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<br /> VOLUME 113 NUMBER 1 JANUARY 2018<br /> www.nature.com/ajg<br /> OFFICIAL PUBLICATION OF THE AMERICAN COLLEGE OF GASTROENTEROLOGY<br /> EDITORS: Brian E. Lacy, PhD, MD, FACG and Brennan Spiegel, MD, MSHS, FACG<br /> VOLUME 113 NUMBER 5 MAY 2018<br /> www.nature.com/ajg<br /> OFFICIAL PUBLICATION OF THE AMERICAN COLLEGE OF GASTROENTEROLOGY<br /> LEADING ARTICLES OF THE MONTH<br /> The Red Section: How I Approach It<br /> 635 Rectal Exam: Yes, it can and should be done in a busy practice!<br /> Satish S.C. Rao<br /> Clinical and Systematic Reviews<br /> 647 Chronic nausea and vomiting: evaluation and treatment CME<br /> Brian E. Lacy, Henry P. Parkman, and Michael Camilleri<br /> Esophagus<br /> 670 Lack of improvement of impaired chemical clearance characterizes<br /> PPI-refractory reflux-related heartburn<br /> Marzio Frazzoni, Leonardo Frazzoni, Salvatore Tolone, et al.<br /> Endoscopy<b<a title="AJG_Vol.113.No5 page 1" href="http://viewer.zmags.com/publication/d9108239?page=1"> VOLUME 113 NUMBER 1 JANUARY 2018 www.nature.com/a</a> <a title="AJG_Vol.113.No5 page 2" href="http://viewer.zmags.com/publication/d9108239?page=2"> VOLUME 113 NUMBER 5 MAY 2018 www.nature.com/ajg </a> <a title="AJG_Vol.113.No5 page 3" href="http://viewer.zmags.com/publication/d9108239?page=3"> INDICATIONS Adult Ulcerative Colitis (UC) ENTYVIO</a> <a title="AJG_Vol.113.No5 page 4" href="http://viewer.zmags.com/publication/d9108239?page=4"> In UC & CD FOR ADULTS WITH MODERATELY TO SEVEREL</a> <a title="AJG_Vol.113.No5 page 5" href="http://viewer.zmags.com/publication/d9108239?page=5"> BRIEF SUMMARY OF FULL PRESCRIBING INFORMATION ENT</a> <a title="AJG_Vol.113.No5 page 6" href="http://viewer.zmags.com/publication/d9108239?page=6"> Table 2. Adverse Reactions in ≥3% of ENTYVIO-trea</a> <a title="AJG_Vol.113.No5 page 7" href="http://viewer.zmags.com/publication/d9108239?page=7"> with persistently positive anti-vedolizumab antib</a> <a title="AJG_Vol.113.No5 page 8" href="http://viewer.zmags.com/publication/d9108239?page=8"> Brief Summary of Prescribing Information for STEL</a> <a title="AJG_Vol.113.No5 page 9" href="http://viewer.zmags.com/publication/d9108239?page=9"> STELARA® (ustekinumab) Table 2: Common adverse r</a> <a title="AJG_Vol.113.No5 page 10" href="http://viewer.zmags.com/publication/d9108239?page=10"> www.nature.com/ajg The American Journal o</a> <a title="AJG_Vol.113.No5 page 11" href="http://viewer.zmags.com/publication/d9108239?page=11"> The flagship journal of the American College of Ga</a> <a title="AJG_Vol.113.No5 page 12" href="http://viewer.zmags.com/publication/d9108239?page=12"> Sofosbuvir-based therapy changed expectations in </a> <a title="AJG_Vol.113.No5 page 13" href="http://viewer.zmags.com/publication/d9108239?page=13"> FOR TREATING CHRONIC HCV GT 1 BE THE ONE WHO </a> <a title="AJG_Vol.113.No5 page 14" href="http://viewer.zmags.com/publication/d9108239?page=14"> FOR TREATING CHRONIC HCV EXPAND WHAT'S POSSIBL</a> <a title="AJG_Vol.113.No5 page 15" href="http://viewer.zmags.com/publication/d9108239?page=15"> HARVONI® (ledipasvir 90 mg and sofosbuvir 400 mg)</a> <a title="AJG_Vol.113.No5 page 16" href="http://viewer.zmags.com/publication/d9108239?page=16"> Brief Summary (cont.) ·Laboratory Abnormalities</a> <a title="AJG_Vol.113.No5 page 17" href="http://viewer.zmags.com/publication/d9108239?page=17"> EPCLUSA® (sofosbuvir 400 mg and velpatasvir 100 m</a> <a title="AJG_Vol.113.No5 page 18" href="http://viewer.zmags.com/publication/d9108239?page=18"> Brief Summary (cont.) In ASTRAL-1, isolated, asym</a> <a title="AJG_Vol.113.No5 page 19" href="http://viewer.zmags.com/publication/d9108239?page=19"> Improve your written English to help your researc</a> <a title="AJG_Vol.113.No5 page 20" href="http://viewer.zmags.com/publication/d9108239?page=20"> RECOMMEND THE BEST WITH NEXIUM® 24HR Nexium® 24HR</a> <a title="AJG_Vol.113.No5 page 21" href="http://viewer.zmags.com/publication/d9108239?page=21"> ACG MOBILE:ACCESS KEY RESOURCES </a> <a title="AJG_Vol.113.No5 page 22" href="http://viewer.zmags.com/publication/d9108239?page=22"> www.nature.com/ajg The American Journal o</a> <a title="AJG_Vol.113.No5 page 23" href="http://viewer.zmags.com/publication/d9108239?page=23"> OFFICIAL PUBLICATION OF THE AMERICAN COLLEGE</a> <a title="AJG_Vol.113.No5 page 24" href="http://viewer.zmags.com/publication/d9108239?page=24"> Clinically validated, physician-endorsed, nonpres</a> <a title="AJG_Vol.113.No5 page 25" href="http://viewer.zmags.com/publication/d9108239?page=25"> For first-line constipation therapy, stick with t</a> <a title="AJG_Vol.113.No5 page 26" href="http://viewer.zmags.com/publication/d9108239?page=26"> Typical histopathological features of IgG4-associ</a> <a title="AJG_Vol.113.No5 page 27" href="http://viewer.zmags.com/publication/d9108239?page=27"> CONTENTS </a> <a title="AJG_Vol.113.No5 page 28" href="http://viewer.zmags.com/publication/d9108239?page=28"> www.nature.com/ajg </a> <a title="AJG_Vol.113.No5 page 29" href="http://viewer.zmags.com/publication/d9108239?page=29"> MAVYRET: FOR CHRONIC HCV TREAT ALL GENOTYPES IN</a> <a title="AJG_Vol.113.No5 page 30" href="http://viewer.zmags.com/publication/d9108239?page=30"> THE ONLY 8-WEEK PANGENOTYPIC REGIMEN. HIGH CURE* </a> <a title="AJG_Vol.113.No5 page 31" href="http://viewer.zmags.com/publication/d9108239?page=31"> MAVYRET™ (glecaprevir and pibrentasvir) tablets, </a> <a title="AJG_Vol.113.No5 page 32" href="http://viewer.zmags.com/publication/d9108239?page=32"> background risk of major birth defects and miscar</a> <a title="AJG_Vol.113.No5 page 33" href="http://viewer.zmags.com/publication/d9108239?page=33"> See you at DDW - Booth #937 ® Look Below</a> <a title="AJG_Vol.113.No5 page 34" href="http://viewer.zmags.com/publication/d9108239?page=34"> Now included in updated IDSA clinical practice</a> <a title="AJG_Vol.113.No5 page 35" href="http://viewer.zmags.com/publication/d9108239?page=35"> BRIEF SUMMARY OF PRESCRIBING INFORMATION DIFICID </a> <a title="AJG_Vol.113.No5 page 36" href="http://viewer.zmags.com/publication/d9108239?page=36"> Cologuard® lets you deliver cutting-edge science </a> <a title="AJG_Vol.113.No5 page 37" href="http://viewer.zmags.com/publication/d9108239?page=37"> ÌÊœőŒř ANNUAL SCIENTIFIC MEETING & POSTGRADU</a> <a title="AJG_Vol.113.No5 page 38" href="http://viewer.zmags.com/publication/d9108239?page=38"> For GI Endoscopic Resections Visit eleviewUS.com </a> <a title="AJG_Vol.113.No5 page 39" href="http://viewer.zmags.com/publication/d9108239?page=39"> Attend an upcoming ACG POSTGRADUATE COURSE </a> <a title="AJG_Vol.113.No5 page 40" href="http://viewer.zmags.com/publication/d9108239?page=40"> Michael R. Charlton, MD The University of Chicago</a> <a title="AJG_Vol.113.No5 page 41" href="http://viewer.zmags.com/publication/d9108239?page=41"> 25 Mucosal Healing Index Score 0 </a> <a title="AJG_Vol.113.No5 page 42" href="http://viewer.zmags.com/publication/d9108239?page=42"> THE REd SEcTion 635 see related editorial</a> <a title="AJG_Vol.113.No5 page 43" href="http://viewer.zmags.com/publication/d9108239?page=43"> 636 THE REd SEcTion DRE mEthoDologY There </a> <a title="AJG_Vol.113.No5 page 44" href="http://viewer.zmags.com/publication/d9108239?page=44"> Fig. 2 a A schematic illustrating the anatomical </a> <a title="AJG_Vol.113.No5 page 45" href="http://viewer.zmags.com/publication/d9108239?page=45"> 638 THE REd SEcTion objective anorectal te</a> <a title="AJG_Vol.113.No5 page 46" href="http://viewer.zmags.com/publication/d9108239?page=46"> THE REd SEcTion 639 see related editorial</a> <a title="AJG_Vol.113.No5 page 47" href="http://viewer.zmags.com/publication/d9108239?page=47"> 640 THE REd SEcTion Board reView Vignette fi</a> <a title="AJG_Vol.113.No5 page 48" href="http://viewer.zmags.com/publication/d9108239?page=48"> protein [1, 3, 15]. Palliative options for patien</a> <a title="AJG_Vol.113.No5 page 49" href="http://viewer.zmags.com/publication/d9108239?page=49"> 642 THE RED SECTION Images of the Month </a> <a title="AJG_Vol.113.No5 page 50" href="http://viewer.zmags.com/publication/d9108239?page=50"> THE RED SECTION 643 see related editorial</a> <a title="AJG_Vol.113.No5 page 51" href="http://viewer.zmags.com/publication/d9108239?page=51"> 644 THE RED SECTION see related editoria</a> <a title="AJG_Vol.113.No5 page 52" href="http://viewer.zmags.com/publication/d9108239?page=52"> CME QuEsTions 645 cme see related editoria</a> <a title="AJG_Vol.113.No5 page 53" href="http://viewer.zmags.com/publication/d9108239?page=53"> 646 CME QuEsTions see related editorial </a> <a title="AJG_Vol.113.No5 page 54" href="http://viewer.zmags.com/publication/d9108239?page=54"> CliniCAl And SySTemATiC ReviewS 647 see re</a> <a title="AJG_Vol.113.No5 page 55" href="http://viewer.zmags.com/publication/d9108239?page=55"> 648 Lacy et al. Review ARTiCLe vomiting aff</a> <a title="AJG_Vol.113.No5 page 56" href="http://viewer.zmags.com/publication/d9108239?page=56"> Table 1 Common causes of chronic nausea and vomit</a> <a title="AJG_Vol.113.No5 page 57" href="http://viewer.zmags.com/publication/d9108239?page=57"> 650 Lacy et al. Review ARTiCLe Table 3 Cate</a> <a title="AJG_Vol.113.No5 page 58" href="http://viewer.zmags.com/publication/d9108239?page=58"> Chronic nausea and vomiting: evaluation and treat</a> <a title="AJG_Vol.113.No5 page 59" href="http://viewer.zmags.com/publication/d9108239?page=59"> 652 Lacy et al. Review ARTiCLe Table 6 Test</a> <a title="AJG_Vol.113.No5 page 60" href="http://viewer.zmags.com/publication/d9108239?page=60"> less sensor technology. The gastric residence tim</a> <a title="AJG_Vol.113.No5 page 61" href="http://viewer.zmags.com/publication/d9108239?page=61"> 654 Lacy et al. Delayed gastric emptying on</a> <a title="AJG_Vol.113.No5 page 62" href="http://viewer.zmags.com/publication/d9108239?page=62"> there is possible publication bias or othe</a> <a title="AJG_Vol.113.No5 page 63" href="http://viewer.zmags.com/publication/d9108239?page=63"> 656 Lacy et al. Delayed gastic empt</a> <a title="AJG_Vol.113.No5 page 64" href="http://viewer.zmags.com/publication/d9108239?page=64"> spective, randomized, controlled trials evaluatin</a> <a title="AJG_Vol.113.No5 page 65" href="http://viewer.zmags.com/publication/d9108239?page=65"> 658 Lacy et al. Review ARTiCLe 33. Wood J</a> <a title="AJG_Vol.113.No5 page 66" href="http://viewer.zmags.com/publication/d9108239?page=66"> Rev. 2011;2:CD001960 https://doi.org/</a> <a title="AJG_Vol.113.No5 page 67" href="http://viewer.zmags.com/publication/d9108239?page=67"> 660 CliniCAl And SySTemATiC ReviewS </a> <a title="AJG_Vol.113.No5 page 68" href="http://viewer.zmags.com/publication/d9108239?page=68"> Evaluation of chronic diarrhea and irritable bowe</a> <a title="AJG_Vol.113.No5 page 69" href="http://viewer.zmags.com/publication/d9108239?page=69"> 662 L. Schiller Review ARTiCLe carcinoid sy</a> <a title="AJG_Vol.113.No5 page 70" href="http://viewer.zmags.com/publication/d9108239?page=70"> Evaluation of chronic diarrhea and irritable bowe</a> <a title="AJG_Vol.113.No5 page 71" href="http://viewer.zmags.com/publication/d9108239?page=71"> 664 L. Schiller Review ARTiCLe producing co</a> <a title="AJG_Vol.113.No5 page 72" href="http://viewer.zmags.com/publication/d9108239?page=72"> Evaluation of chronic diarrhea and irritable bowe</a> <a title="AJG_Vol.113.No5 page 73" href="http://viewer.zmags.com/publication/d9108239?page=73"> 666 L. Schiller ▲ Review ARTiCLe OSMOTIC DI</a> <a title="AJG_Vol.113.No5 page 74" href="http://viewer.zmags.com/publication/d9108239?page=74"> Evaluation of chronic diarrhea and irritable bowe</a> <a title="AJG_Vol.113.No5 page 75" href="http://viewer.zmags.com/publication/d9108239?page=75"> 668 L. Schiller Review ARTiCLe should not b</a> <a title="AJG_Vol.113.No5 page 76" href="http://viewer.zmags.com/publication/d9108239?page=76"> Evaluation of chronic diarrhea and irritable bowe</a> <a title="AJG_Vol.113.No5 page 77" href="http://viewer.zmags.com/publication/d9108239?page=77"> 670 ArTicle </a> <a title="AJG_Vol.113.No5 page 78" href="http://viewer.zmags.com/publication/d9108239?page=78"> Lack of improvement of impaired chemical clearanc</a> <a title="AJG_Vol.113.No5 page 79" href="http://viewer.zmags.com/publication/d9108239?page=79"> 672 Frazzoni et al. Esophagus 9% difference</a> <a title="AJG_Vol.113.No5 page 80" href="http://viewer.zmags.com/publication/d9108239?page=80"> Lack of improvement of impaired chemical clearanc</a> <a title="AJG_Vol.113.No5 page 81" href="http://viewer.zmags.com/publication/d9108239?page=81"> 674 Frazzoni et al. Esophagus Table 4 On-th</a> <a title="AJG_Vol.113.No5 page 82" href="http://viewer.zmags.com/publication/d9108239?page=82"> Lack of improvement of impaired chemical clearanc</a> <a title="AJG_Vol.113.No5 page 83" href="http://viewer.zmags.com/publication/d9108239?page=83"> 676 Frazzoni et al. target of future trea</a> <a title="AJG_Vol.113.No5 page 84" href="http://viewer.zmags.com/publication/d9108239?page=84"> ArTicle 677 see related editorial on page </a> <a title="AJG_Vol.113.No5 page 85" href="http://viewer.zmags.com/publication/d9108239?page=85"> 678 Kappelle et al. Endoscopy IntRoductIon </a> <a title="AJG_Vol.113.No5 page 86" href="http://viewer.zmags.com/publication/d9108239?page=86"> Rapid on-site evaluation during endoscopic ultras</a> <a title="AJG_Vol.113.No5 page 87" href="http://viewer.zmags.com/publication/d9108239?page=87"> 680 Kappelle et al. Endoscopy Patients asse</a> <a title="AJG_Vol.113.No5 page 88" href="http://viewer.zmags.com/publication/d9108239?page=88"> Rapid on-site evaluation during endoscopic ultras</a> <a title="AJG_Vol.113.No5 page 89" href="http://viewer.zmags.com/publication/d9108239?page=89"> 682 Kappelle et al. Endoscopy Table 3 Compa</a> <a title="AJG_Vol.113.No5 page 90" href="http://viewer.zmags.com/publication/d9108239?page=90"> Rapid on-site evaluation during endoscopic ultras</a> <a title="AJG_Vol.113.No5 page 91" href="http://viewer.zmags.com/publication/d9108239?page=91"> 684 Kappelle et al. Endoscopy diagnostic yi</a> <a title="AJG_Vol.113.No5 page 92" href="http://viewer.zmags.com/publication/d9108239?page=92"> Rapid on-site evaluation during endoscopic ultras</a> <a title="AJG_Vol.113.No5 page 93" href="http://viewer.zmags.com/publication/d9108239?page=93"> 686 ArTicle </a> <a title="AJG_Vol.113.No5 page 94" href="http://viewer.zmags.com/publication/d9108239?page=94"> ALT levels and high levels of HBV DNA, with or wi</a> <a title="AJG_Vol.113.No5 page 95" href="http://viewer.zmags.com/publication/d9108239?page=95"> 688 Yi et al. limit of normal (ULN) up to</a> <a title="AJG_Vol.113.No5 page 96" href="http://viewer.zmags.com/publication/d9108239?page=96"> The characteristics and predictors of postpartum.</a> <a title="AJG_Vol.113.No5 page 97" href="http://viewer.zmags.com/publication/d9108239?page=97"> 690 Yi et al. Liver Table 1 Baseline charac</a> <a title="AJG_Vol.113.No5 page 98" href="http://viewer.zmags.com/publication/d9108239?page=98"> delivery and approached the baseline level at pos</a> <a title="AJG_Vol.113.No5 page 99" href="http://viewer.zmags.com/publication/d9108239?page=99"> 692 Yi et al. 100 80 60 Liver </a> <a title="AJG_Vol.113.No5 page 100" href="http://viewer.zmags.com/publication/d9108239?page=100"> was about 1:4 and remained in a very reasonable r</a> <a title="AJG_Vol.113.No5 page 101" href="http://viewer.zmags.com/publication/d9108239?page=101"> 694 ArTicle </a> <a title="AJG_Vol.113.No5 page 102" href="http://viewer.zmags.com/publication/d9108239?page=102"> to find any association between BMI and IBD [5]. </a> <a title="AJG_Vol.113.No5 page 103" href="http://viewer.zmags.com/publication/d9108239?page=103"> 696 Jensen et al. system (Fig.  1). Furth</a> <a title="AJG_Vol.113.No5 page 104" href="http://viewer.zmags.com/publication/d9108239?page=104"> Table 1 Descriptive statistics of the 316,799 stu</a> <a title="AJG_Vol.113.No5 page 105" href="http://viewer.zmags.com/publication/d9108239?page=105"> 698 Jensen et al. Crohn's disease diagnos</a> <a title="AJG_Vol.113.No5 page 106" href="http://viewer.zmags.com/publication/d9108239?page=106"> Childhood body mass index and risk of inflammator</a> <a title="AJG_Vol.113.No5 page 107" href="http://viewer.zmags.com/publication/d9108239?page=107"> 700 Jensen et al. Table 4 Hazard ratio (HR</a> <a title="AJG_Vol.113.No5 page 108" href="http://viewer.zmags.com/publication/d9108239?page=108"> Conflict of interest Guarantor: CBJ had full acce</a> <a title="AJG_Vol.113.No5 page 109" href="http://viewer.zmags.com/publication/d9108239?page=109"> 702 ArTicle </a> <a title="AJG_Vol.113.No5 page 110" href="http://viewer.zmags.com/publication/d9108239?page=110"> reporting is important to make for several reason</a> <a title="AJG_Vol.113.No5 page 111" href="http://viewer.zmags.com/publication/d9108239?page=111"> 704 Gracie et al. INFLAMMATORY BOWEL DISEASE</a> <a title="AJG_Vol.113.No5 page 112" href="http://viewer.zmags.com/publication/d9108239?page=112"> tary Table 2. In brief, patients reporting IBS-ty</a> <a title="AJG_Vol.113.No5 page 113" href="http://viewer.zmags.com/publication/d9108239?page=113"> 706 Gracie et al. INFLAMMATORY BOWEL DISEASE</a> <a title="AJG_Vol.113.No5 page 114" href="http://viewer.zmags.com/publication/d9108239?page=114"> Longitudinal impact of IBS-type symptoms on disea</a> <a title="AJG_Vol.113.No5 page 115" href="http://viewer.zmags.com/publication/d9108239?page=115"> 708 Gracie et al. 1.00 0.95 0.9</a> <a title="AJG_Vol.113.No5 page 116" href="http://viewer.zmags.com/publication/d9108239?page=116"> Longitudinal impact of IBS-type symptoms on disea</a> <a title="AJG_Vol.113.No5 page 117" href="http://viewer.zmags.com/publication/d9108239?page=117"> 710 Gracie et al. INFLAMMATORY BOWEL DISEASE</a> <a title="AJG_Vol.113.No5 page 118" href="http://viewer.zmags.com/publication/d9108239?page=118"> Longitudinal impact of IBS-type symptoms on disea</a> <a title="AJG_Vol.113.No5 page 119" href="http://viewer.zmags.com/publication/d9108239?page=119"> 712 Gracie et al. INFLAMMATORY BOWEL DISEASE</a> <a title="AJG_Vol.113.No5 page 120" href="http://viewer.zmags.com/publication/d9108239?page=120"> ArTicle 713 see related editorial on page </a> <a title="AJG_Vol.113.No5 page 121" href="http://viewer.zmags.com/publication/d9108239?page=121"> 714 Deeke et al. Inflammatory Bowel DIsease </a> <a title="AJG_Vol.113.No5 page 122" href="http://viewer.zmags.com/publication/d9108239?page=122"> AUC upon ROC curve analysis were considered, and </a> <a title="AJG_Vol.113.No5 page 123" href="http://viewer.zmags.com/publication/d9108239?page=123"> 716 Deeke et al. MS discovery cohort </a> <a title="AJG_Vol.113.No5 page 124" href="http://viewer.zmags.com/publication/d9108239?page=124"> Mucosal–luminal interface proteomics... 717 </a> <a title="AJG_Vol.113.No5 page 125" href="http://viewer.zmags.com/publication/d9108239?page=125"> b 20 10 PC2 (11.5%) 0 Control </a> <a title="AJG_Vol.113.No5 page 126" href="http://viewer.zmags.com/publication/d9108239?page=126"> Mucosal–luminal interface proteomics... 719 </a> <a title="AJG_Vol.113.No5 page 127" href="http://viewer.zmags.com/publication/d9108239?page=127"> 720 Deeke et al. a 6 3 0 –3 –</a> <a title="AJG_Vol.113.No5 page 128" href="http://viewer.zmags.com/publication/d9108239?page=128"> Mucosal–luminal interface proteomics... 721 </a> <a title="AJG_Vol.113.No5 page 129" href="http://viewer.zmags.com/publication/d9108239?page=129"> 722 Deeke et al. Inflammatory Bowel DIsease </a> <a title="AJG_Vol.113.No5 page 130" href="http://viewer.zmags.com/publication/d9108239?page=130"> in nature to what is observed by endoscopy. This </a> <a title="AJG_Vol.113.No5 page 131" href="http://viewer.zmags.com/publication/d9108239?page=131"> 724 Deeke et al. Inflammatory Bowel DIsease </a> <a title="AJG_Vol.113.No5 page 132" href="http://viewer.zmags.com/publication/d9108239?page=132"> ArTicle 725 see related editorial on page </a> <a title="AJG_Vol.113.No5 page 133" href="http://viewer.zmags.com/publication/d9108239?page=133"> 726 Oduyebo et al. Functional Gi DisorDers </a> <a title="AJG_Vol.113.No5 page 134" href="http://viewer.zmags.com/publication/d9108239?page=134"> Effects of NGM282, an FGF19 variant, on colonic t</a> <a title="AJG_Vol.113.No5 page 135" href="http://viewer.zmags.com/publication/d9108239?page=135"> 728 Oduyebo et al. Functional Gi DisorDers </a> <a title="AJG_Vol.113.No5 page 136" href="http://viewer.zmags.com/publication/d9108239?page=136"> Effects of NGM282, an FGF19 variant, on colonic t</a> <a title="AJG_Vol.113.No5 page 137" href="http://viewer.zmags.com/publication/d9108239?page=137"> 730 Oduyebo et al. Table 3 Effects of NGM2</a> <a title="AJG_Vol.113.No5 page 138" href="http://viewer.zmags.com/publication/d9108239?page=138"> Effects of NGM282, an FGF19 variant, on colonic t</a> <a title="AJG_Vol.113.No5 page 139" href="http://viewer.zmags.com/publication/d9108239?page=139"> Drug by treatment interaction, p = 0.056 732 </a> <a title="AJG_Vol.113.No5 page 140" href="http://viewer.zmags.com/publication/d9108239?page=140"> Effects of NGM282, an FGF19 variant, on colonic t</a> <a title="AJG_Vol.113.No5 page 141" href="http://viewer.zmags.com/publication/d9108239?page=141"> 734 Oduyebo et al. Functional Gi DisorDers </a> <a title="AJG_Vol.113.No5 page 142" href="http://viewer.zmags.com/publication/d9108239?page=142"> ArTicle 735 see related editorial on page </a> <a title="AJG_Vol.113.No5 page 143" href="http://viewer.zmags.com/publication/d9108239?page=143"> 736 Brenner et al. FUNCTIONAL GI DISORDERS </a> <a title="AJG_Vol.113.No5 page 144" href="http://viewer.zmags.com/publication/d9108239?page=144"> Efficacy, safety, and tolerability of plecanatide</a> <a title="AJG_Vol.113.No5 page 145" href="http://viewer.zmags.com/publication/d9108239?page=145"> 738 Brenner et al. FUNCTIONAL GI DISORDERS </a> <a title="AJG_Vol.113.No5 page 146" href="http://viewer.zmags.com/publication/d9108239?page=146"> Efficacy, safety, and tolerability of plecanatide</a> <a title="AJG_Vol.113.No5 page 147" href="http://viewer.zmags.com/publication/d9108239?page=147"> 740 Brenner et al. FUNCTIONAL GI DISORDERS </a> <a title="AJG_Vol.113.No5 page 148" href="http://viewer.zmags.com/publication/d9108239?page=148"> Efficacy, safety, and tolerability of plecanatide</a> <a title="AJG_Vol.113.No5 page 149" href="http://viewer.zmags.com/publication/d9108239?page=149"> 742 Brenner et al. FUNCTIONAL GI DISORDERS </a> <a title="AJG_Vol.113.No5 page 150" href="http://viewer.zmags.com/publication/d9108239?page=150"> Efficacy, safety, and tolerability of plecanatide</a> <a title="AJG_Vol.113.No5 page 151" href="http://viewer.zmags.com/publication/d9108239?page=151"> 744 Brenner et al. FUNCTIONAL GI DISORDERS </a> <a title="AJG_Vol.113.No5 page 152" href="http://viewer.zmags.com/publication/d9108239?page=152"> Efficacy, safety, and tolerability of plecanatide</a> <a title="AJG_Vol.113.No5 page 153" href="http://viewer.zmags.com/publication/d9108239?page=153"> 746 ArTicle see related editorial on page</a> <a title="AJG_Vol.113.No5 page 154" href="http://viewer.zmags.com/publication/d9108239?page=154"> InTrodUCTIon Colorectal cancer (CRC) is the fourt</a> <a title="AJG_Vol.113.No5 page 155" href="http://viewer.zmags.com/publication/d9108239?page=155"> 748 Singal et al. Colon follow-up period. T</a> <a title="AJG_Vol.113.No5 page 156" href="http://viewer.zmags.com/publication/d9108239?page=156"> Patterns and predictors or repeat fecal immunoche</a> <a title="AJG_Vol.113.No5 page 157" href="http://viewer.zmags.com/publication/d9108239?page=157"> 750 Singal et al. Colon Proportion of patien</a> <a title="AJG_Vol.113.No5 page 158" href="http://viewer.zmags.com/publication/d9108239?page=158"> Patterns and predictors or repeat fecal immunoche</a> <a title="AJG_Vol.113.No5 page 159" href="http://viewer.zmags.com/publication/d9108239?page=159"> 752 Singal et al. Colon even after adjustme</a> <a title="AJG_Vol.113.No5 page 160" href="http://viewer.zmags.com/publication/d9108239?page=160"> Patterns and predictors or repeat fecal immunoche</a> <a title="AJG_Vol.113.No5 page 161" href="http://viewer.zmags.com/publication/d9108239?page=161"> 754 Singal et al. Colon material support (D</a> <a title="AJG_Vol.113.No5 page 162" href="http://viewer.zmags.com/publication/d9108239?page=162"> ArTicle 755 see related editorial on page </a> <a title="AJG_Vol.113.No5 page 163" href="http://viewer.zmags.com/publication/d9108239?page=163"> 756 Buxbaum et al. Pancreas InTroducTIon Ac</a> <a title="AJG_Vol.113.No5 page 164" href="http://viewer.zmags.com/publication/d9108239?page=164"> The pancreatitis activity scoring system predicts</a> <a title="AJG_Vol.113.No5 page 165" href="http://viewer.zmags.com/publication/d9108239?page=165"> 758 Buxbaum et al. Pancreas Table 1 Charact</a> <a title="AJG_Vol.113.No5 page 166" href="http://viewer.zmags.com/publication/d9108239?page=166"> The pancreatitis activity scoring system predicts</a> <a title="AJG_Vol.113.No5 page 167" href="http://viewer.zmags.com/publication/d9108239?page=167"> 760 Buxbaum et al. Pancreas BUN > 20, comor</a> <a title="AJG_Vol.113.No5 page 168" href="http://viewer.zmags.com/publication/d9108239?page=168"> The pancreatitis activity scoring system predicts</a> <a title="AJG_Vol.113.No5 page 169" href="http://viewer.zmags.com/publication/d9108239?page=169"> 762 Buxbaum et al. Pancreas at discharge >6</a> <a title="AJG_Vol.113.No5 page 170" href="http://viewer.zmags.com/publication/d9108239?page=170"> The pancreatitis activity scoring system predicts</a> <a title="AJG_Vol.113.No5 page 171" href="http://viewer.zmags.com/publication/d9108239?page=171"> 764 Buxbaum et al. Pancreas 25. Yadav D, O</a> <a title="AJG_Vol.113.No5 page 172" href="http://viewer.zmags.com/publication/d9108239?page=172"> ArTicle 765 see related editorial on page </a> <a title="AJG_Vol.113.No5 page 173" href="http://viewer.zmags.com/publication/d9108239?page=173"> 766 Roos et al. Pancreas pancreatic manifes</a> <a title="AJG_Vol.113.No5 page 174" href="http://viewer.zmags.com/publication/d9108239?page=174"> Fig. 1 Typical histopathological features of iaC </a> <a title="AJG_Vol.113.No5 page 175" href="http://viewer.zmags.com/publication/d9108239?page=175"> 768 Roos et al. Pancreas Supplementary Tabl</a> <a title="AJG_Vol.113.No5 page 176" href="http://viewer.zmags.com/publication/d9108239?page=176"> Table 3 Features of IAC on histopathology Feature</a> <a title="AJG_Vol.113.No5 page 177" href="http://viewer.zmags.com/publication/d9108239?page=177"> 770 Roos et al. Table 4 IAC patients with </a> <a title="AJG_Vol.113.No5 page 178" href="http://viewer.zmags.com/publication/d9108239?page=178"> 1984–2015 323 patients were resected for PHC 27</a> <a title="AJG_Vol.113.No5 page 179" href="http://viewer.zmags.com/publication/d9108239?page=179"> 772 Roos et al. Financial support: Fundin</a> <a title="AJG_Vol.113.No5 page 180" href="http://viewer.zmags.com/publication/d9108239?page=180"> LeTTer 773 see related editorial on page x</a> <a title="AJG_Vol.113.No5 page 181" href="http://viewer.zmags.com/publication/d9108239?page=181"> 774 Letters [3], have been found to be in</a> <a title="AJG_Vol.113.No5 page 182" href="http://viewer.zmags.com/publication/d9108239?page=182"> CONFLICT OF INTEREST The authors have no relevant</a> <a title="AJG_Vol.113.No5 page 183" href="http://viewer.zmags.com/publication/d9108239?page=183"> 776 Letters work recently published by th</a> <a title="AJG_Vol.113.No5 page 184" href="http://viewer.zmags.com/publication/d9108239?page=184"> Guarantor of the article: Amer Alkhatib MD, FACG.</a> <a title="AJG_Vol.113.No5 page 185" href="http://viewer.zmags.com/publication/d9108239?page=185"> 778 Letters possibly related to nutrient </a> <a title="AJG_Vol.113.No5 page 186" href="http://viewer.zmags.com/publication/d9108239?page=186"> to tell association. Am J Gastroenterol. 2</a> <a title="AJG_Vol.113.No5 page 187" href="http://viewer.zmags.com/publication/d9108239?page=187"> 780 Letters was significantly higher in t</a> <a title="AJG_Vol.113.No5 page 188" href="http://viewer.zmags.com/publication/d9108239?page=188"> colonoscopy-negative subjects, and for that matte</a> <a title="AJG_Vol.113.No5 page 189" href="http://viewer.zmags.com/publication/d9108239?page=189"> 782 Letters eUs-guided methylene blue inj</a> <a title="AJG_Vol.113.No5 page 190" href="http://viewer.zmags.com/publication/d9108239?page=190"> 4 weeks later. The patient continues to do well w</a> <a title="AJG_Vol.113.No5 page 191" href="http://viewer.zmags.com/publication/d9108239?page=191"> 784 Letters </a> <a title="AJG_Vol.113.No5 page 192" href="http://viewer.zmags.com/publication/d9108239?page=192"> AnnouncemenTs 785 see related editorial on</a> <a title="AJG_Vol.113.No5 page 193" href="http://viewer.zmags.com/publication/d9108239?page=193"> 786 AnnouncemenT Abougergi, M</a> <a title="AJG_Vol.113.No5 page 194" href="http://viewer.zmags.com/publication/d9108239?page=194"> Gyawali, C. Prakash Ha, Christina Harris, Lucinda</a> <a title="AJG_Vol.113.No5 page 195" href="http://viewer.zmags.com/publication/d9108239?page=195"> 788 Roman, Sabine Rosen, Michael Rubenstein, </a> <a title="AJG_Vol.113.No5 page 196" href="http://viewer.zmags.com/publication/d9108239?page=196"> Central Maine Medical Center's well-established a</a> <a title="AJG_Vol.113.No5 page 197" href="http://viewer.zmags.com/publication/d9108239?page=197"> CLASSIFIEDS } Gastroenterologist} OPPORTUNITY </a> <a title="AJG_Vol.113.No5 page 198" href="http://viewer.zmags.com/publication/d9108239?page=198"> The week's best science, from the world's #1 scie</a> <a title="AJG_Vol.113.No5 page 199" href="http://viewer.zmags.com/publication/d9108239?page=199"> Help your results stand out. 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