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M AY 2 0 1 1<br />
Huntington's Disease:<br />
A Clinical Review<br />
Mark Gudesblatt, MD, and Daniel Tarsy, MD<br />
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Introduction<br />
Huntington's disease is an autosomal dominant,<br />
fully penetrant, progressive, and fatal neurodegen-<br />
erative disease.1,2 Onset of Huntington's disease is<br />
typically in middle age (mean, approximately 40<br />
years); however, the age span includes those both<br />
young and old.3 Disease duration, typically from<br />
diagnosis to death, is approximately 17 years.4<br />
Adult-onset disease is characterized by a triad<br />
of progressive motor, cognitive, anSUPPLEMENT TOM AY 2 0 1 1Huntington's SUPPLEMENT TOM AY 2 0 1 1Huntington's Huntington's Disease: A Clinical ReviewTABL Huntington's Disease: A Clinical ReviewTABLTABLE 2Symptoms of Huntington's disease21Change TABLE 2Symptoms of Huntington's disease21ChangeHuntington's Disease: A Clinical ReviewTABL Huntington's Disease: A Clinical ReviewTABLTABLE 4Psychiatric Symptoms Linked to Huntington TABLE 4Psychiatric Symptoms Linked to HuntingtonHuntington's Disease: A Clinical Reviewin s Huntington's Disease: A Clinical Reviewin suncertainty. A positive test can assist in decisi uncertainty. A positive test can assist in decisiHuntington's Disease: A Clinical Reviewexpe Huntington's Disease: A Clinical Reviewexpe