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<br /> RESPIRATORY<br /> ISSN 2054-3166 October 2014 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ERS 2014<br /> Munich, Germany<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 4<br /> CONGRESS REVIEW............................................................................................................................... 8<br /> • Review of the European Respiratory Society Congress, held in Munich, Germany,<br /> 6th-10th September 2014<br /> SYMPOSIUM REVIEWS<br /> • There’s more to IgE - Let’s Talk Severe Asthma......................................................................... 28<br /> • COPD Patients’ Needs and Current Treatment Options......................................................... 33<br /> • Nocturnal<a title="EMJ Respiratory 2014 page 1" href="http://viewer.zmags.com/publication/f0edc1b8?page=1"> RESPIRATORY ISSN 2054-3166 </a> <a title="EMJ Respiratory 2014 page 2" href="http://viewer.zmags.com/publication/f0edc1b8?page=2"> CONTENTS EDITORIAL BOARD......................</a> <a title="EMJ Respiratory 2014 page 3" href="http://viewer.zmags.com/publication/f0edc1b8?page=3"> RESPIRATORY RATIONALE FOR ENDOBRONCHIAL COIL T</a> <a title="EMJ Respiratory 2014 page 4" href="http://viewer.zmags.com/publication/f0edc1b8?page=4"> Editorial Board Respiratory Editor-in-Chief: D</a> <a title="EMJ Respiratory 2014 page 5" href="http://viewer.zmags.com/publication/f0edc1b8?page=5"> Welcome Prevention, education, and innovation are</a> <a title="EMJ Respiratory 2014 page 6" href="http://viewer.zmags.com/publication/f0edc1b8?page=6"> SUBSCRIBE TO THE EMJ NEWSLETTER www.news.emjre</a> <a title="EMJ Respiratory 2014 page 7" href="http://viewer.zmags.com/publication/f0edc1b8?page=7"> Foreword Prof Nikolaos Siafakas Department of Tho</a> <a title="EMJ Respiratory 2014 page 8" href="http://viewer.zmags.com/publication/f0edc1b8?page=8"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 9" href="http://viewer.zmags.com/publication/f0edc1b8?page=9"> Welcome to the European Medical Journal review of</a> <a title="EMJ Respiratory 2014 page 10" href="http://viewer.zmags.com/publication/f0edc1b8?page=10"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 11" href="http://viewer.zmags.com/publication/f0edc1b8?page=11"> accepted abstracts, and >100 exhibitors in </a> <a title="EMJ Respiratory 2014 page 12" href="http://viewer.zmags.com/publication/f0edc1b8?page=12"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 13" href="http://viewer.zmags.com/publication/f0edc1b8?page=13"> WHO air quality Guidelines helping to assess </a> <a title="EMJ Respiratory 2014 page 14" href="http://viewer.zmags.com/publication/f0edc1b8?page=14"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 15" href="http://viewer.zmags.com/publication/f0edc1b8?page=15"> DynaPort providing an insight into the life of a </a> <a title="EMJ Respiratory 2014 page 16" href="http://viewer.zmags.com/publication/f0edc1b8?page=16"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 17" href="http://viewer.zmags.com/publication/f0edc1b8?page=17"> Asbestos associated with idiopathic pulmonary fibr</a> <a title="EMJ Respiratory 2014 page 18" href="http://viewer.zmags.com/publication/f0edc1b8?page=18"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 19" href="http://viewer.zmags.com/publication/f0edc1b8?page=19"> New nose technology sniffs out infant asthma type</a> <a title="EMJ Respiratory 2014 page 20" href="http://viewer.zmags.com/publication/f0edc1b8?page=20"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 21" href="http://viewer.zmags.com/publication/f0edc1b8?page=21"> Exhaled breath: new biomarker for lung cancer LU</a> <a title="EMJ Respiratory 2014 page 22" href="http://viewer.zmags.com/publication/f0edc1b8?page=22"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 23" href="http://viewer.zmags.com/publication/f0edc1b8?page=23"> Modern innovations in respiratory care INNOVATION</a> <a title="EMJ Respiratory 2014 page 24" href="http://viewer.zmags.com/publication/f0edc1b8?page=24"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 25" href="http://viewer.zmags.com/publication/f0edc1b8?page=25"> Aerobika coughs 50% of COPD hospital admissions a</a> <a title="EMJ Respiratory 2014 page 26" href="http://viewer.zmags.com/publication/f0edc1b8?page=26"> ERS ANNUAL CONGRESS 2014 ICM-MESSE MÜNCHEN MUNICH</a> <a title="EMJ Respiratory 2014 page 27" href="http://viewer.zmags.com/publication/f0edc1b8?page=27"> Click to see BRONCH Express in action Gain Profi</a> <a title="EMJ Respiratory 2014 page 28" href="http://viewer.zmags.com/publication/f0edc1b8?page=28"> THERE’S MORE TO IgE – LET’S TALK SEVERE ASTHMA Su</a> <a title="EMJ Respiratory 2014 page 29" href="http://viewer.zmags.com/publication/f0edc1b8?page=29"> Chair’s Opening Comments Professor Roland Buhl Th</a> <a title="EMJ Respiratory 2014 page 30" href="http://viewer.zmags.com/publication/f0edc1b8?page=30"> immune response. The risk of exacerbations might </a> <a title="EMJ Respiratory 2014 page 31" href="http://viewer.zmags.com/publication/f0edc1b8?page=31"> Improving the Severe Asthma- Patien</a> <a title="EMJ Respiratory 2014 page 32" href="http://viewer.zmags.com/publication/f0edc1b8?page=32"> In a discussion around the specific use of </a> <a title="EMJ Respiratory 2014 page 33" href="http://viewer.zmags.com/publication/f0edc1b8?page=33"> COPD PATIENTS’ NEEDS AND CURRENT </a> <a title="EMJ Respiratory 2014 page 34" href="http://viewer.zmags.com/publication/f0edc1b8?page=34"> Welcome and Introduction Professor Bartolome Cell</a> <a title="EMJ Respiratory 2014 page 35" href="http://viewer.zmags.com/publication/f0edc1b8?page=35"> the management of COPD. In terms of p</a> <a title="EMJ Respiratory 2014 page 36" href="http://viewer.zmags.com/publication/f0edc1b8?page=36"> Glycopyrronium 50 µg q.d. + SFC 50/500 µg b.i.d. </a> <a title="EMJ Respiratory 2014 page 37" href="http://viewer.zmags.com/publication/f0edc1b8?page=37"> 12 and 26 versus the ICS/LABA combination of salm</a> <a title="EMJ Respiratory 2014 page 38" href="http://viewer.zmags.com/publication/f0edc1b8?page=38"> pneumonia in QVA149-treated patients compared to </a> <a title="EMJ Respiratory 2014 page 39" href="http://viewer.zmags.com/publication/f0edc1b8?page=39"> Conclusions Professor Bartolome Celli COPD is a</a> <a title="EMJ Respiratory 2014 page 40" href="http://viewer.zmags.com/publication/f0edc1b8?page=40"> 13. Decramer M et al. Indacaterol therapy in pati</a> <a title="EMJ Respiratory 2014 page 41" href="http://viewer.zmags.com/publication/f0edc1b8?page=41"> NOCTURNAL NON-INVASIVE VENTILATION FOR CHRONIC </a> <a title="EMJ Respiratory 2014 page 42" href="http://viewer.zmags.com/publication/f0edc1b8?page=42"> several European countries, chronic hypercapn</a> <a title="EMJ Respiratory 2014 page 43" href="http://viewer.zmags.com/publication/f0edc1b8?page=43"> mortality. Researchers should not focus solely on</a> <a title="EMJ Respiratory 2014 page 44" href="http://viewer.zmags.com/publication/f0edc1b8?page=44"> 352 Assessed for eligibility 157 Excluded </a> <a title="EMJ Respiratory 2014 page 45" href="http://viewer.zmags.com/publication/f0edc1b8?page=45"> [SGRQ]) in the control group, but there was a sma</a> <a title="EMJ Respiratory 2014 page 46" href="http://viewer.zmags.com/publication/f0edc1b8?page=46"> 0.40 0.30 0.20 Cumulative mortality 0.10 </a> <a title="EMJ Respiratory 2014 page 47" href="http://viewer.zmags.com/publication/f0edc1b8?page=47"> on the respiratory ward, during which ventilation</a> <a title="EMJ Respiratory 2014 page 48" href="http://viewer.zmags.com/publication/f0edc1b8?page=48"> CPAP favors hypercapnic patients with the overlap</a> <a title="EMJ Respiratory 2014 page 49" href="http://viewer.zmags.com/publication/f0edc1b8?page=49"> </a> <a title="EMJ Respiratory 2014 page 50" href="http://viewer.zmags.com/publication/f0edc1b8?page=50"> NEW EVIDENCE AND NOVEL THERAPIES FOR </a> <a title="EMJ Respiratory 2014 page 51" href="http://viewer.zmags.com/publication/f0edc1b8?page=51"> New Clinical Data on the Efficacy and Safety of I</a> <a title="EMJ Respiratory 2014 page 52" href="http://viewer.zmags.com/publication/f0edc1b8?page=52"> asthma, and comprised data (omalizumab arms, n=85</a> <a title="EMJ Respiratory 2014 page 53" href="http://viewer.zmags.com/publication/f0edc1b8?page=53"> The APEX study: clinical evidence on exacerbation</a> <a title="EMJ Respiratory 2014 page 54" href="http://viewer.zmags.com/publication/f0edc1b8?page=54"> New Clinical Evidence on QGE031 (Ligelizumab) ver</a> <a title="EMJ Respiratory 2014 page 55" href="http://viewer.zmags.com/publication/f0edc1b8?page=55"> therapy was detected, in comparison with th</a> <a title="EMJ Respiratory 2014 page 56" href="http://viewer.zmags.com/publication/f0edc1b8?page=56"> Overall, QAW039 was associated with a favourable </a> <a title="EMJ Respiratory 2014 page 57" href="http://viewer.zmags.com/publication/f0edc1b8?page=57"> Congress 2014, Munich, Germany, 6–10 September. 2</a> <a title="EMJ Respiratory 2014 page 58" href="http://viewer.zmags.com/publication/f0edc1b8?page=58"> NEW OPTIONS FOR OPTIMAL BRONCHODILATION IN C</a> <a title="EMJ Respiratory 2014 page 59" href="http://viewer.zmags.com/publication/f0edc1b8?page=59"> History of exacerbation Age ICS users </a> <a title="EMJ Respiratory 2014 page 60" href="http://viewer.zmags.com/publication/f0edc1b8?page=60"> improvement in lung function, dyspnoea, heal</a> <a title="EMJ Respiratory 2014 page 61" href="http://viewer.zmags.com/publication/f0edc1b8?page=61"> versus placebo or TIO, with significantly improved</a> <a title="EMJ Respiratory 2014 page 62" href="http://viewer.zmags.com/publication/f0edc1b8?page=62"> New Preclinical Data on Drug Delivery with the Br</a> <a title="EMJ Respiratory 2014 page 63" href="http://viewer.zmags.com/publication/f0edc1b8?page=63"> revealed a consistent safety profile with regards </a> <a title="EMJ Respiratory 2014 page 64" href="http://viewer.zmags.com/publication/f0edc1b8?page=64"> COPD exacerbations, with 7.8% of patients sufferi</a> <a title="EMJ Respiratory 2014 page 65" href="http://viewer.zmags.com/publication/f0edc1b8?page=65"> In another subset,36 the results from 11,858 pati</a> <a title="EMJ Respiratory 2014 page 66" href="http://viewer.zmags.com/publication/f0edc1b8?page=66"> with QVA149 reduces patient-reported dyspnoea </a> <a title="EMJ Respiratory 2014 page 67" href="http://viewer.zmags.com/publication/f0edc1b8?page=67"> SUBSCRIBE FREE TO OUR YOUTUBE CHANNEL www.youtube</a> <a title="EMJ Respiratory 2014 page 68" href="http://viewer.zmags.com/publication/f0edc1b8?page=68"> EVENT-DRIVEN STUDIES AND SERIOUS CHRONIC DI</a> <a title="EMJ Respiratory 2014 page 69" href="http://viewer.zmags.com/publication/f0edc1b8?page=69"> cohorts who are studied for longer periods, and w</a> <a title="EMJ Respiratory 2014 page 70" href="http://viewer.zmags.com/publication/f0edc1b8?page=70"> noting that some indirect surrogate endpoint</a> <a title="EMJ Respiratory 2014 page 71" href="http://viewer.zmags.com/publication/f0edc1b8?page=71"> and therapeutic methods.”17 It is also the </a> <a title="EMJ Respiratory 2014 page 72" href="http://viewer.zmags.com/publication/f0edc1b8?page=72"> with the methodology used. Importantly, in vitro </a> <a title="EMJ Respiratory 2014 page 73" href="http://viewer.zmags.com/publication/f0edc1b8?page=73"> REFERENCES 1. Gomberg-Maitland M et al. New tria</a> <a title="EMJ Respiratory 2014 page 74" href="http://viewer.zmags.com/publication/f0edc1b8?page=74"> RATIONALE FOR ENDOBRONCHIAL COIL TREATMENT A</a> <a title="EMJ Respiratory 2014 page 75" href="http://viewer.zmags.com/publication/f0edc1b8?page=75"> RATIONALE FOR ENDOSCOPIC TREATMENT OF EMPHYSEMA P</a> <a title="EMJ Respiratory 2014 page 76" href="http://viewer.zmags.com/publication/f0edc1b8?page=76"> a threshold of >90% integrity to select patients </a> <a title="EMJ Respiratory 2014 page 77" href="http://viewer.zmags.com/publication/f0edc1b8?page=77"> Figure 1: Sub-segmental coil placement, first</a> <a title="EMJ Respiratory 2014 page 78" href="http://viewer.zmags.com/publication/f0edc1b8?page=78"> and cost-effectiveness of bilateral coil treatmen</a> <a title="EMJ Respiratory 2014 page 79" href="http://viewer.zmags.com/publication/f0edc1b8?page=79"> therefore important to carefully consider the ris</a> <a title="EMJ Respiratory 2014 page 80" href="http://viewer.zmags.com/publication/f0edc1b8?page=80"> patients evaluated with MDCT: incidence and inte</a> <a title="EMJ Respiratory 2014 page 81" href="http://viewer.zmags.com/publication/f0edc1b8?page=81"> NOVEL INSIGHTS INTO CHRONIC OBSTRUCTIVE PUL</a> <a title="EMJ Respiratory 2014 page 82" href="http://viewer.zmags.com/publication/f0edc1b8?page=82"> with enhanced breathlessness in COPD, a</a> <a title="EMJ Respiratory 2014 page 83" href="http://viewer.zmags.com/publication/f0edc1b8?page=83"> source of aberrant CAFs. These activated cells in</a> <a title="EMJ Respiratory 2014 page 84" href="http://viewer.zmags.com/publication/f0edc1b8?page=84"> membrane proteoglycans (e.g. perlecan), small</a> <a title="EMJ Respiratory 2014 page 85" href="http://viewer.zmags.com/publication/f0edc1b8?page=85"> are associated with increased airway inflammation,</a> <a title="EMJ Respiratory 2014 page 86" href="http://viewer.zmags.com/publication/f0edc1b8?page=86"> J Intern Med. 2007;262(3):311-40. 4. Viegi G et a</a> <a title="EMJ Respiratory 2014 page 87" href="http://viewer.zmags.com/publication/f0edc1b8?page=87"> (COPD) requiring mechanical ventilation. Am J Res</a> <a title="EMJ Respiratory 2014 page 88" href="http://viewer.zmags.com/publication/f0edc1b8?page=88"> INHALED AMBIENT PARTICULATE MATTER AND </a> <a title="EMJ Respiratory 2014 page 89" href="http://viewer.zmags.com/publication/f0edc1b8?page=89"> lung cancer, pleural fibrosis, pleural plaques, an</a> <a title="EMJ Respiratory 2014 page 90" href="http://viewer.zmags.com/publication/f0edc1b8?page=90"> pre-existing COPD. Lee et al.14 have shown that a</a> <a title="EMJ Respiratory 2014 page 91" href="http://viewer.zmags.com/publication/f0edc1b8?page=91"> systemic circulation, and thereby reach secondary</a> <a title="EMJ Respiratory 2014 page 92" href="http://viewer.zmags.com/publication/f0edc1b8?page=92"> secondary organ, is highly dependent on the parti</a> <a title="EMJ Respiratory 2014 page 93" href="http://viewer.zmags.com/publication/f0edc1b8?page=93"> Ambient particulate matter (PM) Hazard/Particle </a> <a title="EMJ Respiratory 2014 page 94" href="http://viewer.zmags.com/publication/f0edc1b8?page=94"> Oxidative stress and pulmonary inflammation are by</a> <a title="EMJ Respiratory 2014 page 95" href="http://viewer.zmags.com/publication/f0edc1b8?page=95"> with particulate matter and tobacco smoke exp</a> <a title="EMJ Respiratory 2014 page 96" href="http://viewer.zmags.com/publication/f0edc1b8?page=96"> INFLUENCE OF AIR POLLUTION ON RESPIRA</a> <a title="EMJ Respiratory 2014 page 97" href="http://viewer.zmags.com/publication/f0edc1b8?page=97"> Of these common urban air pollutants, PM has been</a> <a title="EMJ Respiratory 2014 page 98" href="http://viewer.zmags.com/publication/f0edc1b8?page=98"> found to modify the risk of asthma associated wit</a> <a title="EMJ Respiratory 2014 page 99" href="http://viewer.zmags.com/publication/f0edc1b8?page=99"> significant association between urban background a</a> <a title="EMJ Respiratory 2014 page 100" href="http://viewer.zmags.com/publication/f0edc1b8?page=100"> alteration of host immunity. Oxidative stres</a> <a title="EMJ Respiratory 2014 page 101" href="http://viewer.zmags.com/publication/f0edc1b8?page=101"> Respir Crit Care Med. 1999;159(3):768–75. 17. Mud</a> <a title="EMJ Respiratory 2014 page 102" href="http://viewer.zmags.com/publication/f0edc1b8?page=102"> chemical composition of fine particle air poll</a> <a title="EMJ Respiratory 2014 page 103" href="http://viewer.zmags.com/publication/f0edc1b8?page=103"> respiratory infections in hospitalized pre-</a> <a title="EMJ Respiratory 2014 page 104" href="http://viewer.zmags.com/publication/f0edc1b8?page=104"> BRIEF CLINICAL REVIEW: NON-RESPONDING PNEUMONIA </a> <a title="EMJ Respiratory 2014 page 105" href="http://viewer.zmags.com/publication/f0edc1b8?page=105"> the stages of clinical recovery.12 Microbiol</a> <a title="EMJ Respiratory 2014 page 106" href="http://viewer.zmags.com/publication/f0edc1b8?page=106"> Although simple, and therefore easier to implemen</a> <a title="EMJ Respiratory 2014 page 107" href="http://viewer.zmags.com/publication/f0edc1b8?page=107"> use of clinical stability criteria in clinical pr</a> <a title="EMJ Respiratory 2014 page 108" href="http://viewer.zmags.com/publication/f0edc1b8?page=108"> The second major classification of infectious caus</a> <a title="EMJ Respiratory 2014 page 109" href="http://viewer.zmags.com/publication/f0edc1b8?page=109"> patients showing any evidence of deteriorati</a> <a title="EMJ Respiratory 2014 page 110" href="http://viewer.zmags.com/publication/f0edc1b8?page=110"> Standard antibiotic therapy varies gr</a> <a title="EMJ Respiratory 2014 page 111" href="http://viewer.zmags.com/publication/f0edc1b8?page=111"> Agents Chemother. 2014. 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