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<br /> SUBSCRIBE<br /> TO RECEIVE<br /> THE LATEST<br /> PUBLICATIONS<br /> NEWSLETTERS<br /> & UPDATES<br /> FROM A HOST OF 14<br /> THERAPEUTIC AREAS<br /> www.emjreviews.com<br /> If you are interested in submitting a paper<br /> to EMJ, contact editor@emjreviews.com<br /> HEMATOLOGY<br /> ISSN 2053-6631 July 2013 • emjreviews.com<br /> INSIDE<br /> Reviews of the<br /> 18th EHA Annual Congress<br /> Stockholm, Sweden,<br /> and the 39th EBMT Annual<br /> Meeting, London, UK<br /> Contents<br /> EDITORIAL PANEL.............................................................................................................................................. 4<br /> CONGRESS REVIEW...........................................................................................................<a title="EMJ - Hematology page 1" href="http://viewer.zmags.com/publication/f8ad81bc?page=1"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS NEW</a> <a title="EMJ - Hematology page 2" href="http://viewer.zmags.com/publication/f8ad81bc?page=2"> HEMATOLOGY ISSN 2053-6631 </a> <a title="EMJ - Hematology page 3" href="http://viewer.zmags.com/publication/f8ad81bc?page=3"> Contents EDITORIAL PANEL.......................</a> <a title="EMJ - Hematology page 4" href="http://viewer.zmags.com/publication/f8ad81bc?page=4"> HEMATOLOGY RNA INTERFERENCE (RNAi): AN EFFECTIV</a> <a title="EMJ - Hematology page 5" href="http://viewer.zmags.com/publication/f8ad81bc?page=5"> HEMATOLOGY Editorial Panel Editor in Chief Prof E</a> <a title="EMJ - Hematology page 6" href="http://viewer.zmags.com/publication/f8ad81bc?page=6"> EMJ EUROPEAN MEDICAL JOURNAL 5 Publisher Claire </a> <a title="EMJ - Hematology page 7" href="http://viewer.zmags.com/publication/f8ad81bc?page=7"> CALL FOR PAPERS IF YOU ARE INTERESTED IN SUBMITT</a> <a title="EMJ - Hematology page 8" href="http://viewer.zmags.com/publication/f8ad81bc?page=8"> Foreword Professor Emili Montserrat Professor of </a> <a title="EMJ - Hematology page 9" href="http://viewer.zmags.com/publication/f8ad81bc?page=9"> EHA ANNUAL CONGRESS 2013 STOCKHOLMSMÄSSAN, STOCKH</a> <a title="EMJ - Hematology page 10" href="http://viewer.zmags.com/publication/f8ad81bc?page=10"> Welcome to the European Medical Journal review of</a> <a title="EMJ - Hematology page 11" href="http://viewer.zmags.com/publication/f8ad81bc?page=11"> EHA ANNUAL CONGRESS 2013 STOCKHOLMSMÄSSAN, STOCKH</a> <a title="EMJ - Hematology page 12" href="http://viewer.zmags.com/publication/f8ad81bc?page=12"> will help doctors discover mutations in c</a> <a title="EMJ - Hematology page 13" href="http://viewer.zmags.com/publication/f8ad81bc?page=13"> EHA ANNUAL CONGRESS 2013 STOCKHOLMSMÄSSAN, STOCKH</a> <a title="EMJ - Hematology page 14" href="http://viewer.zmags.com/publication/f8ad81bc?page=14"> Combination therapy improves outcomes for elderly</a> <a title="EMJ - Hematology page 15" href="http://viewer.zmags.com/publication/f8ad81bc?page=15"> EHA ANNUAL CONGRESS 2013 STOCKHOLMSMÄSSAN, STOCKH</a> <a title="EMJ - Hematology page 16" href="http://viewer.zmags.com/publication/f8ad81bc?page=16"> First guidelines for treating non-transfusion-dep</a> <a title="EMJ - Hematology page 17" href="http://viewer.zmags.com/publication/f8ad81bc?page=17"> EHA ANNUAL CONGRESS 2013 STOCKHOLMSMÄSSAN, STOCKH</a> <a title="EMJ - Hematology page 18" href="http://viewer.zmags.com/publication/f8ad81bc?page=18"> From a host of fourteen therapeutical areas, EURO</a> <a title="EMJ - Hematology page 19" href="http://viewer.zmags.com/publication/f8ad81bc?page=19"> EBMT ANNUAL CONGRESS 2013 EXCEL EXHIBITION AND CO</a> <a title="EMJ - Hematology page 20" href="http://viewer.zmags.com/publication/f8ad81bc?page=20"> “It was great to hear other people ask the</a> <a title="EMJ - Hematology page 21" href="http://viewer.zmags.com/publication/f8ad81bc?page=21"> DELAYED ERYTHROID AND PLATELET RESPONSE TO ECULI</a> <a title="EMJ - Hematology page 22" href="http://viewer.zmags.com/publication/f8ad81bc?page=22"> Table 1. Haematological responses to 4 months cor</a> <a title="EMJ - Hematology page 23" href="http://viewer.zmags.com/publication/f8ad81bc?page=23"> 12 Hemoglobin (g/dL) Meprednisone 40 mg/d 10 </a> <a title="EMJ - Hematology page 24" href="http://viewer.zmags.com/publication/f8ad81bc?page=24"> AB Figure 2. Bone marrow biopsy sh</a> <a title="EMJ - Hematology page 25" href="http://viewer.zmags.com/publication/f8ad81bc?page=25"> eculizumab may also be a delayed phenomenon, requ</a> <a title="EMJ - Hematology page 26" href="http://viewer.zmags.com/publication/f8ad81bc?page=26"> THE CHEMOKINE CCL17/TARC AS A BIOMARKER IN </a> <a title="EMJ - Hematology page 27" href="http://viewer.zmags.com/publication/f8ad81bc?page=27"> of macrophages, which can act in a tumour-</a> <a title="EMJ - Hematology page 28" href="http://viewer.zmags.com/publication/f8ad81bc?page=28"> its receptor CCR4 at the same time, suggesting an</a> <a title="EMJ - Hematology page 29" href="http://viewer.zmags.com/publication/f8ad81bc?page=29"> REFERENCES 1. Eichenauer DA et al. Hod</a> <a title="EMJ - Hematology page 30" href="http://viewer.zmags.com/publication/f8ad81bc?page=30"> 40. Younes A et al. Brentuximab vedotin</a> <a title="EMJ - Hematology page 31" href="http://viewer.zmags.com/publication/f8ad81bc?page=31"> PAIN MANAGEMENT IN PATIENTS WITH SICKLE CELL </a> <a title="EMJ - Hematology page 32" href="http://viewer.zmags.com/publication/f8ad81bc?page=32"> 012345 No Hurt Hurts Hurts </a> <a title="EMJ - Hematology page 33" href="http://viewer.zmags.com/publication/f8ad81bc?page=33"> Other guidelines have used a scale to assess resp</a> <a title="EMJ - Hematology page 34" href="http://viewer.zmags.com/publication/f8ad81bc?page=34"> should generally start with the next step. Once p</a> <a title="EMJ - Hematology page 35" href="http://viewer.zmags.com/publication/f8ad81bc?page=35"> when the intravenous dose is roughly equivalent t</a> <a title="EMJ - Hematology page 36" href="http://viewer.zmags.com/publication/f8ad81bc?page=36"> The hypothesis is that vaporised cannabis c</a> <a title="EMJ - Hematology page 37" href="http://viewer.zmags.com/publication/f8ad81bc?page=37"> validity, reliability, and preference of thre</a> <a title="EMJ - Hematology page 38" href="http://viewer.zmags.com/publication/f8ad81bc?page=38"> </a> <a title="EMJ - Hematology page 39" href="http://viewer.zmags.com/publication/f8ad81bc?page=39"> TREATMENT OF HIV-ASSOCIATED BURKITT LYMPHOMA Gio</a> <a title="EMJ - Hematology page 40" href="http://viewer.zmags.com/publication/f8ad81bc?page=40"> regimen. Evidence from different trials concernin</a> <a title="EMJ - Hematology page 41" href="http://viewer.zmags.com/publication/f8ad81bc?page=41"> Table 1. Diagnosis and staging of HIV-BL. DIAGNOS</a> <a title="EMJ - Hematology page 42" href="http://viewer.zmags.com/publication/f8ad81bc?page=42"> of cell death programs. Moreover, with a lower CD</a> <a title="EMJ - Hematology page 43" href="http://viewer.zmags.com/publication/f8ad81bc?page=43"> Table 2. Schedule of Hyper-CVAD, PETHEMA-LAL3/07-</a> <a title="EMJ - Hematology page 44" href="http://viewer.zmags.com/publication/f8ad81bc?page=44"> MTX 1500 mg/m² i.v. over 24 h d2 MTX 15</a> <a title="EMJ - Hematology page 45" href="http://viewer.zmags.com/publication/f8ad81bc?page=45"> of 8 months, and ~10% of patients alive at 2 year</a> <a title="EMJ - Hematology page 46" href="http://viewer.zmags.com/publication/f8ad81bc?page=46"> Table 3. Feasibility, tolerability and toxicity o</a> <a title="EMJ - Hematology page 47" href="http://viewer.zmags.com/publication/f8ad81bc?page=47"> not be attributed exclusively to rituximab consid</a> <a title="EMJ - Hematology page 48" href="http://viewer.zmags.com/publication/f8ad81bc?page=48"> Table 4. Activity and efficacy of more commonly u</a> <a title="EMJ - Hematology page 49" href="http://viewer.zmags.com/publication/f8ad81bc?page=49"> Table 5. Short-term chemoimmunotherapy proposed b</a> <a title="EMJ - Hematology page 50" href="http://viewer.zmags.com/publication/f8ad81bc?page=50"> single lesion are evaluated for 36-Gy invol</a> <a title="EMJ - Hematology page 51" href="http://viewer.zmags.com/publication/f8ad81bc?page=51"> REFERENCES 1. Jaffe ES. The 2008 WHO classificati</a> <a title="EMJ - Hematology page 52" href="http://viewer.zmags.com/publication/f8ad81bc?page=52"> using a tissue microarray. Blood. 2004;10</a> <a title="EMJ - Hematology page 53" href="http://viewer.zmags.com/publication/f8ad81bc?page=53"> lymphoma: pooled results from 3 phase 2 trials. B</a> <a title="EMJ - Hematology page 54" href="http://viewer.zmags.com/publication/f8ad81bc?page=54"> RNA INTERFERENCE (RNAi): AN EFFECTIVE WAY TO DEV</a> <a title="EMJ - Hematology page 55" href="http://viewer.zmags.com/publication/f8ad81bc?page=55"> and refractory acute leukaemias as well as de nov</a> <a title="EMJ - Hematology page 56" href="http://viewer.zmags.com/publication/f8ad81bc?page=56"> 18% with an ORR of up to 71% and 48% respectively</a> <a title="EMJ - Hematology page 57" href="http://viewer.zmags.com/publication/f8ad81bc?page=57"> An all trans-retinoic acid (ATRA) sensitiser scre</a> <a title="EMJ - Hematology page 58" href="http://viewer.zmags.com/publication/f8ad81bc?page=58"> myeloproliferative neoplasm? Expert Rev Hematol. </a> <a title="EMJ - Hematology page 59" href="http://viewer.zmags.com/publication/f8ad81bc?page=59"> PREVENTING INFECTIONS IN HIGHER-RISK MYE</a> <a title="EMJ - Hematology page 60" href="http://viewer.zmags.com/publication/f8ad81bc?page=60"> reported that the infection rate in patients trea</a> <a title="EMJ - Hematology page 61" href="http://viewer.zmags.com/publication/f8ad81bc?page=61"> Table 1. Infection incidence during hypomethylati</a> <a title="EMJ - Hematology page 62" href="http://viewer.zmags.com/publication/f8ad81bc?page=62"> most prevalent and responsible for the majority o</a> <a title="EMJ - Hematology page 63" href="http://viewer.zmags.com/publication/f8ad81bc?page=63"> REFERENCES 1. Sanz GF, Sanz MA, Vallespi T, Cani</a> <a title="EMJ - Hematology page 64" href="http://viewer.zmags.com/publication/f8ad81bc?page=64"> 2005 Jun 21;142(12 Pt 1):979-95. 27. Freifeld A</a> <a title="EMJ - Hematology page 65" href="http://viewer.zmags.com/publication/f8ad81bc?page=65"> WHAT’S NEW Sickle Cell Society calls for more min</a> <a title="EMJ - Hematology page 66" href="http://viewer.zmags.com/publication/f8ad81bc?page=66"> HEMATOLOGY New child study is Bayer’s new respons</a> <a title="EMJ - Hematology page 67" href="http://viewer.zmags.com/publication/f8ad81bc?page=67"> WHAT’S NEW NHS and Paramount Pictures join in blo</a> <a title="EMJ - Hematology page 68" href="http://viewer.zmags.com/publication/f8ad81bc?page=68"> HEMATOLOGY After many setbacks, the researche</a> <a title="EMJ - Hematology page 69" href="http://viewer.zmags.com/publication/f8ad81bc?page=69"> WHAT’S NEW </a> <a title="EMJ - Hematology page 70" href="http://viewer.zmags.com/publication/f8ad81bc?page=70"> From a host of fourteen therapeutical areas, EURO</a> <a title="EMJ - Hematology page 71" href="http://viewer.zmags.com/publication/f8ad81bc?page=71"> SUPPLIERS FEATURED SUPPLIERS Invivoscribe,</a> <a title="EMJ - Hematology page 72" href="http://viewer.zmags.com/publication/f8ad81bc?page=72"> HEMATOLOGY BUYER’S GUIDE AEAL </a> <a title="EMJ - Hematology page 73" href="http://viewer.zmags.com/publication/f8ad81bc?page=73"> UPCOMING EVENTS International Conference on Hae</a> <a title="EMJ - Hematology page 74" href="http://viewer.zmags.com/publication/f8ad81bc?page=74"> HEMATOLOGY Clinical Updates in Haematology on L</a> <a title="EMJ - Hematology page 75" href="http://viewer.zmags.com/publication/f8ad81bc?page=75"> SUBSCRIBE TO RECEIVE THE LATEST PUBLICATIONS NEW</a>