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<br /> <br /> Contents<br /> + EDITORIAL BOARD 4<br /> + WELCOME 7<br /> + FOREWORD 9<br /> + SYMPOSIUM REVIEW<br /> The IBD Pathway: From a Patient Perspective 10<br /> The IBD Management Puzzle: Do We Have All the Pieces? 18<br /> + ARTICLES<br /> EDITOR’S PICK: Sex Differences in Paediatric and Adult Asthma 27<br /> Anika Naeem and Patricia Silveyra<br /> Epigenetics, Assisted Reproduction, and Intracytoplasmic Sperm Injection: 36<br /> A Review of the Current Data<br /> Delia Hutanu et al.<br /> Immunotherapy in Small Cell Lung<a title="EMJ 4.2 2019 page 1" href="http://viewer.zmags.com/publication/d49ff7ab?page=1"> </a> <a title="EMJ 4.2 2019 page 2" href="http://viewer.zmags.com/publication/d49ff7ab?page=2"> Contents + EDITORIAL BOARD </a> <a title="EMJ 4.2 2019 page 3" href="http://viewer.zmags.com/publication/d49ff7ab?page=3"> “The sharing of concepts, collabo</a> <a title="EMJ 4.2 2019 page 4" href="http://viewer.zmags.com/publication/d49ff7ab?page=4"> Editorial Board Editor-in-Chief Prof Markus Peck-</a> <a title="EMJ 4.2 2019 page 5" href="http://viewer.zmags.com/publication/d49ff7ab?page=5"> Aims and Scope The European Medical Journal (EMJ)</a> <a title="EMJ 4.2 2019 page 6" href="http://viewer.zmags.com/publication/d49ff7ab?page=6"> EMJ 4.2 Chief Executive Officer Spencer Gore Seni</a> <a title="EMJ 4.2 2019 page 7" href="http://viewer.zmags.com/publication/d49ff7ab?page=7"> Welcome The sharing of concepts, collaboration, a</a> <a title="EMJ 4.2 2019 page 8" href="http://viewer.zmags.com/publication/d49ff7ab?page=8"> IN YOUR PATIENTS WITH SEVERE UNCONTROLLED ASTHMA </a> <a title="EMJ 4.2 2019 page 9" href="http://viewer.zmags.com/publication/d49ff7ab?page=9"> Foreword Dear colleagues, It is my great pleasure</a> <a title="EMJ 4.2 2019 page 10" href="http://viewer.zmags.com/publication/d49ff7ab?page=10"> The IBD Pathway: From a Patient Perspective Th</a> <a title="EMJ 4.2 2019 page 11" href="http://viewer.zmags.com/publication/d49ff7ab?page=11"> Meeting Summary The emergence of anti-TNF biosimi</a> <a title="EMJ 4.2 2019 page 12" href="http://viewer.zmags.com/publication/d49ff7ab?page=12"> and expert nurses are more adept at conversing wi</a> <a title="EMJ 4.2 2019 page 13" href="http://viewer.zmags.com/publication/d49ff7ab?page=13"> be shared with, and explained to, the patient by </a> <a title="EMJ 4.2 2019 page 14" href="http://viewer.zmags.com/publication/d49ff7ab?page=14"> Physician Patient Promote positive framin</a> <a title="EMJ 4.2 2019 page 15" href="http://viewer.zmags.com/publication/d49ff7ab?page=15"> the BAB have suggested improvements in commu</a> <a title="EMJ 4.2 2019 page 16" href="http://viewer.zmags.com/publication/d49ff7ab?page=16"> for the safety and effectiveness is convincing fo</a> <a title="EMJ 4.2 2019 page 17" href="http://viewer.zmags.com/publication/d49ff7ab?page=17"> drug monitoring and: “especially, to give them th</a> <a title="EMJ 4.2 2019 page 18" href="http://viewer.zmags.com/publication/d49ff7ab?page=18"> The IBD Management Puzzle: Do We Have All the Pie</a> <a title="EMJ 4.2 2019 page 19" href="http://viewer.zmags.com/publication/d49ff7ab?page=19"> treatment earlier. The use of TDM in the treatmen</a> <a title="EMJ 4.2 2019 page 20" href="http://viewer.zmags.com/publication/d49ff7ab?page=20"> Week 8 was associated with improvements in time </a> <a title="EMJ 4.2 2019 page 21" href="http://viewer.zmags.com/publication/d49ff7ab?page=21"> PK parameters of importance include: • Drug cl</a> <a title="EMJ 4.2 2019 page 22" href="http://viewer.zmags.com/publication/d49ff7ab?page=22"> IBD. Assessment of long-term treatment retention </a> <a title="EMJ 4.2 2019 page 23" href="http://viewer.zmags.com/publication/d49ff7ab?page=23"> equivalence study in which patients wit</a> <a title="EMJ 4.2 2019 page 24" href="http://viewer.zmags.com/publication/d49ff7ab?page=24"> Diagnosis Predictors of treatment repsonse Monito</a> <a title="EMJ 4.2 2019 page 25" href="http://viewer.zmags.com/publication/d49ff7ab?page=25"> disease. World J Gastroenterol. 2014;20(1):64-77.</a> <a title="EMJ 4.2 2019 page 26" href="http://viewer.zmags.com/publication/d49ff7ab?page=26"> Group. Maintenance infliximab for Crohn's disease:</a> <a title="EMJ 4.2 2019 page 27" href="http://viewer.zmags.com/publication/d49ff7ab?page=27"> Sex Differences in Paediatric and Adult Asthma </a> <a title="EMJ 4.2 2019 page 28" href="http://viewer.zmags.com/publication/d49ff7ab?page=28"> INTRODUCTION Asthma is a chronic inflammatory diso</a> <a title="EMJ 4.2 2019 page 29" href="http://viewer.zmags.com/publication/d49ff7ab?page=29"> Table 1: Clinical studies on paediatric asthma ri</a> <a title="EMJ 4.2 2019 page 30" href="http://viewer.zmags.com/publication/d49ff7ab?page=30"> Table 1 continued. Reference Study type S</a> <a title="EMJ 4.2 2019 page 31" href="http://viewer.zmags.com/publication/d49ff7ab?page=31"> was associated with poor prognosis. However, the </a> <a title="EMJ 4.2 2019 page 32" href="http://viewer.zmags.com/publication/d49ff7ab?page=32"> resulting in both respiratory and cardiovascular </a> <a title="EMJ 4.2 2019 page 33" href="http://viewer.zmags.com/publication/d49ff7ab?page=33"> observed sex differences in both the paediatric a</a> <a title="EMJ 4.2 2019 page 34" href="http://viewer.zmags.com/publication/d49ff7ab?page=34"> have been found to increase, and testosterone to </a> <a title="EMJ 4.2 2019 page 35" href="http://viewer.zmags.com/publication/d49ff7ab?page=35"> guidelines. Allergol Immunopathol 20. (M</a> <a title="EMJ 4.2 2019 page 36" href="http://viewer.zmags.com/publication/d49ff7ab?page=36"> Epigenetics, Assisted Reproduction, and Intracyt</a> <a title="EMJ 4.2 2019 page 37" href="http://viewer.zmags.com/publication/d49ff7ab?page=37"> This article reviews important data from th</a> <a title="EMJ 4.2 2019 page 38" href="http://viewer.zmags.com/publication/d49ff7ab?page=38"> zygote has an imprint memory. This memory is ret</a> <a title="EMJ 4.2 2019 page 39" href="http://viewer.zmags.com/publication/d49ff7ab?page=39"> PWS affects approximately 1 in 17,500 children an</a> <a title="EMJ 4.2 2019 page 40" href="http://viewer.zmags.com/publication/d49ff7ab?page=40"> increased risk of rare childhood disorders. </a> <a title="EMJ 4.2 2019 page 41" href="http://viewer.zmags.com/publication/d49ff7ab?page=41"> conceive, but nowadays this technique is used wor</a> <a title="EMJ 4.2 2019 page 42" href="http://viewer.zmags.com/publication/d49ff7ab?page=42"> accessed: 6 November 2018. 25. </a> <a title="EMJ 4.2 2019 page 43" href="http://viewer.zmags.com/publication/d49ff7ab?page=43"> Immunotherapy in Small Cell Lung Cancer Authors</a> <a title="EMJ 4.2 2019 page 44" href="http://viewer.zmags.com/publication/d49ff7ab?page=44"> The multimodality approach is the standard- </a> <a title="EMJ 4.2 2019 page 45" href="http://viewer.zmags.com/publication/d49ff7ab?page=45"> selection is a goal to pursue steadily to optimis</a> <a title="EMJ 4.2 2019 page 46" href="http://viewer.zmags.com/publication/d49ff7ab?page=46"> Atezolizumab, a fully humanised, engineered m</a> <a title="EMJ 4.2 2019 page 47" href="http://viewer.zmags.com/publication/d49ff7ab?page=47"> A sample was considered adequate for PD-L1 assess</a> <a title="EMJ 4.2 2019 page 48" href="http://viewer.zmags.com/publication/d49ff7ab?page=48"> nonrandomised or randomised cohorts of Ch</a> <a title="EMJ 4.2 2019 page 49" href="http://viewer.zmags.com/publication/d49ff7ab?page=49"> Table 2 continued. Author Phase of study </a> <a title="EMJ 4.2 2019 page 50" href="http://viewer.zmags.com/publication/d49ff7ab?page=50"> two parts. Part I of the study will establish the</a> <a title="EMJ 4.2 2019 page 51" href="http://viewer.zmags.com/publication/d49ff7ab?page=51"> Table 3 continued. ID Phase of study Title </a> <a title="EMJ 4.2 2019 page 52" href="http://viewer.zmags.com/publication/d49ff7ab?page=52"> CONCLUSION Immunotherapy through the administrati</a> <a title="EMJ 4.2 2019 page 53" href="http://viewer.zmags.com/publication/d49ff7ab?page=53"> approval for third-line treatment of metastatic s</a> <a title="EMJ 4.2 2019 page 54" href="http://viewer.zmags.com/publication/d49ff7ab?page=54"> Non-melanoma skin cancer (NMSC): Getting to the </a> <a title="EMJ 4.2 2019 page 55" href="http://viewer.zmags.com/publication/d49ff7ab?page=55"> Chemokine Pathway Can Be the Potential Therapeuti</a> <a title="EMJ 4.2 2019 page 56" href="http://viewer.zmags.com/publication/d49ff7ab?page=56"> This review will summarise cellular and</a> <a title="EMJ 4.2 2019 page 57" href="http://viewer.zmags.com/publication/d49ff7ab?page=57"> influencing erythropoiesis were negativel</a> <a title="EMJ 4.2 2019 page 58" href="http://viewer.zmags.com/publication/d49ff7ab?page=58"> Low resolution NS </a> <a title="EMJ 4.2 2019 page 59" href="http://viewer.zmags.com/publication/d49ff7ab?page=59"> appearance in Phase I and II trials.24 Both in vi</a> <a title="EMJ 4.2 2019 page 60" href="http://viewer.zmags.com/publication/d49ff7ab?page=60"> compared with levels recorded in the deeper derma</a> <a title="EMJ 4.2 2019 page 61" href="http://viewer.zmags.com/publication/d49ff7ab?page=61"> NS 2 weeks </a> <a title="EMJ 4.2 2019 page 62" href="http://viewer.zmags.com/publication/d49ff7ab?page=62"> myocardial, vascular, lung, and skin wound repair</a> <a title="EMJ 4.2 2019 page 63" href="http://viewer.zmags.com/publication/d49ff7ab?page=63"> wound healing. J Dermatol Sci. 2013;72(3):206-17.</a> <a title="EMJ 4.2 2019 page 64" href="http://viewer.zmags.com/publication/d49ff7ab?page=64"> A New Twist to Ibuprofen: Alternative Act</a> <a title="EMJ 4.2 2019 page 65" href="http://viewer.zmags.com/publication/d49ff7ab?page=65"> different COX-2-derived products, the highest PGE</a> <a title="EMJ 4.2 2019 page 66" href="http://viewer.zmags.com/publication/d49ff7ab?page=66"> colorectal cancer prevention because excessive β-</a> <a title="EMJ 4.2 2019 page 67" href="http://viewer.zmags.com/publication/d49ff7ab?page=67"> binding provides a mechanism that allows I</a> <a title="EMJ 4.2 2019 page 68" href="http://viewer.zmags.com/publication/d49ff7ab?page=68"> Ibuprofen Growth factors RTK </a> <a title="EMJ 4.2 2019 page 69" href="http://viewer.zmags.com/publication/d49ff7ab?page=69"> AKT: protein kinase B; APC: adenomatous polyposis</a> <a title="EMJ 4.2 2019 page 70" href="http://viewer.zmags.com/publication/d49ff7ab?page=70"> References 1. Vane JR, Botting RM. Mechanism</a> <a title="EMJ 4.2 2019 page 71" href="http://viewer.zmags.com/publication/d49ff7ab?page=71"> 43. Gurpinar E et al. NSAIDs inhibit tum</a> <a title="EMJ 4.2 2019 page 72" href="http://viewer.zmags.com/publication/d49ff7ab?page=72"> FOR YOUR PATIENTS WITH HR+, HER2–, NODE-NEGATIVE,</a> <a title="EMJ 4.2 2019 page 73" href="http://viewer.zmags.com/publication/d49ff7ab?page=73"> The Heart of the Matter: A Unique Convergence of </a> <a title="EMJ 4.2 2019 page 74" href="http://viewer.zmags.com/publication/d49ff7ab?page=74"> CT.7 Echocardiography can help to distinguish bet</a> <a title="EMJ 4.2 2019 page 75" href="http://viewer.zmags.com/publication/d49ff7ab?page=75"> that low-grade tumour histology and survival foll</a> <a title="EMJ 4.2 2019 page 76" href="http://viewer.zmags.com/publication/d49ff7ab?page=76"> They are distributed between 12 left atrial</a> <a title="EMJ 4.2 2019 page 77" href="http://viewer.zmags.com/publication/d49ff7ab?page=77"> Sarcoma in Lynch Syndrome Soft tissue sarcomas ar</a> <a title="EMJ 4.2 2019 page 78" href="http://viewer.zmags.com/publication/d49ff7ab?page=78"> associated palpable ipsilateral lymphadenopathy. </a> <a title="EMJ 4.2 2019 page 79" href="http://viewer.zmags.com/publication/d49ff7ab?page=79"> Figure 3: Biopsy of intrapericardial tissue demon</a> <a title="EMJ 4.2 2019 page 80" href="http://viewer.zmags.com/publication/d49ff7ab?page=80"> presentation with New York Heart Association (NYH</a> <a title="EMJ 4.2 2019 page 81" href="http://viewer.zmags.com/publication/d49ff7ab?page=81"> 14. Shanmugam G. Primary cardiac sarcom</a> <a title="EMJ 4.2 2019 page 82" href="http://viewer.zmags.com/publication/d49ff7ab?page=82"> 65. Leo QJ, Bolger D. Sarcoma: An unusua</a> <a title="EMJ 4.2 2019 page 83" href="http://viewer.zmags.com/publication/d49ff7ab?page=83"> Obesity and the Effects of Weight Reduction: A S</a> <a title="EMJ 4.2 2019 page 84" href="http://viewer.zmags.com/publication/d49ff7ab?page=84"> important risk factor for cardiometabolic</a> <a title="EMJ 4.2 2019 page 85" href="http://viewer.zmags.com/publication/d49ff7ab?page=85"> biological mechanisms that connect obesity an</a> <a title="EMJ 4.2 2019 page 86" href="http://viewer.zmags.com/publication/d49ff7ab?page=86"> challenges related to controlling the energy</a> <a title="EMJ 4.2 2019 page 87" href="http://viewer.zmags.com/publication/d49ff7ab?page=87"> Table 1 continued. Hormone (mediator) Product</a> <a title="EMJ 4.2 2019 page 88" href="http://viewer.zmags.com/publication/d49ff7ab?page=88"> patients receiving chemotherapy (CHT).38</a> <a title="EMJ 4.2 2019 page 89" href="http://viewer.zmags.com/publication/d49ff7ab?page=89"> Table 2: Strategies to improve coping with chroni</a> <a title="EMJ 4.2 2019 page 90" href="http://viewer.zmags.com/publication/d49ff7ab?page=90"> than busy physicians. Moreover, some baseline str</a> <a title="EMJ 4.2 2019 page 91" href="http://viewer.zmags.com/publication/d49ff7ab?page=91"> CONCLUSION In summary, BC outcomes are dependent,</a> <a title="EMJ 4.2 2019 page 92" href="http://viewer.zmags.com/publication/d49ff7ab?page=92"> Sci (Lond). 2016;130(18):1615-28. 37.</a> <a title="EMJ 4.2 2019 page 93" href="http://viewer.zmags.com/publication/d49ff7ab?page=93"> Anthropometric Parameters and Thyroid Morpholog</a> <a title="EMJ 4.2 2019 page 94" href="http://viewer.zmags.com/publication/d49ff7ab?page=94"> INTRODUCTION A goiter is a nodular or diffuse enl</a> <a title="EMJ 4.2 2019 page 95" href="http://viewer.zmags.com/publication/d49ff7ab?page=95"> STATISTICAL ANALYSES Data analysis was performed </a> <a title="EMJ 4.2 2019 page 96" href="http://viewer.zmags.com/publication/d49ff7ab?page=96"> Table 2: Comparison of thyroid volume and thyroid</a> <a title="EMJ 4.2 2019 page 97" href="http://viewer.zmags.com/publication/d49ff7ab?page=97"> Table 4: Comparison of anthropometric parameters </a> <a title="EMJ 4.2 2019 page 98" href="http://viewer.zmags.com/publication/d49ff7ab?page=98"> Syrian females. High prevalence of goiter and u</a> <a title="EMJ 4.2 2019 page 99" href="http://viewer.zmags.com/publication/d49ff7ab?page=99"> Endocr Relat Cancer. 2013;20(1):R1- R17. 38. Kim</a> <a title="EMJ 4.2 2019 page 100" href="http://viewer.zmags.com/publication/d49ff7ab?page=100"> After Conventional Wisdom Has Failed, Wh</a> <a title="EMJ 4.2 2019 page 101" href="http://viewer.zmags.com/publication/d49ff7ab?page=101"> INTRODUCTION According to the Wound Healing Socie</a> <a title="EMJ 4.2 2019 page 102" href="http://viewer.zmags.com/publication/d49ff7ab?page=102"> BB is one of the most potent natural mitogens ide</a> <a title="EMJ 4.2 2019 page 103" href="http://viewer.zmags.com/publication/d49ff7ab?page=103"> DISCOVERY OF A NEW POTENTIAL DRIVER FOR WOUND CLO</a> <a title="EMJ 4.2 2019 page 104" href="http://viewer.zmags.com/publication/d49ff7ab?page=104"> B NTD F-5 LR K270 MD K277 CTD C Extr</a> <a title="EMJ 4.2 2019 page 105" href="http://viewer.zmags.com/publication/d49ff7ab?page=105"> These constructs allowed Cheng et al.37 to test w</a> <a title="EMJ 4.2 2019 page 106" href="http://viewer.zmags.com/publication/d49ff7ab?page=106"> FUNCTIONS OF SECRETED HEAT SHOCK PROTEIN-90ALPHA </a> <a title="EMJ 4.2 2019 page 107" href="http://viewer.zmags.com/publication/d49ff7ab?page=107"> hyperglycaemia, which is believed to be one of th</a> <a title="EMJ 4.2 2019 page 108" href="http://viewer.zmags.com/publication/d49ff7ab?page=108"> PROTEIN-90ALPHA A ‘GENERAL REPAIR MOLECULE’? IS </a> <a title="EMJ 4.2 2019 page 109" href="http://viewer.zmags.com/publication/d49ff7ab?page=109"> dermal wound healing. Neovessel and matrix format</a> <a title="EMJ 4.2 2019 page 110" href="http://viewer.zmags.com/publication/d49ff7ab?page=110"> Using the Novel Approach of an Artificial Pancreas</a> <a title="EMJ 4.2 2019 page 111" href="http://viewer.zmags.com/publication/d49ff7ab?page=111"> oestrogen, prolactin, human placental-lactogen, a</a> <a title="EMJ 4.2 2019 page 112" href="http://viewer.zmags.com/publication/d49ff7ab?page=112"> Available in Europe and the USA, this device has </a> <a title="EMJ 4.2 2019 page 113" href="http://viewer.zmags.com/publication/d49ff7ab?page=113"> at different times of the day according to the ne</a> <a title="EMJ 4.2 2019 page 114" href="http://viewer.zmags.com/publication/d49ff7ab?page=114"> that the improvement in time-in-target with </a> <a title="EMJ 4.2 2019 page 115" href="http://viewer.zmags.com/publication/d49ff7ab?page=115"> The most recent study, CLIP 04,47 had an almost i</a> <a title="EMJ 4.2 2019 page 116" href="http://viewer.zmags.com/publication/d49ff7ab?page=116"> suboptimal. CGM, insulin pumps, and the AP have s</a> <a title="EMJ 4.2 2019 page 117" href="http://viewer.zmags.com/publication/d49ff7ab?page=117"> trial. Am J Obs Gynecol. 2017;216(1 Suppl):S288. </a> <a title="EMJ 4.2 2019 page 118" href="http://viewer.zmags.com/publication/d49ff7ab?page=118"> Never miss an update again. </a>