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<br /> SUPPLEMENT TO<br /> www.neurologyreviews.com<br /> MARCH 2012<br /> Advances in Identifying<br /> and Treating Lennox-<br /> Gastaut Syndrome:<br /> Do You Know LGS When You See It?<br /> Selim R. Benbadis, MD, and Raj D. Sheth, MD<br /> Introduction<br /> Lennox-Gastaut Syndrome (LGS) is an age-specific<br /> epileptic encephalopathy that represents a response<br /> of the immature brain to a variety of insults.1,2 LGS<br /> has a childhood onset but persists into adulthood, is<br /> often refractory to antiepileptic drugs (AEDs), and<br /> remains one of the most difficult epileptic disorders for<br /> both general and pediatric neurologists to manage.3,4<br /> Symptoms of LGS typically begin before the age<br /> of 8 years, with a peak of occurrences between ages<br /> 3 and 5 years, although late-onset cases in early<br /> adulthood have occasionally been reported.4 The<br /> age-specific onset suggests that brain maturation,<br /> specifical<a title="LGS Digital Edition_Sup2 page 1" href="http://viewer.zmags.com/publication/ad53d0bd?page=1"> SUPPLEMENT TO www.neurologyreviews.com MAR</a> <a title="LGS Digital Edition_Sup2 page 2" href="http://viewer.zmags.com/publication/ad53d0bd?page=2"> Advances in Identifying and Treating Lennox-Gasta</a> <a title="LGS Digital Edition_Sup2 page 3" href="http://viewer.zmags.com/publication/ad53d0bd?page=3"> also change with age, and the patient may no long</a> <a title="LGS Digital Edition_Sup2 page 4" href="http://viewer.zmags.com/publication/ad53d0bd?page=4"> Advances in Identifying and Treating Lennox-Gasta</a> <a title="LGS Digital Edition_Sup2 page 5" href="http://viewer.zmags.com/publication/ad53d0bd?page=5"> AEDs that induce or inhibit the same mechanisms </a> <a title="LGS Digital Edition_Sup2 page 6" href="http://viewer.zmags.com/publication/ad53d0bd?page=6"> Advances in Identifying and Treating Lennox-Gasta</a> <a title="LGS Digital Edition_Sup2 page 7" href="http://viewer.zmags.com/publication/ad53d0bd?page=7"> rently approved drugs for LGS as first-line thera</a> <a title="LGS Digital Edition_Sup2 page 8" href="http://viewer.zmags.com/publication/ad53d0bd?page=8"> Advances in Identifying and Treating Lennox-Gasta</a> <a title="LGS Digital Edition_Sup2 page 9" href="http://viewer.zmags.com/publication/ad53d0bd?page=9"> Take this interactive Self-Assessment Quiz and te</a>