<br />
SUPPLEMENT TO<br />
www.neurologyreviews.com<br />
MARCH 2012<br />
Advances in Identifying<br />
and Treating Lennox-<br />
Gastaut Syndrome:<br />
Do You Know LGS When You See It?<br />
Selim R. Benbadis, MD, and Raj D. Sheth, MD<br />
Introduction<br />
Lennox-Gastaut Syndrome (LGS) is an age-specific<br />
epileptic encephalopathy that represents a response<br />
of the immature brain to a variety of insults.1,2 LGS<br />
has a childhood onset but persists into adulthood, is<br />
often refractory to antiepileptic drugs (AEDs), and<br />
remains one of the most difficult epileptic disorders for<br />
both general and pediatric neurologists to manage.3,4<br />
Symptoms of LGS typically begin before the age<br />
of 8 years, with a peak of occurrences between ages<br />
3 and 5 years, although late-onset cases in early<br />
adulthood have occasionally been reported.4 The<br />
age-specific onset suggests that brain maturation,<br />
specifical<a title="LGS Digital Edition_Sup2 page 1" href="http://viewer.zmags.com/publication/ad53d0bd?page=1"> SUPPLEMENT TO www.neurologyreviews.com MAR</a>
<a title="LGS Digital Edition_Sup2 page 2" href="http://viewer.zmags.com/publication/ad53d0bd?page=2"> Advances in Identifying and Treating Lennox-Gasta</a>
<a title="LGS Digital Edition_Sup2 page 3" href="http://viewer.zmags.com/publication/ad53d0bd?page=3"> also change with age, and the patient may no long</a>
<a title="LGS Digital Edition_Sup2 page 4" href="http://viewer.zmags.com/publication/ad53d0bd?page=4"> Advances in Identifying and Treating Lennox-Gasta</a>
<a title="LGS Digital Edition_Sup2 page 5" href="http://viewer.zmags.com/publication/ad53d0bd?page=5"> AEDs that induce or inhibit the same mechanisms </a>
<a title="LGS Digital Edition_Sup2 page 6" href="http://viewer.zmags.com/publication/ad53d0bd?page=6"> Advances in Identifying and Treating Lennox-Gasta</a>
<a title="LGS Digital Edition_Sup2 page 7" href="http://viewer.zmags.com/publication/ad53d0bd?page=7"> rently approved drugs for LGS as first-line thera</a>
<a title="LGS Digital Edition_Sup2 page 8" href="http://viewer.zmags.com/publication/ad53d0bd?page=8"> Advances in Identifying and Treating Lennox-Gasta</a>
<a title="LGS Digital Edition_Sup2 page 9" href="http://viewer.zmags.com/publication/ad53d0bd?page=9"> Take this interactive Self-Assessment Quiz and te</a>