If you are visually impaired or blind, you can visit the PDF version by Pressing CONTROL + ALT + 4
<br /> SPONSORED CONTENT<br /> www.nature.com/reprintcollections/microrna_2013 July 2013<br /> MicroRNAs from bench to clinic<br /> Content selected by:<br /> miR-192: nephropathy<br /> miR-802: diabetes<br /> miR-208a: obesity<br /> miR-122: HCV infection<br /> miR-134: epilepsy<br /> miR-212: addiction<br /> miR-199a: melanoma<br /> miR-21: fibrosis<br /> miR-34a: myocardial infarction<br /> Explore microRNA as<br /> therapeutic targets<br /> Efficient silencing in vivo using LNA™-enhanced inhibitors<br /> In vivo LNA™ microRNA inhibitors have enabled numerous groundbreaking<br /> discoveries about microRNA function and their potential as therapeutic<br /> targets in disease. Designed by experts to ensure:<br /> × Unmatched potency even at low concentrations<br /> × Superior serum stability and nuclease resistance<br /> × Low toxicity and limited off <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 1" href="http://viewer.zmags.com/publication/b0ddd2f8?page=1"> SPONSORED CONTENT www.nature.com/reprin</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 2" href="http://viewer.zmags.com/publication/b0ddd2f8?page=2"> miR-192: nephropathy miR-802: diabetes miR-</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 3" href="http://viewer.zmags.com/publication/b0ddd2f8?page=3"> SPONSORED CONTENT www.nature.com/reprin</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 4" href="http://viewer.zmags.com/publication/b0ddd2f8?page=4"> Unleash your ideas and win cash awards! Innovat</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 5" href="http://viewer.zmags.com/publication/b0ddd2f8?page=5"> Unique events committed to scientific excellence </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 6" href="http://viewer.zmags.com/publication/b0ddd2f8?page=6"> FULL PAPER British Journal of Cancer (2013) 108, </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 7" href="http://viewer.zmags.com/publication/b0ddd2f8?page=7"> Serum miRNA profiles in colon cancer </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 8" href="http://viewer.zmags.com/publication/b0ddd2f8?page=8"> BRITISH JOURNAL OF CANCER </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 9" href="http://viewer.zmags.com/publication/b0ddd2f8?page=9"> Serum miRNA profiles in colon cancer </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 10" href="http://viewer.zmags.com/publication/b0ddd2f8?page=10"> BRITISH JOURNAL OF CANCER </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 11" href="http://viewer.zmags.com/publication/b0ddd2f8?page=11"> Serum miRNA profiles in colon cancer </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 12" href="http://viewer.zmags.com/publication/b0ddd2f8?page=12"> BRITISH JOURNAL OF CANCER </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 13" href="http://viewer.zmags.com/publication/b0ddd2f8?page=13"> Serum miRNA profiles in colon cancer </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 14" href="http://viewer.zmags.com/publication/b0ddd2f8?page=14"> British Journal of Cancer (2012) 107, 1354–1</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 15" href="http://viewer.zmags.com/publication/b0ddd2f8?page=15"> Experimental evidence supports an increasing r</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 16" href="http://viewer.zmags.com/publication/b0ddd2f8?page=16"> miRNA from FNA of localised PC </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 17" href="http://viewer.zmags.com/publication/b0ddd2f8?page=17"> miRNA from FNA of localised PC S Ali et al 1357 </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 18" href="http://viewer.zmags.com/publication/b0ddd2f8?page=18"> miRNA from FNA of localised PC </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 19" href="http://viewer.zmags.com/publication/b0ddd2f8?page=19"> miRNA from FNA of localised PC S Ali et al 1359 </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 20" href="http://viewer.zmags.com/publication/b0ddd2f8?page=20"> miRNA from FNA of localised PC </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 21" href="http://viewer.zmags.com/publication/b0ddd2f8?page=21"> British Journal of Cancer (2012) 107, 1169–1174 &</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 22" href="http://viewer.zmags.com/publication/b0ddd2f8?page=22"> An ISH study of miR-21 in 520 stage II colon canc</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 23" href="http://viewer.zmags.com/publication/b0ddd2f8?page=23"> represented variations in blue and red colo</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 24" href="http://viewer.zmags.com/publication/b0ddd2f8?page=24"> An ISH study of miR-21 in 520 stage II colon canc</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 25" href="http://viewer.zmags.com/publication/b0ddd2f8?page=25"> 1.00 0.75 0.50 0.25 P =0.0215 0.00 0246 T</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 26" href="http://viewer.zmags.com/publication/b0ddd2f8?page=26"> An ISH study of miR-21 in 520 stage II colon canc</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 27" href="http://viewer.zmags.com/publication/b0ddd2f8?page=27"> REVIEWS </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 28" href="http://viewer.zmags.com/publication/b0ddd2f8?page=28"> Box 1 | Clinical trials of antimiR-122 in the tre</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 29" href="http://viewer.zmags.com/publication/b0ddd2f8?page=29"> REVIEWS </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 30" href="http://viewer.zmags.com/publication/b0ddd2f8?page=30"> Phosphorothioate Backbone linkage in which a sulp</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 31" href="http://viewer.zmags.com/publication/b0ddd2f8?page=31"> REVIEWS </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 32" href="http://viewer.zmags.com/publication/b0ddd2f8?page=32"> MyomiRs The collection of microRNAs co-expressed </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 33" href="http://viewer.zmags.com/publication/b0ddd2f8?page=33"> REVIEWS </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 34" href="http://viewer.zmags.com/publication/b0ddd2f8?page=34"> Control of cardiac hypertrophy and fibrosis by mi</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 35" href="http://viewer.zmags.com/publication/b0ddd2f8?page=35"> REVIEWS MYH6 miR-208a MED13 Other targ</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 36" href="http://viewer.zmags.com/publication/b0ddd2f8?page=36"> Angiotensin II type 1 receptor (AT1). The recepto</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 37" href="http://viewer.zmags.com/publication/b0ddd2f8?page=37"> REVIEWS miR-29a miR-29b1 miR-29</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 38" href="http://viewer.zmags.com/publication/b0ddd2f8?page=38"> REVIEWS Miravirsen Pharmacological name for </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 39" href="http://viewer.zmags.com/publication/b0ddd2f8?page=39"> REVIEWS 52. Baek, D. et al. The impact of </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 40" href="http://viewer.zmags.com/publication/b0ddd2f8?page=40"> LETTER doi:10.1038/nature11793 Obesity-induc</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 41" href="http://viewer.zmags.com/publication/b0ddd2f8?page=41"> Control HFD Leprdb/db Control HFD Lepr</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 42" href="http://viewer.zmags.com/publication/b0ddd2f8?page=42"> a 2.0 </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 43" href="http://viewer.zmags.com/publication/b0ddd2f8?page=43"> RESEARCH LETTER Control Leprdb/db a </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 44" href="http://viewer.zmags.com/publication/b0ddd2f8?page=44"> we aimed to restore hepatic Hnf1b expressio</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 45" href="http://viewer.zmags.com/publication/b0ddd2f8?page=45"> ARTICLES Silencing microRNA-134 produces</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 46" href="http://viewer.zmags.com/publication/b0ddd2f8?page=46"> ARTICLES in experimental and human epilepsy an</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 47" href="http://viewer.zmags.com/publication/b0ddd2f8?page=47"> seizures emerge 3–4 d after status epilepticus in</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 48" href="http://viewer.zmags.com/publication/b0ddd2f8?page=48"> ARTICLES Spine density (spines per µm) 1.75 1.</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 49" href="http://viewer.zmags.com/publication/b0ddd2f8?page=49"> bg Scr Ant-134Scr </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 50" href="http://viewer.zmags.com/publication/b0ddd2f8?page=50"> ARTICLES ab HAHFDs (s) 800 700 600 500 400 30</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 51" href="http://viewer.zmags.com/publication/b0ddd2f8?page=51"> injection compared to Scr-injected mice, although</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 52" href="http://viewer.zmags.com/publication/b0ddd2f8?page=52"> ARTICLES AUTHOR CONTRIBUTIONS E.M.J.-M. perfor</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 53" href="http://viewer.zmags.com/publication/b0ddd2f8?page=53"> Figure viewer Search </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 54" href="http://viewer.zmags.com/publication/b0ddd2f8?page=54"> SPONSOR FEATURE Complete solution for discovery </a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 55" href="http://viewer.zmags.com/publication/b0ddd2f8?page=55"> In addition to RNA isolation, sample procurement,</a> <a title="Nature Reprint Collection: MicroRNAs from bench to clinic page 56" href="http://viewer.zmags.com/publication/b0ddd2f8?page=56"> www.nature.com/reprintcollections/microrna_2013</a>