If you are visually impaired or blind, you can visit the PDF version by Pressing CONTROL + ALT + 4
<br /> <br /> Contents<br /> + EDITORIAL BOARD 4<br /> + WELCOME 7<br /> + FOREWORD 9<br /> + CONGRESS REVIEW<br /> Review of the 5th European Academy of Neurology (EAN) Congress 2019, 10<br /> held in Oslo, Norway, 29th June – 2nd July 2019.<br /> + CONGRESS FEATURE<br /> Neuroinflammation and its Influence on ‘Non-Inflammatory’ 22<br /> Neurological Diseases<br /> Layla Southcombe<br /> #BrainLifeGoals 24<br /> Kirstie Turner<br /> + CONGRESS INTERVIEWS<br /> Antonio Federico <a title="EMJ Neurology 7.1 2019 page 1" href="http://viewer.zmags.com/publication/b42cba38?page=1"> </a> <a title="EMJ Neurology 7.1 2019 page 2" href="http://viewer.zmags.com/publication/b42cba38?page=2"> Contents + EDITORIAL BOARD </a> <a title="EMJ Neurology 7.1 2019 page 3" href="http://viewer.zmags.com/publication/b42cba38?page=3"> “Considering the country’s longstanding history o</a> <a title="EMJ Neurology 7.1 2019 page 4" href="http://viewer.zmags.com/publication/b42cba38?page=4"> Editorial Board Editor-in-Chief Prof Lászlo Vécse</a> <a title="EMJ Neurology 7.1 2019 page 5" href="http://viewer.zmags.com/publication/b42cba38?page=5"> Aims and Scope The European Medical Journal (EMJ)</a> <a title="EMJ Neurology 7.1 2019 page 6" href="http://viewer.zmags.com/publication/b42cba38?page=6"> EMJ Neurol. Chief Executive Officer Spencer Gore </a> <a title="EMJ Neurology 7.1 2019 page 7" href="http://viewer.zmags.com/publication/b42cba38?page=7"> Welcome Esteemed readers, collaborators, and frie</a> <a title="EMJ Neurology 7.1 2019 page 8" href="http://viewer.zmags.com/publication/b42cba38?page=8"> Share your knowledge with the world. </a> <a title="EMJ Neurology 7.1 2019 page 9" href="http://viewer.zmags.com/publication/b42cba38?page=9"> Foreword Dear colleagues, It is with great pleasu</a> <a title="EMJ Neurology 7.1 2019 page 10" href="http://viewer.zmags.com/publication/b42cba38?page=10"> </a> <a title="EMJ Neurology 7.1 2019 page 11" href="http://viewer.zmags.com/publication/b42cba38?page=11"> Congress Review Review of the European Academy</a> <a title="EMJ Neurology 7.1 2019 page 12" href="http://viewer.zmags.com/publication/b42cba38?page=12"> Following the screening of a 5-year annivers</a> <a title="EMJ Neurology 7.1 2019 page 13" href="http://viewer.zmags.com/publication/b42cba38?page=13"> possess for the reduction of seizure frequency an</a> <a title="EMJ Neurology 7.1 2019 page 14" href="http://viewer.zmags.com/publication/b42cba38?page=14"> Multiple Sclerosis Incidence Linked to </a> <a title="EMJ Neurology 7.1 2019 page 15" href="http://viewer.zmags.com/publication/b42cba38?page=15"> One in Ten People Report Having had ‘Near-Death’ </a> <a title="EMJ Neurology 7.1 2019 page 16" href="http://viewer.zmags.com/publication/b42cba38?page=16"> Finding the Time and Space to Combat Alzheimer’s </a> <a title="EMJ Neurology 7.1 2019 page 17" href="http://viewer.zmags.com/publication/b42cba38?page=17"> Study Reveals the Impact of the Holocaust on B</a> <a title="EMJ Neurology 7.1 2019 page 18" href="http://viewer.zmags.com/publication/b42cba38?page=18"> Earlier Intervention is Pivotal for the Successfu</a> <a title="EMJ Neurology 7.1 2019 page 19" href="http://viewer.zmags.com/publication/b42cba38?page=19"> “However, the effect of statins on these two outc</a> <a title="EMJ Neurology 7.1 2019 page 20" href="http://viewer.zmags.com/publication/b42cba38?page=20"> Norway Introduces First European Brai</a> <a title="EMJ Neurology 7.1 2019 page 21" href="http://viewer.zmags.com/publication/b42cba38?page=21"> Infant Language Impairment Associated with </a> <a title="EMJ Neurology 7.1 2019 page 22" href="http://viewer.zmags.com/publication/b42cba38?page=22"> Neuroinflammation and its Influence on ‘Non-</a> <a title="EMJ Neurology 7.1 2019 page 23" href="http://viewer.zmags.com/publication/b42cba38?page=23"> The identification of biomarkers in pre-symptomat</a> <a title="EMJ Neurology 7.1 2019 page 24" href="http://viewer.zmags.com/publication/b42cba38?page=24"> #BrainLifeGoals Kirstie Turner Editorial</a> <a title="EMJ Neurology 7.1 2019 page 25" href="http://viewer.zmags.com/publication/b42cba38?page=25"> 4. Depression and anxiety. 5. Access to employm</a> <a title="EMJ Neurology 7.1 2019 page 26" href="http://viewer.zmags.com/publication/b42cba38?page=26"> Congress Interviews Find out more about EAN from</a> <a title="EMJ Neurology 7.1 2019 page 27" href="http://viewer.zmags.com/publication/b42cba38?page=27"> Q7 try to improve the care in many areas of E</a> <a title="EMJ Neurology 7.1 2019 page 28" href="http://viewer.zmags.com/publication/b42cba38?page=28"> Prof Dr Riccardo Soffietti  Chairman of the EAN E</a> <a title="EMJ Neurology 7.1 2019 page 29" href="http://viewer.zmags.com/publication/b42cba38?page=29"> I have been involved in EAN activities for</a> <a title="EMJ Neurology 7.1 2019 page 30" href="http://viewer.zmags.com/publication/b42cba38?page=30"> The EMJ Neurology Editorial Board: A Roundtable I</a> <a title="EMJ Neurology 7.1 2019 page 31" href="http://viewer.zmags.com/publication/b42cba38?page=31"> Q2 This year, EAN is expected to host >6,000 </a> <a title="EMJ Neurology 7.1 2019 page 32" href="http://viewer.zmags.com/publication/b42cba38?page=32"> Prof Gilhus: One of the differences now is tha</a> <a title="EMJ Neurology 7.1 2019 page 33" href="http://viewer.zmags.com/publication/b42cba38?page=33"> they do not necessarily arrive at the right ti</a> <a title="EMJ Neurology 7.1 2019 page 34" href="http://viewer.zmags.com/publication/b42cba38?page=34"> Optimism and Opportunities with Anti-CGRP Biologi</a> <a title="EMJ Neurology 7.1 2019 page 35" href="http://viewer.zmags.com/publication/b42cba38?page=35"> suboptimal efficacy and tolerability of existing </a> <a title="EMJ Neurology 7.1 2019 page 36" href="http://viewer.zmags.com/publication/b42cba38?page=36"> Prof Dickenson further explained the models </a> <a title="EMJ Neurology 7.1 2019 page 37" href="http://viewer.zmags.com/publication/b42cba38?page=37"> HALO CM was a multinational RCT conducted across </a> <a title="EMJ Neurology 7.1 2019 page 38" href="http://viewer.zmags.com/publication/b42cba38?page=38"> quality of life and minimise disease burden</a> <a title="EMJ Neurology 7.1 2019 page 39" href="http://viewer.zmags.com/publication/b42cba38?page=39"> References 1. Steiner TJ et al. Migraine: Th</a> <a title="EMJ Neurology 7.1 2019 page 40" href="http://viewer.zmags.com/publication/b42cba38?page=40"> Abstract Reviews Here, you will find some a colle</a> <a title="EMJ Neurology 7.1 2019 page 41" href="http://viewer.zmags.com/publication/b42cba38?page=41"> RESULTS Analysis of 150 ALS patient’s data showed</a> <a title="EMJ Neurology 7.1 2019 page 42" href="http://viewer.zmags.com/publication/b42cba38?page=42"> experience sleep disturbances in the form of insu</a> <a title="EMJ Neurology 7.1 2019 page 43" href="http://viewer.zmags.com/publication/b42cba38?page=43"> Table 1: Normative data stratified by age and educ</a> <a title="EMJ Neurology 7.1 2019 page 44" href="http://viewer.zmags.com/publication/b42cba38?page=44"> Benefit of Coenzyme Q10, Riboflavin, Pe</a> <a title="EMJ Neurology 7.1 2019 page 45" href="http://viewer.zmags.com/publication/b42cba38?page=45"> At the 12-month follow-up assessment, both n</a> <a title="EMJ Neurology 7.1 2019 page 46" href="http://viewer.zmags.com/publication/b42cba38?page=46"> with neurological diseases, action observatio</a> <a title="EMJ Neurology 7.1 2019 page 47" href="http://viewer.zmags.com/publication/b42cba38?page=47"> RESULTS At t0, no significant differences were fou</a> <a title="EMJ Neurology 7.1 2019 page 48" href="http://viewer.zmags.com/publication/b42cba38?page=48"> employees of Pharnext. This research was financed </a> <a title="EMJ Neurology 7.1 2019 page 49" href="http://viewer.zmags.com/publication/b42cba38?page=49"> over-expression and improves myelination, axonal </a> <a title="EMJ Neurology 7.1 2019 page 50" href="http://viewer.zmags.com/publication/b42cba38?page=50"> Figure 1: Hand Test System: an engineered glove t</a> <a title="EMJ Neurology 7.1 2019 page 51" href="http://viewer.zmags.com/publication/b42cba38?page=51"> Comparative Analysis of High Frequency </a> <a title="EMJ Neurology 7.1 2019 page 52" href="http://viewer.zmags.com/publication/b42cba38?page=52"> Classification of Pontocerebellar Hypoplasia: </a> <a title="EMJ Neurology 7.1 2019 page 53" href="http://viewer.zmags.com/publication/b42cba38?page=53"> INTRODUCTION Pontocerebellar hypoplasia (PCH) des</a> <a title="EMJ Neurology 7.1 2019 page 54" href="http://viewer.zmags.com/publication/b42cba38?page=54"> There is much clinical variability betw</a> <a title="EMJ Neurology 7.1 2019 page 55" href="http://viewer.zmags.com/publication/b42cba38?page=55"> cognitive development and limited speech. Other E</a> <a title="EMJ Neurology 7.1 2019 page 56" href="http://viewer.zmags.com/publication/b42cba38?page=56"> Lastly, PCH1A (MIM #607596) is caused by mu</a> <a title="EMJ Neurology 7.1 2019 page 57" href="http://viewer.zmags.com/publication/b42cba38?page=57"> die within the first month of life. Brain MRI show</a> <a title="EMJ Neurology 7.1 2019 page 58" href="http://viewer.zmags.com/publication/b42cba38?page=58"> callosum has been reported. Mutations in the AMDP</a> <a title="EMJ Neurology 7.1 2019 page 59" href="http://viewer.zmags.com/publication/b42cba38?page=59"> Figure 2: Depiction of pathological overlap betwe</a> <a title="EMJ Neurology 7.1 2019 page 60" href="http://viewer.zmags.com/publication/b42cba38?page=60"> precludes a classification based on mechanism. The</a> <a title="EMJ Neurology 7.1 2019 page 61" href="http://viewer.zmags.com/publication/b42cba38?page=61"> 2016;139(11):2877-90. </a> <a title="EMJ Neurology 7.1 2019 page 62" href="http://viewer.zmags.com/publication/b42cba38?page=62"> Seizures in Childhood: Aetiology, Diagnosis, Tre</a> <a title="EMJ Neurology 7.1 2019 page 63" href="http://viewer.zmags.com/publication/b42cba38?page=63"> found to be 0.45% at the age of 5 and 0.66% at th</a> <a title="EMJ Neurology 7.1 2019 page 64" href="http://viewer.zmags.com/publication/b42cba38?page=64"> the ages of 3 and 10 years old as significant, exp</a> <a title="EMJ Neurology 7.1 2019 page 65" href="http://viewer.zmags.com/publication/b42cba38?page=65"> seizures.1 Roughly 80–85% of epilepsy patients in</a> <a title="EMJ Neurology 7.1 2019 page 66" href="http://viewer.zmags.com/publication/b42cba38?page=66"> Most of the genes identified encode fo</a> <a title="EMJ Neurology 7.1 2019 page 67" href="http://viewer.zmags.com/publication/b42cba38?page=67"> of children with medication-refractory epilepsy o</a> <a title="EMJ Neurology 7.1 2019 page 68" href="http://viewer.zmags.com/publication/b42cba38?page=68"> Neuromodulation is another treatment modality ava</a> <a title="EMJ Neurology 7.1 2019 page 69" href="http://viewer.zmags.com/publication/b42cba38?page=69"> targeted medications. Everolimus is a medication </a> <a title="EMJ Neurology 7.1 2019 page 70" href="http://viewer.zmags.com/publication/b42cba38?page=70"> 13. Camfield P, Camfield C. Febrile seizu</a> <a title="EMJ Neurology 7.1 2019 page 71" href="http://viewer.zmags.com/publication/b42cba38?page=71"> At Physiologically Relevant Concentrations, Valpr</a> <a title="EMJ Neurology 7.1 2019 page 72" href="http://viewer.zmags.com/publication/b42cba38?page=72"> incorporate components of mitochondrial </a> <a title="EMJ Neurology 7.1 2019 page 73" href="http://viewer.zmags.com/publication/b42cba38?page=73"> relevant concentrations of LICA and VPA on </a> <a title="EMJ Neurology 7.1 2019 page 74" href="http://viewer.zmags.com/publication/b42cba38?page=74"> groups, variance was assessed by using Bartlett’s</a> <a title="EMJ Neurology 7.1 2019 page 75" href="http://viewer.zmags.com/publication/b42cba38?page=75"> following exposure to 480 μM H O . This was 22 co</a> <a title="EMJ Neurology 7.1 2019 page 76" href="http://viewer.zmags.com/publication/b42cba38?page=76"> The present findings demonstrated that in the</a> <a title="EMJ Neurology 7.1 2019 page 77" href="http://viewer.zmags.com/publication/b42cba38?page=77"> Furthermore, a growing body of research has demon</a> <a title="EMJ Neurology 7.1 2019 page 78" href="http://viewer.zmags.com/publication/b42cba38?page=78"> treatment and diagnosis. Importantly, sai</a> <a title="EMJ Neurology 7.1 2019 page 79" href="http://viewer.zmags.com/publication/b42cba38?page=79"> brain. Neurology. 1992;42(3 Pt 1): </a> <a title="EMJ Neurology 7.1 2019 page 80" href="http://viewer.zmags.com/publication/b42cba38?page=80"> A Possible Explanation For Neurodegenerative Dise</a> <a title="EMJ Neurology 7.1 2019 page 81" href="http://viewer.zmags.com/publication/b42cba38?page=81"> (DLB), 2% for frontotemporal dementia (FTD), 2% </a> <a title="EMJ Neurology 7.1 2019 page 82" href="http://viewer.zmags.com/publication/b42cba38?page=82"> proteins may exhibit ‘prion-like’ behaviour and s</a> <a title="EMJ Neurology 7.1 2019 page 83" href="http://viewer.zmags.com/publication/b42cba38?page=83"> Ageing May Differentially Affect Anatomical Pathw</a> <a title="EMJ Neurology 7.1 2019 page 84" href="http://viewer.zmags.com/publication/b42cba38?page=84"> innervation.51 Finally, the formation of NFT in A</a> <a title="EMJ Neurology 7.1 2019 page 85" href="http://viewer.zmags.com/publication/b42cba38?page=85"> disconnection results in the upregulation and dep</a> <a title="EMJ Neurology 7.1 2019 page 86" href="http://viewer.zmags.com/publication/b42cba38?page=86"> +α-synuclein APOE ε2/3 </a> <a title="EMJ Neurology 7.1 2019 page 87" href="http://viewer.zmags.com/publication/b42cba38?page=87"> amyloidosis, tauopathy, gliosis, apoptotic lo</a> <a title="EMJ Neurology 7.1 2019 page 88" href="http://viewer.zmags.com/publication/b42cba38?page=88"> observations: 1) neurodegenerative disease may be</a> <a title="EMJ Neurology 7.1 2019 page 89" href="http://viewer.zmags.com/publication/b42cba38?page=89"> molecules, and morphology. Folia Neuropathol. 201</a> <a title="EMJ Neurology 7.1 2019 page 90" href="http://viewer.zmags.com/publication/b42cba38?page=90"> The Autonomic Nervous System: Delineating </a> <a title="EMJ Neurology 7.1 2019 page 91" href="http://viewer.zmags.com/publication/b42cba38?page=91"> A Short History of the Autonomic Nervous System W</a> <a title="EMJ Neurology 7.1 2019 page 92" href="http://viewer.zmags.com/publication/b42cba38?page=92"> complications, in particular urinary </a> <a title="EMJ Neurology 7.1 2019 page 93" href="http://viewer.zmags.com/publication/b42cba38?page=93"> The Diversity of Transmitter Receptor Molecules –</a> <a title="EMJ Neurology 7.1 2019 page 94" href="http://viewer.zmags.com/publication/b42cba38?page=94"> their synthesising enzymes and the degrading PDE </a> <a title="EMJ Neurology 7.1 2019 page 95" href="http://viewer.zmags.com/publication/b42cba38?page=95"> THE INTERDIGITATION OF AUTONOMIC NERVOUS SYSTEM A</a> <a title="EMJ Neurology 7.1 2019 page 96" href="http://viewer.zmags.com/publication/b42cba38?page=96"> Table 1: The evolution of key concepts on autonom</a> <a title="EMJ Neurology 7.1 2019 page 97" href="http://viewer.zmags.com/publication/b42cba38?page=97"> The impact of the discovery of the endogenous neu</a> <a title="EMJ Neurology 7.1 2019 page 98" href="http://viewer.zmags.com/publication/b42cba38?page=98"> action of amines. J Physiol. 1910;41(1- 45. </a> <a title="EMJ Neurology 7.1 2019 page 99" href="http://viewer.zmags.com/publication/b42cba38?page=99"> circulating lymphocytes as putative 79. bi</a> <a title="EMJ Neurology 7.1 2019 page 100" href="http://viewer.zmags.com/publication/b42cba38?page=100"> We want you to write for the EMJ blog. </a> <a title="EMJ Neurology 7.1 2019 page 101" href="http://viewer.zmags.com/publication/b42cba38?page=101"> Acquired Language Disorders in Bilinguals Autho</a> <a title="EMJ Neurology 7.1 2019 page 102" href="http://viewer.zmags.com/publication/b42cba38?page=102"> 1977, the first structured classification: a) paral</a> <a title="EMJ Neurology 7.1 2019 page 103" href="http://viewer.zmags.com/publication/b42cba38?page=103"> as a teacher for 18 years. In this case, the high</a> <a title="EMJ Neurology 7.1 2019 page 104" href="http://viewer.zmags.com/publication/b42cba38?page=104"> observed in bilinguals with respect </a> <a title="EMJ Neurology 7.1 2019 page 105" href="http://viewer.zmags.com/publication/b42cba38?page=105"> This is a case of paradoxical use of one language</a> <a title="EMJ Neurology 7.1 2019 page 106" href="http://viewer.zmags.com/publication/b42cba38?page=106"> Figure 3: Switching from L2 to L1. In neurosurgic</a> <a title="EMJ Neurology 7.1 2019 page 107" href="http://viewer.zmags.com/publication/b42cba38?page=107"> translate from one language to the other, while n</a> <a title="EMJ Neurology 7.1 2019 page 108" href="http://viewer.zmags.com/publication/b42cba38?page=108"> References 1. Ardila A, Ramos E. Speech and </a> <a title="EMJ Neurology 7.1 2019 page 109" href="http://viewer.zmags.com/publication/b42cba38?page=109"> Archiv Neurol Psychiatr. 1927;21:43-72. (Article </a> <a title="EMJ Neurology 7.1 2019 page 110" href="http://viewer.zmags.com/publication/b42cba38?page=110"> Never miss an update again. J</a>