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<br /> CARDIOLOGY<br /> ISSN 2054-3174 October 2014 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ESC 2014<br /> Barcelona, Spain<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 5<br /> CONGRESS REVIEW............................................................................................................................... 10<br /> • Review of the European Society of Cardiology Congress, held in Barcelona, Spain,<br /> 30th August - 3rd September 2014<br /> SYMPOSIUM REVIEWS<br /> • Emerging Options for Patients with Atrial Fibrillation............................................................ 31<br /> • Meeting the Challenges in Atrial Fibrillation Management: The Role of New<br /> Anticoagulants..............................<a title="EMJ Cardiology 2014 page 1" href="http://viewer.zmags.com/publication/b8e4842a?page=1"> CARDIOLOGY ISSN 2054-3174 </a> <a title="EMJ Cardiology 2014 page 2" href="http://viewer.zmags.com/publication/b8e4842a?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Cardiology 2014 page 3" href="http://viewer.zmags.com/publication/b8e4842a?page=3"> CARDIOLOGY THE QUEST FOR A MEDICAL TREATMENT O</a> <a title="EMJ Cardiology 2014 page 4" href="http://viewer.zmags.com/publication/b8e4842a?page=4"> Susan, 64 years old: NONCOMPLIANT </a> <a title="EMJ Cardiology 2014 page 5" href="http://viewer.zmags.com/publication/b8e4842a?page=5"> Editorial Board Cardiology Editor-in-Chief: Pr</a> <a title="EMJ Cardiology 2014 page 6" href="http://viewer.zmags.com/publication/b8e4842a?page=6"> Workflow The ne</a> <a title="EMJ Cardiology 2014 page 7" href="http://viewer.zmags.com/publication/b8e4842a?page=7"> Welcome The field of cardiology is a rapidly growi</a> <a title="EMJ Cardiology 2014 page 8" href="http://viewer.zmags.com/publication/b8e4842a?page=8"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjre</a> <a title="EMJ Cardiology 2014 page 9" href="http://viewer.zmags.com/publication/b8e4842a?page=9"> Foreword Prof Dr Jawahar Mehta </a> <a title="EMJ Cardiology 2014 page 10" href="http://viewer.zmags.com/publication/b8e4842a?page=10"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 11" href="http://viewer.zmags.com/publication/b8e4842a?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ Cardiology 2014 page 12" href="http://viewer.zmags.com/publication/b8e4842a?page=12"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 13" href="http://viewer.zmags.com/publication/b8e4842a?page=13"> important, what will change practice, and what to</a> <a title="EMJ Cardiology 2014 page 14" href="http://viewer.zmags.com/publication/b8e4842a?page=14"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 15" href="http://viewer.zmags.com/publication/b8e4842a?page=15"> Heart-powered pacemaker ticks closer to cardiac c</a> <a title="EMJ Cardiology 2014 page 16" href="http://viewer.zmags.com/publication/b8e4842a?page=16"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 17" href="http://viewer.zmags.com/publication/b8e4842a?page=17"> Hypertension: a growing problem for obese youths </a> <a title="EMJ Cardiology 2014 page 18" href="http://viewer.zmags.com/publication/b8e4842a?page=18"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 19" href="http://viewer.zmags.com/publication/b8e4842a?page=19"> Heart health hampered by high-energy drinks ENERG</a> <a title="EMJ Cardiology 2014 page 20" href="http://viewer.zmags.com/publication/b8e4842a?page=20"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 21" href="http://viewer.zmags.com/publication/b8e4842a?page=21"> Iron supplementation: the elixir of life for hear</a> <a title="EMJ Cardiology 2014 page 22" href="http://viewer.zmags.com/publication/b8e4842a?page=22"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 23" href="http://viewer.zmags.com/publication/b8e4842a?page=23"> Home comforts for implantable cardiac defibrillato</a> <a title="EMJ Cardiology 2014 page 24" href="http://viewer.zmags.com/publication/b8e4842a?page=24"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 25" href="http://viewer.zmags.com/publication/b8e4842a?page=25"> Synthetic hormone battles worsening heart failure</a> <a title="EMJ Cardiology 2014 page 26" href="http://viewer.zmags.com/publication/b8e4842a?page=26"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 27" href="http://viewer.zmags.com/publication/b8e4842a?page=27"> Vagus stimulation leads to improvement in cardiac</a> <a title="EMJ Cardiology 2014 page 28" href="http://viewer.zmags.com/publication/b8e4842a?page=28"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 29" href="http://viewer.zmags.com/publication/b8e4842a?page=29"> PAST TRIALS, FUTURE TECHNOLOGIES A Canadian tria</a> <a title="EMJ Cardiology 2014 page 30" href="http://viewer.zmags.com/publication/b8e4842a?page=30"> ESC ANNUAL CONGRESS 2014 FIRA GRAN VIA, BARCELONA</a> <a title="EMJ Cardiology 2014 page 31" href="http://viewer.zmags.com/publication/b8e4842a?page=31"> EMERGING OPTIONS FOR PATIENTS WITH </a> <a title="EMJ Cardiology 2014 page 32" href="http://viewer.zmags.com/publication/b8e4842a?page=32"> major bleeding, as per the International Society </a> <a title="EMJ Cardiology 2014 page 33" href="http://viewer.zmags.com/publication/b8e4842a?page=33"> A </a> <a title="EMJ Cardiology 2014 page 34" href="http://viewer.zmags.com/publication/b8e4842a?page=34"> Stroke-Risk and AF-Duration MOde Selection Trial </a> <a title="EMJ Cardiology 2014 page 35" href="http://viewer.zmags.com/publication/b8e4842a?page=35"> Table 1: Suggestions for reversal of target-speci</a> <a title="EMJ Cardiology 2014 page 36" href="http://viewer.zmags.com/publication/b8e4842a?page=36"> plasma (FFP) or activated factor VIIa should not </a> <a title="EMJ Cardiology 2014 page 37" href="http://viewer.zmags.com/publication/b8e4842a?page=37"> 12. Glotzer TV et al. Atrial high rate epi</a> <a title="EMJ Cardiology 2014 page 38" href="http://viewer.zmags.com/publication/b8e4842a?page=38"> MEETING THE CHALLENGES IN ATRIAL FIBRILLATION MA</a> <a title="EMJ Cardiology 2014 page 39" href="http://viewer.zmags.com/publication/b8e4842a?page=39"> cohort studies. For example, a Swedish AF cohort </a> <a title="EMJ Cardiology 2014 page 40" href="http://viewer.zmags.com/publication/b8e4842a?page=40"> inferior to warfarin for the prevention of stroke</a> <a title="EMJ Cardiology 2014 page 41" href="http://viewer.zmags.com/publication/b8e4842a?page=41"> Patients were assessed at baseline and at a 1-yea</a> <a title="EMJ Cardiology 2014 page 42" href="http://viewer.zmags.com/publication/b8e4842a?page=42"> There is evidence that combination treatment can </a> <a title="EMJ Cardiology 2014 page 43" href="http://viewer.zmags.com/publication/b8e4842a?page=43"> What does ENGAGE AF-TIMI 48 add to the Managemen</a> <a title="EMJ Cardiology 2014 page 44" href="http://viewer.zmags.com/publication/b8e4842a?page=44"> than warfarin.27 The same result was found when a</a> <a title="EMJ Cardiology 2014 page 45" href="http://viewer.zmags.com/publication/b8e4842a?page=45"> CHADS2, CHA2DS2-VASc and HAS-BLED scores for th</a> <a title="EMJ Cardiology 2014 page 46" href="http://viewer.zmags.com/publication/b8e4842a?page=46"> PREMATURE HEART ATTACKS: BAD LIFESTYLE, </a> <a title="EMJ Cardiology 2014 page 47" href="http://viewer.zmags.com/publication/b8e4842a?page=47"> Keywords: Homozygous familial hypercholesterol</a> <a title="EMJ Cardiology 2014 page 48" href="http://viewer.zmags.com/publication/b8e4842a?page=48"> genes controlling lipid metabolism.7,8 Delete</a> <a title="EMJ Cardiology 2014 page 49" href="http://viewer.zmags.com/publication/b8e4842a?page=49"> 0% -10% -20% -30% -40% -50% Change in LDL-C l</a> <a title="EMJ Cardiology 2014 page 50" href="http://viewer.zmags.com/publication/b8e4842a?page=50"> study involving 29 patients with HoFH receiving l</a> <a title="EMJ Cardiology 2014 page 51" href="http://viewer.zmags.com/publication/b8e4842a?page=51"> and physicians should not wait for these d</a> <a title="EMJ Cardiology 2014 page 52" href="http://viewer.zmags.com/publication/b8e4842a?page=52"> Overall, statin therapy also produced a cle</a> <a title="EMJ Cardiology 2014 page 53" href="http://viewer.zmags.com/publication/b8e4842a?page=53"> (mipomersen sodium) injection solution for subcut</a> <a title="EMJ Cardiology 2014 page 54" href="http://viewer.zmags.com/publication/b8e4842a?page=54"> IMAGING DURING TRANSCATHETER INTERVENTIONS </a> <a title="EMJ Cardiology 2014 page 55" href="http://viewer.zmags.com/publication/b8e4842a?page=55"> When the c-arm is moved, echocardiography images </a> <a title="EMJ Cardiology 2014 page 56" href="http://viewer.zmags.com/publication/b8e4842a?page=56"> During deployment of the prosthesis, TEE is very </a> <a title="EMJ Cardiology 2014 page 57" href="http://viewer.zmags.com/publication/b8e4842a?page=57"> Figure 2: Transseptal puncture site has been mark</a> <a title="EMJ Cardiology 2014 page 58" href="http://viewer.zmags.com/publication/b8e4842a?page=58"> After crossing the MV, the orientation of the Cli</a> <a title="EMJ Cardiology 2014 page 59" href="http://viewer.zmags.com/publication/b8e4842a?page=59"> In cases of unsatisfactory MR redu</a> <a title="EMJ Cardiology 2014 page 60" href="http://viewer.zmags.com/publication/b8e4842a?page=60"> root dimensions and geometries before and after </a> <a title="EMJ Cardiology 2014 page 61" href="http://viewer.zmags.com/publication/b8e4842a?page=61"> RED CELL DISTRIBUTION WIDTH FOR PREDICTING CARD</a> <a title="EMJ Cardiology 2014 page 62" href="http://viewer.zmags.com/publication/b8e4842a?page=62"> disease (CHD), stroke, peripheral artery dis</a> <a title="EMJ Cardiology 2014 page 63" href="http://viewer.zmags.com/publication/b8e4842a?page=63"> It is, therefore, unsurprising that RDW correlate</a> <a title="EMJ Cardiology 2014 page 64" href="http://viewer.zmags.com/publication/b8e4842a?page=64"> Table 3: Summary of published case-control studie</a> <a title="EMJ Cardiology 2014 page 65" href="http://viewer.zmags.com/publication/b8e4842a?page=65"> Events study of patients with prior myocard</a> <a title="EMJ Cardiology 2014 page 66" href="http://viewer.zmags.com/publication/b8e4842a?page=66"> in the third quintile, 1.4 (95% CI 1.2-1.8) in th</a> <a title="EMJ Cardiology 2014 page 67" href="http://viewer.zmags.com/publication/b8e4842a?page=67"> Support and Acknowledgements This work and the</a> <a title="EMJ Cardiology 2014 page 68" href="http://viewer.zmags.com/publication/b8e4842a?page=68"> width in patients with obstructive sleep apnea </a> <a title="EMJ Cardiology 2014 page 69" href="http://viewer.zmags.com/publication/b8e4842a?page=69"> cell distribution width and 1-year mortality in a</a> <a title="EMJ Cardiology 2014 page 70" href="http://viewer.zmags.com/publication/b8e4842a?page=70"> unselected critically ill patients. Crit Care. </a> <a title="EMJ Cardiology 2014 page 71" href="http://viewer.zmags.com/publication/b8e4842a?page=71"> CASE REPORT: DOUBLE ORIFICE MITRAL VALVE WITH CL</a> <a title="EMJ Cardiology 2014 page 72" href="http://viewer.zmags.com/publication/b8e4842a?page=72"> as in the index case, Type 2, an incomplete bridg</a> <a title="EMJ Cardiology 2014 page 73" href="http://viewer.zmags.com/publication/b8e4842a?page=73"> magnetic resonance imaging, and computed </a> <a title="EMJ Cardiology 2014 page 74" href="http://viewer.zmags.com/publication/b8e4842a?page=74"> FR 47Hz 17cm 2D 34% C 50 P Low HGen M3 PV MV1 R</a> <a title="EMJ Cardiology 2014 page 75" href="http://viewer.zmags.com/publication/b8e4842a?page=75"> FR 14Hz 17cm 2D 34% C 50 P Low HGen CF 67% 2.5MH</a> <a title="EMJ Cardiology 2014 page 76" href="http://viewer.zmags.com/publication/b8e4842a?page=76"> FR 14Hz 17cm 2D 34% C 50 P Low HGen CF 67% 2.5MH</a> <a title="EMJ Cardiology 2014 page 77" href="http://viewer.zmags.com/publication/b8e4842a?page=77"> FR 47Hz 17cm M3 2D 57% C 50 P Low HGen CLEFT </a> <a title="EMJ Cardiology 2014 page 78" href="http://viewer.zmags.com/publication/b8e4842a?page=78"> THE QUEST FOR A MEDICAL TREATMENT OF AORTIC </a> <a title="EMJ Cardiology 2014 page 79" href="http://viewer.zmags.com/publication/b8e4842a?page=79"> stenosis, a continuum of pathophysiologic</a> <a title="EMJ Cardiology 2014 page 80" href="http://viewer.zmags.com/publication/b8e4842a?page=80"> Table 1: Studies of statins in aortic stenosis. S</a> <a title="EMJ Cardiology 2014 page 81" href="http://viewer.zmags.com/publication/b8e4842a?page=81"> Valvular osteoblasts secrete osteogenic proteins,</a> <a title="EMJ Cardiology 2014 page 82" href="http://viewer.zmags.com/publication/b8e4842a?page=82"> containing apolipoprotein B-100, which can b</a> <a title="EMJ Cardiology 2014 page 83" href="http://viewer.zmags.com/publication/b8e4842a?page=83"> TARGETING INFLAMMATION Also intracellular meta</a> <a title="EMJ Cardiology 2014 page 84" href="http://viewer.zmags.com/publication/b8e4842a?page=84"> beneficial effects on AS progression. A number of </a> <a title="EMJ Cardiology 2014 page 85" href="http://viewer.zmags.com/publication/b8e4842a?page=85"> CONCLUSION The molecular and cellular pathophysi</a> <a title="EMJ Cardiology 2014 page 86" href="http://viewer.zmags.com/publication/b8e4842a?page=86"> 539-84. 27. Nagy E et al. Increased transcript le</a> <a title="EMJ Cardiology 2014 page 87" href="http://viewer.zmags.com/publication/b8e4842a?page=87"> FACTORS AFFECTING SERUM PARAOXONASE 1 A</a> <a title="EMJ Cardiology 2014 page 88" href="http://viewer.zmags.com/publication/b8e4842a?page=88"> prevalence in cities reaches similar levels to th</a> <a title="EMJ Cardiology 2014 page 89" href="http://viewer.zmags.com/publication/b8e4842a?page=89"> Laboratory Analyses Venous blood was collected</a> <a title="EMJ Cardiology 2014 page 90" href="http://viewer.zmags.com/publication/b8e4842a?page=90"> Table 1: Demographic details of the study populat</a> <a title="EMJ Cardiology 2014 page 91" href="http://viewer.zmags.com/publication/b8e4842a?page=91"> PON1 gene is upregulated by high gluc</a> <a title="EMJ Cardiology 2014 page 92" href="http://viewer.zmags.com/publication/b8e4842a?page=92"> Table 3: Spearman’s rank correlation analysis of </a> <a title="EMJ Cardiology 2014 page 93" href="http://viewer.zmags.com/publication/b8e4842a?page=93"> lack of gender differences is due to higher than </a> <a title="EMJ Cardiology 2014 page 94" href="http://viewer.zmags.com/publication/b8e4842a?page=94"> genotyping the PON1 gene will need to be </a> <a title="EMJ Cardiology 2014 page 95" href="http://viewer.zmags.com/publication/b8e4842a?page=95"> insulin signalling in PON2-deficient mice: a novel</a> <a title="EMJ Cardiology 2014 page 96" href="http://viewer.zmags.com/publication/b8e4842a?page=96"> RATIONALE FOR PROMISING NOVEL THERAPEUTIC APPR</a> <a title="EMJ Cardiology 2014 page 97" href="http://viewer.zmags.com/publication/b8e4842a?page=97"> and hypoxia. Mature ET-1 is formed from pre-pro- </a> <a title="EMJ Cardiology 2014 page 98" href="http://viewer.zmags.com/publication/b8e4842a?page=98"> ET-1 • VASOCONSTRICTIVE MEDIATOR EFFECT • PRO</a> <a title="EMJ Cardiology 2014 page 99" href="http://viewer.zmags.com/publication/b8e4842a?page=99"> association between clinical severity and elevate</a> <a title="EMJ Cardiology 2014 page 100" href="http://viewer.zmags.com/publication/b8e4842a?page=100"> factor, being released abluminally to act on ET r</a> <a title="EMJ Cardiology 2014 page 101" href="http://viewer.zmags.com/publication/b8e4842a?page=101"> in human venous bypass conduits from patients wit</a> <a title="EMJ Cardiology 2014 page 102" href="http://viewer.zmags.com/publication/b8e4842a?page=102"> of the symptomatology over time as a result of ve</a> <a title="EMJ Cardiology 2014 page 103" href="http://viewer.zmags.com/publication/b8e4842a?page=103"> 1993;88(6):2923–8. 12. Lerman A et al. Circu</a> <a title="EMJ Cardiology 2014 page 104" href="http://viewer.zmags.com/publication/b8e4842a?page=104"> mediates superoxide production and vasoconstri</a> <a title="EMJ Cardiology 2014 page 105" href="http://viewer.zmags.com/publication/b8e4842a?page=105"> CURRENT CONTROVERSIES IN INFECTIVE ENDOCARDITIS </a> <a title="EMJ Cardiology 2014 page 106" href="http://viewer.zmags.com/publication/b8e4842a?page=106"> PROPHYLAXIS Prophylaxis for the prevention of</a> <a title="EMJ Cardiology 2014 page 107" href="http://viewer.zmags.com/publication/b8e4842a?page=107"> Staphylococcus aureus bacteraemia Haemodynamic </a> <a title="EMJ Cardiology 2014 page 108" href="http://viewer.zmags.com/publication/b8e4842a?page=108"> 7% of the patients. Subsequent studies usin</a> <a title="EMJ Cardiology 2014 page 109" href="http://viewer.zmags.com/publication/b8e4842a?page=109"> compared to medical therapy (94% versus 82%) with</a> <a title="EMJ Cardiology 2014 page 110" href="http://viewer.zmags.com/publication/b8e4842a?page=110"> Odds Ratio, 95% CI Croft et al.54 Vikram et</a> <a title="EMJ Cardiology 2014 page 111" href="http://viewer.zmags.com/publication/b8e4842a?page=111"> from generator/pocket infections, although </a> <a title="EMJ Cardiology 2014 page 112" href="http://viewer.zmags.com/publication/b8e4842a?page=112"> Acknowledgements NH acknowledges support from t</a> <a title="EMJ Cardiology 2014 page 113" href="http://viewer.zmags.com/publication/b8e4842a?page=113"> bacteremia. Clin Infect Dis. 2011;53(1):1-9. 31. </a> <a title="EMJ Cardiology 2014 page 114" href="http://viewer.zmags.com/publication/b8e4842a?page=114"> WHAT’S NEW A happy marriage makes for a happy hea</a> <a title="EMJ Cardiology 2014 page 115" href="http://viewer.zmags.com/publication/b8e4842a?page=115"> CARDIOLOGY Athletes set the pace for endurance tr</a> <a title="EMJ Cardiology 2014 page 116" href="http://viewer.zmags.com/publication/b8e4842a?page=116"> WHAT’S NEW Promising biomarker test may reduce de</a> <a title="EMJ Cardiology 2014 page 117" href="http://viewer.zmags.com/publication/b8e4842a?page=117"> CARDIOLOGY Remote monitoring lowers risk of morta</a> <a title="EMJ Cardiology 2014 page 118" href="http://viewer.zmags.com/publication/b8e4842a?page=118"> WHAT’S NEW New parameter assesses acute heart fai</a> <a title="EMJ Cardiology 2014 page 119" href="http://viewer.zmags.com/publication/b8e4842a?page=119"> CARDIOLOGY The latest accessory to lower blood pr</a> <a title="EMJ Cardiology 2014 page 120" href="http://viewer.zmags.com/publication/b8e4842a?page=120"> WHAT’S NEW Eplerenone: a new hope for acute myoca</a> <a title="EMJ Cardiology 2014 page 121" href="http://viewer.zmags.com/publication/b8e4842a?page=121"> Susan, 64 years old: NONCOMPLIANT </a> <a title="EMJ Cardiology 2014 page 122" href="http://viewer.zmags.com/publication/b8e4842a?page=122"> Featured Suppliers Cardiology A fast-growing </a> <a title="EMJ Cardiology 2014 page 123" href="http://viewer.zmags.com/publication/b8e4842a?page=123"> From a host of fifteen therapeutic areas, EUROPEAN</a> <a title="EMJ Cardiology 2014 page 124" href="http://viewer.zmags.com/publication/b8e4842a?page=124"> Buyer’s Guide Exhibitors • ABBOTT • ABBOTT VAS</a> <a title="EMJ Cardiology 2014 page 125" href="http://viewer.zmags.com/publication/b8e4842a?page=125"> • I-COR • INBODY CO., LTD. • ITAMAR MEDICAL LTD. </a> <a title="EMJ Cardiology 2014 page 126" href="http://viewer.zmags.com/publication/b8e4842a?page=126"> UPCOMING EVENTS British Society for Heart Failur</a> <a title="EMJ Cardiology 2014 page 127" href="http://viewer.zmags.com/publication/b8e4842a?page=127"> CARDIOLOGY Nuclear Cardiology and Cardiac Comput</a> <a title="EMJ Cardiology 2014 page 128" href="http://viewer.zmags.com/publication/b8e4842a?page=128"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS PUBLI</a>