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<br /> ARCHIVE<br /> 2<br /> VOLUME 112 NUMBER 1 JANUARY 2017<br /> www.nature.com/ajg<br /> official publication of the american college of gastroenterology<br /> LEADING ARTICLES OF THE MONTH<br /> Practice Guidelines<br /> 18 ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries CME<br /> Paul Y. Kwo, Stanley M. Cohen and Joseph K. Lim<br /> 37 Recommendations on Fecal Immunochemical Testing to Screen for<br /> Colorectal Neoplasia: A Consensus Statement by the US<br /> Multi-Society Task Force on Colorectal Cancer<br /> Douglas J. Robertson, Jeffrey K. Lee, C. Richard Boland, Jason A. Dominitz,<br /> Francis M. Giardiello, David A. Johnson, Tonya Kaltenbach,<br /> David Lieberman, Theodore R. Levin and Douglas K. Rex<br /> Clinical and Systematic Reviews<br /> 65 Screening for Celiac Disease in Irritable Bowel Syndrome:<br /> An Upd<a title="AJG_Vol.112.No2 page 1" href="http://viewer.zmags.com/publication/859bb139?page=1"> ARCHIVE 2 VOLUME 112 NUMBER 1 JANUARY 2017 www</a> <a title="AJG_Vol.112.No2 page 2" href="http://viewer.zmags.com/publication/859bb139?page=2"> VOLUME 112 NUMBER 2 FEBRUARY 2017 www.nature.com/</a> <a title="AJG_Vol.112.No2 page 3" href="http://viewer.zmags.com/publication/859bb139?page=3"> Treat IBS-Differently A 2-week treatment for IBS</a> <a title="AJG_Vol.112.No2 page 4" href="http://viewer.zmags.com/publication/859bb139?page=4"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This Bri</a> <a title="AJG_Vol.112.No2 page 5" href="http://viewer.zmags.com/publication/859bb139?page=5"> www.nature.com/ajg The American Journal o</a> <a title="AJG_Vol.112.No2 page 6" href="http://viewer.zmags.com/publication/859bb139?page=6"> WHAT ARE BIOSIMILARS? Let’s Clarify Biosimilar</a> <a title="AJG_Vol.112.No2 page 7" href="http://viewer.zmags.com/publication/859bb139?page=7"> You buy store brands for your family. Recommend t</a> <a title="AJG_Vol.112.No2 page 8" href="http://viewer.zmags.com/publication/859bb139?page=8"> A CURE FOR EVERY TYPE Patients of any HCV genotyp</a> <a title="AJG_Vol.112.No2 page 9" href="http://viewer.zmags.com/publication/859bb139?page=9"> Albert Einstein used with permission of the HUJ/G</a> <a title="AJG_Vol.112.No2 page 10" href="http://viewer.zmags.com/publication/859bb139?page=10"> THE FIRST AND ONLY PAN-GENOTYPIC ONCE-DAILY SINGL</a> <a title="AJG_Vol.112.No2 page 11" href="http://viewer.zmags.com/publication/859bb139?page=11"> HARVONI® (ledipasvir 90 mg and sofosbuvir 400 mg)</a> <a title="AJG_Vol.112.No2 page 12" href="http://viewer.zmags.com/publication/859bb139?page=12"> Brief Summary (cont.) Postmarketing Experience: B</a> <a title="AJG_Vol.112.No2 page 13" href="http://viewer.zmags.com/publication/859bb139?page=13"> EPCLUSA® (sofosbuvir 400 mg and velpatasvir 100 m</a> <a title="AJG_Vol.112.No2 page 14" href="http://viewer.zmags.com/publication/859bb139?page=14"> Brief Summary (cont.) DRUG INTERACTIONS: Sofosbuv</a> <a title="AJG_Vol.112.No2 page 15" href="http://viewer.zmags.com/publication/859bb139?page=15"> official publication of the american college</a> <a title="AJG_Vol.112.No2 page 16" href="http://viewer.zmags.com/publication/859bb139?page=16"> ACCELERATE capsule reading times by up to 64%* </a> <a title="AJG_Vol.112.No2 page 17" href="http://viewer.zmags.com/publication/859bb139?page=17"> Leading the way in gastroenterology. At Children</a> <a title="AJG_Vol.112.No2 page 18" href="http://viewer.zmags.com/publication/859bb139?page=18"> Selected individual images of colon volume during</a> <a title="AJG_Vol.112.No2 page 19" href="http://viewer.zmags.com/publication/859bb139?page=19"> CONTENTS Placebo Lubiprostone Mea</a> <a title="AJG_Vol.112.No2 page 20" href="http://viewer.zmags.com/publication/859bb139?page=20"> www.nature.com/ajg </a> <a title="AJG_Vol.112.No2 page 21" href="http://viewer.zmags.com/publication/859bb139?page=21"> NEW THE FIRST AND ONLY INTERLEUKIN-12 AND INTERLE</a> <a title="AJG_Vol.112.No2 page 22" href="http://viewer.zmags.com/publication/859bb139?page=22"> + STELARA® combines a single intravenous (I</a> <a title="AJG_Vol.112.No2 page 23" href="http://viewer.zmags.com/publication/859bb139?page=23"> Brief Summary of Prescribing Information for STEL</a> <a title="AJG_Vol.112.No2 page 24" href="http://viewer.zmags.com/publication/859bb139?page=24"> STELARA® (ustekinumab) Table 2: Common adverse re</a> <a title="AJG_Vol.112.No2 page 25" href="http://viewer.zmags.com/publication/859bb139?page=25"> VEMLIDY is a novel, targeted prodrug of tenofovir</a> <a title="AJG_Vol.112.No2 page 26" href="http://viewer.zmags.com/publication/859bb139?page=26"> NOW AVAILABLE FOR THE TREATMENT OF CHRONIC HEPATI</a> <a title="AJG_Vol.112.No2 page 27" href="http://viewer.zmags.com/publication/859bb139?page=27"> VEMLIDY® (tenofovir alafenamide 25mg) tablets, fo</a> <a title="AJG_Vol.112.No2 page 28" href="http://viewer.zmags.com/publication/859bb139?page=28"> Laboratory Abnormalities: Laboratory abnormalitie</a> <a title="AJG_Vol.112.No2 page 29" href="http://viewer.zmags.com/publication/859bb139?page=29"> American College of Gastroenterology & World Gast</a> <a title="AJG_Vol.112.No2 page 30" href="http://viewer.zmags.com/publication/859bb139?page=30"> #1 MOST PRESCRIBED, BRANDED BOWEL PREP KIT1 </a> <a title="AJG_Vol.112.No2 page 31" href="http://viewer.zmags.com/publication/859bb139?page=31"> IMPORTANT SAFETY INFORMATION SUPREP® Bowel Prep K</a> <a title="AJG_Vol.112.No2 page 32" href="http://viewer.zmags.com/publication/859bb139?page=32"> FOR PATIENTS WITH ACTIVE, MILD TO MODERATE ULCERA</a> <a title="AJG_Vol.112.No2 page 33" href="http://viewer.zmags.com/publication/859bb139?page=33"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This bri</a> <a title="AJG_Vol.112.No2 page 34" href="http://viewer.zmags.com/publication/859bb139?page=34"> PROVIDING ACHALASIA PATIENTS WITH OPTIONS INSTEAD</a> <a title="AJG_Vol.112.No2 page 35" href="http://viewer.zmags.com/publication/859bb139?page=35"> Attend an ACG Regional Postgraduate Course close </a> <a title="AJG_Vol.112.No2 page 36" href="http://viewer.zmags.com/publication/859bb139?page=36"> 2017 ACG AWARD NOMINATIONS Honor Your Colleague </a> <a title="AJG_Vol.112.No2 page 37" href="http://viewer.zmags.com/publication/859bb139?page=37"> RECOMMEND THE MOST POWERFUL OTC PPI FROM THE STAR</a> <a title="AJG_Vol.112.No2 page 38" href="http://viewer.zmags.com/publication/859bb139?page=38"> THE RED SECTION 195 see related editorial</a> <a title="AJG_Vol.112.No2 page 39" href="http://viewer.zmags.com/publication/859bb139?page=39"> 196 THE RED SECTION HOW I APPROACH IT Ini</a> <a title="AJG_Vol.112.No2 page 40" href="http://viewer.zmags.com/publication/859bb139?page=40"> THE RED SECTION 197 see related editorial</a> <a title="AJG_Vol.112.No2 page 41" href="http://viewer.zmags.com/publication/859bb139?page=41"> 198 THE RED SECTION Baseline 6 f</a> <a title="AJG_Vol.112.No2 page 42" href="http://viewer.zmags.com/publication/859bb139?page=42"> Pre-dilation Post-dilation Pa</a> <a title="AJG_Vol.112.No2 page 43" href="http://viewer.zmags.com/publication/859bb139?page=43"> 200 THE RED SECTION HOW I APPROACH IT INTROD</a> <a title="AJG_Vol.112.No2 page 44" href="http://viewer.zmags.com/publication/859bb139?page=44"> Table 1. Overview of management in patients with </a> <a title="AJG_Vol.112.No2 page 45" href="http://viewer.zmags.com/publication/859bb139?page=45"> 202 THE RED SECTION </a> <a title="AJG_Vol.112.No2 page 46" href="http://viewer.zmags.com/publication/859bb139?page=46"> Table 4. King’s College Criteria—prognostic model</a> <a title="AJG_Vol.112.No2 page 47" href="http://viewer.zmags.com/publication/859bb139?page=47"> 204 THE RED SECTION HOW I APPROACH IT Table </a> <a title="AJG_Vol.112.No2 page 48" href="http://viewer.zmags.com/publication/859bb139?page=48"> THE RED SECTION 205 Table 5. Continued Organ</a> <a title="AJG_Vol.112.No2 page 49" href="http://viewer.zmags.com/publication/859bb139?page=49"> 206 THE RED SECTION HOW I APPROACH IT PROGNO</a> <a title="AJG_Vol.112.No2 page 50" href="http://viewer.zmags.com/publication/859bb139?page=50"> Springer Nature </a> <a title="AJG_Vol.112.No2 page 51" href="http://viewer.zmags.com/publication/859bb139?page=51"> 208 THE RED SECTION An Ingested Fish Bone </a> <a title="AJG_Vol.112.No2 page 52" href="http://viewer.zmags.com/publication/859bb139?page=52"> THE RED SECTION 209 Bile Duct Stricture Af</a> <a title="AJG_Vol.112.No2 page 53" href="http://viewer.zmags.com/publication/859bb139?page=53"> 210 THE RED SECTION Video of the Month En</a> <a title="AJG_Vol.112.No2 page 54" href="http://viewer.zmags.com/publication/859bb139?page=54"> CLINICAL GUIDELINES 211 CME Continuing M</a> <a title="AJG_Vol.112.No2 page 55" href="http://viewer.zmags.com/publication/859bb139?page=55"> 212 CLINICAL GUIDELINES CME ACG Clinical</a> <a title="AJG_Vol.112.No2 page 56" href="http://viewer.zmags.com/publication/859bb139?page=56"> research would be expected to have an impact on t</a> <a title="AJG_Vol.112.No2 page 57" href="http://viewer.zmags.com/publication/859bb139?page=57"> 214 Chey et al. Table 1. Recommendation st</a> <a title="AJG_Vol.112.No2 page 58" href="http://viewer.zmags.com/publication/859bb139?page=58"> Treatment of H. pylori Infection 215 Table </a> <a title="AJG_Vol.112.No2 page 59" href="http://viewer.zmags.com/publication/859bb139?page=59"> 216 Chey et al. The ACG’s 2007 treatmen</a> <a title="AJG_Vol.112.No2 page 60" href="http://viewer.zmags.com/publication/859bb139?page=60"> H -receptor antagonist in managing dyspepsia (rel</a> <a title="AJG_Vol.112.No2 page 61" href="http://viewer.zmags.com/publication/859bb139?page=61"> 218 Chey et al. cardiovascular event (56)</a> <a title="AJG_Vol.112.No2 page 62" href="http://viewer.zmags.com/publication/859bb139?page=62"> H. pylori infection be considered in adults with </a> <a title="AJG_Vol.112.No2 page 63" href="http://viewer.zmags.com/publication/859bb139?page=63"> 220 Chey et al. Sequential therapy </a> <a title="AJG_Vol.112.No2 page 64" href="http://viewer.zmags.com/publication/859bb139?page=64"> Treatment of H. pylori Infection 221 Table </a> <a title="AJG_Vol.112.No2 page 65" href="http://viewer.zmags.com/publication/859bb139?page=65"> 222 Chey et al. Key Questions: 1. Is th</a> <a title="AJG_Vol.112.No2 page 66" href="http://viewer.zmags.com/publication/859bb139?page=66"> that the two treatments had similar efficacy, com</a> <a title="AJG_Vol.112.No2 page 67" href="http://viewer.zmags.com/publication/859bb139?page=67"> 224 Chey et al. was observed (RR 0.95; 95</a> <a title="AJG_Vol.112.No2 page 68" href="http://viewer.zmags.com/publication/859bb139?page=68"> Similar to many of the other newer therapies fo</a> <a title="AJG_Vol.112.No2 page 69" href="http://viewer.zmags.com/publication/859bb139?page=69"> 226 Chey et al. unlike clarithromycin and</a> <a title="AJG_Vol.112.No2 page 70" href="http://viewer.zmags.com/publication/859bb139?page=70"> not suitable for identifying metronidazole resist</a> <a title="AJG_Vol.112.No2 page 71" href="http://viewer.zmags.com/publication/859bb139?page=71"> 228 Chey et al. Bismuth quadruple t</a> <a title="AJG_Vol.112.No2 page 72" href="http://viewer.zmags.com/publication/859bb139?page=72"> Treatment of H. pylori Infection 229 Pers</a> <a title="AJG_Vol.112.No2 page 73" href="http://viewer.zmags.com/publication/859bb139?page=73"> 230 Chey et al. Levofloxacin triple</a> <a title="AJG_Vol.112.No2 page 74" href="http://viewer.zmags.com/publication/859bb139?page=74"> As mentioned above, repeating the same triple re</a> <a title="AJG_Vol.112.No2 page 75" href="http://viewer.zmags.com/publication/859bb139?page=75"> 232 Chey et al. We were unable to ident</a> <a title="AJG_Vol.112.No2 page 76" href="http://viewer.zmags.com/publication/859bb139?page=76"> regimens, which have been found to be most effect</a> <a title="AJG_Vol.112.No2 page 77" href="http://viewer.zmags.com/publication/859bb139?page=77"> 234 Chey et al. 21. Cheung J, Goodman KJ,</a> <a title="AJG_Vol.112.No2 page 78" href="http://viewer.zmags.com/publication/859bb139?page=78"> 68. Lai KC, Lau CS, Ip WY et al. Effect of treat</a> <a title="AJG_Vol.112.No2 page 79" href="http://viewer.zmags.com/publication/859bb139?page=79"> 236 Chey et al. 114. Chiba N, Van Zanten S</a> <a title="AJG_Vol.112.No2 page 80" href="http://viewer.zmags.com/publication/859bb139?page=80"> 160. Hicks LA, Taylor TH Jr., Hunkler RJ. U.S. ou</a> <a title="AJG_Vol.112.No2 page 81" href="http://viewer.zmags.com/publication/859bb139?page=81"> 238 Chey et al. 206. Yang JC, Lin CJ, Wang</a> <a title="AJG_Vol.112.No2 page 82" href="http://viewer.zmags.com/publication/859bb139?page=82"> CLINICAL GUIDELINES 239 CME Continuing M</a> <a title="AJG_Vol.112.No2 page 83" href="http://viewer.zmags.com/publication/859bb139?page=83"> 240 CLINICAL GUIDELINES CME Continuing </a> <a title="AJG_Vol.112.No2 page 84" href="http://viewer.zmags.com/publication/859bb139?page=84"> CLINICAL GUIDELINES 241 CME ACG Clinical </a> <a title="AJG_Vol.112.No2 page 85" href="http://viewer.zmags.com/publication/859bb139?page=85"> 242 Farraye et al. Table 1. Preventive hea</a> <a title="AJG_Vol.112.No2 page 86" href="http://viewer.zmags.com/publication/859bb139?page=86"> Preventive Care in IBD Patients 243 Table 2</a> <a title="AJG_Vol.112.No2 page 87" href="http://viewer.zmags.com/publication/859bb139?page=87"> 244 Farraye et al. Table 3. Live vaccine r</a> <a title="AJG_Vol.112.No2 page 88" href="http://viewer.zmags.com/publication/859bb139?page=88"> Vaccination against influenza has been shown to</a> <a title="AJG_Vol.112.No2 page 89" href="http://viewer.zmags.com/publication/859bb139?page=89"> 246 Farraye et al. time as influenza vacc</a> <a title="AJG_Vol.112.No2 page 90" href="http://viewer.zmags.com/publication/859bb139?page=90"> not tested in immunosuppressed patients, an inact</a> <a title="AJG_Vol.112.No2 page 91" href="http://viewer.zmags.com/publication/859bb139?page=91"> 248 Farraye et al. MENINGOCOCCAL VACCINAT</a> <a title="AJG_Vol.112.No2 page 92" href="http://viewer.zmags.com/publication/859bb139?page=92"> and evidence quality noted are as follows but the</a> <a title="AJG_Vol.112.No2 page 93" href="http://viewer.zmags.com/publication/859bb139?page=93"> 250 Farraye et al. source but scored high</a> <a title="AJG_Vol.112.No2 page 94" href="http://viewer.zmags.com/publication/859bb139?page=94"> In a study on patient adherence, 85 IBD patie</a> <a title="AJG_Vol.112.No2 page 95" href="http://viewer.zmags.com/publication/859bb139?page=95"> 252 Farraye et al. cancer. The risk of me</a> <a title="AJG_Vol.112.No2 page 96" href="http://viewer.zmags.com/publication/859bb139?page=96"> factors such as steroid treatment, systemic effec</a> <a title="AJG_Vol.112.No2 page 97" href="http://viewer.zmags.com/publication/859bb139?page=97"> 254 Farraye et al. teristics, disease com</a> <a title="AJG_Vol.112.No2 page 98" href="http://viewer.zmags.com/publication/859bb139?page=98"> REFERENCES </a> <a title="AJG_Vol.112.No2 page 99" href="http://viewer.zmags.com/publication/859bb139?page=99"> 256 Farraye et al. 50. Nguyen DL, Nguyen </a> <a title="AJG_Vol.112.No2 page 100" href="http://viewer.zmags.com/publication/859bb139?page=100"> 99. Singh H, Nugent Z, Demers AA et al. Screenin</a> <a title="AJG_Vol.112.No2 page 101" href="http://viewer.zmags.com/publication/859bb139?page=101"> 258 Farraye et al. 149. Abbas AM, Almukhta</a> <a title="AJG_Vol.112.No2 page 102" href="http://viewer.zmags.com/publication/859bb139?page=102"> CLINICAL GUIDELINES 259 CME Continuing M</a> <a title="AJG_Vol.112.No2 page 103" href="http://viewer.zmags.com/publication/859bb139?page=103"> 260 CLINICAL AND SYSTEMATIC REVIEWS see r</a> <a title="AJG_Vol.112.No2 page 104" href="http://viewer.zmags.com/publication/859bb139?page=104"> self-expandable metal stent (SEMS) helps to relie</a> <a title="AJG_Vol.112.No2 page 105" href="http://viewer.zmags.com/publication/859bb139?page=105"> 262 Almadi et al. REVIEW The presence of he</a> <a title="AJG_Vol.112.No2 page 106" href="http://viewer.zmags.com/publication/859bb139?page=106"> Use of SEMS Compared With Plastic Stents 263 </a> <a title="AJG_Vol.112.No2 page 107" href="http://viewer.zmags.com/publication/859bb139?page=107"> 264 Almadi et al. REVIEW Table 1. Continued</a> <a title="AJG_Vol.112.No2 page 108" href="http://viewer.zmags.com/publication/859bb139?page=108"> Use of SEMS Compared With Plastic Stents 265 </a> <a title="AJG_Vol.112.No2 page 109" href="http://viewer.zmags.com/publication/859bb139?page=109"> 266 Almadi et al. REVIEW Table 2. Continued</a> <a title="AJG_Vol.112.No2 page 110" href="http://viewer.zmags.com/publication/859bb139?page=110"> Use of SEMS Compared With Plastic Stents 267 </a> <a title="AJG_Vol.112.No2 page 111" href="http://viewer.zmags.com/publication/859bb139?page=111"> 268 Almadi et al. REVIEW Study </a> <a title="AJG_Vol.112.No2 page 112" href="http://viewer.zmags.com/publication/859bb139?page=112"> Use of SEMS Compared With Plastic Stents 269 </a> <a title="AJG_Vol.112.No2 page 113" href="http://viewer.zmags.com/publication/859bb139?page=113"> 270 Almadi et al. SEMS </a> <a title="AJG_Vol.112.No2 page 114" href="http://viewer.zmags.com/publication/859bb139?page=114"> Use of SEMS Compared With Plastic Stents 271 </a> <a title="AJG_Vol.112.No2 page 115" href="http://viewer.zmags.com/publication/859bb139?page=115"> 272 Almadi et al. REVIEW CONCLUSION The cur</a> <a title="AJG_Vol.112.No2 page 116" href="http://viewer.zmags.com/publication/859bb139?page=116"> 27. Pinol V, Castells A, Bordas JM et al. Percuta</a> <a title="AJG_Vol.112.No2 page 117" href="http://viewer.zmags.com/publication/859bb139?page=117"> CLINICAL AND SYSTEMATIC REVIEWS 274 </a> <a title="AJG_Vol.112.No2 page 118" href="http://viewer.zmags.com/publication/859bb139?page=118"> and Mannucci et al. (19) aimed to see whether or </a> <a title="AJG_Vol.112.No2 page 119" href="http://viewer.zmags.com/publication/859bb139?page=119"> 276 Tripodi et al. Procoagulant drivers </a> <a title="AJG_Vol.112.No2 page 120" href="http://viewer.zmags.com/publication/859bb139?page=120"> operating in vivo than platelet aggregation tests</a> <a title="AJG_Vol.112.No2 page 121" href="http://viewer.zmags.com/publication/859bb139?page=121"> 278 Tripodi et al. REVIEW PTnormal)ISIliver</a> <a title="AJG_Vol.112.No2 page 122" href="http://viewer.zmags.com/publication/859bb139?page=122"> receive prophylaxis with FFP or coagulation facto</a> <a title="AJG_Vol.112.No2 page 123" href="http://viewer.zmags.com/publication/859bb139?page=123"> 280 Tripodi et al. Translating these adva</a> <a title="AJG_Vol.112.No2 page 124" href="http://viewer.zmags.com/publication/859bb139?page=124"> 39. Lisman T, Bongers TN, Adelmeijer J et al. Ele</a> <a title="AJG_Vol.112.No2 page 125" href="http://viewer.zmags.com/publication/859bb139?page=125"> 282 ORIGINAL CONTRIBUTIONS see related ed</a> <a title="AJG_Vol.112.No2 page 126" href="http://viewer.zmags.com/publication/859bb139?page=126"> than aspirin (2). Clopidogrel monotherapy is also</a> <a title="AJG_Vol.112.No2 page 127" href="http://viewer.zmags.com/publication/859bb139?page=127"> 284 Hsu et al. STOMACH Manufacturing Practi</a> <a title="AJG_Vol.112.No2 page 128" href="http://viewer.zmags.com/publication/859bb139?page=128"> planned to discontinue the trial if difference in</a> <a title="AJG_Vol.112.No2 page 129" href="http://viewer.zmags.com/publication/859bb139?page=129"> 286 Hsu et al. STOMACH Assessed for eligibi</a> <a title="AJG_Vol.112.No2 page 130" href="http://viewer.zmags.com/publication/859bb139?page=130"> Table 1. Baseline characteristics of the patients</a> <a title="AJG_Vol.112.No2 page 131" href="http://viewer.zmags.com/publication/859bb139?page=131"> 288 Hsu et al. STOMACH Table 3. Ischemic ev</a> <a title="AJG_Vol.112.No2 page 132" href="http://viewer.zmags.com/publication/859bb139?page=132"> Study Highlights WHAT IS CURRENT KNOWLEDGE ✓ Ath</a> <a title="AJG_Vol.112.No2 page 133" href="http://viewer.zmags.com/publication/859bb139?page=133"> 290 ORIGINAL CONTRIBUTIONS see related ed</a> <a title="AJG_Vol.112.No2 page 134" href="http://viewer.zmags.com/publication/859bb139?page=134"> procedures has strained the limits of what may be</a> <a title="AJG_Vol.112.No2 page 135" href="http://viewer.zmags.com/publication/859bb139?page=135"> 292 Buxbaum et al. ENDOSCOPY maintained by </a> <a title="AJG_Vol.112.No2 page 136" href="http://viewer.zmags.com/publication/859bb139?page=136"> Table 2. Association between sedation strategy an</a> <a title="AJG_Vol.112.No2 page 137" href="http://viewer.zmags.com/publication/859bb139?page=137"> 294 Buxbaum et al. ENDOSCOPY Table 4. Assoc</a> <a title="AJG_Vol.112.No2 page 138" href="http://viewer.zmags.com/publication/859bb139?page=138"> Randomized trials have shown that the use of p</a> <a title="AJG_Vol.112.No2 page 139" href="http://viewer.zmags.com/publication/859bb139?page=139"> 296 Buxbaum et al. ENDOSCOPY CONFLICT OF IN</a> <a title="AJG_Vol.112.No2 page 140" href="http://viewer.zmags.com/publication/859bb139?page=140"> ORIGINAL CONTRIBUTIONS 297 see related ed</a> <a title="AJG_Vol.112.No2 page 141" href="http://viewer.zmags.com/publication/859bb139?page=141"> 298 Predmore et al. ENDOSCOPY associated wi</a> <a title="AJG_Vol.112.No2 page 142" href="http://viewer.zmags.com/publication/859bb139?page=142"> Anesthesia Service Use During Outpatient Gastroen</a> <a title="AJG_Vol.112.No2 page 143" href="http://viewer.zmags.com/publication/859bb139?page=143"> 300 Predmore et al. ENDOSCOPY lowest rate o</a> <a title="AJG_Vol.112.No2 page 144" href="http://viewer.zmags.com/publication/859bb139?page=144"> Anesthesia Service Use During Outpatient Gastroen</a> <a title="AJG_Vol.112.No2 page 145" href="http://viewer.zmags.com/publication/859bb139?page=145"> 302 Predmore et al. ENDOSCOPY towards a mor</a> <a title="AJG_Vol.112.No2 page 146" href="http://viewer.zmags.com/publication/859bb139?page=146"> EDITORIAL 303 see related articles on pag</a> <a title="AJG_Vol.112.No2 page 147" href="http://viewer.zmags.com/publication/859bb139?page=147"> 304 Inadomi ENDOSCOPY a mathematical model </a> <a title="AJG_Vol.112.No2 page 148" href="http://viewer.zmags.com/publication/859bb139?page=148"> CONFLICT OF INTEREST Guarantor of the article: Jo</a> <a title="AJG_Vol.112.No2 page 149" href="http://viewer.zmags.com/publication/859bb139?page=149"> 306 ORIGINAL CONTRIBUTIONS see related ed</a> <a title="AJG_Vol.112.No2 page 150" href="http://viewer.zmags.com/publication/859bb139?page=150"> Various prognostic models have been developed</a> <a title="AJG_Vol.112.No2 page 151" href="http://viewer.zmags.com/publication/859bb139?page=151"> 308 Garcia-Saenz-de-Sicilia et al. LIVER St</a> <a title="AJG_Vol.112.No2 page 152" href="http://viewer.zmags.com/publication/859bb139?page=152"> Patients admitted with SAH </a> <a title="AJG_Vol.112.No2 page 153" href="http://viewer.zmags.com/publication/859bb139?page=153"> 310 Garcia-Saenz-de-Sicilia et al. LIVER Ta</a> <a title="AJG_Vol.112.No2 page 154" href="http://viewer.zmags.com/publication/859bb139?page=154"> Prediction of Response by Using Lille Model on Da</a> <a title="AJG_Vol.112.No2 page 155" href="http://viewer.zmags.com/publication/859bb139?page=155"> 312 Garcia-Saenz-de-Sicilia et al. LIVER Ta</a> <a title="AJG_Vol.112.No2 page 156" href="http://viewer.zmags.com/publication/859bb139?page=156"> Prediction of Response by Using Lille Model on Da</a> <a title="AJG_Vol.112.No2 page 157" href="http://viewer.zmags.com/publication/859bb139?page=157"> 314 Garcia-Saenz-de-Sicilia et al. LIVER re</a> <a title="AJG_Vol.112.No2 page 158" href="http://viewer.zmags.com/publication/859bb139?page=158"> 15. Bone RC, Balk RA, Cerra FB et al. Definitions</a> <a title="AJG_Vol.112.No2 page 159" href="http://viewer.zmags.com/publication/859bb139?page=159"> 316 ORIGINAL CONTRIBUTIONS see related e</a> <a title="AJG_Vol.112.No2 page 160" href="http://viewer.zmags.com/publication/859bb139?page=160"> Video Games for Covert Hepatic Encephalopathy </a> <a title="AJG_Vol.112.No2 page 161" href="http://viewer.zmags.com/publication/859bb139?page=161"> 318 Bajaj et al. LIVER The period betwee</a> <a title="AJG_Vol.112.No2 page 162" href="http://viewer.zmags.com/publication/859bb139?page=162"> Video Games for Covert Hepatic Encephalopathy </a> <a title="AJG_Vol.112.No2 page 163" href="http://viewer.zmags.com/publication/859bb139?page=163"> 320 Bajaj et al. (mean, 95% CI) NCTA score </a> <a title="AJG_Vol.112.No2 page 164" href="http://viewer.zmags.com/publication/859bb139?page=164"> a 12 11 10 9 </a> <a title="AJG_Vol.112.No2 page 165" href="http://viewer.zmags.com/publication/859bb139?page=165"> 322 Bajaj et al. LIVER R z=+26 mm z=+2</a> <a title="AJG_Vol.112.No2 page 166" href="http://viewer.zmags.com/publication/859bb139?page=166"> research is warranted including a larger study sa</a> <a title="AJG_Vol.112.No2 page 167" href="http://viewer.zmags.com/publication/859bb139?page=167"> 324 Bajaj et al. LIVER 28. Lampit A, Halloc</a> <a title="AJG_Vol.112.No2 page 168" href="http://viewer.zmags.com/publication/859bb139?page=168"> ORIGINAL CONTRIBUTIONS 325 see related edi</a> <a title="AJG_Vol.112.No2 page 169" href="http://viewer.zmags.com/publication/859bb139?page=169"> 326 Jeuring et al. INFLAMMATORY BOWEL DISEAS</a> <a title="AJG_Vol.112.No2 page 170" href="http://viewer.zmags.com/publication/859bb139?page=170"> Immunomodulators comprised azathioprine, mercap</a> <a title="AJG_Vol.112.No2 page 171" href="http://viewer.zmags.com/publication/859bb139?page=171"> 328 Jeuring et al. INFLAMMATORY BOWEL DISEAS</a> <a title="AJG_Vol.112.No2 page 172" href="http://viewer.zmags.com/publication/859bb139?page=172"> a Distribution of disease behavior over course</a> <a title="AJG_Vol.112.No2 page 173" href="http://viewer.zmags.com/publication/859bb139?page=173"> 330 Jeuring et al. INFLAMMATORY BOWEL DISEAS</a> <a title="AJG_Vol.112.No2 page 174" href="http://viewer.zmags.com/publication/859bb139?page=174"> Changes in Long-Term Outcome of Crohn’s Disease </a> <a title="AJG_Vol.112.No2 page 175" href="http://viewer.zmags.com/publication/859bb139?page=175"> 332 Jeuring et al. a Cumulative</a> <a title="AJG_Vol.112.No2 page 176" href="http://viewer.zmags.com/publication/859bb139?page=176"> Changes in Long-Term Outcome of Crohn’s Disease </a> <a title="AJG_Vol.112.No2 page 177" href="http://viewer.zmags.com/publication/859bb139?page=177"> 334 Jeuring et al. INFLAMMATORY BOWEL DISEAS</a> <a title="AJG_Vol.112.No2 page 178" href="http://viewer.zmags.com/publication/859bb139?page=178"> Study Highlights WHAT IS CURRENT KNOWLEDGE ✓ The</a> <a title="AJG_Vol.112.No2 page 179" href="http://viewer.zmags.com/publication/859bb139?page=179"> 336 Jeuring et al. INFLAMMATORY BOWEL DISEAS</a> <a title="AJG_Vol.112.No2 page 180" href="http://viewer.zmags.com/publication/859bb139?page=180"> ORIGINAL CONTRIBUTIONS 337 see related ed</a> <a title="AJG_Vol.112.No2 page 181" href="http://viewer.zmags.com/publication/859bb139?page=181"> 338 Fumery et al. INFLAMMATORY BOWEL DISEASE</a> <a title="AJG_Vol.112.No2 page 182" href="http://viewer.zmags.com/publication/859bb139?page=182"> Postoperative Complications in Crohn’s Disease </a> <a title="AJG_Vol.112.No2 page 183" href="http://viewer.zmags.com/publication/859bb139?page=183"> 340 Fumery et al. INFLAMMATORY BOWEL DISEASE</a> <a title="AJG_Vol.112.No2 page 184" href="http://viewer.zmags.com/publication/859bb139?page=184"> Postoperative Complications in Crohn’s Disease </a> <a title="AJG_Vol.112.No2 page 185" href="http://viewer.zmags.com/publication/859bb139?page=185"> 342 Fumery et al. 100% 95% Two-stage</a> <a title="AJG_Vol.112.No2 page 186" href="http://viewer.zmags.com/publication/859bb139?page=186"> preoperative corticosteroid use, and the presence</a> <a title="AJG_Vol.112.No2 page 187" href="http://viewer.zmags.com/publication/859bb139?page=187"> 344 Fumery et al. Yoram Bouhnik, Olivier </a> <a title="AJG_Vol.112.No2 page 188" href="http://viewer.zmags.com/publication/859bb139?page=188"> 14. Dindo D, Demartines N, Clavien PA. Classifica</a> <a title="AJG_Vol.112.No2 page 189" href="http://viewer.zmags.com/publication/859bb139?page=189"> 346 ORIGINAL CONTRIBUTIONS FUNCTIONAL GI DISO</a> <a title="AJG_Vol.112.No2 page 190" href="http://viewer.zmags.com/publication/859bb139?page=190"> with decreased small bowel water content (SBWC) (</a> <a title="AJG_Vol.112.No2 page 191" href="http://viewer.zmags.com/publication/859bb139?page=191"> 348 Lam et al. MRI scanning –45 </a> <a title="AJG_Vol.112.No2 page 192" href="http://viewer.zmags.com/publication/859bb139?page=192"> Regional Intestinal Volumes in IBS 349 Tabl</a> <a title="AJG_Vol.112.No2 page 193" href="http://viewer.zmags.com/publication/859bb139?page=193"> 350 Lam et al. a 300 200 </a> <a title="AJG_Vol.112.No2 page 194" href="http://viewer.zmags.com/publication/859bb139?page=194"> Regional Intestinal Volumes in IBS 351 Tabl</a> <a title="AJG_Vol.112.No2 page 195" href="http://viewer.zmags.com/publication/859bb139?page=195"> 352 Lam et al. 200 150 100 50 </a> <a title="AJG_Vol.112.No2 page 196" href="http://viewer.zmags.com/publication/859bb139?page=196"> Regional Intestinal Volumes in IBS 353 IBS</a> <a title="AJG_Vol.112.No2 page 197" href="http://viewer.zmags.com/publication/859bb139?page=197"> 354 Lam et al. FUNCTIONAL GI DISORDERS Limi</a> <a title="AJG_Vol.112.No2 page 198" href="http://viewer.zmags.com/publication/859bb139?page=198"> Study Highlights WHAT IS CURRENT KNOWLEDGE ✓ The</a> <a title="AJG_Vol.112.No2 page 199" href="http://viewer.zmags.com/publication/859bb139?page=199"> 356 ORIGINAL CONTRIBUTIONS see related e</a> <a title="AJG_Vol.112.No2 page 200" href="http://viewer.zmags.com/publication/859bb139?page=200"> occurs in approximated two-thirds of patients wit</a> <a title="AJG_Vol.112.No2 page 201" href="http://viewer.zmags.com/publication/859bb139?page=201"> ORIGINAL CONTRIBUTIONS 358 Christie</a> <a title="AJG_Vol.112.No2 page 202" href="http://viewer.zmags.com/publication/859bb139?page=202"> Table 1. Patient demographics and baseline charac</a> <a title="AJG_Vol.112.No2 page 203" href="http://viewer.zmags.com/publication/859bb139?page=203"> ORIGINAL CONTRIBUTIONS 360 Christie</a> <a title="AJG_Vol.112.No2 page 204" href="http://viewer.zmags.com/publication/859bb139?page=204"> Lubiprostone in Diabetics With Constipation 36</a> <a title="AJG_Vol.112.No2 page 205" href="http://viewer.zmags.com/publication/859bb139?page=205"> ORIGINAL CONTRIBUTIONS 362 Christie</a> <a title="AJG_Vol.112.No2 page 206" href="http://viewer.zmags.com/publication/859bb139?page=206"> Importantly, we utilized the wireless motility</a> <a title="AJG_Vol.112.No2 page 207" href="http://viewer.zmags.com/publication/859bb139?page=207"> ORIGINAL CONTRIBUTIONS 364 Christie</a> <a title="AJG_Vol.112.No2 page 208" href="http://viewer.zmags.com/publication/859bb139?page=208"> ORIGINAL CONTRIBUTIONS 365 see related ed</a> <a title="AJG_Vol.112.No2 page 209" href="http://viewer.zmags.com/publication/859bb139?page=209"> 366 Cash et al. FUNCTIONAL GI DISORDERS hav</a> <a title="AJG_Vol.112.No2 page 210" href="http://viewer.zmags.com/publication/859bb139?page=210"> criteria: abdominal pain suggestive of biliary or</a> <a title="AJG_Vol.112.No2 page 211" href="http://viewer.zmags.com/publication/859bb139?page=211"> 368 Cash et al. FUNCTIONAL GI DISORDERS AEs</a> <a title="AJG_Vol.112.No2 page 212" href="http://viewer.zmags.com/publication/859bb139?page=212"> Eluxadoline Safety in IBS-D 369 Table 2. Su</a> <a title="AJG_Vol.112.No2 page 213" href="http://viewer.zmags.com/publication/859bb139?page=213"> 370 Cash et al. FUNCTIONAL GI DISORDERS Tab</a> <a title="AJG_Vol.112.No2 page 214" href="http://viewer.zmags.com/publication/859bb139?page=214"> first 3 months of treatment was also similar acro</a> <a title="AJG_Vol.112.No2 page 215" href="http://viewer.zmags.com/publication/859bb139?page=215"> 372 Cash et al. FUNCTIONAL GI DISORDERS AEs</a> <a title="AJG_Vol.112.No2 page 216" href="http://viewer.zmags.com/publication/859bb139?page=216"> causal relationship with eluxadoline for these ev</a> <a title="AJG_Vol.112.No2 page 217" href="http://viewer.zmags.com/publication/859bb139?page=217"> 374 Cash et al. FUNCTIONAL GI DISORDERS 5. </a> <a title="AJG_Vol.112.No2 page 218" href="http://viewer.zmags.com/publication/859bb139?page=218"> ORIGINAL CONTRIBUTIONS 375 see related edi</a> <a title="AJG_Vol.112.No2 page 219" href="http://viewer.zmags.com/publication/859bb139?page=219"> 376 Issaka et al. COLON/SMALL BOWEL Impli</a> <a title="AJG_Vol.112.No2 page 220" href="http://viewer.zmags.com/publication/859bb139?page=220"> Colonoscopy Utilization in Safety-Net System 3</a> <a title="AJG_Vol.112.No2 page 221" href="http://viewer.zmags.com/publication/859bb139?page=221"> 378 Issaka et al. COLON/SMALL BOWEL Table 1</a> <a title="AJG_Vol.112.No2 page 222" href="http://viewer.zmags.com/publication/859bb139?page=222"> Colonoscopy Utilization in Safety-Net System 3</a> <a title="AJG_Vol.112.No2 page 223" href="http://viewer.zmags.com/publication/859bb139?page=223"> 380 Issaka et al. COLON/SMALL BOWEL decline</a> <a title="AJG_Vol.112.No2 page 224" href="http://viewer.zmags.com/publication/859bb139?page=224"> primary and specialty care and their patients and</a> <a title="AJG_Vol.112.No2 page 225" href="http://viewer.zmags.com/publication/859bb139?page=225"> 382 Issaka et al. COLON/SMALL BOWEL REFEREN</a> <a title="AJG_Vol.112.No2 page 226" href="http://viewer.zmags.com/publication/859bb139?page=226"> LETTERS TO THE EDITOR 383 Statins Reduce</a> <a title="AJG_Vol.112.No2 page 227" href="http://viewer.zmags.com/publication/859bb139?page=227"> 384 Letters to the Editor Table 1. Risk fac</a> <a title="AJG_Vol.112.No2 page 228" href="http://viewer.zmags.com/publication/859bb139?page=228"> models (1), and protecting from acute liver failu</a> <a title="AJG_Vol.112.No2 page 229" href="http://viewer.zmags.com/publication/859bb139?page=229"> 386 Letters to the Editor Table 2. Risk fac</a> <a title="AJG_Vol.112.No2 page 230" href="http://viewer.zmags.com/publication/859bb139?page=230"> Letters to the Editor 387 drugs are well d</a> <a title="AJG_Vol.112.No2 page 231" href="http://viewer.zmags.com/publication/859bb139?page=231"> 388 Letters to the Editor Table 2. Risk fac</a> <a title="AJG_Vol.112.No2 page 232" href="http://viewer.zmags.com/publication/859bb139?page=232"> Second, the reasons for endotracheal intubation </a> <a title="AJG_Vol.112.No2 page 233" href="http://viewer.zmags.com/publication/859bb139?page=233"> 390 Letters to the Editor 4. American Soc</a> <a title="AJG_Vol.112.No2 page 234" href="http://viewer.zmags.com/publication/859bb139?page=234"> To the Editor: We read with interest the study by</a> <a title="AJG_Vol.112.No2 page 235" href="http://viewer.zmags.com/publication/859bb139?page=235"> 392 Letters to the Editor compared to good</a> <a title="AJG_Vol.112.No2 page 236" href="http://viewer.zmags.com/publication/859bb139?page=236"> CVID and Celiac Disease Silje F Jørgensen, MD1,2</a> <a title="AJG_Vol.112.No2 page 237" href="http://viewer.zmags.com/publication/859bb139?page=237"> 394 Letters to the Editor </a> <a title="AJG_Vol.112.No2 page 238" href="http://viewer.zmags.com/publication/859bb139?page=238"> also repeated the post-test when the cam- paign w</a> <a title="AJG_Vol.112.No2 page 239" href="http://viewer.zmags.com/publication/859bb139?page=239"> 396 Letters to the Editor even further to </a> <a title="AJG_Vol.112.No2 page 240" href="http://viewer.zmags.com/publication/859bb139?page=240"> Letters to the Editor 397 a f</a> <a title="AJG_Vol.112.No2 page 241" href="http://viewer.zmags.com/publication/859bb139?page=241"> 398 Letters to the Editor 1Department of D</a> <a title="AJG_Vol.112.No2 page 242" href="http://viewer.zmags.com/publication/859bb139?page=242"> a b c </a> <a title="AJG_Vol.112.No2 page 243" href="http://viewer.zmags.com/publication/859bb139?page=243"> 400 Letters to the Editor and only public </a> <a title="AJG_Vol.112.No2 page 244" href="http://viewer.zmags.com/publication/859bb139?page=244"> ANNOUNCEMENTS 401 CALENDAR OF COURSES, S</a> <a title="AJG_Vol.112.No2 page 245" href="http://viewer.zmags.com/publication/859bb139?page=245"> 402 ERRATA, CORRIGENDA AND RETRACTIONS Corr</a> <a title="AJG_Vol.112.No2 page 246" href="http://viewer.zmags.com/publication/859bb139?page=246"> CLASSIFIEDS Simple life. 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