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<br /> HEPATOLOGY<br /> ISSN 2053-4213 Vol 7.1 • May 2019 • europeanmedical-journal.com<br /> + Review of<br /> ILC 2019<br /> Vienna, Austria<br /> Contents<br /> + EDITORIAL BOARD 4<br /> + WELCOME 7<br /> + FOREWORD 9<br /> + CONGRESS REVIEW<br /> Review of the European Association for the Study of the Liver’s (EASL) 10<br /> International Liver Congress (ILC) 2019, held in Vienna, Austria, 10th–14th<br /> April 2019<br /> + CONGRESS INTERVIEW<br /> Prof Dina Tiniakos 26<br <a title="EMJ Hepatology 7.1 page 1" href="http://viewer.zmags.com/publication/f1bedd6f?page=1"> HEPATOLOGY ISSN 2053-4213 </a> <a title="EMJ Hepatology 7.1 page 2" href="http://viewer.zmags.com/publication/f1bedd6f?page=2"> Contents + EDITORIAL BOARD </a> <a title="EMJ Hepatology 7.1 page 3" href="http://viewer.zmags.com/publication/f1bedd6f?page=3"> “The congress review is not all that EMJ Hepatolo</a> <a title="EMJ Hepatology 7.1 page 4" href="http://viewer.zmags.com/publication/f1bedd6f?page=4"> Editorial Board Editor-in-Chief Prof Markus Peck-</a> <a title="EMJ Hepatology 7.1 page 5" href="http://viewer.zmags.com/publication/f1bedd6f?page=5"> Aims and Scope The European Medical Journal (EMJ)</a> <a title="EMJ Hepatology 7.1 page 6" href="http://viewer.zmags.com/publication/f1bedd6f?page=6"> EMJ Hepatol. 7.1 Chief Executive Officer Spencer </a> <a title="EMJ Hepatology 7.1 page 7" href="http://viewer.zmags.com/publication/f1bedd6f?page=7"> Welcome A warm welcome to all our readers to this</a> <a title="EMJ Hepatology 7.1 page 8" href="http://viewer.zmags.com/publication/f1bedd6f?page=8"> Shionogi Europe works to meet the needs of pat</a> <a title="EMJ Hepatology 7.1 page 9" href="http://viewer.zmags.com/publication/f1bedd6f?page=9"> Foreword Dear colleagues, Allow me to welcome you</a> <a title="EMJ Hepatology 7.1 page 10" href="http://viewer.zmags.com/publication/f1bedd6f?page=10"> 10 HEPATOLOGY • May 2019 </a> <a title="EMJ Hepatology 7.1 page 11" href="http://viewer.zmags.com/publication/f1bedd6f?page=11"> Congress Review Review of the European Associat</a> <a title="EMJ Hepatology 7.1 page 12" href="http://viewer.zmags.com/publication/f1bedd6f?page=12"> 5. General Hepatology 6. Cirrhosis and Complica</a> <a title="EMJ Hepatology 7.1 page 13" href="http://viewer.zmags.com/publication/f1bedd6f?page=13"> There was an impressive variety in the t</a> <a title="EMJ Hepatology 7.1 page 14" href="http://viewer.zmags.com/publication/f1bedd6f?page=14"> Encouraging Progress in the Treatment </a> <a title="EMJ Hepatology 7.1 page 15" href="http://viewer.zmags.com/publication/f1bedd6f?page=15"> Real-World Studies Demonstrate Glecaprevir/ Pibre</a> <a title="EMJ Hepatology 7.1 page 16" href="http://viewer.zmags.com/publication/f1bedd6f?page=16"> Hepatitis B Virus Treatment Tenofovir Could Lo</a> <a title="EMJ Hepatology 7.1 page 17" href="http://viewer.zmags.com/publication/f1bedd6f?page=17"> Elafibranor Oral Treatment Decreases Primary Bilia</a> <a title="EMJ Hepatology 7.1 page 18" href="http://viewer.zmags.com/publication/f1bedd6f?page=18"> Nonalcoholic Steatohepatitis Could Be Treate</a> <a title="EMJ Hepatology 7.1 page 19" href="http://viewer.zmags.com/publication/f1bedd6f?page=19"> The Future of Liver Disease in People with HIV </a> <a title="EMJ Hepatology 7.1 page 20" href="http://viewer.zmags.com/publication/f1bedd6f?page=20"> Could This Novel Molecule Be the Holy Grail </a> <a title="EMJ Hepatology 7.1 page 21" href="http://viewer.zmags.com/publication/f1bedd6f?page=21"> “Oral faecal microbiota capsules are an </a> <a title="EMJ Hepatology 7.1 page 22" href="http://viewer.zmags.com/publication/f1bedd6f?page=22"> Large Numbers of Teenagers and Young People </a> <a title="EMJ Hepatology 7.1 page 23" href="http://viewer.zmags.com/publication/f1bedd6f?page=23"> Environmental Exposure and the Risk of Autoimmune</a> <a title="EMJ Hepatology 7.1 page 24" href="http://viewer.zmags.com/publication/f1bedd6f?page=24"> Georgia’s Road to Hepatitis C Virus Elimination </a> <a title="EMJ Hepatology 7.1 page 25" href="http://viewer.zmags.com/publication/f1bedd6f?page=25"> needing treatment (around 150,000 people);2 G</a> <a title="EMJ Hepatology 7.1 page 26" href="http://viewer.zmags.com/publication/f1bedd6f?page=26"> Congress Interview Professor Dina Tini</a> <a title="EMJ Hepatology 7.1 page 27" href="http://viewer.zmags.com/publication/f1bedd6f?page=27"> "AI is also entering the field of gas</a> <a title="EMJ Hepatology 7.1 page 28" href="http://viewer.zmags.com/publication/f1bedd6f?page=28"> to look for and identify polyps dur</a> <a title="EMJ Hepatology 7.1 page 29" href="http://viewer.zmags.com/publication/f1bedd6f?page=29"> </a> <a title="EMJ Hepatology 7.1 page 30" href="http://viewer.zmags.com/publication/f1bedd6f?page=30"> Procedural Risk of Bleeding: Does the Management </a> <a title="EMJ Hepatology 7.1 page 31" href="http://viewer.zmags.com/publication/f1bedd6f?page=31"> Prof Mark Thursz presented a case of a nonalcohol</a> <a title="EMJ Hepatology 7.1 page 32" href="http://viewer.zmags.com/publication/f1bedd6f?page=32"> 2,500 2,000 1,500 'Normal' 1,000 </a> <a title="EMJ Hepatology 7.1 page 33" href="http://viewer.zmags.com/publication/f1bedd6f?page=33"> count following platelet transfusion, but levels </a> <a title="EMJ Hepatology 7.1 page 34" href="http://viewer.zmags.com/publication/f1bedd6f?page=34"> levels (79x109/L) had dropped. Renal function had</a> <a title="EMJ Hepatology 7.1 page 35" href="http://viewer.zmags.com/publication/f1bedd6f?page=35"> Case 2 (Response) Professor Mark Thursz Prof Th</a> <a title="EMJ Hepatology 7.1 page 36" href="http://viewer.zmags.com/publication/f1bedd6f?page=36"> in the placebo group (27.1%) compared to the lusu</a> <a title="EMJ Hepatology 7.1 page 37" href="http://viewer.zmags.com/publication/f1bedd6f?page=37"> He noted that dental sepsis can be an issue for </a> <a title="EMJ Hepatology 7.1 page 38" href="http://viewer.zmags.com/publication/f1bedd6f?page=38"> Beyond the International Normalized Ratio. Hepato</a> <a title="EMJ Hepatology 7.1 page 39" href="http://viewer.zmags.com/publication/f1bedd6f?page=39"> Abstract Reviews Written by the presenters them</a> <a title="EMJ Hepatology 7.1 page 40" href="http://viewer.zmags.com/publication/f1bedd6f?page=40"> visceral adipose tissue (VAT), and intramuscular </a> <a title="EMJ Hepatology 7.1 page 41" href="http://viewer.zmags.com/publication/f1bedd6f?page=41"> Park, New Jersey, USA 7. Global Project M</a> <a title="EMJ Hepatology 7.1 page 42" href="http://viewer.zmags.com/publication/f1bedd6f?page=42"> Certain CLD aetiologies, such as alcohol abuse an</a> <a title="EMJ Hepatology 7.1 page 43" href="http://viewer.zmags.com/publication/f1bedd6f?page=43"> A Comparison of Currently Available</a> <a title="EMJ Hepatology 7.1 page 44" href="http://viewer.zmags.com/publication/f1bedd6f?page=44"> and SV: 100% (86/86). These results can be seen i</a> <a title="EMJ Hepatology 7.1 page 45" href="http://viewer.zmags.com/publication/f1bedd6f?page=45"> The NIACE Score: A Prognostic Indicator in Hep</a> <a title="EMJ Hepatology 7.1 page 46" href="http://viewer.zmags.com/publication/f1bedd6f?page=46"> the accuracy of survival prognostication,</a> <a title="EMJ Hepatology 7.1 page 47" href="http://viewer.zmags.com/publication/f1bedd6f?page=47"> L-carnitine Could Be Beneficial in Non</a> <a title="EMJ Hepatology 7.1 page 48" href="http://viewer.zmags.com/publication/f1bedd6f?page=48"> concentrations. This study demonstrated that </a> <a title="EMJ Hepatology 7.1 page 49" href="http://viewer.zmags.com/publication/f1bedd6f?page=49"> miRNA-21 Ablation in Mice Protects Against </a> <a title="EMJ Hepatology 7.1 page 50" href="http://viewer.zmags.com/publication/f1bedd6f?page=50"> Q1 WT mice after BDL but remained unaltered</a> <a title="EMJ Hepatology 7.1 page 51" href="http://viewer.zmags.com/publication/f1bedd6f?page=51"> Q4 Congratulations on winning an award </a> <a title="EMJ Hepatology 7.1 page 52" href="http://viewer.zmags.com/publication/f1bedd6f?page=52"> (NLR) may reflect the systemic inflammatory respons</a> <a title="EMJ Hepatology 7.1 page 53" href="http://viewer.zmags.com/publication/f1bedd6f?page=53"> treatment: 23.3% versus 46.4%; p=0.036; hazard ra</a> <a title="EMJ Hepatology 7.1 page 54" href="http://viewer.zmags.com/publication/f1bedd6f?page=54"> 120 100 80 60 40 20 0 </a> <a title="EMJ Hepatology 7.1 page 55" href="http://viewer.zmags.com/publication/f1bedd6f?page=55"> hepatotoxicity was variable: good for chronic alc</a> <a title="EMJ Hepatology 7.1 page 56" href="http://viewer.zmags.com/publication/f1bedd6f?page=56"> </a> <a title="EMJ Hepatology 7.1 page 57" href="http://viewer.zmags.com/publication/f1bedd6f?page=57"> Management of Hepatitis C in People Who Inject Dr</a> <a title="EMJ Hepatology 7.1 page 58" href="http://viewer.zmags.com/publication/f1bedd6f?page=58"> hepatitis elimination and a clear explanation of </a> <a title="EMJ Hepatology 7.1 page 59" href="http://viewer.zmags.com/publication/f1bedd6f?page=59"> Furthermore, being flexible in the therapeutic rel</a> <a title="EMJ Hepatology 7.1 page 60" href="http://viewer.zmags.com/publication/f1bedd6f?page=60"> References 1. Lazarus JV et al. The micro- </a> <a title="EMJ Hepatology 7.1 page 61" href="http://viewer.zmags.com/publication/f1bedd6f?page=61"> Transjugular Intrahepatic Portosystemic Stent-Shu</a> <a title="EMJ Hepatology 7.1 page 62" href="http://viewer.zmags.com/publication/f1bedd6f?page=62"> Table 1: Pre-emptive transjugular intrahepatic po</a> <a title="EMJ Hepatology 7.1 page 63" href="http://viewer.zmags.com/publication/f1bedd6f?page=63"> The definition of pre-emptive or ‘early’ TIPSS was</a> <a title="EMJ Hepatology 7.1 page 64" href="http://viewer.zmags.com/publication/f1bedd6f?page=64"> References 1. Rosch J et al. Transjugular po</a> <a title="EMJ Hepatology 7.1 page 65" href="http://viewer.zmags.com/publication/f1bedd6f?page=65"> Overview of Alpha-1 Antitrypsin Deficiency- </a> <a title="EMJ Hepatology 7.1 page 66" href="http://viewer.zmags.com/publication/f1bedd6f?page=66"> Abstract Alpha-1 antitrypsin (AAT), encoded by th</a> <a title="EMJ Hepatology 7.1 page 67" href="http://viewer.zmags.com/publication/f1bedd6f?page=67"> of SERPINA1 results in 11 mRNA divided into 5 mRN</a> <a title="EMJ Hepatology 7.1 page 68" href="http://viewer.zmags.com/publication/f1bedd6f?page=68"> aggregates.18 Due to the retention of the </a> <a title="EMJ Hepatology 7.1 page 69" href="http://viewer.zmags.com/publication/f1bedd6f?page=69"> Table 1: Alpha-1 antitrypsin variant-mediated liv</a> <a title="EMJ Hepatology 7.1 page 70" href="http://viewer.zmags.com/publication/f1bedd6f?page=70"> Much of what is known about AATD-associated liver</a> <a title="EMJ Hepatology 7.1 page 71" href="http://viewer.zmags.com/publication/f1bedd6f?page=71"> gene showed that no genetic polymorphisms in the</a> <a title="EMJ Hepatology 7.1 page 72" href="http://viewer.zmags.com/publication/f1bedd6f?page=72"> Finally, further research is needed to define the </a> <a title="EMJ Hepatology 7.1 page 73" href="http://viewer.zmags.com/publication/f1bedd6f?page=73"> Finally, it has been recently described that an E</a> <a title="EMJ Hepatology 7.1 page 74" href="http://viewer.zmags.com/publication/f1bedd6f?page=74"> absence of UPR activation might be caused by the </a> <a title="EMJ Hepatology 7.1 page 75" href="http://viewer.zmags.com/publication/f1bedd6f?page=75"> on 30 AATD patients with severe liver disease. </a> <a title="EMJ Hepatology 7.1 page 76" href="http://viewer.zmags.com/publication/f1bedd6f?page=76"> As observed with CBZ, another pro-autophagic agen</a> <a title="EMJ Hepatology 7.1 page 77" href="http://viewer.zmags.com/publication/f1bedd6f?page=77"> Homozygous ZZ patients have low circulating level</a> <a title="EMJ Hepatology 7.1 page 78" href="http://viewer.zmags.com/publication/f1bedd6f?page=78"> in adolescents with alpha 1-antitrypsin deficiency</a> <a title="EMJ Hepatology 7.1 page 79" href="http://viewer.zmags.com/publication/f1bedd6f?page=79"> mice. J Clin Invest. 2014;124(1):251-61. 71. So</a> <a title="EMJ Hepatology 7.1 page 80" href="http://viewer.zmags.com/publication/f1bedd6f?page=80"> Non-Invasive Imaging Modalities in Nonalcoholic </a> <a title="EMJ Hepatology 7.1 page 81" href="http://viewer.zmags.com/publication/f1bedd6f?page=81"> a key role in ruling out focal liver lesions and </a> <a title="EMJ Hepatology 7.1 page 82" href="http://viewer.zmags.com/publication/f1bedd6f?page=82"> Magnetic Resonance Spectroscopy (MRS) is the gold</a> <a title="EMJ Hepatology 7.1 page 83" href="http://viewer.zmags.com/publication/f1bedd6f?page=83"> SWE are limited; thus, further studies are needed</a> <a title="EMJ Hepatology 7.1 page 84" href="http://viewer.zmags.com/publication/f1bedd6f?page=84"> 13. Saverymuttu SH et al. Ultrasound sc</a> <a title="EMJ Hepatology 7.1 page 85" href="http://viewer.zmags.com/publication/f1bedd6f?page=85"> use of ultrasound elastography: Part 3: Liver. Ul</a> <a title="EMJ Hepatology 7.1 page 86" href="http://viewer.zmags.com/publication/f1bedd6f?page=86"> Predictors of Fibrosis Progression in Chronic </a> <a title="EMJ Hepatology 7.1 page 87" href="http://viewer.zmags.com/publication/f1bedd6f?page=87"> 15% in 15–59-year-old patients in 2008;</a> <a title="EMJ Hepatology 7.1 page 88" href="http://viewer.zmags.com/publication/f1bedd6f?page=88"> with chronic active hepatitis C virus witho</a> <a title="EMJ Hepatology 7.1 page 89" href="http://viewer.zmags.com/publication/f1bedd6f?page=89"> Abdominal Ultrasonography All patients were exami</a> <a title="EMJ Hepatology 7.1 page 90" href="http://viewer.zmags.com/publication/f1bedd6f?page=90"> Table 1: Baseline laboratory, metabolic, and fibro</a> <a title="EMJ Hepatology 7.1 page 91" href="http://viewer.zmags.com/publication/f1bedd6f?page=91"> should also be highlighted due to the possibility</a> <a title="EMJ Hepatology 7.1 page 92" href="http://viewer.zmags.com/publication/f1bedd6f?page=92"> A positive, significant correlation betwee</a> <a title="EMJ Hepatology 7.1 page 93" href="http://viewer.zmags.com/publication/f1bedd6f?page=93"> resistance, hyperinsulinemia, and renal injury: M</a> <a title="EMJ Hepatology 7.1 page 94" href="http://viewer.zmags.com/publication/f1bedd6f?page=94"> Available now. </a> <a title="EMJ Hepatology 7.1 page 95" href="http://viewer.zmags.com/publication/f1bedd6f?page=95"> d labe con diag l of AI </a> <a title="EMJ Hepatology 7.1 page 96" href="http://viewer.zmags.com/publication/f1bedd6f?page=96"> The significance of these overlap syndromes i</a> <a title="EMJ Hepatology 7.1 page 97" href="http://viewer.zmags.com/publication/f1bedd6f?page=97"> Larger studies of PSC patients have a definite dia</a> <a title="EMJ Hepatology 7.1 page 98" href="http://viewer.zmags.com/publication/f1bedd6f?page=98"> eight definite AIH and one probable AIH in </a> <a title="EMJ Hepatology 7.1 page 99" href="http://viewer.zmags.com/publication/f1bedd6f?page=99"> When assigning a diagnosis of AIH/PSC, experts ad</a> <a title="EMJ Hepatology 7.1 page 100" href="http://viewer.zmags.com/publication/f1bedd6f?page=100"> A Diagnosis of AIH At diagnosis or during follow </a> <a title="EMJ Hepatology 7.1 page 101" href="http://viewer.zmags.com/publication/f1bedd6f?page=101"> Outcomes Despite treatment with currently recomme</a> <a title="EMJ Hepatology 7.1 page 102" href="http://viewer.zmags.com/publication/f1bedd6f?page=102"> Although lacking formal diagnostic criteria, </a> <a title="EMJ Hepatology 7.1 page 103" href="http://viewer.zmags.com/publication/f1bedd6f?page=103"> of progressive cholangiopathy and chronic liver d</a> <a title="EMJ Hepatology 7.1 page 104" href="http://viewer.zmags.com/publication/f1bedd6f?page=104"> Practice Guidelines: Management of cholestatic li</a> <a title="EMJ Hepatology 7.1 page 105" href="http://viewer.zmags.com/publication/f1bedd6f?page=105"> Liver Fibrosis: A Clinical Update Authors: </a> <a title="EMJ Hepatology 7.1 page 106" href="http://viewer.zmags.com/publication/f1bedd6f?page=106"> diagnosis; however, many recent advances in </a> <a title="EMJ Hepatology 7.1 page 107" href="http://viewer.zmags.com/publication/f1bedd6f?page=107"> senescence, and reversion to an inactivated </a> <a title="EMJ Hepatology 7.1 page 108" href="http://viewer.zmags.com/publication/f1bedd6f?page=108"> Table 2: Assessing the degree of liver fibrosis. </a> <a title="EMJ Hepatology 7.1 page 109" href="http://viewer.zmags.com/publication/f1bedd6f?page=109"> fibrosis, and cirrhosis in chronic hepatitis B is </a> <a title="EMJ Hepatology 7.1 page 110" href="http://viewer.zmags.com/publication/f1bedd6f?page=110"> significant fibrosis and cirrhosis and thus it is r</a> <a title="EMJ Hepatology 7.1 page 111" href="http://viewer.zmags.com/publication/f1bedd6f?page=111"> Recommended vaccinations, other than those recomm</a> <a title="EMJ Hepatology 7.1 page 112" href="http://viewer.zmags.com/publication/f1bedd6f?page=112"> disease and is thought to falsely show lower fib</a> <a title="EMJ Hepatology 7.1 page 113" href="http://viewer.zmags.com/publication/f1bedd6f?page=113"> and alcoholic hepatitis (AH), although results ar</a> <a title="EMJ Hepatology 7.1 page 114" href="http://viewer.zmags.com/publication/f1bedd6f?page=114"> risk factors, several new therapeutic approaches </a> <a title="EMJ Hepatology 7.1 page 115" href="http://viewer.zmags.com/publication/f1bedd6f?page=115"> Liver Int. 2010;30(4):538-45. 39. Jiang T et al.</a> <a title="EMJ Hepatology 7.1 page 116" href="http://viewer.zmags.com/publication/f1bedd6f?page=116"> 81. Tsuboi Y et al. Common clinicopatho</a> <a title="EMJ Hepatology 7.1 page 117" href="http://viewer.zmags.com/publication/f1bedd6f?page=117"> Hepatol. 1998;28(1):54-60. 119. Singh V et al. G</a> <a title="EMJ Hepatology 7.1 page 118" href="http://viewer.zmags.com/publication/f1bedd6f?page=118"> </a>