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<br /> SUBSCRIBE<br /> TO RECEIVE<br /> THE LATEST<br /> CATIONS <br /> PUBLI<br /> & UPDATES<br /> FROM A HOST OF FIFTEEN <br /> ETTERS <br /> NEWSL<br /> THERAPEUTIC AREAS<br /> If you are interested in submitting a paper<br /> to EMJ, contact editor@emjreviews.com<br /> Follow us:<br /> www.emjreviews.com<br /> <br /> <br /> NEUROLOGY<br /> ISSN 2054-4529 July 2014 • emjreviews.com<br /> INSIDE<br /> Review of<br /> JOINT CONGRESS OF<br /> EUROPEAN NEUROLOGY 2014<br /> Istanbul, Turkey<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 4<br /> CONGRESS REVIEW.....................................................................<a title="EMJ Neurology 2014 page 1" href="http://viewer.zmags.com/publication/73c492e9?page=1"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS PUBLI</a> <a title="EMJ Neurology 2014 page 2" href="http://viewer.zmags.com/publication/73c492e9?page=2"> NEUROLOGY ISSN 2054-4529 </a> <a title="EMJ Neurology 2014 page 3" href="http://viewer.zmags.com/publication/73c492e9?page=3"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Neurology 2014 page 4" href="http://viewer.zmags.com/publication/73c492e9?page=4"> NEUROLOGY A SCARLET ENEMY OF THE BRAIN – A PRA</a> <a title="EMJ Neurology 2014 page 5" href="http://viewer.zmags.com/publication/73c492e9?page=5"> Editorial Board Neurology Editor-in-Chief: Dr </a> <a title="EMJ Neurology 2014 page 6" href="http://viewer.zmags.com/publication/73c492e9?page=6"> Welcome I am pleased to introduce to you this sec</a> <a title="EMJ Neurology 2014 page 7" href="http://viewer.zmags.com/publication/73c492e9?page=7"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjre</a> <a title="EMJ Neurology 2014 page 8" href="http://viewer.zmags.com/publication/73c492e9?page=8"> Foreword Dr Rita Krishnamurthi </a> <a title="EMJ Neurology 2014 page 9" href="http://viewer.zmags.com/publication/73c492e9?page=9"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 10" href="http://viewer.zmags.com/publication/73c492e9?page=10"> Welcome to the European Medical Journal review of</a> <a title="EMJ Neurology 2014 page 11" href="http://viewer.zmags.com/publication/73c492e9?page=11"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 12" href="http://viewer.zmags.com/publication/73c492e9?page=12"> Alzheimer’s disease (AD). Another stu</a> <a title="EMJ Neurology 2014 page 13" href="http://viewer.zmags.com/publication/73c492e9?page=13"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 14" href="http://viewer.zmags.com/publication/73c492e9?page=14"> One biomarker more for multiple sclerosis </a> <a title="EMJ Neurology 2014 page 15" href="http://viewer.zmags.com/publication/73c492e9?page=15"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 16" href="http://viewer.zmags.com/publication/73c492e9?page=16"> Calling for change in European regulations OPTIMU</a> <a title="EMJ Neurology 2014 page 17" href="http://viewer.zmags.com/publication/73c492e9?page=17"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 18" href="http://viewer.zmags.com/publication/73c492e9?page=18"> Fruit flies: the key to Parkinson’s disease FRUIT </a> <a title="EMJ Neurology 2014 page 19" href="http://viewer.zmags.com/publication/73c492e9?page=19"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 20" href="http://viewer.zmags.com/publication/73c492e9?page=20"> Neurological disorders: the underestimated threat</a> <a title="EMJ Neurology 2014 page 21" href="http://viewer.zmags.com/publication/73c492e9?page=21"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 22" href="http://viewer.zmags.com/publication/73c492e9?page=22"> One small step in the early detection of Parkinso</a> <a title="EMJ Neurology 2014 page 23" href="http://viewer.zmags.com/publication/73c492e9?page=23"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 24" href="http://viewer.zmags.com/publication/73c492e9?page=24"> Women suffer worse outcomes than men after stroke</a> <a title="EMJ Neurology 2014 page 25" href="http://viewer.zmags.com/publication/73c492e9?page=25"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 26" href="http://viewer.zmags.com/publication/73c492e9?page=26"> Drug overuse top ten conditions responsible for t</a> <a title="EMJ Neurology 2014 page 27" href="http://viewer.zmags.com/publication/73c492e9?page=27"> JOINT CONGRESS OF EUROPEAN NEUROLOGY 2014 ISTANBU</a> <a title="EMJ Neurology 2014 page 28" href="http://viewer.zmags.com/publication/73c492e9?page=28"> APOMORPHINE PENJECT – EMERGING EVIDENCE AND TREAT</a> <a title="EMJ Neurology 2014 page 29" href="http://viewer.zmags.com/publication/73c492e9?page=29"> video evidence of real patient cases showing just</a> <a title="EMJ Neurology 2014 page 30" href="http://viewer.zmags.com/publication/73c492e9?page=30"> Levodopa plasma levels (ng/ml) 1400 1200 1000 80</a> <a title="EMJ Neurology 2014 page 31" href="http://viewer.zmags.com/publication/73c492e9?page=31"> therapeutic effect of each levodopa dose is rapid</a> <a title="EMJ Neurology 2014 page 32" href="http://viewer.zmags.com/publication/73c492e9?page=32"> therapies. In addition, they had never been offer</a> <a title="EMJ Neurology 2014 page 33" href="http://viewer.zmags.com/publication/73c492e9?page=33"> 3.50 at baseline to a mean of 2.31 at the end of </a> <a title="EMJ Neurology 2014 page 34" href="http://viewer.zmags.com/publication/73c492e9?page=34"> Case 3 • 78-year-old male with an 18-year history</a> <a title="EMJ Neurology 2014 page 35" href="http://viewer.zmags.com/publication/73c492e9?page=35"> Statement APO2-0614-0489 Date of preparation: Jun</a> <a title="EMJ Neurology 2014 page 36" href="http://viewer.zmags.com/publication/73c492e9?page=36"> AM IMPAKT study interim results out now! Please c</a> <a title="EMJ Neurology 2014 page 37" href="http://viewer.zmags.com/publication/73c492e9?page=37"> THE EVOLVING MS LANDSCAPE: CHALLENGES AND OPPO</a> <a title="EMJ Neurology 2014 page 38" href="http://viewer.zmags.com/publication/73c492e9?page=38"> Adherence plays a crucial role in long-term</a> <a title="EMJ Neurology 2014 page 39" href="http://viewer.zmags.com/publication/73c492e9?page=39"> the TOWER42 studies examined teriflunomide at 7 mg</a> <a title="EMJ Neurology 2014 page 40" href="http://viewer.zmags.com/publication/73c492e9?page=40"> antibody. Based on the knowledge of t</a> <a title="EMJ Neurology 2014 page 41" href="http://viewer.zmags.com/publication/73c492e9?page=41"> and CAMMS223.67 Patients receiving alemtuzumab in</a> <a title="EMJ Neurology 2014 page 42" href="http://viewer.zmags.com/publication/73c492e9?page=42"> term efficacy in chronic disease: use of recursiv</a> <a title="EMJ Neurology 2014 page 43" href="http://viewer.zmags.com/publication/73c492e9?page=43"> reduces MS disease activity in active relaps</a> <a title="EMJ Neurology 2014 page 44" href="http://viewer.zmags.com/publication/73c492e9?page=44"> GE Healthcare What’s going on inside isn’t alwa</a> <a title="EMJ Neurology 2014 page 45" href="http://viewer.zmags.com/publication/73c492e9?page=45"> PARADIGMS: A NEW INITIATIVE TO CUT THROUGH </a> <a title="EMJ Neurology 2014 page 46" href="http://viewer.zmags.com/publication/73c492e9?page=46"> Table 1: The members of ParadigMS. Position N</a> <a title="EMJ Neurology 2014 page 47" href="http://viewer.zmags.com/publication/73c492e9?page=47"> organise by the academy or by an independent team</a> <a title="EMJ Neurology 2014 page 48" href="http://viewer.zmags.com/publication/73c492e9?page=48"> patients who are part of a group who meet along w</a> <a title="EMJ Neurology 2014 page 49" href="http://viewer.zmags.com/publication/73c492e9?page=49"> conference CME new insights p</a> <a title="EMJ Neurology 2014 page 50" href="http://viewer.zmags.com/publication/73c492e9?page=50"> NEUROIMAGING OF ACUTE ISCHAEMIC STROKE: </a> <a title="EMJ Neurology 2014 page 51" href="http://viewer.zmags.com/publication/73c492e9?page=51"> MAGNETIC RESONANCE IMAGING (MRI) IN ACUTE STROKE </a> <a title="EMJ Neurology 2014 page 52" href="http://viewer.zmags.com/publication/73c492e9?page=52"> MTT CBV 12.17 CTA DWI FLAIR 3h 1.56 4h 21d </a> <a title="EMJ Neurology 2014 page 53" href="http://viewer.zmags.com/publication/73c492e9?page=53"> 2): a prospective, randomised, double- blind, pla</a> <a title="EMJ Neurology 2014 page 54" href="http://viewer.zmags.com/publication/73c492e9?page=54"> DEPRESSION AND PSYCHOLOGICAL DISTRESS AS</a> <a title="EMJ Neurology 2014 page 55" href="http://viewer.zmags.com/publication/73c492e9?page=55"> in patients younger than 65 years was 4.2-fold hi</a> <a title="EMJ Neurology 2014 page 56" href="http://viewer.zmags.com/publication/73c492e9?page=56"> Robinson et al.16 described that the use o</a> <a title="EMJ Neurology 2014 page 57" href="http://viewer.zmags.com/publication/73c492e9?page=57"> Table 1: Overview of prospective placebo-controll</a> <a title="EMJ Neurology 2014 page 58" href="http://viewer.zmags.com/publication/73c492e9?page=58"> ranged from 55-77 years. The effect of treatment </a> <a title="EMJ Neurology 2014 page 59" href="http://viewer.zmags.com/publication/73c492e9?page=59"> 26. Wassertheil-Smoller S et al. Depr</a> <a title="EMJ Neurology 2014 page 60" href="http://viewer.zmags.com/publication/73c492e9?page=60"> IMAGING AND TREATMENT DECISIONS IN SEIZ</a> <a title="EMJ Neurology 2014 page 61" href="http://viewer.zmags.com/publication/73c492e9?page=61"> safe for the patient, it is also the preferred me</a> <a title="EMJ Neurology 2014 page 62" href="http://viewer.zmags.com/publication/73c492e9?page=62"> 45 degrees. Therefore atrophy as well as signal i</a> <a title="EMJ Neurology 2014 page 63" href="http://viewer.zmags.com/publication/73c492e9?page=63"> Implication on Structural Lesion and Treatment De</a> <a title="EMJ Neurology 2014 page 64" href="http://viewer.zmags.com/publication/73c492e9?page=64"> CONCLUSION In summary, imaging in epilepsy needs</a> <a title="EMJ Neurology 2014 page 65" href="http://viewer.zmags.com/publication/73c492e9?page=65"> 28. Wagner J et al. Morphometric MRI analysis im</a> <a title="EMJ Neurology 2014 page 66" href="http://viewer.zmags.com/publication/73c492e9?page=66"> A SCARLET ENEMY OF THE BRAIN – A PRACTICAL APPROA</a> <a title="EMJ Neurology 2014 page 67" href="http://viewer.zmags.com/publication/73c492e9?page=67"> Table 1: Causes of subarachnoid haemorrhage with </a> <a title="EMJ Neurology 2014 page 68" href="http://viewer.zmags.com/publication/73c492e9?page=68"> ab Figure 2: a) Gradient echo T2 scan (T2*) show</a> <a title="EMJ Neurology 2014 page 69" href="http://viewer.zmags.com/publication/73c492e9?page=69"> Some patients with convexal subarachnoid </a> <a title="EMJ Neurology 2014 page 70" href="http://viewer.zmags.com/publication/73c492e9?page=70"> It is important to recognise CAA-related inflammat</a> <a title="EMJ Neurology 2014 page 71" href="http://viewer.zmags.com/publication/73c492e9?page=71"> Table 2: Classic and modified Boston criteria for </a> <a title="EMJ Neurology 2014 page 72" href="http://viewer.zmags.com/publication/73c492e9?page=72"> Neurology. 2013;81(7):626–32. 6. Linn J et al. Pr</a> <a title="EMJ Neurology 2014 page 73" href="http://viewer.zmags.com/publication/73c492e9?page=73"> ENCEPHALOPATHY ASSOCIATED WITH AUTOIMMUNE TH</a> <a title="EMJ Neurology 2014 page 74" href="http://viewer.zmags.com/publication/73c492e9?page=74"> seems to be the underlying cause.10,11 Seve</a> <a title="EMJ Neurology 2014 page 75" href="http://viewer.zmags.com/publication/73c492e9?page=75"> picture of hypothyroidism to a certain degree of </a> <a title="EMJ Neurology 2014 page 76" href="http://viewer.zmags.com/publication/73c492e9?page=76"> and EEG are also required for EAATD diagnosis and</a> <a title="EMJ Neurology 2014 page 77" href="http://viewer.zmags.com/publication/73c492e9?page=77"> thyroiditis (SREAT) has been proposed as a </a> <a title="EMJ Neurology 2014 page 78" href="http://viewer.zmags.com/publication/73c492e9?page=78"> “Hashimoto’s encephalopathy”). Clin Ter. 2005;156</a> <a title="EMJ Neurology 2014 page 79" href="http://viewer.zmags.com/publication/73c492e9?page=79"> CURRENT CONCEPTS OF NEURODEGENERATIVE DIS</a> <a title="EMJ Neurology 2014 page 80" href="http://viewer.zmags.com/publication/73c492e9?page=80"> In most cases, there is an overlap and convergenc</a> <a title="EMJ Neurology 2014 page 81" href="http://viewer.zmags.com/publication/73c492e9?page=81"> FTD + MD </a> <a title="EMJ Neurology 2014 page 82" href="http://viewer.zmags.com/publication/73c492e9?page=82"> a) Extracellular deposits comprise deposits with </a> <a title="EMJ Neurology 2014 page 83" href="http://viewer.zmags.com/publication/73c492e9?page=83"> Table 1: Overview of neurodegenerative diseases a</a> <a title="EMJ Neurology 2014 page 84" href="http://viewer.zmags.com/publication/73c492e9?page=84"> 4. Clinico-Neuropathological Correlations Differe</a> <a title="EMJ Neurology 2014 page 85" href="http://viewer.zmags.com/publication/73c492e9?page=85"> or argyrophilic grain disease (AGD) (up to 30- 40</a> <a title="EMJ Neurology 2014 page 86" href="http://viewer.zmags.com/publication/73c492e9?page=86"> protein deposit than from an intracellular inclus</a> <a title="EMJ Neurology 2014 page 87" href="http://viewer.zmags.com/publication/73c492e9?page=87"> 43 pathology and hippocampal sclerosis in progres</a> <a title="EMJ Neurology 2014 page 88" href="http://viewer.zmags.com/publication/73c492e9?page=88"> A NOTE ON CHANGING APPROACH TO DIAGNOSIS OF ALZHE</a> <a title="EMJ Neurology 2014 page 89" href="http://viewer.zmags.com/publication/73c492e9?page=89"> Contrariwise, the new criteria maintain that AD-P</a> <a title="EMJ Neurology 2014 page 90" href="http://viewer.zmags.com/publication/73c492e9?page=90"> Table 2: National Institute of Aging and the Alzh</a> <a title="EMJ Neurology 2014 page 91" href="http://viewer.zmags.com/publication/73c492e9?page=91"> Conversion from prodromal at risk state to AD mig</a> <a title="EMJ Neurology 2014 page 92" href="http://viewer.zmags.com/publication/73c492e9?page=92"> Frequency (%) 50 40 30 20 10 0 Pre</a> <a title="EMJ Neurology 2014 page 93" href="http://viewer.zmags.com/publication/73c492e9?page=93"> At the other extreme of the continuum, the</a> <a title="EMJ Neurology 2014 page 94" href="http://viewer.zmags.com/publication/73c492e9?page=94"> Useful information comes from amyloid</a> <a title="EMJ Neurology 2014 page 95" href="http://viewer.zmags.com/publication/73c492e9?page=95"> Lancet Neurol. 2013;12:357-67. 25. Schneider LS. </a> <a title="EMJ Neurology 2014 page 96" href="http://viewer.zmags.com/publication/73c492e9?page=96"> NEUROPSYCHIATRIC FEATURES OF PARKINSON’S DI</a> <a title="EMJ Neurology 2014 page 97" href="http://viewer.zmags.com/publication/73c492e9?page=97"> NPS commonly exist in people with mild cognitive </a> <a title="EMJ Neurology 2014 page 98" href="http://viewer.zmags.com/publication/73c492e9?page=98"> MCI IN PD Until recently, there were no cle</a> <a title="EMJ Neurology 2014 page 99" href="http://viewer.zmags.com/publication/73c492e9?page=99"> depression was significantly more prevalent i</a> <a title="EMJ Neurology 2014 page 100" href="http://viewer.zmags.com/publication/73c492e9?page=100"> Table 2: Most common NPS in Parkinson’s disease w</a> <a title="EMJ Neurology 2014 page 101" href="http://viewer.zmags.com/publication/73c492e9?page=101"> on NPS. We have therefore summarised some o</a> <a title="EMJ Neurology 2014 page 102" href="http://viewer.zmags.com/publication/73c492e9?page=102"> placebo, suggesting that such interventions may h</a> <a title="EMJ Neurology 2014 page 103" href="http://viewer.zmags.com/publication/73c492e9?page=103"> 8. Aarsland D et al. Range of neurops</a> <a title="EMJ Neurology 2014 page 104" href="http://viewer.zmags.com/publication/73c492e9?page=104"> MOTOR SYSTEM PLASTICITY AND COMPENSATION </a> <a title="EMJ Neurology 2014 page 105" href="http://viewer.zmags.com/publication/73c492e9?page=105"> kinds of adaptive changes are attributed to neura</a> <a title="EMJ Neurology 2014 page 106" href="http://viewer.zmags.com/publication/73c492e9?page=106"> We found the PAS-induced enhancement of</a> <a title="EMJ Neurology 2014 page 107" href="http://viewer.zmags.com/publication/73c492e9?page=107"> patients, but partly based on systems different f</a> <a title="EMJ Neurology 2014 page 108" href="http://viewer.zmags.com/publication/73c492e9?page=108"> neocortical–cerebellar functional connectivity </a> <a title="EMJ Neurology 2014 page 109" href="http://viewer.zmags.com/publication/73c492e9?page=109"> preclinical MS benign MS paediatric MS CIS </a> <a title="EMJ Neurology 2014 page 110" href="http://viewer.zmags.com/publication/73c492e9?page=110"> Compared to healthy people, MS patients may</a> <a title="EMJ Neurology 2014 page 111" href="http://viewer.zmags.com/publication/73c492e9?page=111"> repetitive transcranial magnetic stim</a> <a title="EMJ Neurology 2014 page 112" href="http://viewer.zmags.com/publication/73c492e9?page=112"> We're steadfast in our commitment to the MS commu</a> <a title="EMJ Neurology 2014 page 113" href="http://viewer.zmags.com/publication/73c492e9?page=113"> WHAT’S NEW Snail venom rivals morphine monopoly M</a> <a title="EMJ Neurology 2014 page 114" href="http://viewer.zmags.com/publication/73c492e9?page=114"> NEUROLOGY Autism: the </a> <a title="EMJ Neurology 2014 page 115" href="http://viewer.zmags.com/publication/73c492e9?page=115"> WHAT’S NEW Sleepers and dreamers differ in recall</a> <a title="EMJ Neurology 2014 page 116" href="http://viewer.zmags.com/publication/73c492e9?page=116"> NEUROLOGY Statins: the guardian of nerves BRAIN </a> <a title="EMJ Neurology 2014 page 117" href="http://viewer.zmags.com/publication/73c492e9?page=117"> WHAT’S NEW REST is all you need to protect from d</a> <a title="EMJ Neurology 2014 page 118" href="http://viewer.zmags.com/publication/73c492e9?page=118"> NEUROLOGY Headgear </a> <a title="EMJ Neurology 2014 page 119" href="http://viewer.zmags.com/publication/73c492e9?page=119"> WHAT’S NEW Tunnelling for Alzheimer’s cure “We c</a> <a title="EMJ Neurology 2014 page 120" href="http://viewer.zmags.com/publication/73c492e9?page=120"> NEUROLOGY Larger amygdalae shown to instil greate</a> <a title="EMJ Neurology 2014 page 121" href="http://viewer.zmags.com/publication/73c492e9?page=121"> WHAT’S NEW New treatment for alcohol-obsessed bra</a> <a title="EMJ Neurology 2014 page 122" href="http://viewer.zmags.com/publication/73c492e9?page=122"> NEUROLOGY Astrocytes are more than plain old vani</a> <a title="EMJ Neurology 2014 page 123" href="http://viewer.zmags.com/publication/73c492e9?page=123"> WHAT’S NEW Mind shock treatment zaps mentally ill</a> <a title="EMJ Neurology 2014 page 124" href="http://viewer.zmags.com/publication/73c492e9?page=124"> From a host of fifteen therapeutic areas, EUROPEAN</a> <a title="EMJ Neurology 2014 page 125" href="http://viewer.zmags.com/publication/73c492e9?page=125"> Featured Suppliers Neurology Responsible for </a> <a title="EMJ Neurology 2014 page 126" href="http://viewer.zmags.com/publication/73c492e9?page=126"> Buyer’s Guide Exhibitors • ACTELION PHARMACEUT</a> <a title="EMJ Neurology 2014 page 127" href="http://viewer.zmags.com/publication/73c492e9?page=127"> UPCOMING EVENTS Mechanisms of Epilepsy and Neuro</a> <a title="EMJ Neurology 2014 page 128" href="http://viewer.zmags.com/publication/73c492e9?page=128"> NEUROLOGY 44th Annual Meeting of the Society for</a> <a title="EMJ Neurology 2014 page 129" href="http://viewer.zmags.com/publication/73c492e9?page=129"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS PUBLI</a>