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<br /> ARCHIVE<br /> VOLUME 111 NUMBER 1 JANUARY 2016<br /> www.nature.com/ajg<br /> official publication of the american college of gastroenterology<br /> LEADING ARTICLES OF THE MONTH<br /> The Red Section: EndoTech Update<br /> 6 Just Clip It: Endoscopic Clipping in the 21st Century<br /> B. Joseph Elmunzer<br /> Practice Guidelines<br /> 30 ACG Clinical Guideline: Diagnosis and Management of Barrett’s<br /> Esophagus CME<br /> N.J. Shaheen, G.W. Falk, P.G. Iyer and L.B. Gerson<br /> Clinical and Systematic Reviews<br /> 53 Diagnosis and Management of Functional Heartburn CME<br /> C. Hachem and N.J. Shaheen<br /> Endoscopy<br /> 63 Effect of Dynamic Position Changes on Adenoma Detection during<br /> Colonoscope Withdrawal: A Randomized Controlled Multicenter Trial<br /> S.-W. Lee, J.H. Chang, J.-S. Ji et al.<br /> Liver<br /> 78 Diagnosis of Minima<a title="AJG_Vol.111.No.02 page 1" href="http://viewer.zmags.com/publication/c927db7c?page=1"> ARCHIVE VOLUME 111 NUMBER 1 JANUARY 2016 www.na</a> <a title="AJG_Vol.111.No.02 page 2" href="http://viewer.zmags.com/publication/c927db7c?page=2"> VOLUME 111 NUMBER 2 FEBRUARY 2016 www.nature.com/</a> <a title="AJG_Vol.111.No.02 page 3" href="http://viewer.zmags.com/publication/c927db7c?page=3"> NEW INDICATION FOR IBS-D Treat IBS-Differently</a> <a title="AJG_Vol.111.No.02 page 4" href="http://viewer.zmags.com/publication/c927db7c?page=4"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This Bri</a> <a title="AJG_Vol.111.No.02 page 5" href="http://viewer.zmags.com/publication/c927db7c?page=5"> www.amjgastro.com The American Journal of</a> <a title="AJG_Vol.111.No.02 page 6" href="http://viewer.zmags.com/publication/c927db7c?page=6"> The following is a brief summary only. See comple</a> <a title="AJG_Vol.111.No.02 page 7" href="http://viewer.zmags.com/publication/c927db7c?page=7"> MAKE THE MOVE APRISO SAVINGS PROGRAM $0 $</a> <a title="AJG_Vol.111.No.02 page 8" href="http://viewer.zmags.com/publication/c927db7c?page=8"> official publication of the american college</a> <a title="AJG_Vol.111.No.02 page 9" href="http://viewer.zmags.com/publication/c927db7c?page=9"> LEARN AND EARN CME WHILE YOU </a> <a title="AJG_Vol.111.No.02 page 10" href="http://viewer.zmags.com/publication/c927db7c?page=10"> #1 MOST PRESCRIBED, BRANDED BOWEL PREP KIT1 </a> <a title="AJG_Vol.111.No.02 page 11" href="http://viewer.zmags.com/publication/c927db7c?page=11"> IMPORTANT SAFETY INFORMATION SUPREP® Bowel Prep K</a> <a title="AJG_Vol.111.No.02 page 12" href="http://viewer.zmags.com/publication/c927db7c?page=12"> In active, mild to moderate ulcerative colitis (U</a> <a title="AJG_Vol.111.No.02 page 13" href="http://viewer.zmags.com/publication/c927db7c?page=13"> BRIEF SUMMARY UCERIS (budesonide) extended releas</a> <a title="AJG_Vol.111.No.02 page 14" href="http://viewer.zmags.com/publication/c927db7c?page=14"> the new standard of Pancreatic Cyst diagnos</a> <a title="AJG_Vol.111.No.02 page 15" href="http://viewer.zmags.com/publication/c927db7c?page=15"> Balance is free from gluten and is sweete</a> <a title="AJG_Vol.111.No.02 page 16" href="http://viewer.zmags.com/publication/c927db7c?page=16"> DETECT EARLY. 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At Childre</a> <a title="AJG_Vol.111.No.02 page 19" href="http://viewer.zmags.com/publication/c927db7c?page=19"> The Naturejobs newsletter delivers a pick of the </a> <a title="AJG_Vol.111.No.02 page 20" href="http://viewer.zmags.com/publication/c927db7c?page=20"> The following is a brief summary only; see full P</a> <a title="AJG_Vol.111.No.02 page 21" href="http://viewer.zmags.com/publication/c927db7c?page=21"> CRANBERRY FLAVOR NOW AVAILABLE! </a> <a title="AJG_Vol.111.No.02 page 22" href="http://viewer.zmags.com/publication/c927db7c?page=22"> Computerized tomography confirmed massive hepatome</a> <a title="AJG_Vol.111.No.02 page 23" href="http://viewer.zmags.com/publication/c927db7c?page=23"> CONTENTS </a> <a title="AJG_Vol.111.No.02 page 24" href="http://viewer.zmags.com/publication/c927db7c?page=24"> www.nature.com/ajg Overall survival estimate</a> <a title="AJG_Vol.111.No.02 page 25" href="http://viewer.zmags.com/publication/c927db7c?page=25"> GI QUALITY IMPROVEMENT CONSORTIUM LTD 3 Se ing</a> <a title="AJG_Vol.111.No.02 page 26" href="http://viewer.zmags.com/publication/c927db7c?page=26"> NOW AVAILABLE FOR THE</a> <a title="AJG_Vol.111.No.02 page 27" href="http://viewer.zmags.com/publication/c927db7c?page=27"> Brief Summary of Prescribing Information UCERIS® </a> <a title="AJG_Vol.111.No.02 page 28" href="http://viewer.zmags.com/publication/c927db7c?page=28"> YOUR LAB EQUIPMENT RESOURCE nature.com/marketplac</a> <a title="AJG_Vol.111.No.02 page 29" href="http://viewer.zmags.com/publication/c927db7c?page=29"> Albert Einstein used with permission of the HUJ/G</a> <a title="AJG_Vol.111.No.02 page 30" href="http://viewer.zmags.com/publication/c927db7c?page=30"> HARVONI IS NOW APPROVED FOR MORE CHRONIC HCV PATI</a> <a title="AJG_Vol.111.No.02 page 31" href="http://viewer.zmags.com/publication/c927db7c?page=31"> HARVONI IS THE ONLY SINGLE-TABLET REGIMEN FOR HCV</a> <a title="AJG_Vol.111.No.02 page 32" href="http://viewer.zmags.com/publication/c927db7c?page=32"> FOR TREATING CHRONIC HCV GT 1 BE THE ONE WHO CAN</a> <a title="AJG_Vol.111.No.02 page 33" href="http://viewer.zmags.com/publication/c927db7c?page=33"> HARVONI® (ledipasvir 90 mg and sofosbuvir 400 mg)</a> <a title="AJG_Vol.111.No.02 page 34" href="http://viewer.zmags.com/publication/c927db7c?page=34"> Brief Summary (cont.) This list includes potentia</a> <a title="AJG_Vol.111.No.02 page 35" href="http://viewer.zmags.com/publication/c927db7c?page=35"> Download the NatureJournals app for iPad, iPhone </a> <a title="AJG_Vol.111.No.02 page 36" href="http://viewer.zmags.com/publication/c927db7c?page=36"> Clinical Evidence Supports a New Approa</a> <a title="AJG_Vol.111.No.02 page 37" href="http://viewer.zmags.com/publication/c927db7c?page=37"> INDICATION AND IMPORTANT SAFETY INFORMATION FOR H</a> <a title="AJG_Vol.111.No.02 page 38" href="http://viewer.zmags.com/publication/c927db7c?page=38"> Achieve UC remission— </a> <a title="AJG_Vol.111.No.02 page 39" href="http://viewer.zmags.com/publication/c927db7c?page=39"> HUMIRA® (adalimumab) </a> <a title="AJG_Vol.111.No.02 page 40" href="http://viewer.zmags.com/publication/c927db7c?page=40"> Autoimmunity Treatment with HUMIRA may result in </a> <a title="AJG_Vol.111.No.02 page 41" href="http://viewer.zmags.com/publication/c927db7c?page=41"> Hidradenitis Suppurativa Clinical Studies HUMIRA </a> <a title="AJG_Vol.111.No.02 page 42" href="http://viewer.zmags.com/publication/c927db7c?page=42"> With IBSchek™, now you can get a confident </a> <a title="AJG_Vol.111.No.02 page 43" href="http://viewer.zmags.com/publication/c927db7c?page=43"> Brought to you by the American College of Gastroe</a> <a title="AJG_Vol.111.No.02 page 44" href="http://viewer.zmags.com/publication/c927db7c?page=44"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This Br</a> <a title="AJG_Vol.111.No.02 page 45" href="http://viewer.zmags.com/publication/c927db7c?page=45"> Hepatic Encephalopathy (HE) CAUSES EPISODIC NEURO</a> <a title="AJG_Vol.111.No.02 page 46" href="http://viewer.zmags.com/publication/c927db7c?page=46"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 47" href="http://viewer.zmags.com/publication/c927db7c?page=47"> 158 THE RED SECTION </a> <a title="AJG_Vol.111.No.02 page 48" href="http://viewer.zmags.com/publication/c927db7c?page=48"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 49" href="http://viewer.zmags.com/publication/c927db7c?page=49"> 160 THE RED SECTION marijuana use does c</a> <a title="AJG_Vol.111.No.02 page 50" href="http://viewer.zmags.com/publication/c927db7c?page=50"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 51" href="http://viewer.zmags.com/publication/c927db7c?page=51"> 162 THE RED SECTION people met the Di</a> <a title="AJG_Vol.111.No.02 page 52" href="http://viewer.zmags.com/publication/c927db7c?page=52"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 53" href="http://viewer.zmags.com/publication/c927db7c?page=53"> 164 THE RED SECTION reservoir from which</a> <a title="AJG_Vol.111.No.02 page 54" href="http://viewer.zmags.com/publication/c927db7c?page=54"> THE RED SECTION 165 </a> <a title="AJG_Vol.111.No.02 page 55" href="http://viewer.zmags.com/publication/c927db7c?page=55"> 166 THE RED SECTION Lee 2015 Korea NA NA NA </a> <a title="AJG_Vol.111.No.02 page 56" href="http://viewer.zmags.com/publication/c927db7c?page=56"> THE RED SECTION 167 Lumen </a> <a title="AJG_Vol.111.No.02 page 57" href="http://viewer.zmags.com/publication/c927db7c?page=57"> 168 THE RED SECTION of microbiota in the</a> <a title="AJG_Vol.111.No.02 page 58" href="http://viewer.zmags.com/publication/c927db7c?page=58"> 36. Krieglstein CF, Cerwinka WH, Laroux FS et al.</a> <a title="AJG_Vol.111.No.02 page 59" href="http://viewer.zmags.com/publication/c927db7c?page=59"> 170 THE RED SECTION </a> <a title="AJG_Vol.111.No.02 page 60" href="http://viewer.zmags.com/publication/c927db7c?page=60"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 61" href="http://viewer.zmags.com/publication/c927db7c?page=61"> 172 THE RED SECTION </a> <a title="AJG_Vol.111.No.02 page 62" href="http://viewer.zmags.com/publication/c927db7c?page=62"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 63" href="http://viewer.zmags.com/publication/c927db7c?page=63"> 174 THE RED SECTION </a> <a title="AJG_Vol.111.No.02 page 64" href="http://viewer.zmags.com/publication/c927db7c?page=64"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 65" href="http://viewer.zmags.com/publication/c927db7c?page=65"> 176 PRACTICE GUIDELINES </a> <a title="AJG_Vol.111.No.02 page 66" href="http://viewer.zmags.com/publication/c927db7c?page=66"> Liver Disease and Pregnancy 177 Table 1.</a> <a title="AJG_Vol.111.No.02 page 67" href="http://viewer.zmags.com/publication/c927db7c?page=67"> 178 Tran et al. Table 1. Continued Pla</a> <a title="AJG_Vol.111.No.02 page 68" href="http://viewer.zmags.com/publication/c927db7c?page=68"> Pregnant woman: initial workup of abnormal li</a> <a title="AJG_Vol.111.No.02 page 69" href="http://viewer.zmags.com/publication/c927db7c?page=69"> 180 Tran et al. MANAGEMENT OF BILIARY </a> <a title="AJG_Vol.111.No.02 page 70" href="http://viewer.zmags.com/publication/c927db7c?page=70"> Liver Disease and Pregnancy 181 Table 3.</a> <a title="AJG_Vol.111.No.02 page 71" href="http://viewer.zmags.com/publication/c927db7c?page=71"> 182 Tran et al. Preeclampsia and eclam</a> <a title="AJG_Vol.111.No.02 page 72" href="http://viewer.zmags.com/publication/c927db7c?page=72"> Table 4. Swansea criteria for diagnosis of acute </a> <a title="AJG_Vol.111.No.02 page 73" href="http://viewer.zmags.com/publication/c927db7c?page=73"> 184 Tran et al. HSV infection is not s</a> <a title="AJG_Vol.111.No.02 page 74" href="http://viewer.zmags.com/publication/c927db7c?page=74"> for immunoprophylaxis failure (those with HBV DNA</a> <a title="AJG_Vol.111.No.02 page 75" href="http://viewer.zmags.com/publication/c927db7c?page=75"> 186 Tran et al. Although there is on</a> <a title="AJG_Vol.111.No.02 page 76" href="http://viewer.zmags.com/publication/c927db7c?page=76"> pregnancies, with no increase in orofacial cleft </a> <a title="AJG_Vol.111.No.02 page 77" href="http://viewer.zmags.com/publication/c927db7c?page=77"> 188 Tran et al. the second trimester, </a> <a title="AJG_Vol.111.No.02 page 78" href="http://viewer.zmags.com/publication/c927db7c?page=78"> who are breastfed while mothers are on immunosupp</a> <a title="AJG_Vol.111.No.02 page 79" href="http://viewer.zmags.com/publication/c927db7c?page=79"> 190 Tran et al. 40. Ropponen A, Sund </a> <a title="AJG_Vol.111.No.02 page 80" href="http://viewer.zmags.com/publication/c927db7c?page=80"> 92. Andrews EB, Yankaskas BC, Cordero JF et al.</a> <a title="AJG_Vol.111.No.02 page 81" href="http://viewer.zmags.com/publication/c927db7c?page=81"> 192 Tran et al. 146. Lindor KD, Gershwi</a> <a title="AJG_Vol.111.No.02 page 82" href="http://viewer.zmags.com/publication/c927db7c?page=82"> 203. Armenti VT, Moritz MJ, Davison JM. Breastfee</a> <a title="AJG_Vol.111.No.02 page 83" href="http://viewer.zmags.com/publication/c927db7c?page=83"> 194 Tran et al. • Fertility • Co</a> <a title="AJG_Vol.111.No.02 page 84" href="http://viewer.zmags.com/publication/c927db7c?page=84"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 85" href="http://viewer.zmags.com/publication/c927db7c?page=85"> 196 CLINICAL AND SYSTEMATIC REVIEWS </a> <a title="AJG_Vol.111.No.02 page 86" href="http://viewer.zmags.com/publication/c927db7c?page=86"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 87" href="http://viewer.zmags.com/publication/c927db7c?page=87"> 198 Parmar et al. REVIEW popularity of bot</a> <a title="AJG_Vol.111.No.02 page 88" href="http://viewer.zmags.com/publication/c927db7c?page=88"> Validated Scales for Colon Cleansing 199 </a> <a title="AJG_Vol.111.No.02 page 89" href="http://viewer.zmags.com/publication/c927db7c?page=89"> 200 Parmar et al. Table 1. Scoring metho</a> <a title="AJG_Vol.111.No.02 page 90" href="http://viewer.zmags.com/publication/c927db7c?page=90"> Validated Scales for Colon Cleansing 201 </a> <a title="AJG_Vol.111.No.02 page 91" href="http://viewer.zmags.com/publication/c927db7c?page=91"> 202 Parmar et al. REVIEW 0.84) (10). A fin</a> <a title="AJG_Vol.111.No.02 page 92" href="http://viewer.zmags.com/publication/c927db7c?page=92"> vs. liquid) of residual material within each colo</a> <a title="AJG_Vol.111.No.02 page 93" href="http://viewer.zmags.com/publication/c927db7c?page=93"> 204 Parmar et al. REVIEW extensively valid</a> <a title="AJG_Vol.111.No.02 page 94" href="http://viewer.zmags.com/publication/c927db7c?page=94"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 95" href="http://viewer.zmags.com/publication/c927db7c?page=95"> 206 ORIGINAL CONTRIBUTIONS </a> <a title="AJG_Vol.111.No.02 page 96" href="http://viewer.zmags.com/publication/c927db7c?page=96"> dysphagia, as well as food impaction, of which Eo</a> <a title="AJG_Vol.111.No.02 page 97" href="http://viewer.zmags.com/publication/c927db7c?page=97"> 208 Runge et al. ESOPHAGUS (interquartile </a> <a title="AJG_Vol.111.No.02 page 98" href="http://viewer.zmags.com/publication/c927db7c?page=98"> Table 2. Efficacy and safety of dilation Any dilat</a> <a title="AJG_Vol.111.No.02 page 99" href="http://viewer.zmags.com/publication/c927db7c?page=99"> 210 Runge et al. ESOPHAGUS Table 4. Compar</a> <a title="AJG_Vol.111.No.02 page 100" href="http://viewer.zmags.com/publication/c927db7c?page=100"> narrowing are encountered (32,52,55,56), but </a> <a title="AJG_Vol.111.No.02 page 101" href="http://viewer.zmags.com/publication/c927db7c?page=101"> 212 Runge et al. ESOPHAGUS Thomas M. Runge</a> <a title="AJG_Vol.111.No.02 page 102" href="http://viewer.zmags.com/publication/c927db7c?page=102"> 34. Straumann A, Spichtin HP , Grize L et al. Nat</a> <a title="AJG_Vol.111.No.02 page 103" href="http://viewer.zmags.com/publication/c927db7c?page=103"> 214 EDITORIAL </a> <a title="AJG_Vol.111.No.02 page 104" href="http://viewer.zmags.com/publication/c927db7c?page=104"> Editorial 215 Table 1. General guideline</a> <a title="AJG_Vol.111.No.02 page 105" href="http://viewer.zmags.com/publication/c927db7c?page=105"> 216 Richter ESOPHAGUS diameter with bougie</a> <a title="AJG_Vol.111.No.02 page 106" href="http://viewer.zmags.com/publication/c927db7c?page=106"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 107" href="http://viewer.zmags.com/publication/c927db7c?page=107"> 218 Limsrivilai et al. ESOPHAGUS functiona</a> <a title="AJG_Vol.111.No.02 page 108" href="http://viewer.zmags.com/publication/c927db7c?page=108"> Study end points The primary end point was the di</a> <a title="AJG_Vol.111.No.02 page 109" href="http://viewer.zmags.com/publication/c927db7c?page=109"> 220 Limsrivilai et al. 150 patients wit</a> <a title="AJG_Vol.111.No.02 page 110" href="http://viewer.zmags.com/publication/c927db7c?page=110"> 100 Percentage of GERD improvement>50% 80 60</a> <a title="AJG_Vol.111.No.02 page 111" href="http://viewer.zmags.com/publication/c927db7c?page=111"> 222 Limsrivilai et al. a Heartburn </a> <a title="AJG_Vol.111.No.02 page 112" href="http://viewer.zmags.com/publication/c927db7c?page=112"> a ImipraminePlaceb</a> <a title="AJG_Vol.111.No.02 page 113" href="http://viewer.zmags.com/publication/c927db7c?page=113"> 224 Limsrivilai et al. ESOPHAGUS Study Hig</a> <a title="AJG_Vol.111.No.02 page 114" href="http://viewer.zmags.com/publication/c927db7c?page=114"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 115" href="http://viewer.zmags.com/publication/c927db7c?page=115"> 226 Keefer and Kahrilas ESOPHAGUS from TCA</a> <a title="AJG_Vol.111.No.02 page 116" href="http://viewer.zmags.com/publication/c927db7c?page=116"> 3. Cremonini F, Ziogas DC, Chang HY et al. Meta-</a> <a title="AJG_Vol.111.No.02 page 117" href="http://viewer.zmags.com/publication/c927db7c?page=117"> 228 ORIGINAL CONTRIBUTIONS </a> <a title="AJG_Vol.111.No.02 page 118" href="http://viewer.zmags.com/publication/c927db7c?page=118"> both reflux and EAC and the increasing prevalence</a> <a title="AJG_Vol.111.No.02 page 119" href="http://viewer.zmags.com/publication/c927db7c?page=119"> 230 Derakhshan et al. ESOPHAGUS Table 1. E</a> <a title="AJG_Vol.111.No.02 page 120" href="http://viewer.zmags.com/publication/c927db7c?page=120"> Association of Esophageal Adenocarcinoma and Gast</a> <a title="AJG_Vol.111.No.02 page 121" href="http://viewer.zmags.com/publication/c927db7c?page=121"> 232 Derakhshan et al. Table 2. List of </a> <a title="AJG_Vol.111.No.02 page 122" href="http://viewer.zmags.com/publication/c927db7c?page=122"> Italy, Romagna 1988–2007 (20) Singapore, Chinese</a> <a title="AJG_Vol.111.No.02 page 123" href="http://viewer.zmags.com/publication/c927db7c?page=123"> 234 Derakhshan et al. adenocarcinoma Esopha</a> <a title="AJG_Vol.111.No.02 page 124" href="http://viewer.zmags.com/publication/c927db7c?page=124"> Association of Esophageal Adenocarcinoma and Gast</a> <a title="AJG_Vol.111.No.02 page 125" href="http://viewer.zmags.com/publication/c927db7c?page=125"> 236 Derakhshan et al. ESOPHAGUS Table 3. C</a> <a title="AJG_Vol.111.No.02 page 126" href="http://viewer.zmags.com/publication/c927db7c?page=126"> Association of Esophageal Adenocarcinoma and Gast</a> <a title="AJG_Vol.111.No.02 page 127" href="http://viewer.zmags.com/publication/c927db7c?page=127"> 238 Derakhshan et al. ESOPHAGUS CONFLICT O</a> <a title="AJG_Vol.111.No.02 page 128" href="http://viewer.zmags.com/publication/c927db7c?page=128"> 31. Feldman M, Cryer B, McArthur KE et al. Effect</a> <a title="AJG_Vol.111.No.02 page 129" href="http://viewer.zmags.com/publication/c927db7c?page=129"> 240 ORIGINAL CONTRIBUTIONS </a> <a title="AJG_Vol.111.No.02 page 130" href="http://viewer.zmags.com/publication/c927db7c?page=130"> INTRODUCTION Although the mortality rate and inci</a> <a title="AJG_Vol.111.No.02 page 131" href="http://viewer.zmags.com/publication/c927db7c?page=131"> 242 Pyo et al. STOMACH determined from the</a> <a title="AJG_Vol.111.No.02 page 132" href="http://viewer.zmags.com/publication/c927db7c?page=132"> Endoscopic Resection vs. Surgery for EGC 243 </a> <a title="AJG_Vol.111.No.02 page 133" href="http://viewer.zmags.com/publication/c927db7c?page=133"> 244 Pyo et al. STOMACH Table 1. Continued </a> <a title="AJG_Vol.111.No.02 page 134" href="http://viewer.zmags.com/publication/c927db7c?page=134"> a Overall survival estimates </a> <a title="AJG_Vol.111.No.02 page 135" href="http://viewer.zmags.com/publication/c927db7c?page=135"> 246 Pyo et al. Events (%) </a> <a title="AJG_Vol.111.No.02 page 136" href="http://viewer.zmags.com/publication/c927db7c?page=136"> Table 3. Predictors of the overall survival in mu</a> <a title="AJG_Vol.111.No.02 page 137" href="http://viewer.zmags.com/publication/c927db7c?page=137"> 248 Pyo et al. Table 4. Previous studies</a> <a title="AJG_Vol.111.No.02 page 138" href="http://viewer.zmags.com/publication/c927db7c?page=138"> Study Highlights WHAT IS CURRENT KNOWLEDGE ✓ Pre</a> <a title="AJG_Vol.111.No.02 page 139" href="http://viewer.zmags.com/publication/c927db7c?page=139"> 250 ORIGINAL CONTRIBUTIONS </a> <a title="AJG_Vol.111.No.02 page 140" href="http://viewer.zmags.com/publication/c927db7c?page=140"> historically has been the most common cause of gr</a> <a title="AJG_Vol.111.No.02 page 141" href="http://viewer.zmags.com/publication/c927db7c?page=141"> 252 Pillai et al. overrepresentation o</a> <a title="AJG_Vol.111.No.02 page 142" href="http://viewer.zmags.com/publication/c927db7c?page=142"> Simeprevir and Sofosbuvir in Genotype 1 HCV Infec</a> <a title="AJG_Vol.111.No.02 page 143" href="http://viewer.zmags.com/publication/c927db7c?page=143"> 254 Pillai et al. LIVER Table 1. Baseline </a> <a title="AJG_Vol.111.No.02 page 144" href="http://viewer.zmags.com/publication/c927db7c?page=144"> Simeprevir and Sofosbuvir in Genotype 1 HCV Infec</a> <a title="AJG_Vol.111.No.02 page 145" href="http://viewer.zmags.com/publication/c927db7c?page=145"> 256 Pillai et al. Total cohort N =170 </a> <a title="AJG_Vol.111.No.02 page 146" href="http://viewer.zmags.com/publication/c927db7c?page=146"> Table 3. Univariate analysis of the entire cohort</a> <a title="AJG_Vol.111.No.02 page 147" href="http://viewer.zmags.com/publication/c927db7c?page=147"> 258 Pillai et al. LIVER ITT and per protoc</a> <a title="AJG_Vol.111.No.02 page 148" href="http://viewer.zmags.com/publication/c927db7c?page=148"> 17. Hagan LM, Sulkowski MS, Schinazi RF. Cost ana</a> <a title="AJG_Vol.111.No.02 page 149" href="http://viewer.zmags.com/publication/c927db7c?page=149"> 260 Pillai et al. LIVER Table 6. Univariat</a> <a title="AJG_Vol.111.No.02 page 150" href="http://viewer.zmags.com/publication/c927db7c?page=150"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 151" href="http://viewer.zmags.com/publication/c927db7c?page=151"> 262 Marín-Jiménez et al. INFLAMMATORY BOWEL</a> <a title="AJG_Vol.111.No.02 page 152" href="http://viewer.zmags.com/publication/c927db7c?page=152"> online website, compared with the SCCAI evaluatio</a> <a title="AJG_Vol.111.No.02 page 153" href="http://viewer.zmags.com/publication/c927db7c?page=153"> 264 Marín-Jiménez et al. OWEL DISEASE INFLA</a> <a title="AJG_Vol.111.No.02 page 154" href="http://viewer.zmags.com/publication/c927db7c?page=154"> Online Patient Self-Administration of the SCCAI </a> <a title="AJG_Vol.111.No.02 page 155" href="http://viewer.zmags.com/publication/c927db7c?page=155"> 266 Marín-Jiménez et al. INFLAMMATORY BOWEL</a> <a title="AJG_Vol.111.No.02 page 156" href="http://viewer.zmags.com/publication/c927db7c?page=156"> cannot be established. Third, there is currently </a> <a title="AJG_Vol.111.No.02 page 157" href="http://viewer.zmags.com/publication/c927db7c?page=157"> 268 Marín-Jiménez et al. INFLAMMATORY BOWEL</a> <a title="AJG_Vol.111.No.02 page 158" href="http://viewer.zmags.com/publication/c927db7c?page=158"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 159" href="http://viewer.zmags.com/publication/c927db7c?page=159"> 270 Markland et al. FUNCTIONAL GI DISORDERS</a> <a title="AJG_Vol.111.No.02 page 160" href="http://viewer.zmags.com/publication/c927db7c?page=160"> accident, chronic lower respiratory tract disease</a> <a title="AJG_Vol.111.No.02 page 161" href="http://viewer.zmags.com/publication/c927db7c?page=161"> 272 Markland et al. GI DISORDERS FUNCTIONAL</a> <a title="AJG_Vol.111.No.02 page 162" href="http://viewer.zmags.com/publication/c927db7c?page=162"> Anal Intercourse and Fecal Incontinence 273 </a> <a title="AJG_Vol.111.No.02 page 163" href="http://viewer.zmags.com/publication/c927db7c?page=163"> 274 Markland et al. FUNCTIONAL GI DISORDERS</a> <a title="AJG_Vol.111.No.02 page 164" href="http://viewer.zmags.com/publication/c927db7c?page=164"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 165" href="http://viewer.zmags.com/publication/c927db7c?page=165"> 276 Aronson et al. COLON/SMALL BOWEL INTRO</a> <a title="AJG_Vol.111.No.02 page 166" href="http://viewer.zmags.com/publication/c927db7c?page=166"> Gastrointestinal Findings in Biallelic MMR Defici</a> <a title="AJG_Vol.111.No.02 page 167" href="http://viewer.zmags.com/publication/c927db7c?page=167"> 278 Aronson et al. Finding at basel</a> <a title="AJG_Vol.111.No.02 page 168" href="http://viewer.zmags.com/publication/c927db7c?page=168"> Gastrointestinal Findings in Biallelic MMR Defici</a> <a title="AJG_Vol.111.No.02 page 169" href="http://viewer.zmags.com/publication/c927db7c?page=169"> 280 Aronson et al. COLON/SMALL BOWEL Table</a> <a title="AJG_Vol.111.No.02 page 170" href="http://viewer.zmags.com/publication/c927db7c?page=170"> Gastrointestinal Findings in Biallelic MMR Defici</a> <a title="AJG_Vol.111.No.02 page 171" href="http://viewer.zmags.com/publication/c927db7c?page=171"> 282 Aronson et al. Baseline screen (n=2</a> <a title="AJG_Vol.111.No.02 page 172" href="http://viewer.zmags.com/publication/c927db7c?page=172"> phenotype in this rare genetic condition. The pre</a> <a title="AJG_Vol.111.No.02 page 173" href="http://viewer.zmags.com/publication/c927db7c?page=173"> 284 Aronson et al. COLON/SMALL BOWEL 29. R</a> <a title="AJG_Vol.111.No.02 page 174" href="http://viewer.zmags.com/publication/c927db7c?page=174"> nature publishing group </a> <a title="AJG_Vol.111.No.02 page 175" href="http://viewer.zmags.com/publication/c927db7c?page=175"> 286 Patel et al. COLON/SMALL BOWEL INTRODU</a> <a title="AJG_Vol.111.No.02 page 176" href="http://viewer.zmags.com/publication/c927db7c?page=176"> Study aims Knowledge and uptake of geneti</a> <a title="AJG_Vol.111.No.02 page 177" href="http://viewer.zmags.com/publication/c927db7c?page=177"> 288 Patel et al. COLON/SMALL BOWEL Table 1</a> <a title="AJG_Vol.111.No.02 page 178" href="http://viewer.zmags.com/publication/c927db7c?page=178"> Patient and Endoscopist Knowledge of Lynch Syndro</a> <a title="AJG_Vol.111.No.02 page 179" href="http://viewer.zmags.com/publication/c927db7c?page=179"> 290 Patel et al. COLON/SMALL BOWEL Table 4</a> <a title="AJG_Vol.111.No.02 page 180" href="http://viewer.zmags.com/publication/c927db7c?page=180"> reported in our study suggest that efforts to imp</a> <a title="AJG_Vol.111.No.02 page 181" href="http://viewer.zmags.com/publication/c927db7c?page=181"> 292 Patel et al. COLON/SMALL BOWEL unlikel</a> <a title="AJG_Vol.111.No.02 page 182" href="http://viewer.zmags.com/publication/c927db7c?page=182"> 10. Hampel H, de la Chapelle A. 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