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<br /> RHEUMATOLOGY<br /> ISSN 2056-6395 Vol 2.1 • July 2015 • emjreviews.com<br /> INSIDE<br /> Review of<br /> EULAR 2015<br /> Rome, Italy<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 4<br /> CONGRESS REVIEW........................................................................................................................................ 10<br /> • Review of the 16th EULAR Annual European Congress of Rheumatology, held in<br /> Rome, Italy, 10th-13th June 2015<br /> BEST ABSTRACT AWARD WINNERS AT EULAR 2015………………………................................................. 29<br /> INTERVIEWS WITH EMJ RHEUMATOLOGY EDITORIAL BOARD AND AUTHORS........................... 36<br /> SYMPOSIUM REVIEWS<br /> • IL-17 INHIBITION: EMERGING PERSPECTIVES IN THE FUTURE MA<a title="EMJ Rheumatology 2.1 2015 page 1" href="http://viewer.zmags.com/publication/f41cfe2f?page=1"> RHEUMATOLOGY ISSN 2056-6395 </a> <a title="EMJ Rheumatology 2.1 2015 page 2" href="http://viewer.zmags.com/publication/f41cfe2f?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Rheumatology 2.1 2015 page 3" href="http://viewer.zmags.com/publication/f41cfe2f?page=3"> RHEUMATOLOGY • OBESITY AND OSTEOARTHRITIS: MORE</a> <a title="EMJ Rheumatology 2.1 2015 page 4" href="http://viewer.zmags.com/publication/f41cfe2f?page=4"> Editorial Board Editor-in-Chief: Dr Ian Chik</a> <a title="EMJ Rheumatology 2.1 2015 page 5" href="http://viewer.zmags.com/publication/f41cfe2f?page=5"> Rheumatology Prof Gary Steven Gilkeson, P</a> <a title="EMJ Rheumatology 2.1 2015 page 6" href="http://viewer.zmags.com/publication/f41cfe2f?page=6"> European Medical Journal EMJ Rheumatology Vol 2</a> <a title="EMJ Rheumatology 2.1 2015 page 7" href="http://viewer.zmags.com/publication/f41cfe2f?page=7"> Welcome Hello, and a very warm welcome to this</a> <a title="EMJ Rheumatology 2.1 2015 page 8" href="http://viewer.zmags.com/publication/f41cfe2f?page=8"> The most accurate test for TB infection New Quant</a> <a title="EMJ Rheumatology 2.1 2015 page 9" href="http://viewer.zmags.com/publication/f41cfe2f?page=9"> Foreword </a> <a title="EMJ Rheumatology 2.1 2015 page 10" href="http://viewer.zmags.com/publication/f41cfe2f?page=10"> EULAR ANNUAL CONGRESS 2015 FIERA DI ROMA, ROME, </a> <a title="EMJ Rheumatology 2.1 2015 page 11" href="http://viewer.zmags.com/publication/f41cfe2f?page=11"> Welcome to the European Medical Journal review of</a> <a title="EMJ Rheumatology 2.1 2015 page 12" href="http://viewer.zmags.com/publication/f41cfe2f?page=12"> EULAR ANNUAL CONGRESS 2015 professionals, imp</a> <a title="EMJ Rheumatology 2.1 2015 page 13" href="http://viewer.zmags.com/publication/f41cfe2f?page=13"> H IGHLIGHTS Ultrasound Diagnosi</a> <a title="EMJ Rheumatology 2.1 2015 page 14" href="http://viewer.zmags.com/publication/f41cfe2f?page=14"> EULAR ANNUAL CONGRESS 2015 18 months using th</a> <a title="EMJ Rheumatology 2.1 2015 page 15" href="http://viewer.zmags.com/publication/f41cfe2f?page=15"> “Our data provide an argument for updating existi</a> <a title="EMJ Rheumatology 2.1 2015 page 16" href="http://viewer.zmags.com/publication/f41cfe2f?page=16"> EULAR ANNUAL CONGRESS 2015 “O</a> <a title="EMJ Rheumatology 2.1 2015 page 17" href="http://viewer.zmags.com/publication/f41cfe2f?page=17"> patients using anti-tumour necrosis factor t</a> <a title="EMJ Rheumatology 2.1 2015 page 18" href="http://viewer.zmags.com/publication/f41cfe2f?page=18"> EULAR ANNUAL CONGRESS 2015 “The findings from our </a> <a title="EMJ Rheumatology 2.1 2015 page 19" href="http://viewer.zmags.com/publication/f41cfe2f?page=19"> PsA occurs in 1-3% of the population and up to 30</a> <a title="EMJ Rheumatology 2.1 2015 page 20" href="http://viewer.zmags.com/publication/f41cfe2f?page=20"> EULAR ANNUAL CONGRESS 2015 “‘This Feeling!’ uses </a> <a title="EMJ Rheumatology 2.1 2015 page 21" href="http://viewer.zmags.com/publication/f41cfe2f?page=21"> Environmental Factors Increase Risk of Ankylosing</a> <a title="EMJ Rheumatology 2.1 2015 page 22" href="http://viewer.zmags.com/publication/f41cfe2f?page=22"> EULAR ANNUAL CONGRESS 2015 These results demonst</a> <a title="EMJ Rheumatology 2.1 2015 page 23" href="http://viewer.zmags.com/publication/f41cfe2f?page=23"> New Genetic Variants Linked with Autoinflammatory </a> <a title="EMJ Rheumatology 2.1 2015 page 24" href="http://viewer.zmags.com/publication/f41cfe2f?page=24"> EULAR ANNUAL CONGRESS 2015 to directly investi</a> <a title="EMJ Rheumatology 2.1 2015 page 25" href="http://viewer.zmags.com/publication/f41cfe2f?page=25"> other diseases,” said study investigator Dr Cécil</a> <a title="EMJ Rheumatology 2.1 2015 page 26" href="http://viewer.zmags.com/publication/f41cfe2f?page=26"> EULAR ANNUAL CONGRESS 2015 The benefits of DMARD </a> <a title="EMJ Rheumatology 2.1 2015 page 27" href="http://viewer.zmags.com/publication/f41cfe2f?page=27"> susceptible children aged 2-18 who were rec</a> <a title="EMJ Rheumatology 2.1 2015 page 28" href="http://viewer.zmags.com/publication/f41cfe2f?page=28"> EULAR ANNUAL CONGRESS 2015 patients in each grou</a> <a title="EMJ Rheumatology 2.1 2015 page 29" href="http://viewer.zmags.com/publication/f41cfe2f?page=29"> BEST ABSTRACT AWARD WINNERS AT EULAR 2015 </a> <a title="EMJ Rheumatology 2.1 2015 page 30" href="http://viewer.zmags.com/publication/f41cfe2f?page=30"> EULAR ANNUAL CONGRESS 2015 patterns demonstrate</a> <a title="EMJ Rheumatology 2.1 2015 page 31" href="http://viewer.zmags.com/publication/f41cfe2f?page=31"> significance. Not only did the study identify</a> <a title="EMJ Rheumatology 2.1 2015 page 32" href="http://viewer.zmags.com/publication/f41cfe2f?page=32"> EULAR ANNUAL CONGRESS 2015 (i.e. undifferentiate</a> <a title="EMJ Rheumatology 2.1 2015 page 33" href="http://viewer.zmags.com/publication/f41cfe2f?page=33"> with an increased risk of primary SS (OR: 8.1, 95</a> <a title="EMJ Rheumatology 2.1 2015 page 34" href="http://viewer.zmags.com/publication/f41cfe2f?page=34"> EULAR ANNUAL CONGRESS 2015 Biologic agents hav</a> <a title="EMJ Rheumatology 2.1 2015 page 35" href="http://viewer.zmags.com/publication/f41cfe2f?page=35"> Would you like to write for the EMJ blog? Interac</a> <a title="EMJ Rheumatology 2.1 2015 page 36" href="http://viewer.zmags.com/publication/f41cfe2f?page=36"> I n Interview with P</a> <a title="EMJ Rheumatology 2.1 2015 page 37" href="http://viewer.zmags.com/publication/f41cfe2f?page=37"> SUBSCRIBE FREE TO OUR YOUTUBE CHANNEL www.youtube</a> <a title="EMJ Rheumatology 2.1 2015 page 38" href="http://viewer.zmags.com/publication/f41cfe2f?page=38"> INTERVIEWS Prodromos Sidiropoulos Associate Profe</a> <a title="EMJ Rheumatology 2.1 2015 page 39" href="http://viewer.zmags.com/publication/f41cfe2f?page=39"> Elaine Dennison Professor of Musculoskeletal Epid</a> <a title="EMJ Rheumatology 2.1 2015 page 40" href="http://viewer.zmags.com/publication/f41cfe2f?page=40"> INTERVIEWS and improve care for our pa</a> <a title="EMJ Rheumatology 2.1 2015 page 41" href="http://viewer.zmags.com/publication/f41cfe2f?page=41"> we were the first group to use a biologic </a> <a title="EMJ Rheumatology 2.1 2015 page 42" href="http://viewer.zmags.com/publication/f41cfe2f?page=42"> INTERVIEWS </a> <a title="EMJ Rheumatology 2.1 2015 page 43" href="http://viewer.zmags.com/publication/f41cfe2f?page=43"> defined in the community and many patients with in</a> <a title="EMJ Rheumatology 2.1 2015 page 44" href="http://viewer.zmags.com/publication/f41cfe2f?page=44"> INTERVIEWS A: My main research focus is in vascu</a> <a title="EMJ Rheumatology 2.1 2015 page 45" href="http://viewer.zmags.com/publication/f41cfe2f?page=45"> If you are interested in submitting a paper to </a> <a title="EMJ Rheumatology 2.1 2015 page 46" href="http://viewer.zmags.com/publication/f41cfe2f?page=46"> IL-17 INHIBITION: EMERGING PERSPECTIVES IN T</a> <a title="EMJ Rheumatology 2.1 2015 page 47" href="http://viewer.zmags.com/publication/f41cfe2f?page=47"> to other pathologies such as fractures, infection</a> <a title="EMJ Rheumatology 2.1 2015 page 48" href="http://viewer.zmags.com/publication/f41cfe2f?page=48"> immune tolerance) is mediated by iT cells.19 T </a> <a title="EMJ Rheumatology 2.1 2015 page 49" href="http://viewer.zmags.com/publication/f41cfe2f?page=49"> Approximately 25% of the genetic loci involved in</a> <a title="EMJ Rheumatology 2.1 2015 page 50" href="http://viewer.zmags.com/publication/f41cfe2f?page=50"> patients with AS and those with non-radiographic </a> <a title="EMJ Rheumatology 2.1 2015 page 51" href="http://viewer.zmags.com/publication/f41cfe2f?page=51"> Table 1: IL-17 blockade in human immune-mediated </a> <a title="EMJ Rheumatology 2.1 2015 page 52" href="http://viewer.zmags.com/publication/f41cfe2f?page=52"> of chronic back pain, indistinguishable from any </a> <a title="EMJ Rheumatology 2.1 2015 page 53" href="http://viewer.zmags.com/publication/f41cfe2f?page=53"> unmet needs and treatment challen</a> <a title="EMJ Rheumatology 2.1 2015 page 54" href="http://viewer.zmags.com/publication/f41cfe2f?page=54"> γt+ CD3+CD4-CD8- entheseal resident T cells. Nat </a> <a title="EMJ Rheumatology 2.1 2015 page 55" href="http://viewer.zmags.com/publication/f41cfe2f?page=55"> IL-17 INHIBITION IN SPONDYLOARTHRITIS: A </a> <a title="EMJ Rheumatology 2.1 2015 page 56" href="http://viewer.zmags.com/publication/f41cfe2f?page=56"> Peripheral arthritis Skin and nail disease Axia</a> <a title="EMJ Rheumatology 2.1 2015 page 57" href="http://viewer.zmags.com/publication/f41cfe2f?page=57"> Psoriatic Arthritis (MIPA) study26 showed</a> <a title="EMJ Rheumatology 2.1 2015 page 58" href="http://viewer.zmags.com/publication/f41cfe2f?page=58"> cells, whilst CD8+ cells predominate over CD4+ ce</a> <a title="EMJ Rheumatology 2.1 2015 page 59" href="http://viewer.zmags.com/publication/f41cfe2f?page=59"> IL-6/R inhibitors TNF inhibitors Adalimumab </a> <a title="EMJ Rheumatology 2.1 2015 page 60" href="http://viewer.zmags.com/publication/f41cfe2f?page=60"> inclusion of a 300 mg dose of secukinumab which g</a> <a title="EMJ Rheumatology 2.1 2015 page 61" href="http://viewer.zmags.com/publication/f41cfe2f?page=61"> few joints showed pencil-in-cup deformities and n</a> <a title="EMJ Rheumatology 2.1 2015 page 62" href="http://viewer.zmags.com/publication/f41cfe2f?page=62"> enthesitis, and bone erosion in PsA.IL-17 inhibit</a> <a title="EMJ Rheumatology 2.1 2015 page 63" href="http://viewer.zmags.com/publication/f41cfe2f?page=63"> 31. Miossec P, Kolls JK. Targeting IL-17 and Th17</a> <a title="EMJ Rheumatology 2.1 2015 page 64" href="http://viewer.zmags.com/publication/f41cfe2f?page=64"> (Oxford). 2003;42(12):1469-76. 71. Torre Alonso J</a> <a title="EMJ Rheumatology 2.1 2015 page 65" href="http://viewer.zmags.com/publication/f41cfe2f?page=65"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Rheumatology 2.1 2015 page 66" href="http://viewer.zmags.com/publication/f41cfe2f?page=66"> PREGNANCY IN CHRONIC ARTHRITIS: ONLY A MATT</a> <a title="EMJ Rheumatology 2.1 2015 page 67" href="http://viewer.zmags.com/publication/f41cfe2f?page=67"> criteria,5 and almost 50% overall had at l</a> <a title="EMJ Rheumatology 2.1 2015 page 68" href="http://viewer.zmags.com/publication/f41cfe2f?page=68"> and experience with therapy often derives from co</a> <a title="EMJ Rheumatology 2.1 2015 page 69" href="http://viewer.zmags.com/publication/f41cfe2f?page=69"> Table 2 continued. Drug USA FDA risk category</a> <a title="EMJ Rheumatology 2.1 2015 page 70" href="http://viewer.zmags.com/publication/f41cfe2f?page=70"> LEF is a pyrimidine synthesis inhibitor tha</a> <a title="EMJ Rheumatology 2.1 2015 page 71" href="http://viewer.zmags.com/publication/f41cfe2f?page=71"> and infliximab (IFX), are considered Category B (T</a> <a title="EMJ Rheumatology 2.1 2015 page 72" href="http://viewer.zmags.com/publication/f41cfe2f?page=72"> Table 3: Practical points to consider when treati</a> <a title="EMJ Rheumatology 2.1 2015 page 73" href="http://viewer.zmags.com/publication/f41cfe2f?page=73"> rheumatoid arthritis during pregnancy: results</a> <a title="EMJ Rheumatology 2.1 2015 page 74" href="http://viewer.zmags.com/publication/f41cfe2f?page=74"> 2008;26:854-9. 50. Vinet E et al. Biologic therap</a> <a title="EMJ Rheumatology 2.1 2015 page 75" href="http://viewer.zmags.com/publication/f41cfe2f?page=75"> OBESITY AND OSTEOARTHRITIS: MORE THAN JUST MECH</a> <a title="EMJ Rheumatology 2.1 2015 page 76" href="http://viewer.zmags.com/publication/f41cfe2f?page=76"> Obesity is rapidly becoming one of the world’s mo</a> <a title="EMJ Rheumatology 2.1 2015 page 77" href="http://viewer.zmags.com/publication/f41cfe2f?page=77"> Levels of leptin in synovial fluid also correlate </a> <a title="EMJ Rheumatology 2.1 2015 page 78" href="http://viewer.zmags.com/publication/f41cfe2f?page=78"> to date. The prohibitive cost of these agents is </a> <a title="EMJ Rheumatology 2.1 2015 page 79" href="http://viewer.zmags.com/publication/f41cfe2f?page=79"> OA exist. Current evidence suggests that IL</a> <a title="EMJ Rheumatology 2.1 2015 page 80" href="http://viewer.zmags.com/publication/f41cfe2f?page=80"> methylation in OA chondrocytes, as well as a role</a> <a title="EMJ Rheumatology 2.1 2015 page 81" href="http://viewer.zmags.com/publication/f41cfe2f?page=81"> REFERENCES 1. Cross M et al. The global burden o</a> <a title="EMJ Rheumatology 2.1 2015 page 82" href="http://viewer.zmags.com/publication/f41cfe2f?page=82"> resulting from intra-articular transforming growt</a> <a title="EMJ Rheumatology 2.1 2015 page 83" href="http://viewer.zmags.com/publication/f41cfe2f?page=83"> of print]. 82. Baker KR et al. Association of pla</a> <a title="EMJ Rheumatology 2.1 2015 page 84" href="http://viewer.zmags.com/publication/f41cfe2f?page=84"> DIFFUSE LARGE B CELL LYMPHOMA OF THE FOOT IN A </a> <a title="EMJ Rheumatology 2.1 2015 page 85" href="http://viewer.zmags.com/publication/f41cfe2f?page=85"> haematological malignancy. The patient was a</a> <a title="EMJ Rheumatology 2.1 2015 page 86" href="http://viewer.zmags.com/publication/f41cfe2f?page=86"> approximately 25% of all NHL in the develope</a> <a title="EMJ Rheumatology 2.1 2015 page 87" href="http://viewer.zmags.com/publication/f41cfe2f?page=87"> Patients with DLBCL typically present with a mass</a> <a title="EMJ Rheumatology 2.1 2015 page 88" href="http://viewer.zmags.com/publication/f41cfe2f?page=88"> lymphoma mimicking an articular relapse </a> <a title="EMJ Rheumatology 2.1 2015 page 89" href="http://viewer.zmags.com/publication/f41cfe2f?page=89"> DECIPHERING ECTOPIC CALCIFICATION: CONTRIBUTI</a> <a title="EMJ Rheumatology 2.1 2015 page 90" href="http://viewer.zmags.com/publication/f41cfe2f?page=90"> concentration (about 100-200 nmol/dm3) is finely r</a> <a title="EMJ Rheumatology 2.1 2015 page 91" href="http://viewer.zmags.com/publication/f41cfe2f?page=91"> by loss of function in the gene enc</a> <a title="EMJ Rheumatology 2.1 2015 page 92" href="http://viewer.zmags.com/publication/f41cfe2f?page=92"> in the ATP-binding cassette, subfamily C member 6</a> <a title="EMJ Rheumatology 2.1 2015 page 93" href="http://viewer.zmags.com/publication/f41cfe2f?page=93"> AB Figure 1: Skin alterations </a> <a title="EMJ Rheumatology 2.1 2015 page 94" href="http://viewer.zmags.com/publication/f41cfe2f?page=94"> in Abcc6 -/- transgenic mice,67,80 confirmed </a> <a title="EMJ Rheumatology 2.1 2015 page 95" href="http://viewer.zmags.com/publication/f41cfe2f?page=95"> in high-risk diabetic patients in the Diabet</a> <a title="EMJ Rheumatology 2.1 2015 page 96" href="http://viewer.zmags.com/publication/f41cfe2f?page=96"> in chronic kidney disease is induced by bone mor</a> <a title="EMJ Rheumatology 2.1 2015 page 97" href="http://viewer.zmags.com/publication/f41cfe2f?page=97"> cells from normal subjects and from Pseudoxa</a> <a title="EMJ Rheumatology 2.1 2015 page 98" href="http://viewer.zmags.com/publication/f41cfe2f?page=98"> AXIAL SPONDYLOARTHRITIS: AN EVOLVING CONCEPT </a> <a title="EMJ Rheumatology 2.1 2015 page 99" href="http://viewer.zmags.com/publication/f41cfe2f?page=99"> CLASSIFICATION OF AXIAL SPONDYLOARTHRITIS The t</a> <a title="EMJ Rheumatology 2.1 2015 page 100" href="http://viewer.zmags.com/publication/f41cfe2f?page=100"> Table 1: Comparison of the two main classification</a> <a title="EMJ Rheumatology 2.1 2015 page 101" href="http://viewer.zmags.com/publication/f41cfe2f?page=101"> cohort, where ASDAS correlated significantly with </a> <a title="EMJ Rheumatology 2.1 2015 page 102" href="http://viewer.zmags.com/publication/f41cfe2f?page=102"> Spine. 2014;81:197-9. 15. 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