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<br /> HEPATOLOGY<br /> ISSN 2053-4221 May 2014 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ILC 2014<br /> London, UK<br /> <br /> SOVALDI® transforms HCV therapy, allowing<br /> more adult patients the opportunity of cure<br /> In clinical trials<br /> · The first approved nucleotide polymerase inhibitor with pan-genotypic<br /> activity and a high barrier to resistance1<br /> · ≥90% of treatment-naïve adults, across all genotypes are cured with 12 weeks<br /> of SOVALDI + Peg-IFN + RBV (No Peg-IFN required for GT 2)1<br /> · The first all-oral 24-week option across all genotypes for those unsuitable for IFN<br /> (12-24 week treatment duration for GT 2)1<br /> · No specific adverse drug reactions identified for SOVALDI within SOVALDI + RBV<br /> ± Peg-IFN regimens1<br /> SOVALDI is indicated in combination with other medicinal<br /> products for the treatment of chro<a title="EMJ Hepatology 2014 page 1" href="http://viewer.zmags.com/publication/6b6592a8?page=1"> HEPATOLOGY ISSN 2053-4221 </a> <a title="EMJ Hepatology 2014 page 2" href="http://viewer.zmags.com/publication/6b6592a8?page=2"> </a> <a title="EMJ Hepatology 2014 page 3" href="http://viewer.zmags.com/publication/6b6592a8?page=3"> SOVALDI® transforms HCV therapy, allowing more a</a> <a title="EMJ Hepatology 2014 page 4" href="http://viewer.zmags.com/publication/6b6592a8?page=4"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Hepatology 2014 page 5" href="http://viewer.zmags.com/publication/6b6592a8?page=5"> HEPATOLOGY USE OF HBSAG QUANTIFICATION TO GUID</a> <a title="EMJ Hepatology 2014 page 6" href="http://viewer.zmags.com/publication/6b6592a8?page=6"> Editorial Board Hepatology Editor-in-Chief: Pr</a> <a title="EMJ Hepatology 2014 page 7" href="http://viewer.zmags.com/publication/6b6592a8?page=7"> Welcome Spring has now sprung, as has our second </a> <a title="EMJ Hepatology 2014 page 8" href="http://viewer.zmags.com/publication/6b6592a8?page=8"> European Medical Journal Hepatology May 2014 P</a> <a title="EMJ Hepatology 2014 page 9" href="http://viewer.zmags.com/publication/6b6592a8?page=9"> Foreword Univ Prof Dr Markus Peck-Radosavljevic </a> <a title="EMJ Hepatology 2014 page 10" href="http://viewer.zmags.com/publication/6b6592a8?page=10"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 11" href="http://viewer.zmags.com/publication/6b6592a8?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ Hepatology 2014 page 12" href="http://viewer.zmags.com/publication/6b6592a8?page=12"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 13" href="http://viewer.zmags.com/publication/6b6592a8?page=13"> The presentation of these new, direct-acting, ant</a> <a title="EMJ Hepatology 2014 page 14" href="http://viewer.zmags.com/publication/6b6592a8?page=14"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 15" href="http://viewer.zmags.com/publication/6b6592a8?page=15"> Potential Hepatitis C cure blooms in Chinese foli</a> <a title="EMJ Hepatology 2014 page 16" href="http://viewer.zmags.com/publication/6b6592a8?page=16"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 17" href="http://viewer.zmags.com/publication/6b6592a8?page=17"> Confronting hepatitis C: a comprehensive approach</a> <a title="EMJ Hepatology 2014 page 18" href="http://viewer.zmags.com/publication/6b6592a8?page=18"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 19" href="http://viewer.zmags.com/publication/6b6592a8?page=19"> Liver disease gets gutsy FAECAL microbiota tr</a> <a title="EMJ Hepatology 2014 page 20" href="http://viewer.zmags.com/publication/6b6592a8?page=20"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 21" href="http://viewer.zmags.com/publication/6b6592a8?page=21"> T cell clone wars ADOPTIVE T cell therapy could b</a> <a title="EMJ Hepatology 2014 page 22" href="http://viewer.zmags.com/publication/6b6592a8?page=22"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 23" href="http://viewer.zmags.com/publication/6b6592a8?page=23"> Hepatic encephalopathy is not the end of the road</a> <a title="EMJ Hepatology 2014 page 24" href="http://viewer.zmags.com/publication/6b6592a8?page=24"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 25" href="http://viewer.zmags.com/publication/6b6592a8?page=25"> Host of therapeutic options to improve HCC patien</a> <a title="EMJ Hepatology 2014 page 26" href="http://viewer.zmags.com/publication/6b6592a8?page=26"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 27" href="http://viewer.zmags.com/publication/6b6592a8?page=27"> Fatty livers lead to dangerous hearts CARDIOVASCU</a> <a title="EMJ Hepatology 2014 page 28" href="http://viewer.zmags.com/publication/6b6592a8?page=28"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 29" href="http://viewer.zmags.com/publication/6b6592a8?page=29"> Three against one: the attack on hepatitis B EXPE</a> <a title="EMJ Hepatology 2014 page 30" href="http://viewer.zmags.com/publication/6b6592a8?page=30"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 31" href="http://viewer.zmags.com/publication/6b6592a8?page=31"> Triangle of action against hepatitis C “These dat</a> <a title="EMJ Hepatology 2014 page 32" href="http://viewer.zmags.com/publication/6b6592a8?page=32"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 33" href="http://viewer.zmags.com/publication/6b6592a8?page=33"> Hepatitis C drug shows glittering prowess through</a> <a title="EMJ Hepatology 2014 page 34" href="http://viewer.zmags.com/publication/6b6592a8?page=34"> ILC ANNUAL CONGRESS 2014 EXCEL LONDON EXHIBITION </a> <a title="EMJ Hepatology 2014 page 35" href="http://viewer.zmags.com/publication/6b6592a8?page=35"> Bristol-Myers Squibb: at the Core of HCV Research</a> <a title="EMJ Hepatology 2014 page 36" href="http://viewer.zmags.com/publication/6b6592a8?page=36"> TRANSFORMING HCV MANAGEMENT Summary of Presentati</a> <a title="EMJ Hepatology 2014 page 37" href="http://viewer.zmags.com/publication/6b6592a8?page=37"> development of the second-generation - more </a> <a title="EMJ Hepatology 2014 page 38" href="http://viewer.zmags.com/publication/6b6592a8?page=38"> Initial treatment regimens with IFN </a> <a title="EMJ Hepatology 2014 page 39" href="http://viewer.zmags.com/publication/6b6592a8?page=39"> Perspectives on Therapy for Challenging Pa</a> <a title="EMJ Hepatology 2014 page 40" href="http://viewer.zmags.com/publication/6b6592a8?page=40"> demonstrated up to 98% SVR for GT1 patients in a </a> <a title="EMJ Hepatology 2014 page 41" href="http://viewer.zmags.com/publication/6b6592a8?page=41"> data. AASLD 1–5 November 2013, Washington</a> <a title="EMJ Hepatology 2014 page 42" href="http://viewer.zmags.com/publication/6b6592a8?page=42"> NEWS AT SIX: HEPATITIS C SPECIAL Summary of Pre</a> <a title="EMJ Hepatology 2014 page 43" href="http://viewer.zmags.com/publication/6b6592a8?page=43"> lower against HCV GT 3 and they possess a</a> <a title="EMJ Hepatology 2014 page 44" href="http://viewer.zmags.com/publication/6b6592a8?page=44"> of RBV, must be taken into account.12 Care</a> <a title="EMJ Hepatology 2014 page 45" href="http://viewer.zmags.com/publication/6b6592a8?page=45"> Discrimination and practical difficulties </a> <a title="EMJ Hepatology 2014 page 46" href="http://viewer.zmags.com/publication/6b6592a8?page=46"> transplantation,50 and with current therapies the</a> <a title="EMJ Hepatology 2014 page 47" href="http://viewer.zmags.com/publication/6b6592a8?page=47"> MK-5172/MK-8742 +/- RBV for 12 weeks in HCV genot</a> <a title="EMJ Hepatology 2014 page 48" href="http://viewer.zmags.com/publication/6b6592a8?page=48"> TRANSLATION FROM MICE TO MEN: ARE DOGS A </a> <a title="EMJ Hepatology 2014 page 49" href="http://viewer.zmags.com/publication/6b6592a8?page=49"> Requirements for Animal Models Important requirem</a> <a title="EMJ Hepatology 2014 page 50" href="http://viewer.zmags.com/publication/6b6592a8?page=50"> Table 1: Markers used to investigate mouse, dog o</a> <a title="EMJ Hepatology 2014 page 51" href="http://viewer.zmags.com/publication/6b6592a8?page=51"> Using a plate-and-wait method, colonies of canine</a> <a title="EMJ Hepatology 2014 page 52" href="http://viewer.zmags.com/publication/6b6592a8?page=52"> provides an excellent model for clinical HP</a> <a title="EMJ Hepatology 2014 page 53" href="http://viewer.zmags.com/publication/6b6592a8?page=53"> REFERENCES 1. Riehle KJ et al. New concepts in li</a> <a title="EMJ Hepatology 2014 page 54" href="http://viewer.zmags.com/publication/6b6592a8?page=54"> 48. Kim H et al. Human hepatocellular carcinomas </a> <a title="EMJ Hepatology 2014 page 55" href="http://viewer.zmags.com/publication/6b6592a8?page=55"> OVERLAPPING CLINICAL FEATURES BETWEEN NAFLD </a> <a title="EMJ Hepatology 2014 page 56" href="http://viewer.zmags.com/publication/6b6592a8?page=56"> of specific signs of these diseases that ma</a> <a title="EMJ Hepatology 2014 page 57" href="http://viewer.zmags.com/publication/6b6592a8?page=57"> NAFLD GENETIC BACKGROUND CIRCULATING ADIPOCY</a> <a title="EMJ Hepatology 2014 page 58" href="http://viewer.zmags.com/publication/6b6592a8?page=58"> for the Kruppel-like factor 6 (KLF6), which</a> <a title="EMJ Hepatology 2014 page 59" href="http://viewer.zmags.com/publication/6b6592a8?page=59"> Although the real role of these two adipocytokine</a> <a title="EMJ Hepatology 2014 page 60" href="http://viewer.zmags.com/publication/6b6592a8?page=60"> either for establishing the primary determin</a> <a title="EMJ Hepatology 2014 page 61" href="http://viewer.zmags.com/publication/6b6592a8?page=61"> children with non-alcoholic fatty liver disea</a> <a title="EMJ Hepatology 2014 page 62" href="http://viewer.zmags.com/publication/6b6592a8?page=62"> ADIPOSE TISSUE, METABOLIC SYNDROME, AND NON- ALCO</a> <a title="EMJ Hepatology 2014 page 63" href="http://viewer.zmags.com/publication/6b6592a8?page=63"> the central role of adiposity in the patho</a> <a title="EMJ Hepatology 2014 page 64" href="http://viewer.zmags.com/publication/6b6592a8?page=64"> resistance is accompanied by hyperinsulinaemi</a> <a title="EMJ Hepatology 2014 page 65" href="http://viewer.zmags.com/publication/6b6592a8?page=65"> expanding its adipose tissue, thus these effects </a> <a title="EMJ Hepatology 2014 page 66" href="http://viewer.zmags.com/publication/6b6592a8?page=66"> Some examples include the UCP1 -3826 A>G po</a> <a title="EMJ Hepatology 2014 page 67" href="http://viewer.zmags.com/publication/6b6592a8?page=67"> interventions. Although randomised controll</a> <a title="EMJ Hepatology 2014 page 68" href="http://viewer.zmags.com/publication/6b6592a8?page=68"> the hepatic manifestation of MetS, while in patie</a> <a title="EMJ Hepatology 2014 page 69" href="http://viewer.zmags.com/publication/6b6592a8?page=69"> 2001;96(10):2957–61. 40. Schwimmer JB et al. Prev</a> <a title="EMJ Hepatology 2014 page 70" href="http://viewer.zmags.com/publication/6b6592a8?page=70"> 82. Sookoian S et al. Modest alcohol consum</a> <a title="EMJ Hepatology 2014 page 71" href="http://viewer.zmags.com/publication/6b6592a8?page=71"> COST-EFFECTIVE INTERVENTIONS IN THE CONTROL </a> <a title="EMJ Hepatology 2014 page 72" href="http://viewer.zmags.com/publication/6b6592a8?page=72"> have, as yet, introduced universal HBV vaccinatio</a> <a title="EMJ Hepatology 2014 page 73" href="http://viewer.zmags.com/publication/6b6592a8?page=73"> Table 1: Summary of recently published cost-effec</a> <a title="EMJ Hepatology 2014 page 74" href="http://viewer.zmags.com/publication/6b6592a8?page=74"> Intervention Country/Target Group Summary of </a> <a title="EMJ Hepatology 2014 page 75" href="http://viewer.zmags.com/publication/6b6592a8?page=75"> born abroad but are currently living in Canada. T</a> <a title="EMJ Hepatology 2014 page 76" href="http://viewer.zmags.com/publication/6b6592a8?page=76"> would cost to expand the coverage of existing r</a> <a title="EMJ Hepatology 2014 page 77" href="http://viewer.zmags.com/publication/6b6592a8?page=77"> USE OF HBSAG QUANTIFICATION TO GUIDE HBIG PROPHYL</a> <a title="EMJ Hepatology 2014 page 78" href="http://viewer.zmags.com/publication/6b6592a8?page=78"> from high-dose intravenous (i.v.) HBIG - administ</a> <a title="EMJ Hepatology 2014 page 79" href="http://viewer.zmags.com/publication/6b6592a8?page=79"> complications) or in patients with HCC and </a> <a title="EMJ Hepatology 2014 page 80" href="http://viewer.zmags.com/publication/6b6592a8?page=80"> mIU/mL at day 7. The secondary endpoints were: ev</a> <a title="EMJ Hepatology 2014 page 81" href="http://viewer.zmags.com/publication/6b6592a8?page=81"> HCC was present in 24 (58.5%) and H</a> <a title="EMJ Hepatology 2014 page 82" href="http://viewer.zmags.com/publication/6b6592a8?page=82"> Table 3: Univariate comparison between efficacy p</a> <a title="EMJ Hepatology 2014 page 83" href="http://viewer.zmags.com/publication/6b6592a8?page=83"> DISCUSSION In the setting of LT for HBsAg-relate</a> <a title="EMJ Hepatology 2014 page 84" href="http://viewer.zmags.com/publication/6b6592a8?page=84"> 30,000 IU HBIG (p=0.0002) and underwent further b</a> <a title="EMJ Hepatology 2014 page 85" href="http://viewer.zmags.com/publication/6b6592a8?page=85"> recurrent hepatitis B virus by vaccination after </a> <a title="EMJ Hepatology 2014 page 86" href="http://viewer.zmags.com/publication/6b6592a8?page=86"> LIVER TRANSPLANTATION FOR ALCOHOLIC LIVER </a> <a title="EMJ Hepatology 2014 page 87" href="http://viewer.zmags.com/publication/6b6592a8?page=87"> Recently, increased risk of mortality due to live</a> <a title="EMJ Hepatology 2014 page 88" href="http://viewer.zmags.com/publication/6b6592a8?page=88"> European Association for the Study of the Liver (</a> <a title="EMJ Hepatology 2014 page 89" href="http://viewer.zmags.com/publication/6b6592a8?page=89"> CONCLUSION LT for alcoholic cirrhosis is a matte</a> <a title="EMJ Hepatology 2014 page 90" href="http://viewer.zmags.com/publication/6b6592a8?page=90"> physical complications. London: Royal College </a> <a title="EMJ Hepatology 2014 page 91" href="http://viewer.zmags.com/publication/6b6592a8?page=91"> ACUTE LIVER FAILURE: A DANGEROUS AND </a> <a title="EMJ Hepatology 2014 page 92" href="http://viewer.zmags.com/publication/6b6592a8?page=92"> Acute liver failure (ALF) -Recovery under conse</a> <a title="EMJ Hepatology 2014 page 93" href="http://viewer.zmags.com/publication/6b6592a8?page=93"> A Acute liv</a> <a title="EMJ Hepatology 2014 page 94" href="http://viewer.zmags.com/publication/6b6592a8?page=94"> Table 1: Aetiologies of acute liver failure (ALF)</a> <a title="EMJ Hepatology 2014 page 95" href="http://viewer.zmags.com/publication/6b6592a8?page=95"> of inflammatory cells.31 However, apoptosis itself</a> <a title="EMJ Hepatology 2014 page 96" href="http://viewer.zmags.com/publication/6b6592a8?page=96"> Table 2: Scoring systems in patients with acute l</a> <a title="EMJ Hepatology 2014 page 97" href="http://viewer.zmags.com/publication/6b6592a8?page=97"> of novel markers and diagnostic methods should be</a> <a title="EMJ Hepatology 2014 page 98" href="http://viewer.zmags.com/publication/6b6592a8?page=98"> consumption ingesting paracetamol at the</a> <a title="EMJ Hepatology 2014 page 99" href="http://viewer.zmags.com/publication/6b6592a8?page=99"> ACUTE LIVER FAILURE: PATHOPHYSIOLOGIC BASIS, A</a> <a title="EMJ Hepatology 2014 page 100" href="http://viewer.zmags.com/publication/6b6592a8?page=100"> ALF is a rare condition, with a reported annual i</a> <a title="EMJ Hepatology 2014 page 101" href="http://viewer.zmags.com/publication/6b6592a8?page=101"> blood flow (CBF) and cerebral autoregulation,</a> <a title="EMJ Hepatology 2014 page 102" href="http://viewer.zmags.com/publication/6b6592a8?page=102"> Controversy continues to rage about the use of IC</a> <a title="EMJ Hepatology 2014 page 103" href="http://viewer.zmags.com/publication/6b6592a8?page=103"> Infections and Sepsis in ALF Immune paralysis, </a> <a title="EMJ Hepatology 2014 page 104" href="http://viewer.zmags.com/publication/6b6592a8?page=104"> such as ventilator associated pneumonias, acute l</a> <a title="EMJ Hepatology 2014 page 105" href="http://viewer.zmags.com/publication/6b6592a8?page=105"> subacute ALF), are occasionally used. Although th</a> <a title="EMJ Hepatology 2014 page 106" href="http://viewer.zmags.com/publication/6b6592a8?page=106"> muscles as phenylacetylglutamine (PAGN), and </a> <a title="EMJ Hepatology 2014 page 107" href="http://viewer.zmags.com/publication/6b6592a8?page=107"> hyperammonemia to cerebral edema. Metab Brain </a> <a title="EMJ Hepatology 2014 page 108" href="http://viewer.zmags.com/publication/6b6592a8?page=108"> WHAT’S NEW: INTERVIEW Sovaldi®: winning the battl</a> <a title="EMJ Hepatology 2014 page 109" href="http://viewer.zmags.com/publication/6b6592a8?page=109"> HEPATOLOGY molecule is being targeting to be cov</a> <a title="EMJ Hepatology 2014 page 110" href="http://viewer.zmags.com/publication/6b6592a8?page=110"> WHAT’S NEW New liver </a> <a title="EMJ Hepatology 2014 page 111" href="http://viewer.zmags.com/publication/6b6592a8?page=111"> HEPATOLOGY Transforming skin cells into liver cel</a> <a title="EMJ Hepatology 2014 page 112" href="http://viewer.zmags.com/publication/6b6592a8?page=112"> WHAT’S NEW Mysterious mutation causing liver canc</a> <a title="EMJ Hepatology 2014 page 113" href="http://viewer.zmags.com/publication/6b6592a8?page=113"> HEPATOLOGY New budding treatment for hepatitis B </a> <a title="EMJ Hepatology 2014 page 114" href="http://viewer.zmags.com/publication/6b6592a8?page=114"> WHAT’S NEW Topiramate, curbing alcohol consumptio</a> <a title="EMJ Hepatology 2014 page 115" href="http://viewer.zmags.com/publication/6b6592a8?page=115"> HEPATOLOGY From stem cells to pure liver and panc</a> <a title="EMJ Hepatology 2014 page 116" href="http://viewer.zmags.com/publication/6b6592a8?page=116"> WHAT’S NEW Preventing the lethal consequences of </a> <a title="EMJ Hepatology 2014 page 117" href="http://viewer.zmags.com/publication/6b6592a8?page=117"> HEPATOLOGY Zebrafish model used to detect new canc</a> <a title="EMJ Hepatology 2014 page 118" href="http://viewer.zmags.com/publication/6b6592a8?page=118"> WHAT’S NEW Last-minute holiday deals may harm liv</a> <a title="EMJ Hepatology 2014 page 119" href="http://viewer.zmags.com/publication/6b6592a8?page=119"> HEPATOLOGY Omega-3 fighting fatty liver disease OM</a> <a title="EMJ Hepatology 2014 page 120" href="http://viewer.zmags.com/publication/6b6592a8?page=120"> WHAT’S NEW Stop blaming fructose for NAFLD FRUCTO</a> <a title="EMJ Hepatology 2014 page 121" href="http://viewer.zmags.com/publication/6b6592a8?page=121"> HEPATOLOGY Mood-stabilising drug to treat ATD </a> <a title="EMJ Hepatology 2014 page 122" href="http://viewer.zmags.com/publication/6b6592a8?page=122"> WHAT’S NEW Breakthrough potential hepatitis C vac</a> <a title="EMJ Hepatology 2014 page 123" href="http://viewer.zmags.com/publication/6b6592a8?page=123"> HEPATOLOGY Saliva protein reducing mortality in A</a> <a title="EMJ Hepatology 2014 page 124" href="http://viewer.zmags.com/publication/6b6592a8?page=124"> WHAT’S NEW GPB shows promise for cirrhosis patien</a> <a title="EMJ Hepatology 2014 page 125" href="http://viewer.zmags.com/publication/6b6592a8?page=125"> A HISTORY OF INNOVATION. A COMMITMENT TO CHRONIC </a> <a title="EMJ Hepatology 2014 page 126" href="http://viewer.zmags.com/publication/6b6592a8?page=126"> Featured Suppliers Hepatology Almirall is an in</a> <a title="EMJ Hepatology 2014 page 127" href="http://viewer.zmags.com/publication/6b6592a8?page=127"> Bristol-Myers Squibb: at the Core of HCV Research</a> <a title="EMJ Hepatology 2014 page 128" href="http://viewer.zmags.com/publication/6b6592a8?page=128"> Buyer’s Guide & Societies Exhibitors • ABBOTT </a> <a title="EMJ Hepatology 2014 page 129" href="http://viewer.zmags.com/publication/6b6592a8?page=129"> Hepatology Partner Associations • AASLD - AMER</a> <a title="EMJ Hepatology 2014 page 130" href="http://viewer.zmags.com/publication/6b6592a8?page=130"> UPCOMING EVENTS International Liver Transplantat</a> <a title="EMJ Hepatology 2014 page 131" href="http://viewer.zmags.com/publication/6b6592a8?page=131"> HEPATOLOGY European Association for the Study of</a> <a title="EMJ Hepatology 2014 page 132" href="http://viewer.zmags.com/publication/6b6592a8?page=132"> From a host of fifteen therapeutic areas, EUROPEAN</a>