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<br /> ARCHIVE<br /> VOLUME 111 NUMBER 1 JANUARY 2016<br /> www.nature.com/ajg<br /> official publication of the american college of gastroenterology<br /> LEADING ARTICLES OF THE MONTH<br /> The Red Section: EndoTech Update<br /> 6 Just Clip It: Endoscopic Clipping in the 21st Century<br /> B. Joseph Elmunzer<br /> Practice Guidelines<br /> 30 ACG Clinical Guideline: Diagnosis and Management of Barrett’s<br /> Esophagus CME<br /> N.J. Shaheen, G.W. Falk, P.G. Iyer and L.B. Gerson<br /> Clinical and Systematic Reviews<br /> 53 Diagnosis and Management of Functional Heartburn CME<br /> C. Hachem and N.J. Shaheen<br /> Endoscopy<br /> 63 Effect of Dynamic Position Changes on Adenoma Detection during<br /> Colonoscope Withdrawal: A Randomized Controlled Multicenter Trial<br /> S.-W. Lee, J.H. Chang, J.-S. Ji et al.<br /> Liver<br /> 78 Diagnosis of Minima<a title="AJG_Vol.111.No.12 page 1" href="http://viewer.zmags.com/publication/ed34beaa?page=1"> ARCHIVE VOLUME 111 NUMBER 1 JANUARY 2016 www.nat</a> <a title="AJG_Vol.111.No.12 page 2" href="http://viewer.zmags.com/publication/ed34beaa?page=2"> VOLUME 111 NUMBER 12 DECEMBER 2016 www.nature.com</a> <a title="AJG_Vol.111.No.12 page 3" href="http://viewer.zmags.com/publication/ed34beaa?page=3"> Treat IBS-Di erently A 2-week treatment for IBS-</a> <a title="AJG_Vol.111.No.12 page 4" href="http://viewer.zmags.com/publication/ed34beaa?page=4"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This Bri</a> <a title="AJG_Vol.111.No.12 page 5" href="http://viewer.zmags.com/publication/ed34beaa?page=5"> www.nature.com/ajg The American Journal o</a> <a title="AJG_Vol.111.No.12 page 6" href="http://viewer.zmags.com/publication/ed34beaa?page=6"> Patients of any HCV genotype can now be cured wit</a> <a title="AJG_Vol.111.No.12 page 7" href="http://viewer.zmags.com/publication/ed34beaa?page=7"> Albert Einstein used with permission of the HUJ/G</a> <a title="AJG_Vol.111.No.12 page 8" href="http://viewer.zmags.com/publication/ed34beaa?page=8"> NOW APPROVED THE FIRST AND ONLY PAN-GENOTYPIC ONC</a> <a title="AJG_Vol.111.No.12 page 9" href="http://viewer.zmags.com/publication/ed34beaa?page=9"> HARVONI® (ledipasvir 90 mg and sofosbuvir 400 mg)</a> <a title="AJG_Vol.111.No.12 page 10" href="http://viewer.zmags.com/publication/ed34beaa?page=10"> Brief Summary (cont.) Postmarketing Experience: B</a> <a title="AJG_Vol.111.No.12 page 11" href="http://viewer.zmags.com/publication/ed34beaa?page=11"> EPCLUSA® (sofosbuvir 400 mg and velpatasvir 100 m</a> <a title="AJG_Vol.111.No.12 page 12" href="http://viewer.zmags.com/publication/ed34beaa?page=12"> Brief Summary (cont.) DRUG INTERACTIONS: Sofosbuv</a> <a title="AJG_Vol.111.No.12 page 13" href="http://viewer.zmags.com/publication/ed34beaa?page=13"> official publication of the american college</a> <a title="AJG_Vol.111.No.12 page 14" href="http://viewer.zmags.com/publication/ed34beaa?page=14"> Leading the way in gastroenterology. At Children</a> <a title="AJG_Vol.111.No.12 page 15" href="http://viewer.zmags.com/publication/ed34beaa?page=15"> American College of Gastroenterology & World Gast</a> <a title="AJG_Vol.111.No.12 page 16" href="http://viewer.zmags.com/publication/ed34beaa?page=16"> WHAT ARE BIOSIMILARS? Let’s Clarify Biosimilar</a> <a title="AJG_Vol.111.No.12 page 17" href="http://viewer.zmags.com/publication/ed34beaa?page=17"> Another Miracle? No, it's MiraFIBER™ </a> <a title="AJG_Vol.111.No.12 page 18" href="http://viewer.zmags.com/publication/ed34beaa?page=18"> (Top) CT scan showing pneumatosis linearis of the</a> <a title="AJG_Vol.111.No.12 page 19" href="http://viewer.zmags.com/publication/ed34beaa?page=19"> CONTENTS 80 60 Frequency 40 20 </a> <a title="AJG_Vol.111.No.12 page 20" href="http://viewer.zmags.com/publication/ed34beaa?page=20"> www.nature.com/ajg 35 30 25 20 15 Incid</a> <a title="AJG_Vol.111.No.12 page 21" href="http://viewer.zmags.com/publication/ed34beaa?page=21"> INDICATION AND IMPORTANT SAFETY INFORMATION FOR H</a> <a title="AJG_Vol.111.No.12 page 22" href="http://viewer.zmags.com/publication/ed34beaa?page=22"> MODERATE TO SEVERE CROHN'S DISEASE (CD) My n</a> <a title="AJG_Vol.111.No.12 page 23" href="http://viewer.zmags.com/publication/ed34beaa?page=23"> HUMIRA® (adalimumab) </a> <a title="AJG_Vol.111.No.12 page 24" href="http://viewer.zmags.com/publication/ed34beaa?page=24"> Use with Anakinra Concurrent use of anakinra (an </a> <a title="AJG_Vol.111.No.12 page 25" href="http://viewer.zmags.com/publication/ed34beaa?page=25"> week was similar to the safety profile seen in pa</a> <a title="AJG_Vol.111.No.12 page 26" href="http://viewer.zmags.com/publication/ed34beaa?page=26"> The first treatment in nearly 20 years for PBC1 </a> <a title="AJG_Vol.111.No.12 page 27" href="http://viewer.zmags.com/publication/ed34beaa?page=27"> Delivered Significant, Sustained Reductions </a> <a title="AJG_Vol.111.No.12 page 28" href="http://viewer.zmags.com/publication/ed34beaa?page=28"> For patients with PBC who have had an inadequate </a> <a title="AJG_Vol.111.No.12 page 29" href="http://viewer.zmags.com/publication/ed34beaa?page=29"> Brief Summary of Prescribing Information for OCAL</a> <a title="AJG_Vol.111.No.12 page 30" href="http://viewer.zmags.com/publication/ed34beaa?page=30"> [see Clinical Pharmacology (12.3) in Full Prescri</a> <a title="AJG_Vol.111.No.12 page 31" href="http://viewer.zmags.com/publication/ed34beaa?page=31"> NEW THE FIRST AND ONLY INTERLEUKIN-12 AND INTERLE</a> <a title="AJG_Vol.111.No.12 page 32" href="http://viewer.zmags.com/publication/ed34beaa?page=32"> + STELARA® combines a single intravenous (I</a> <a title="AJG_Vol.111.No.12 page 33" href="http://viewer.zmags.com/publication/ed34beaa?page=33"> Brief Summary of Prescribing Information for STEL</a> <a title="AJG_Vol.111.No.12 page 34" href="http://viewer.zmags.com/publication/ed34beaa?page=34"> STELARA® (ustekinumab) Table 2: Common adverse re</a> <a title="AJG_Vol.111.No.12 page 35" href="http://viewer.zmags.com/publication/ed34beaa?page=35"> Attend an ACG Regional Postgraduate Course 2017 W</a> <a title="AJG_Vol.111.No.12 page 36" href="http://viewer.zmags.com/publication/ed34beaa?page=36"> BOOKS & ARTS Nature's Books & Arts section has </a> <a title="AJG_Vol.111.No.12 page 37" href="http://viewer.zmags.com/publication/ed34beaa?page=37"> GI QUALITY IMPROVEMENT CONSORTIUM LTD 3 Se ing</a> <a title="AJG_Vol.111.No.12 page 38" href="http://viewer.zmags.com/publication/ed34beaa?page=38"> FOR PATIENTS WITH ACTIVE, MILD TO MODERATE ULCERA</a> <a title="AJG_Vol.111.No.12 page 39" href="http://viewer.zmags.com/publication/ed34beaa?page=39"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This bri</a> <a title="AJG_Vol.111.No.12 page 40" href="http://viewer.zmags.com/publication/ed34beaa?page=40"> #1 MOST PRESCRIBED, BRANDED BOWEL PREP KIT1 </a> <a title="AJG_Vol.111.No.12 page 41" href="http://viewer.zmags.com/publication/ed34beaa?page=41"> IMPORTANT SAFETY INFORMATION SUPREP® Bowel Prep K</a> <a title="AJG_Vol.111.No.12 page 42" href="http://viewer.zmags.com/publication/ed34beaa?page=42"> BRIEF SUMMARY OF PRESCRIBING INFORMATION This Br</a> <a title="AJG_Vol.111.No.12 page 43" href="http://viewer.zmags.com/publication/ed34beaa?page=43"> Hepatic Encephalopathy (HE) CAUSES EPISODIC NEURO</a> <a title="AJG_Vol.111.No.12 page 44" href="http://viewer.zmags.com/publication/ed34beaa?page=44"> THE RED SECTION 1669 see related edito</a> <a title="AJG_Vol.111.No.12 page 45" href="http://viewer.zmags.com/publication/ed34beaa?page=45"> 1670 THE RED SECTION Fig</a> <a title="AJG_Vol.111.No.12 page 46" href="http://viewer.zmags.com/publication/ed34beaa?page=46"> ing the gastroesophageal junction. USEMS a</a> <a title="AJG_Vol.111.No.12 page 47" href="http://viewer.zmags.com/publication/ed34beaa?page=47"> 1672 THE RED SECTION </a> <a title="AJG_Vol.111.No.12 page 48" href="http://viewer.zmags.com/publication/ed34beaa?page=48"> Figure 1. CT scan showing portal venous gas in a </a> <a title="AJG_Vol.111.No.12 page 49" href="http://viewer.zmags.com/publication/ed34beaa?page=49"> 1674 THE RED SECTION with 1–3 of the fol</a> <a title="AJG_Vol.111.No.12 page 50" href="http://viewer.zmags.com/publication/ed34beaa?page=50"> THE RED SECTION 1675 see related edito</a> <a title="AJG_Vol.111.No.12 page 51" href="http://viewer.zmags.com/publication/ed34beaa?page=51"> 1676 THE RED SECTION Figur</a> <a title="AJG_Vol.111.No.12 page 52" href="http://viewer.zmags.com/publication/ed34beaa?page=52"> nature publishing group </a> <a title="AJG_Vol.111.No.12 page 53" href="http://viewer.zmags.com/publication/ed34beaa?page=53"> 1678 THE RED SECTION Endoscopic Ultrasound</a> <a title="AJG_Vol.111.No.12 page 54" href="http://viewer.zmags.com/publication/ed34beaa?page=54"> THE RED SECTION 1679 Gastric Submucosal He</a> <a title="AJG_Vol.111.No.12 page 55" href="http://viewer.zmags.com/publication/ed34beaa?page=55"> 1680 THE RED SECTION Video of the Month E</a> <a title="AJG_Vol.111.No.12 page 56" href="http://viewer.zmags.com/publication/ed34beaa?page=56"> CLINICAL AND SYSTEMATIC REVIEWS 1681 C</a> <a title="AJG_Vol.111.No.12 page 57" href="http://viewer.zmags.com/publication/ed34beaa?page=57"> 1682 CLINICAL AND SYSTEMATIC REVIEWS REVIEW PR</a> <a title="AJG_Vol.111.No.12 page 58" href="http://viewer.zmags.com/publication/ed34beaa?page=58"> innovation is emerging with synergy arising from </a> <a title="AJG_Vol.111.No.12 page 59" href="http://viewer.zmags.com/publication/ed34beaa?page=59"> 1684 Boyapati et al. REVIEW Box 2. Why hav</a> <a title="AJG_Vol.111.No.12 page 60" href="http://viewer.zmags.com/publication/ed34beaa?page=60"> Challenges of Precision Medicine and Biomarkers i</a> <a title="AJG_Vol.111.No.12 page 61" href="http://viewer.zmags.com/publication/ed34beaa?page=61"> 1686 Boyapati et al. REVIEW treatment opti</a> <a title="AJG_Vol.111.No.12 page 62" href="http://viewer.zmags.com/publication/ed34beaa?page=62"> Challenges of Precision Medicine and Biomarkers i</a> <a title="AJG_Vol.111.No.12 page 63" href="http://viewer.zmags.com/publication/ed34beaa?page=63"> 1688 Boyapati et al. REVIEW all possible b</a> <a title="AJG_Vol.111.No.12 page 64" href="http://viewer.zmags.com/publication/ed34beaa?page=64"> 15. van Rheenen PF, Van de Vijver E, Fidler V. Fa</a> <a title="AJG_Vol.111.No.12 page 65" href="http://viewer.zmags.com/publication/ed34beaa?page=65"> 1690 Boyapati et al. REVIEW 65. Siegel CA,</a> <a title="AJG_Vol.111.No.12 page 66" href="http://viewer.zmags.com/publication/ed34beaa?page=66"> CLINICAL AND SYSTEMATIC REVIEWS 1691 C</a> <a title="AJG_Vol.111.No.12 page 67" href="http://viewer.zmags.com/publication/ed34beaa?page=67"> CLINICAL AND SYSTEMATIC REVIEWS 169</a> <a title="AJG_Vol.111.No.12 page 68" href="http://viewer.zmags.com/publication/ed34beaa?page=68"> based on observational studies, particularly in u</a> <a title="AJG_Vol.111.No.12 page 69" href="http://viewer.zmags.com/publication/ed34beaa?page=69"> 1694 Park et al. REVIEW of relative risks </a> <a title="AJG_Vol.111.No.12 page 70" href="http://viewer.zmags.com/publication/ed34beaa?page=70"> Histological Activity as Predictor of UC Relapse </a> <a title="AJG_Vol.111.No.12 page 71" href="http://viewer.zmags.com/publication/ed34beaa?page=71"> 1696 Park et al. REVIEW Table 2. Definition</a> <a title="AJG_Vol.111.No.12 page 72" href="http://viewer.zmags.com/publication/ed34beaa?page=72"> Histological Activity as Predictor of UC Relapse </a> <a title="AJG_Vol.111.No.12 page 73" href="http://viewer.zmags.com/publication/ed34beaa?page=73"> 1698 Park et al. 0.0 Standard error </a> <a title="AJG_Vol.111.No.12 page 74" href="http://viewer.zmags.com/publication/ed34beaa?page=74"> definitions. When any measure of mucosal ne</a> <a title="AJG_Vol.111.No.12 page 75" href="http://viewer.zmags.com/publication/ed34beaa?page=75"> 1700 Park et al. REVIEW As one-third of pa</a> <a title="AJG_Vol.111.No.12 page 76" href="http://viewer.zmags.com/publication/ed34beaa?page=76"> 43. Marchal Bressenot A, Riddell RH, Boulagnon-Ro</a> <a title="AJG_Vol.111.No.12 page 77" href="http://viewer.zmags.com/publication/ed34beaa?page=77"> 1702 ORIGINAL CONTRIBUTIONS ESOPHAGUS INTRODUC</a> <a title="AJG_Vol.111.No.12 page 78" href="http://viewer.zmags.com/publication/ed34beaa?page=78"> Although manometry is considered the optimal te</a> <a title="AJG_Vol.111.No.12 page 79" href="http://viewer.zmags.com/publication/ed34beaa?page=79"> 1704 Carlson et al. ESOPHAGUS baseline. Us</a> <a title="AJG_Vol.111.No.12 page 80" href="http://viewer.zmags.com/publication/ed34beaa?page=80"> HRIM Metrics and Achalasia Outcomes 1705 </a> <a title="AJG_Vol.111.No.12 page 81" href="http://viewer.zmags.com/publication/ed34beaa?page=81"> 1706 Carlson et al. ESOPHAGUS Table 1. Pat</a> <a title="AJG_Vol.111.No.12 page 82" href="http://viewer.zmags.com/publication/ed34beaa?page=82"> a 1.0 0.9 0.8 0.7 0.6 Sensitivity 0.5 0.4 </a> <a title="AJG_Vol.111.No.12 page 83" href="http://viewer.zmags.com/publication/ed34beaa?page=83"> 1708 Carlson et al. ESOPHAGUS Table 3. Sen</a> <a title="AJG_Vol.111.No.12 page 84" href="http://viewer.zmags.com/publication/ed34beaa?page=84"> necessary to support practical application of the</a> <a title="AJG_Vol.111.No.12 page 85" href="http://viewer.zmags.com/publication/ed34beaa?page=85"> 1710 Carlson et al. ESOPHAGUS 13. Hong SJ,</a> <a title="AJG_Vol.111.No.12 page 86" href="http://viewer.zmags.com/publication/ed34beaa?page=86"> ORIGINAL CONTRIBUTIONS 1711 see relate</a> <a title="AJG_Vol.111.No.12 page 87" href="http://viewer.zmags.com/publication/ed34beaa?page=87"> 1712 de Bortoli et al. ESOPHAGUS a link be</a> <a title="AJG_Vol.111.No.12 page 88" href="http://viewer.zmags.com/publication/ed34beaa?page=88"> pH data were used to determine the number and typ</a> <a title="AJG_Vol.111.No.12 page 89" href="http://viewer.zmags.com/publication/ed34beaa?page=89"> 1714 de Bortoli et al. ESOPHAGUS patients </a> <a title="AJG_Vol.111.No.12 page 90" href="http://viewer.zmags.com/publication/ed34beaa?page=90"> Table 2. Variables associated with hypersensitive</a> <a title="AJG_Vol.111.No.12 page 91" href="http://viewer.zmags.com/publication/ed34beaa?page=91"> 1716 de Bortoli et al. GERD </a> <a title="AJG_Vol.111.No.12 page 92" href="http://viewer.zmags.com/publication/ed34beaa?page=92"> 26. Snaith RP, Zigmond AS. The hospital anxiety a</a> <a title="AJG_Vol.111.No.12 page 93" href="http://viewer.zmags.com/publication/ed34beaa?page=93"> 1718 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 94" href="http://viewer.zmags.com/publication/ed34beaa?page=94"> Multiple specialty societies have established </a> <a title="AJG_Vol.111.No.12 page 95" href="http://viewer.zmags.com/publication/ed34beaa?page=95"> 1720 Prabhu et al. ESOPHAGUS Non-smoker No</a> <a title="AJG_Vol.111.No.12 page 96" href="http://viewer.zmags.com/publication/ed34beaa?page=96"> Esophageal Squamous Cell Cancer Risk 1721 </a> <a title="AJG_Vol.111.No.12 page 97" href="http://viewer.zmags.com/publication/ed34beaa?page=97"> 1722 Prabhu et al. The race-specific ex</a> <a title="AJG_Vol.111.No.12 page 98" href="http://viewer.zmags.com/publication/ed34beaa?page=98"> Esophageal Squamous Cell Cancer Risk 1723 </a> <a title="AJG_Vol.111.No.12 page 99" href="http://viewer.zmags.com/publication/ed34beaa?page=99"> 1724 Prabhu et al. ESOPHAGUS individuals f</a> <a title="AJG_Vol.111.No.12 page 100" href="http://viewer.zmags.com/publication/ed34beaa?page=100"> 10. Kahrilas PJ, Shaheen NJ, Vaezi MF et al. Amer</a> <a title="AJG_Vol.111.No.12 page 101" href="http://viewer.zmags.com/publication/ed34beaa?page=101"> 1726 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 102" href="http://viewer.zmags.com/publication/ed34beaa?page=102"> initial studies utilizing esophageal impedance pl</a> <a title="AJG_Vol.111.No.12 page 103" href="http://viewer.zmags.com/publication/ed34beaa?page=103"> 1728 Carlson et al. ESOPHAGUS latency. Eso</a> <a title="AJG_Vol.111.No.12 page 104" href="http://viewer.zmags.com/publication/ed34beaa?page=104"> Esophageal Motility Assessment with FLIP Topograp</a> <a title="AJG_Vol.111.No.12 page 105" href="http://viewer.zmags.com/publication/ed34beaa?page=105"> 1730 Carlson et al. a ESOPHAGUS 16 cm</a> <a title="AJG_Vol.111.No.12 page 106" href="http://viewer.zmags.com/publication/ed34beaa?page=106"> Table 2. Sedation dosages and utilization among F</a> <a title="AJG_Vol.111.No.12 page 107" href="http://viewer.zmags.com/publication/ed34beaa?page=107"> 1732 Carlson et al. ESOPHAGUS Table 3. FLI</a> <a title="AJG_Vol.111.No.12 page 108" href="http://viewer.zmags.com/publication/ed34beaa?page=108"> Esophageal Motility Assessment with FLIP Topograp</a> <a title="AJG_Vol.111.No.12 page 109" href="http://viewer.zmags.com/publication/ed34beaa?page=109"> 1734 Carlson et al. ESOPHAGUS evaluation u</a> <a title="AJG_Vol.111.No.12 page 110" href="http://viewer.zmags.com/publication/ed34beaa?page=110"> 3. Pandolfino JE, de Ruigh A, Nicodeme F et al. </a> <a title="AJG_Vol.111.No.12 page 111" href="http://viewer.zmags.com/publication/ed34beaa?page=111"> 1736 ORIGINAL CONTRIBUTIONS STOMACH INTRODUCTI</a> <a title="AJG_Vol.111.No.12 page 112" href="http://viewer.zmags.com/publication/ed34beaa?page=112"> to amoxicillin are rare. We recently showed that </a> <a title="AJG_Vol.111.No.12 page 113" href="http://viewer.zmags.com/publication/ed34beaa?page=113"> 1738 Chen et al. STOMACH as the lowest dru</a> <a title="AJG_Vol.111.No.12 page 114" href="http://viewer.zmags.com/publication/ed34beaa?page=114"> Amoxicillin therapy fulfilled the criteria </a> <a title="AJG_Vol.111.No.12 page 115" href="http://viewer.zmags.com/publication/ed34beaa?page=115"> 1740 Chen et al. STOMACH Table 4. Adverse </a> <a title="AJG_Vol.111.No.12 page 116" href="http://viewer.zmags.com/publication/ed34beaa?page=116"> metronidazole-amoxicillin or tetracycline therapy</a> <a title="AJG_Vol.111.No.12 page 117" href="http://viewer.zmags.com/publication/ed34beaa?page=117"> 1742 Chen et al. STOMACH 4. Cao Z, Chen Q</a> <a title="AJG_Vol.111.No.12 page 118" href="http://viewer.zmags.com/publication/ed34beaa?page=118"> ORIGINAL CONTRIBUTIONS 1743 see related</a> <a title="AJG_Vol.111.No.12 page 119" href="http://viewer.zmags.com/publication/ed34beaa?page=119"> 1744 Hilsden et al. ENDOSCOPY INTRODUCTION</a> <a title="AJG_Vol.111.No.12 page 120" href="http://viewer.zmags.com/publication/ed34beaa?page=120"> reconcile each polyp reported at colonoscopy with</a> <a title="AJG_Vol.111.No.12 page 121" href="http://viewer.zmags.com/publication/ed34beaa?page=121"> 1746 Hilsden et al. benchmark, it woul</a> <a title="AJG_Vol.111.No.12 page 122" href="http://viewer.zmags.com/publication/ed34beaa?page=122"> Table 1. Patient characteristics Average risk (n=</a> <a title="AJG_Vol.111.No.12 page 123" href="http://viewer.zmags.com/publication/ed34beaa?page=123"> 1748 Hilsden et al. ENDOSCOPY The goal o</a> <a title="AJG_Vol.111.No.12 page 124" href="http://viewer.zmags.com/publication/ed34beaa?page=124"> benchmarks we defined may not be generalizable to</a> <a title="AJG_Vol.111.No.12 page 125" href="http://viewer.zmags.com/publication/ed34beaa?page=125"> 1750 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 126" href="http://viewer.zmags.com/publication/ed34beaa?page=126"> Therefore, treatment options that involve less-</a> <a title="AJG_Vol.111.No.12 page 127" href="http://viewer.zmags.com/publication/ed34beaa?page=127"> 1752 Shimatani et al. ENDOSCOPY Table 1. T</a> <a title="AJG_Vol.111.No.12 page 128" href="http://viewer.zmags.com/publication/ed34beaa?page=128"> Assessed for eligibility (316 patients) Enrolle</a> <a title="AJG_Vol.111.No.12 page 129" href="http://viewer.zmags.com/publication/ed34beaa?page=129"> 1754 Shimatani et al. ENDOSCOPY Table 2. C</a> <a title="AJG_Vol.111.No.12 page 130" href="http://viewer.zmags.com/publication/ed34beaa?page=130"> Short-Type Double-Balloon Endoscopy Assisted ERC </a> <a title="AJG_Vol.111.No.12 page 131" href="http://viewer.zmags.com/publication/ed34beaa?page=131"> 1756 Shimatani et al. ENDOSCOPY Sever</a> <a title="AJG_Vol.111.No.12 page 132" href="http://viewer.zmags.com/publication/ed34beaa?page=132"> In the present study, the adverse event rate w</a> <a title="AJG_Vol.111.No.12 page 133" href="http://viewer.zmags.com/publication/ed34beaa?page=133"> 1758 Shimatani et al. ENDOSCOPY 7. Kim M</a> <a title="AJG_Vol.111.No.12 page 134" href="http://viewer.zmags.com/publication/ed34beaa?page=134"> ORIGINAL CONTRIBUTIONS 1759 see related</a> <a title="AJG_Vol.111.No.12 page 135" href="http://viewer.zmags.com/publication/ed34beaa?page=135"> 1760 Tandon et al. LIVER have been estimat</a> <a title="AJG_Vol.111.No.12 page 136" href="http://viewer.zmags.com/publication/ed34beaa?page=136"> Rapid Frailty Screen to Predict Hospitalization i</a> <a title="AJG_Vol.111.No.12 page 137" href="http://viewer.zmags.com/publication/ed34beaa?page=137"> 1762 Tandon et al. LIVER RESULTS A total o</a> <a title="AJG_Vol.111.No.12 page 138" href="http://viewer.zmags.com/publication/ed34beaa?page=138"> Rapid Frailty Screen to Predict Hospitalization i</a> <a title="AJG_Vol.111.No.12 page 139" href="http://viewer.zmags.com/publication/ed34beaa?page=139"> 1764 Tandon et al. LIVER Table 5. Logistic</a> <a title="AJG_Vol.111.No.12 page 140" href="http://viewer.zmags.com/publication/ed34beaa?page=140"> Rapid Frailty Screen to Predict Hospitalization i</a> <a title="AJG_Vol.111.No.12 page 141" href="http://viewer.zmags.com/publication/ed34beaa?page=141"> 1766 Tandon et al. cirrhosis (33–38), </a> <a title="AJG_Vol.111.No.12 page 142" href="http://viewer.zmags.com/publication/ed34beaa?page=142"> 14. Rockwood K, Song X, MacKnight C et al. A glob</a> <a title="AJG_Vol.111.No.12 page 143" href="http://viewer.zmags.com/publication/ed34beaa?page=143"> 1768 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 144" href="http://viewer.zmags.com/publication/ed34beaa?page=144"> adipose, brain, and gut compartments suggests tha</a> <a title="AJG_Vol.111.No.12 page 145" href="http://viewer.zmags.com/publication/ed34beaa?page=145"> 1770 Dunn et al. LIVER described, and who </a> <a title="AJG_Vol.111.No.12 page 146" href="http://viewer.zmags.com/publication/ed34beaa?page=146"> associations between either gait speed or grip st</a> <a title="AJG_Vol.111.No.12 page 147" href="http://viewer.zmags.com/publication/ed34beaa?page=147"> 1772 Dunn et al. LIVER Table 3A. Rate rati</a> <a title="AJG_Vol.111.No.12 page 148" href="http://viewer.zmags.com/publication/ed34beaa?page=148"> Frailty and Hospitalization Risk in Cirrhosis </a> <a title="AJG_Vol.111.No.12 page 149" href="http://viewer.zmags.com/publication/ed34beaa?page=149"> 1774 Dunn et al. LIVER solid organ transpl</a> <a title="AJG_Vol.111.No.12 page 150" href="http://viewer.zmags.com/publication/ed34beaa?page=150"> 28. Clegg A, Rogers L, Young J. Diagnostic test a</a> <a title="AJG_Vol.111.No.12 page 151" href="http://viewer.zmags.com/publication/ed34beaa?page=151"> 1776 EDITORIAL see related articles on</a> <a title="AJG_Vol.111.No.12 page 152" href="http://viewer.zmags.com/publication/ed34beaa?page=152"> captures the clinicians' assessment of the patien</a> <a title="AJG_Vol.111.No.12 page 153" href="http://viewer.zmags.com/publication/ed34beaa?page=153"> 1778 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 154" href="http://viewer.zmags.com/publication/ed34beaa?page=154"> bleeding whereas a decrease of ≤12 mm Hg essentia</a> <a title="AJG_Vol.111.No.12 page 155" href="http://viewer.zmags.com/publication/ed34beaa?page=155"> 1780 Shukla et al. LIVER We classified t</a> <a title="AJG_Vol.111.No.12 page 156" href="http://viewer.zmags.com/publication/ed34beaa?page=156"> Careful Monitoring of Cirrhotic Patients on NSBB </a> <a title="AJG_Vol.111.No.12 page 157" href="http://viewer.zmags.com/publication/ed34beaa?page=157"> 1782 Shukla et al. LIVER Table 1. Continue</a> <a title="AJG_Vol.111.No.12 page 158" href="http://viewer.zmags.com/publication/ed34beaa?page=158"> Careful Monitoring of Cirrhotic Patients on NSBB </a> <a title="AJG_Vol.111.No.12 page 159" href="http://viewer.zmags.com/publication/ed34beaa?page=159"> 1784 Shukla et al. LIVER Table 3. Factors </a> <a title="AJG_Vol.111.No.12 page 160" href="http://viewer.zmags.com/publication/ed34beaa?page=160"> Careful Monitoring of Cirrhotic Patients on NSBB </a> <a title="AJG_Vol.111.No.12 page 161" href="http://viewer.zmags.com/publication/ed34beaa?page=161"> 1786 Shukla et al. LIVER other reports and</a> <a title="AJG_Vol.111.No.12 page 162" href="http://viewer.zmags.com/publication/ed34beaa?page=162"> Financial support: None. Potential competing inte</a> <a title="AJG_Vol.111.No.12 page 163" href="http://viewer.zmags.com/publication/ed34beaa?page=163"> 1788 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 164" href="http://viewer.zmags.com/publication/ed34beaa?page=164"> persistently low levels of viral transcription (6</a> <a title="AJG_Vol.111.No.12 page 165" href="http://viewer.zmags.com/publication/ed34beaa?page=165"> 1790 Seto et al. LIVER variables and the χ</a> <a title="AJG_Vol.111.No.12 page 166" href="http://viewer.zmags.com/publication/ed34beaa?page=166"> HBcrAg and HBV Reactivation 1791 Table 2</a> <a title="AJG_Vol.111.No.12 page 167" href="http://viewer.zmags.com/publication/ed34beaa?page=167"> 1792 Seto et al. LIVER Table 3. Univariate</a> <a title="AJG_Vol.111.No.12 page 168" href="http://viewer.zmags.com/publication/ed34beaa?page=168"> a </a> <a title="AJG_Vol.111.No.12 page 169" href="http://viewer.zmags.com/publication/ed34beaa?page=169"> 1794 Seto et al. HBsAg-negative, anti</a> <a title="AJG_Vol.111.No.12 page 170" href="http://viewer.zmags.com/publication/ed34beaa?page=170"> Study Highlights WHAT IS CURRENT KNOWLEDGE ✓ Rea</a> <a title="AJG_Vol.111.No.12 page 171" href="http://viewer.zmags.com/publication/ed34beaa?page=171"> 1796 ORIGINAL CONTRIBUTIONS INFLAMMATORY BOWEL</a> <a title="AJG_Vol.111.No.12 page 172" href="http://viewer.zmags.com/publication/ed34beaa?page=172"> Blood-based biomarkers provide a non-invasive e</a> <a title="AJG_Vol.111.No.12 page 173" href="http://viewer.zmags.com/publication/ed34beaa?page=173"> 1798 Kalla et al. Clinical course in I</a> <a title="AJG_Vol.111.No.12 page 174" href="http://viewer.zmags.com/publication/ed34beaa?page=174"> Table 2. Study demographics, Montreal classificati</a> <a title="AJG_Vol.111.No.12 page 175" href="http://viewer.zmags.com/publication/ed34beaa?page=175"> 1800 Kalla et al. 1.0 1.0 0.8 0.8 </a> <a title="AJG_Vol.111.No.12 page 176" href="http://viewer.zmags.com/publication/ed34beaa?page=176"> Serum Calprotectin as an IBD Marker 1801 </a> <a title="AJG_Vol.111.No.12 page 177" href="http://viewer.zmags.com/publication/ed34beaa?page=177"> 1802 Kalla et al. INFLAMMATORY BOWEL DISEAS</a> <a title="AJG_Vol.111.No.12 page 178" href="http://viewer.zmags.com/publication/ed34beaa?page=178"> patients with gastrointestinal symptoms in primar</a> <a title="AJG_Vol.111.No.12 page 179" href="http://viewer.zmags.com/publication/ed34beaa?page=179"> 1804 Kalla et al. INFLAMMATORY BOWEL DISEAS</a> <a title="AJG_Vol.111.No.12 page 180" href="http://viewer.zmags.com/publication/ed34beaa?page=180"> 41. Kennedy NA, Clark A, Walkden A et al. Clinica</a> <a title="AJG_Vol.111.No.12 page 181" href="http://viewer.zmags.com/publication/ed34beaa?page=181"> 1806 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 182" href="http://viewer.zmags.com/publication/ed34beaa?page=182"> demonstrated that the risk of serious infection h</a> <a title="AJG_Vol.111.No.12 page 183" href="http://viewer.zmags.com/publication/ed34beaa?page=183"> 1808 Osterman et al. CLASSIC-I/II Dou</a> <a title="AJG_Vol.111.No.12 page 184" href="http://viewer.zmags.com/publication/ed34beaa?page=184"> when combined with adalimumab, compared with adal</a> <a title="AJG_Vol.111.No.12 page 185" href="http://viewer.zmags.com/publication/ed34beaa?page=185"> 1810 Osterman et al. INFLAMMATORY BOWEL DIS</a> <a title="AJG_Vol.111.No.12 page 186" href="http://viewer.zmags.com/publication/ed34beaa?page=186"> Infections With CD Activity and Medications 1</a> <a title="AJG_Vol.111.No.12 page 187" href="http://viewer.zmags.com/publication/ed34beaa?page=187"> 1812 Osterman et al. INFLAMMATORY BOWEL DIS</a> <a title="AJG_Vol.111.No.12 page 188" href="http://viewer.zmags.com/publication/ed34beaa?page=188"> of serious and opportunistic infections with conc</a> <a title="AJG_Vol.111.No.12 page 189" href="http://viewer.zmags.com/publication/ed34beaa?page=189"> 1814 Osterman et al. INFLAMMATORY BOWEL DIS</a> <a title="AJG_Vol.111.No.12 page 190" href="http://viewer.zmags.com/publication/ed34beaa?page=190"> 2. Lichtenstein GR, Feagan BG, Cohen RD et al. S</a> <a title="AJG_Vol.111.No.12 page 191" href="http://viewer.zmags.com/publication/ed34beaa?page=191"> 1816 ORIGINAL CONTRIBUTIONS see relate</a> <a title="AJG_Vol.111.No.12 page 192" href="http://viewer.zmags.com/publication/ed34beaa?page=192"> to predict response to these therapies. Most prio</a> <a title="AJG_Vol.111.No.12 page 193" href="http://viewer.zmags.com/publication/ed34beaa?page=193"> 1818 Barber et al. INFLAMMATORY BOWEL DISEA</a> <a title="AJG_Vol.111.No.12 page 194" href="http://viewer.zmags.com/publication/ed34beaa?page=194"> Responders Primary non-res</a> <a title="AJG_Vol.111.No.12 page 195" href="http://viewer.zmags.com/publication/ed34beaa?page=195"> 1820 Barber et al. INFLAMMATORY BOWEL DISEA</a> <a title="AJG_Vol.111.No.12 page 196" href="http://viewer.zmags.com/publication/ed34beaa?page=196"> patients with prior anti-TNF exposure, those with</a> <a title="AJG_Vol.111.No.12 page 197" href="http://viewer.zmags.com/publication/ed34beaa?page=197"> 1822 Barber et al. INFLAMMATORY BOWEL DISEA</a> <a title="AJG_Vol.111.No.12 page 198" href="http://viewer.zmags.com/publication/ed34beaa?page=198"> ORIGINAL CONTRIBUTIONS 1823 CME Con</a> <a title="AJG_Vol.111.No.12 page 199" href="http://viewer.zmags.com/publication/ed34beaa?page=199"> 1824 ORIGINAL CONTRIBUTIONS FUNCTIONAL GI DISO</a> <a title="AJG_Vol.111.No.12 page 200" href="http://viewer.zmags.com/publication/ed34beaa?page=200"> Like the clinical phenotype, the pathogenesis</a> <a title="AJG_Vol.111.No.12 page 201" href="http://viewer.zmags.com/publication/ed34beaa?page=201"> 1826 Eswaran et al. Screening visit </a> <a title="AJG_Vol.111.No.12 page 202" href="http://viewer.zmags.com/publication/ed34beaa?page=202"> Low FODMAP Diet vs. mNICE Guidelines in IBS 1</a> <a title="AJG_Vol.111.No.12 page 203" href="http://viewer.zmags.com/publication/ed34beaa?page=203"> 1828 Eswaran et al. FUNCTIONAL GI DISORDERS</a> <a title="AJG_Vol.111.No.12 page 204" href="http://viewer.zmags.com/publication/ed34beaa?page=204"> Low FODMAP Diet vs. mNICE Guidelines in IBS 1</a> <a title="AJG_Vol.111.No.12 page 205" href="http://viewer.zmags.com/publication/ed34beaa?page=205"> Baseline Week 1 Week 2 Week 3 Week 4 </a> <a title="AJG_Vol.111.No.12 page 206" href="http://viewer.zmags.com/publication/ed34beaa?page=206"> There are a number of limitations which should</a> <a title="AJG_Vol.111.No.12 page 207" href="http://viewer.zmags.com/publication/ed34beaa?page=207"> 1832 Eswaran et al. FUNCTIONAL GI DISORDERS</a> <a title="AJG_Vol.111.No.12 page 208" href="http://viewer.zmags.com/publication/ed34beaa?page=208"> ORIGINAL CONTRIBUTIONS 1833 CME Con</a> <a title="AJG_Vol.111.No.12 page 209" href="http://viewer.zmags.com/publication/ed34beaa?page=209"> 1834 ORIGINAL CONTRIBUTIONS COLON/SMALL BOWEL </a> <a title="AJG_Vol.111.No.12 page 210" href="http://viewer.zmags.com/publication/ed34beaa?page=210"> as secondary prophylaxis in addition to concomita</a> <a title="AJG_Vol.111.No.12 page 211" href="http://viewer.zmags.com/publication/ed34beaa?page=211"> 1836 Carignan et al. COLON/SMALL BOWEL Ini</a> <a title="AJG_Vol.111.No.12 page 212" href="http://viewer.zmags.com/publication/ed34beaa?page=212"> Table 1. Characteristics of patients with Clostri</a> <a title="AJG_Vol.111.No.12 page 213" href="http://viewer.zmags.com/publication/ed34beaa?page=213"> 1838 Carignan et al. COLON/SMALL BOWEL Tab</a> <a title="AJG_Vol.111.No.12 page 214" href="http://viewer.zmags.com/publication/ed34beaa?page=214"> superiority over vancomycin in the prevention of </a> <a title="AJG_Vol.111.No.12 page 215" href="http://viewer.zmags.com/publication/ed34beaa?page=215"> 1840 Carignan et al. COLON/SMALL BOWEL 17.</a> <a title="AJG_Vol.111.No.12 page 216" href="http://viewer.zmags.com/publication/ed34beaa?page=216"> ORIGINAL CONTRIBUTIONS 1841 see related</a> <a title="AJG_Vol.111.No.12 page 217" href="http://viewer.zmags.com/publication/ed34beaa?page=217"> 1842 Buxbaum et al. a Assistant </a> <a title="AJG_Vol.111.No.12 page 218" href="http://viewer.zmags.com/publication/ed34beaa?page=218"> and 0.35-inch diameter in those randomized </a> <a title="AJG_Vol.111.No.12 page 219" href="http://viewer.zmags.com/publication/ed34beaa?page=219"> 1844 Buxbaum et al. AND BILIARY TRACT PANCR</a> <a title="AJG_Vol.111.No.12 page 220" href="http://viewer.zmags.com/publication/ed34beaa?page=220"> Endoscopist vs. Assistant-Controlled Cannulation </a> <a title="AJG_Vol.111.No.12 page 221" href="http://viewer.zmags.com/publication/ed34beaa?page=221"> 1846 Buxbaum et al. (49%), assistant-c</a> <a title="AJG_Vol.111.No.12 page 222" href="http://viewer.zmags.com/publication/ed34beaa?page=222"> endoscopists to favor physician-controlled wi</a> <a title="AJG_Vol.111.No.12 page 223" href="http://viewer.zmags.com/publication/ed34beaa?page=223"> 1848 EDITORIAL see related article on </a> <a title="AJG_Vol.111.No.12 page 224" href="http://viewer.zmags.com/publication/ed34beaa?page=224"> Does pancreatic stent placement mitigate the </a> <a title="AJG_Vol.111.No.12 page 225" href="http://viewer.zmags.com/publication/ed34beaa?page=225"> 1850 Srinivasan et al. PANCREAS AND BILIARY</a> <a title="AJG_Vol.111.No.12 page 226" href="http://viewer.zmags.com/publication/ed34beaa?page=226"> LETTERS TO THE EDITOR 1851 Statins a</a> <a title="AJG_Vol.111.No.12 page 227" href="http://viewer.zmags.com/publication/ed34beaa?page=227"> 1852 Letters to the Editor In their s</a> <a title="AJG_Vol.111.No.12 page 228" href="http://viewer.zmags.com/publication/ed34beaa?page=228"> 200 100 CGA-positive cells/ mm2 0 * CGA-p</a> <a title="AJG_Vol.111.No.12 page 229" href="http://viewer.zmags.com/publication/ed34beaa?page=229"> 1854 Letters to the Editor Mean Differe</a> <a title="AJG_Vol.111.No.12 page 230" href="http://viewer.zmags.com/publication/ed34beaa?page=230"> Letters to the Editor 1855 Pillai et al. (th</a> <a title="AJG_Vol.111.No.12 page 231" href="http://viewer.zmags.com/publication/ed34beaa?page=231"> 1856 Letters to the Editor active hepat</a> <a title="AJG_Vol.111.No.12 page 232" href="http://viewer.zmags.com/publication/ed34beaa?page=232"> ANNOUNCEMENTS 1857 CALENDAR OF COURS</a> <a title="AJG_Vol.111.No.12 page 233" href="http://viewer.zmags.com/publication/ed34beaa?page=233"> 1858 ERRATA, CORRIGENDA AND RETRACTIONS ERRAT</a> <a title="AJG_Vol.111.No.12 page 234" href="http://viewer.zmags.com/publication/ed34beaa?page=234"> CLASSIFIEDS Bring your family to the Beach and ca</a> <a title="AJG_Vol.111.No.12 page 235" href="http://viewer.zmags.com/publication/ed34beaa?page=235"> LIFESTYLE WITH EXCEPTIONAL INCOME POTENTIAL IN CE</a> <a title="AJG_Vol.111.No.12 page 236" href="http://viewer.zmags.com/publication/ed34beaa?page=236"> Brought to you by the American College of Gastroe</a> <a title="AJG_Vol.111.No.12 page 237" href="http://viewer.zmags.com/publication/ed34beaa?page=237"> </a>