatology page 94" href="http://viewer.zmags.com/publication/683d5226?page=94"> From a host of fourteen therapeutical areas, EURO</a>