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<br /> DIABETES<br /> ISSN 2054-6181 October 2014 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EASD 2014<br /> Vienna, Austria<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 5<br /> CONGRESS REVIEW............................................................................................................................... 10<br /> • Review of the 50th Annual Meeting of the European Association for the Study of<br /> Diabetes, held in Vienna, Austria, 15th-19th September 2014<br /> SYMPOSIUM REVIEW<br /> • Investigating the Different Dimensions of DPP-4 Inhibitors................................................. 35<br /> DIFFUSION TENSOR IMAGING OF THE BRAIN IN TYPE 1 DIABETES................................................ 42<br /> • Jo Ann V. Antenor-Dor<a title="EMJ Diabetes 2014 page 1" href="http://viewer.zmags.com/publication/e960b138?page=1"> DIABETES ISSN 2054-6181 </a> <a title="EMJ Diabetes 2014 page 2" href="http://viewer.zmags.com/publication/e960b138?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Diabetes 2014 page 3" href="http://viewer.zmags.com/publication/e960b138?page=3"> DIABETES RESIDUAL CARDIOVASCULAR RISK IN DIABE</a> <a title="EMJ Diabetes 2014 page 4" href="http://viewer.zmags.com/publication/e960b138?page=4"> Duxes Healthcare Series Asia Pacific Healthcare P</a> <a title="EMJ Diabetes 2014 page 5" href="http://viewer.zmags.com/publication/e960b138?page=5"> Editorial Board Diabetes Editor-in-Chief: Dr G</a> <a title="EMJ Diabetes 2014 page 6" href="http://viewer.zmags.com/publication/e960b138?page=6"> Vipidia In type 2 diabetes and CV risk </a> <a title="EMJ Diabetes 2014 page 7" href="http://viewer.zmags.com/publication/e960b138?page=7"> Welcome I would like to welcome you all to this e</a> <a title="EMJ Diabetes 2014 page 8" href="http://viewer.zmags.com/publication/e960b138?page=8"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjre</a> <a title="EMJ Diabetes 2014 page 9" href="http://viewer.zmags.com/publication/e960b138?page=9"> Foreword Dr Gill Hood Research Delivery Manager, </a> <a title="EMJ Diabetes 2014 page 10" href="http://viewer.zmags.com/publication/e960b138?page=10"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 11" href="http://viewer.zmags.com/publication/e960b138?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ Diabetes 2014 page 12" href="http://viewer.zmags.com/publication/e960b138?page=12"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 13" href="http://viewer.zmags.com/publication/e960b138?page=13"> Sadly, gestational diabetes, in tandem with </a> <a title="EMJ Diabetes 2014 page 14" href="http://viewer.zmags.com/publication/e960b138?page=14"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 15" href="http://viewer.zmags.com/publication/e960b138?page=15"> Mutations can be good for diabetes prevention MUT</a> <a title="EMJ Diabetes 2014 page 16" href="http://viewer.zmags.com/publication/e960b138?page=16"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 17" href="http://viewer.zmags.com/publication/e960b138?page=17"> Renal failure reduced to rubble in Type 2 diabete</a> <a title="EMJ Diabetes 2014 page 18" href="http://viewer.zmags.com/publication/e960b138?page=18"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 19" href="http://viewer.zmags.com/publication/e960b138?page=19"> Insulin pumps defy death in Type 1 diabetes patie</a> <a title="EMJ Diabetes 2014 page 20" href="http://viewer.zmags.com/publication/e960b138?page=20"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 21" href="http://viewer.zmags.com/publication/e960b138?page=21"> Improving glucose control via an artificial pancre</a> <a title="EMJ Diabetes 2014 page 22" href="http://viewer.zmags.com/publication/e960b138?page=22"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 23" href="http://viewer.zmags.com/publication/e960b138?page=23"> Facultative pancreatic tissue stem cells: fact or</a> <a title="EMJ Diabetes 2014 page 24" href="http://viewer.zmags.com/publication/e960b138?page=24"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 25" href="http://viewer.zmags.com/publication/e960b138?page=25"> Do not put heart failure in the corner of diabete</a> <a title="EMJ Diabetes 2014 page 26" href="http://viewer.zmags.com/publication/e960b138?page=26"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 27" href="http://viewer.zmags.com/publication/e960b138?page=27"> Traumas of </a> <a title="EMJ Diabetes 2014 page 28" href="http://viewer.zmags.com/publication/e960b138?page=28"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 29" href="http://viewer.zmags.com/publication/e960b138?page=29"> Weight gain across the ages “Our findings pro</a> <a title="EMJ Diabetes 2014 page 30" href="http://viewer.zmags.com/publication/e960b138?page=30"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 31" href="http://viewer.zmags.com/publication/e960b138?page=31"> Tresiba®: new hope for diabetic children and adol</a> <a title="EMJ Diabetes 2014 page 32" href="http://viewer.zmags.com/publication/e960b138?page=32"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 33" href="http://viewer.zmags.com/publication/e960b138?page=33"> IDegLira boosts glycaemic control in Type 2 diabe</a> <a title="EMJ Diabetes 2014 page 34" href="http://viewer.zmags.com/publication/e960b138?page=34"> EASD ANNUAL CONGRESS 2014 MESSEZENTRUM VIENNA, VI</a> <a title="EMJ Diabetes 2014 page 35" href="http://viewer.zmags.com/publication/e960b138?page=35"> INVESTIGATING THE DIFFERENT DIMENSIONS </a> <a title="EMJ Diabetes 2014 page 36" href="http://viewer.zmags.com/publication/e960b138?page=36"> insulin resistance and CV disease, which formed t</a> <a title="EMJ Diabetes 2014 page 37" href="http://viewer.zmags.com/publication/e960b138?page=37"> progressive disease associated with a decline in </a> <a title="EMJ Diabetes 2014 page 38" href="http://viewer.zmags.com/publication/e960b138?page=38"> resistance and increased risk of vascular events.</a> <a title="EMJ Diabetes 2014 page 39" href="http://viewer.zmags.com/publication/e960b138?page=39"> The fixed combination of a DPP-4 inhibitor plus pi</a> <a title="EMJ Diabetes 2014 page 40" href="http://viewer.zmags.com/publication/e960b138?page=40"> Saxagliptin was associated with superior glycaemi</a> <a title="EMJ Diabetes 2014 page 41" href="http://viewer.zmags.com/publication/e960b138?page=41"> 20. Liebl A et al. Evaluation of risk factors for</a> <a title="EMJ Diabetes 2014 page 42" href="http://viewer.zmags.com/publication/e960b138?page=42"> DIFFUSION TENSOR IMAGING OF THE BRAIN IN </a> <a title="EMJ Diabetes 2014 page 43" href="http://viewer.zmags.com/publication/e960b138?page=43"> Studies are beginning to use DTI to understand th</a> <a title="EMJ Diabetes 2014 page 44" href="http://viewer.zmags.com/publication/e960b138?page=44"> birth to adulthood and is quite heterogeneous in </a> <a title="EMJ Diabetes 2014 page 45" href="http://viewer.zmags.com/publication/e960b138?page=45"> In addition, a history of </a> <a title="EMJ Diabetes 2014 page 46" href="http://viewer.zmags.com/publication/e960b138?page=46"> and manner in which their exposure to glycaemic e</a> <a title="EMJ Diabetes 2014 page 47" href="http://viewer.zmags.com/publication/e960b138?page=47"> REFERENCES 1. Mauras N et al. A randomized clini</a> <a title="EMJ Diabetes 2014 page 48" href="http://viewer.zmags.com/publication/e960b138?page=48"> DETECTION AND EARLY LIFESTYLE INTERVENTION IN </a> <a title="EMJ Diabetes 2014 page 49" href="http://viewer.zmags.com/publication/e960b138?page=49"> those with normal blood glucose levels; estimates</a> <a title="EMJ Diabetes 2014 page 50" href="http://viewer.zmags.com/publication/e960b138?page=50"> has been shown to be the most cost-effecti</a> <a title="EMJ Diabetes 2014 page 51" href="http://viewer.zmags.com/publication/e960b138?page=51"> Table 2: Characteristics of the primary lifestyle</a> <a title="EMJ Diabetes 2014 page 52" href="http://viewer.zmags.com/publication/e960b138?page=52"> after randomisation (7 years after the interventi</a> <a title="EMJ Diabetes 2014 page 53" href="http://viewer.zmags.com/publication/e960b138?page=53"> the prevention and control of non-communicable </a> <a title="EMJ Diabetes 2014 page 54" href="http://viewer.zmags.com/publication/e960b138?page=54"> Research targeted to the prevention of T2DM</a> <a title="EMJ Diabetes 2014 page 55" href="http://viewer.zmags.com/publication/e960b138?page=55"> suggest that focusing on sedentary time and</a> <a title="EMJ Diabetes 2014 page 56" href="http://viewer.zmags.com/publication/e960b138?page=56"> intervention in a multi-ethnic UK pop</a> <a title="EMJ Diabetes 2014 page 57" href="http://viewer.zmags.com/publication/e960b138?page=57"> of mobile phone messaging in prevention of type 2</a> <a title="EMJ Diabetes 2014 page 58" href="http://viewer.zmags.com/publication/e960b138?page=58"> A PRACTICAL REVIEW OF INSULIN PEN DEVICES </a> <a title="EMJ Diabetes 2014 page 59" href="http://viewer.zmags.com/publication/e960b138?page=59"> one co-payment per box of pens, the cost to the p</a> <a title="EMJ Diabetes 2014 page 60" href="http://viewer.zmags.com/publication/e960b138?page=60"> Insulin cartridges or prefilled disposable pens ar</a> <a title="EMJ Diabetes 2014 page 61" href="http://viewer.zmags.com/publication/e960b138?page=61"> are aware of these to ensure the best outcomes. T</a> <a title="EMJ Diabetes 2014 page 62" href="http://viewer.zmags.com/publication/e960b138?page=62"> Because it is possible for insulin to still be flo</a> <a title="EMJ Diabetes 2014 page 63" href="http://viewer.zmags.com/publication/e960b138?page=63"> REFERENCES 1. Inzucchi SE et al. Management</a> <a title="EMJ Diabetes 2014 page 64" href="http://viewer.zmags.com/publication/e960b138?page=64"> www.bd.com/us/diabetes/page. aspx?cat=7002&id=102</a> <a title="EMJ Diabetes 2014 page 65" href="http://viewer.zmags.com/publication/e960b138?page=65"> MEMBRANE FLEXIBILITY AND CELLULAR ENERGY MANAGEME</a> <a title="EMJ Diabetes 2014 page 66" href="http://viewer.zmags.com/publication/e960b138?page=66"> pair of carbon atoms, which can be calculated wit</a> <a title="EMJ Diabetes 2014 page 67" href="http://viewer.zmags.com/publication/e960b138?page=67"> Table 1: Experimental data of fully hydrated fluid</a> <a title="EMJ Diabetes 2014 page 68" href="http://viewer.zmags.com/publication/e960b138?page=68"> overheating of the larger cubic cell, evolu</a> <a title="EMJ Diabetes 2014 page 69" href="http://viewer.zmags.com/publication/e960b138?page=69"> depends on its plasma membrane flexibility, and th</a> <a title="EMJ Diabetes 2014 page 70" href="http://viewer.zmags.com/publication/e960b138?page=70"> ↓ Mitochondrial ATP ↑ Insulin ↑ Plasma FFA ↓ I</a> <a title="EMJ Diabetes 2014 page 71" href="http://viewer.zmags.com/publication/e960b138?page=71"> metabolic rate, should be higher in individuals w</a> <a title="EMJ Diabetes 2014 page 72" href="http://viewer.zmags.com/publication/e960b138?page=72"> 20. Graybill C et al. Ultrastructure of human e</a> <a title="EMJ Diabetes 2014 page 73" href="http://viewer.zmags.com/publication/e960b138?page=73"> TARGETING ADIPOSE TISSUE LIPID METABOLISM </a> <a title="EMJ Diabetes 2014 page 74" href="http://viewer.zmags.com/publication/e960b138?page=74"> interesting to note that surgical removal of eith</a> <a title="EMJ Diabetes 2014 page 75" href="http://viewer.zmags.com/publication/e960b138?page=75"> A α2-ADR β-hydroxybutyrate SCFA, lactat</a> <a title="EMJ Diabetes 2014 page 76" href="http://viewer.zmags.com/publication/e960b138?page=76"> ADIPOSE TISSUE LIPID METABOLISM IN OBESITY AND CV</a> <a title="EMJ Diabetes 2014 page 77" href="http://viewer.zmags.com/publication/e960b138?page=77"> As illustrated in Figure 2B, induction </a> <a title="EMJ Diabetes 2014 page 78" href="http://viewer.zmags.com/publication/e960b138?page=78"> white adipose tissue have, so far, not provided p</a> <a title="EMJ Diabetes 2014 page 79" href="http://viewer.zmags.com/publication/e960b138?page=79"> Recently, we have shown that dietary polyphenols,</a> <a title="EMJ Diabetes 2014 page 80" href="http://viewer.zmags.com/publication/e960b138?page=80"> 12. Dicker A et al. Primary differences in lipoly</a> <a title="EMJ Diabetes 2014 page 81" href="http://viewer.zmags.com/publication/e960b138?page=81"> natriuretic peptide and natriuretic pept</a> <a title="EMJ Diabetes 2014 page 82" href="http://viewer.zmags.com/publication/e960b138?page=82"> 5-phosphodiesterase inhibition on energy metaboli</a> <a title="EMJ Diabetes 2014 page 83" href="http://viewer.zmags.com/publication/e960b138?page=83"> RESIDUAL CARDIOVASCULAR RISK IN DIABETIC PA</a> <a title="EMJ Diabetes 2014 page 84" href="http://viewer.zmags.com/publication/e960b138?page=84"> progression in patients with T2DM, including the </a> <a title="EMJ Diabetes 2014 page 85" href="http://viewer.zmags.com/publication/e960b138?page=85"> significantly improved inflammatory markers, such a</a> <a title="EMJ Diabetes 2014 page 86" href="http://viewer.zmags.com/publication/e960b138?page=86"> SV, an effect that seems promising for the</a> <a title="EMJ Diabetes 2014 page 87" href="http://viewer.zmags.com/publication/e960b138?page=87"> Drug Targets. 2009;10(4):336-43. 27. Filippatos T</a> <a title="EMJ Diabetes 2014 page 88" href="http://viewer.zmags.com/publication/e960b138?page=88"> PATHOPHYSIOLOGY AND IMAGING TECHNIQUES </a> <a title="EMJ Diabetes 2014 page 89" href="http://viewer.zmags.com/publication/e960b138?page=89"> In a process called myocardial steatosis (M</a> <a title="EMJ Diabetes 2014 page 90" href="http://viewer.zmags.com/publication/e960b138?page=90"> a linear correlation between calibrated integrate</a> <a title="EMJ Diabetes 2014 page 91" href="http://viewer.zmags.com/publication/e960b138?page=91"> V IBS values (dB) -37.2 -43.2 -3.5</a> <a title="EMJ Diabetes 2014 page 92" href="http://viewer.zmags.com/publication/e960b138?page=92"> MVD AND ED ED and MVD can be evaluated dir</a> <a title="EMJ Diabetes 2014 page 93" href="http://viewer.zmags.com/publication/e960b138?page=93"> without prior CAD or MI, 60% had abnormal stress </a> <a title="EMJ Diabetes 2014 page 94" href="http://viewer.zmags.com/publication/e960b138?page=94"> Traditionally, invasive coronary angiogr</a> <a title="EMJ Diabetes 2014 page 95" href="http://viewer.zmags.com/publication/e960b138?page=95"> On echocardiography, transmitral inflow patterns a</a> <a title="EMJ Diabetes 2014 page 96" href="http://viewer.zmags.com/publication/e960b138?page=96"> heart. J Pathol. 2013;229:232-41. 11. McGavock </a> <a title="EMJ Diabetes 2014 page 97" href="http://viewer.zmags.com/publication/e960b138?page=97"> 123I-metaiodobenzylguanidine (MIBG) parameter</a> <a title="EMJ Diabetes 2014 page 98" href="http://viewer.zmags.com/publication/e960b138?page=98"> assessed with novel automated function imaging a</a> <a title="EMJ Diabetes 2014 page 99" href="http://viewer.zmags.com/publication/e960b138?page=99"> EXERCISE: A POWERFUL TOOL TO MANAGE TYPE 2 </a> <a title="EMJ Diabetes 2014 page 100" href="http://viewer.zmags.com/publication/e960b138?page=100"> higher intensity, greater frequency, and/or longe</a> <a title="EMJ Diabetes 2014 page 101" href="http://viewer.zmags.com/publication/e960b138?page=101"> latest ACSM-ADA position stand.19 The most releva</a> <a title="EMJ Diabetes 2014 page 102" href="http://viewer.zmags.com/publication/e960b138?page=102"> visceral fat. This was followed by numerous other</a> <a title="EMJ Diabetes 2014 page 103" href="http://viewer.zmags.com/publication/e960b138?page=103"> subjects. As a result, a considerable amount of l</a> <a title="EMJ Diabetes 2014 page 104" href="http://viewer.zmags.com/publication/e960b138?page=104"> Diabetes. 1996;45(4):440–5. 15. Andreassen CS </a> <a title="EMJ Diabetes 2014 page 105" href="http://viewer.zmags.com/publication/e960b138?page=105"> WHO GETS DIABETIC MACULAR OEDEMA; WHEN; AND WHY?</a> <a title="EMJ Diabetes 2014 page 106" href="http://viewer.zmags.com/publication/e960b138?page=106"> As these data show, visual disability from diabet</a> <a title="EMJ Diabetes 2014 page 107" href="http://viewer.zmags.com/publication/e960b138?page=107"> by oxygen tension in the tissue; its produ</a> <a title="EMJ Diabetes 2014 page 108" href="http://viewer.zmags.com/publication/e960b138?page=108"> DMO prevalence has been studied in many ethnic gr</a> <a title="EMJ Diabetes 2014 page 109" href="http://viewer.zmags.com/publication/e960b138?page=109"> also have unmodifiable risk factors like gen</a> <a title="EMJ Diabetes 2014 page 110" href="http://viewer.zmags.com/publication/e960b138?page=110"> REFERENCES 1. World Health Organization. Diabete</a> <a title="EMJ Diabetes 2014 page 111" href="http://viewer.zmags.com/publication/e960b138?page=111"> diabetes mellitus patients in a 15-year follow-up</a> <a title="EMJ Diabetes 2014 page 112" href="http://viewer.zmags.com/publication/e960b138?page=112"> WHAT’S NEW INTERVIEW One pen needle making one bi</a> <a title="EMJ Diabetes 2014 page 113" href="http://viewer.zmags.com/publication/e960b138?page=113"> DIABETES your new needle adds to the convenience </a> <a title="EMJ Diabetes 2014 page 114" href="http://viewer.zmags.com/publication/e960b138?page=114"> WHAT’S NEW Maternal antidepressants: health risk </a> <a title="EMJ Diabetes 2014 page 115" href="http://viewer.zmags.com/publication/e960b138?page=115"> DIABETES Gut changing diabetes circumstances </a> <a title="EMJ Diabetes 2014 page 116" href="http://viewer.zmags.com/publication/e960b138?page=116"> WHAT’S NEW Healthy obesity: fact or fiction? LINKS</a> <a title="EMJ Diabetes 2014 page 117" href="http://viewer.zmags.com/publication/e960b138?page=117"> DIABETES Polycystic ovary syndrome contributing t</a> <a title="EMJ Diabetes 2014 page 118" href="http://viewer.zmags.com/publication/e960b138?page=118"> WHAT’S NEW Microchip magnifies Type 1 diabetes dia</a> <a title="EMJ Diabetes 2014 page 119" href="http://viewer.zmags.com/publication/e960b138?page=119"> DIABETES Sleep apnoea Other risk factors of diabe</a> <a title="EMJ Diabetes 2014 page 120" href="http://viewer.zmags.com/publication/e960b138?page=120"> WHAT’S NEW The evolution of diabetes therapy DIAB</a> <a title="EMJ Diabetes 2014 page 121" href="http://viewer.zmags.com/publication/e960b138?page=121"> DIABETES Of mice and men: new diabetes gene disco</a> <a title="EMJ Diabetes 2014 page 122" href="http://viewer.zmags.com/publication/e960b138?page=122"> WHAT’S NEW The key to coping with diabetes “We</a> <a title="EMJ Diabetes 2014 page 123" href="http://viewer.zmags.com/publication/e960b138?page=123"> From a host of fifteen therapeutic areas, EUROPEAN</a> <a title="EMJ Diabetes 2014 page 124" href="http://viewer.zmags.com/publication/e960b138?page=124"> Featured Suppliers Diabetes Responsible for t</a> <a title="EMJ Diabetes 2014 page 125" href="http://viewer.zmags.com/publication/e960b138?page=125"> Buyer’s Guide Exhibitors • A. 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