<br />
A SUPPLEMENT TO NEUROLOGY REVIEWS<br />
<br />
Clinical Reviews of JCV and PML<br />
JULY 2011<br />
<br />
<br />
Understanding the Complexities of<br />
JCV and PML<br />
<br />
An Overview of<br />
JC Virus and<br />
Progressive Multifocal<br />
Leukoencephalopathy<br />
<br />
<br />
<br />
The Epidemiology of<br />
Progressive Multifocal<br />
Leukoencephalopathy<br />
<br />
<br />
<br />
Progressive Multifocal<br />
Leukoencephalopathy:<br />
Survival Statistics<br />
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<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
Supported by Biogen Idec<br />
Understanding the<br />
Complexities of<br />
JCV and PML<br <a title="Biogen digital.pdf page 1" href="http://viewer.zmags.com/publication/f84595ef?page=1">A SUPPLEMENT TO NEUROLOGY REVIEWSClinical Rev</a> A SUPPLEMENT TO NEUROLOGY REVIEWSClinical Rev<a title="Biogen digital.pdf page 2" href="http://viewer.zmags.com/publication/f84595ef?page=2">Understanding theComplexities ofJCV and PML</a> Understanding theComplexities ofJCV and PML<a title="Biogen digital.pdf page 3" href="http://viewer.zmags.com/publication/f84595ef?page=3">An Overview of JC Virusand Progressive Multifoca</a> An Overview of JC Virusand Progressive Multifoca<a title="Biogen digital.pdf page 4" href="http://viewer.zmags.com/publication/f84595ef?page=4">rus of the genus Papovaviridae that was firstiso</a> rus of the genus Papovaviridae that was firstiso<a title="Biogen digital.pdf page 5" href="http://viewer.zmags.com/publication/f84595ef?page=5">cation. Although PML is generally consideredto b</a> cation. Although PML is generally consideredto b<a title="Biogen digital.pdf page 6" href="http://viewer.zmags.com/publication/f84595ef?page=6">VP1 capsid protein are associated with the de-ve</a> VP1 capsid protein are associated with the de-ve<a title="Biogen digital.pdf page 7" href="http://viewer.zmags.com/publication/f84595ef?page=7">JCV exposure than those who are not immu-nocompe</a> JCV exposure than those who are not immu-nocompe<a title="Biogen digital.pdf page 8" href="http://viewer.zmags.com/publication/f84595ef?page=8">References1. Tan CS, Koralnik IJ. Progressi</a> References1. Tan CS, Koralnik IJ. Progressi<a title="Biogen digital.pdf page 9" href="http://viewer.zmags.com/publication/f84595ef?page=9">39. Weber F, Goldmann C, Krämer M, et al. Ce</a> 39. Weber F, Goldmann C, Krämer M, et al. Ce<a title="Biogen digital.pdf page 10" href="http://viewer.zmags.com/publication/f84595ef?page=10">The Epidemiologyof Progressive MultifocalLeukoe</a> The Epidemiologyof Progressive MultifocalLeukoe<a title="Biogen digital.pdf page 11" href="http://viewer.zmags.com/publication/f84595ef?page=11">ticularly oligodendrocytes. PML is now knownto b</a> ticularly oligodendrocytes. PML is now knownto b<a title="Biogen digital.pdf page 12" href="http://viewer.zmags.com/publication/f84595ef?page=12">diseases, which represent an autoimmune in- </a> diseases, which represent an autoimmune in- <a title="Biogen digital.pdf page 13" href="http://viewer.zmags.com/publication/f84595ef?page=13">tive therapies appear to exert some change onthe</a> tive therapies appear to exert some change onthe<a title="Biogen digital.pdf page 14" href="http://viewer.zmags.com/publication/f84595ef?page=14">tainment of JCV in the CNS as well as influ-ence</a> tainment of JCV in the CNS as well as influ-ence<a title="Biogen digital.pdf page 15" href="http://viewer.zmags.com/publication/f84595ef?page=15">For example, CSF assays of JCV DNA have cor-rela</a> For example, CSF assays of JCV DNA have cor-rela<a title="Biogen digital.pdf page 16" href="http://viewer.zmags.com/publication/f84595ef?page=16">10. Chapagain ML, Nerurkar VR. Human poly</a> 10. Chapagain ML, Nerurkar VR. Human poly<a title="Biogen digital.pdf page 17" href="http://viewer.zmags.com/publication/f84595ef?page=17">Progressive MultifocalLeukoencephalopathy:Survi</a> Progressive MultifocalLeukoencephalopathy:Survi<a title="Biogen digital.pdf page 18" href="http://viewer.zmags.com/publication/f84595ef?page=18">TABLE 1 Common clinical features of AIDS-associa</a> TABLE 1 Common clinical features of AIDS-associa<a title="Biogen digital.pdf page 19" href="http://viewer.zmags.com/publication/f84595ef?page=19">TABLE 2 Different forms of PML Classic PMLPML</a> TABLE 2 Different forms of PML Classic PMLPML<a title="Biogen digital.pdf page 20" href="http://viewer.zmags.com/publication/f84595ef?page=20">TABLE 3 Summary of agents predisposing to PMLAg</a> TABLE 3 Summary of agents predisposing to PMLAg<a title="Biogen digital.pdf page 21" href="http://viewer.zmags.com/publication/f84595ef?page=21">characteristic brain changes on magnetic res-ona</a> characteristic brain changes on magnetic res-ona<a title="Biogen digital.pdf page 22" href="http://viewer.zmags.com/publication/f84595ef?page=22">88% (22 of 25) sera from natalizumab-associ-ated</a> 88% (22 of 25) sera from natalizumab-associ-ated<a title="Biogen digital.pdf page 23" href="http://viewer.zmags.com/publication/f84595ef?page=23">with HIV-associated PML, recent studies sug-gest</a> with HIV-associated PML, recent studies sug-gest<a title="Biogen digital.pdf page 24" href="http://viewer.zmags.com/publication/f84595ef?page=24"> The marked difference in survival in thatmul</a> The marked difference in survival in thatmul<a title="Biogen digital.pdf page 25" href="http://viewer.zmags.com/publication/f84595ef?page=25"> Natalizumab, the first monoclonal anti-bo</a> Natalizumab, the first monoclonal anti-bo<a title="Biogen digital.pdf page 26" href="http://viewer.zmags.com/publication/f84595ef?page=26">was employed, the patient developed PMLseve</a> was employed, the patient developed PMLseve<a title="Biogen digital.pdf page 27" href="http://viewer.zmags.com/publication/f84595ef?page=27">22. Lebwohl M, Tyring SK, Hamilton TK, et al. </a> 22. Lebwohl M, Tyring SK, Hamilton TK, et al. <a title="Biogen digital.pdf page 28" href="http://viewer.zmags.com/publication/f84595ef?page=28"></a>