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<br /> RESPIRATORY<br /> ISSN 2054-3166 Vol 3.1 • May 2015 • emjreviews.com<br /> CONTENTS<br /> EDITORIAL BOARD................................................................................................................................. 4<br /> EDITOR’S PICK: THE ELECTRONIC NOSE ARISES INTO THE 21ST CENTURY................................... 12<br /> • Federico Fiorentino et al.<br /> TREATMENT OF ISOLATED INTRACRANIAL PROGRESSION OF LUNG CANCER DURING<br /> TREATMENT WITH SYSTEMIC EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE<br /> KINASE INHIBITORS (EGFR-TKIs)………………………..................................................................................... 19<br /> • Amanda Tufman et al.<br /> FREQUENT EXACERBATORS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: FROM<br /> RESEARCH TO CLINICAL PRACTICE ....................................................................................................<a title="EMJ Respiratory 3.1 2015 page 1" href="http://viewer.zmags.com/publication/35f950e2?page=1"> RESPIRATORY ISSN 2054-3166 </a> <a title="EMJ Respiratory 3.1 2015 page 2" href="http://viewer.zmags.com/publication/35f950e2?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Respiratory 3.1 2015 page 3" href="http://viewer.zmags.com/publication/35f950e2?page=3"> RESPIRATORY NERVES, COUGH, AND IDIOPATHIC PULMO</a> <a title="EMJ Respiratory 3.1 2015 page 4" href="http://viewer.zmags.com/publication/35f950e2?page=4"> Editorial Board Editor-in-Chief: Prof Nikolaos</a> <a title="EMJ Respiratory 3.1 2015 page 5" href="http://viewer.zmags.com/publication/35f950e2?page=5"> Respiratory Disease, Helmholtz Zentrum Münch</a> <a title="EMJ Respiratory 3.1 2015 page 6" href="http://viewer.zmags.com/publication/35f950e2?page=6"> European Medical Journal EMJ Respiratory Vol 3.</a> <a title="EMJ Respiratory 3.1 2015 page 7" href="http://viewer.zmags.com/publication/35f950e2?page=7"> Welcome Hello and a warm welcome to the latest</a> <a title="EMJ Respiratory 3.1 2015 page 8" href="http://viewer.zmags.com/publication/35f950e2?page=8"> 18th ECCO - 40th ESMO E</a> <a title="EMJ Respiratory 3.1 2015 page 9" href="http://viewer.zmags.com/publication/35f950e2?page=9"> Foreword </a> <a title="EMJ Respiratory 3.1 2015 page 10" href="http://viewer.zmags.com/publication/35f950e2?page=10"> Available Now! The additional EMJ eJournals i</a> <a title="EMJ Respiratory 3.1 2015 page 11" href="http://viewer.zmags.com/publication/35f950e2?page=11"> Editor’s Pick: State of the Art of Aortic Valve I</a> <a title="EMJ Respiratory 3.1 2015 page 12" href="http://viewer.zmags.com/publication/35f950e2?page=12"> EDITOR’S PICK An e</a> <a title="EMJ Respiratory 3.1 2015 page 13" href="http://viewer.zmags.com/publication/35f950e2?page=13"> important information. For example, ‘smellprints’</a> <a title="EMJ Respiratory 3.1 2015 page 14" href="http://viewer.zmags.com/publication/35f950e2?page=14"> Breathprints from AECOPD patients wer</a> <a title="EMJ Respiratory 3.1 2015 page 15" href="http://viewer.zmags.com/publication/35f950e2?page=15"> sleep apnoea syndrome (OSAS) has also been </a> <a title="EMJ Respiratory 3.1 2015 page 16" href="http://viewer.zmags.com/publication/35f950e2?page=16"> The sensitivity and specificity were 100% an</a> <a title="EMJ Respiratory 3.1 2015 page 17" href="http://viewer.zmags.com/publication/35f950e2?page=17"> studies including population-based screening for </a> <a title="EMJ Respiratory 3.1 2015 page 18" href="http://viewer.zmags.com/publication/35f950e2?page=18"> SUBSCRIBE FREE TO OUR YOUTUBE CHANNEL www.youtube</a> <a title="EMJ Respiratory 3.1 2015 page 19" href="http://viewer.zmags.com/publication/35f950e2?page=19"> TREATMENT OF ISOLATED INTRACRANIAL P</a> <a title="EMJ Respiratory 3.1 2015 page 20" href="http://viewer.zmags.com/publication/35f950e2?page=20"> BACKGROUND Advanced-stage lung cancer carries a </a> <a title="EMJ Respiratory 3.1 2015 page 21" href="http://viewer.zmags.com/publication/35f950e2?page=21"> tomography showed metastases in the liv</a> <a title="EMJ Respiratory 3.1 2015 page 22" href="http://viewer.zmags.com/publication/35f950e2?page=22"> A PFS or OS advantage for concurrent erlotinib du</a> <a title="EMJ Respiratory 3.1 2015 page 23" href="http://viewer.zmags.com/publication/35f950e2?page=23"> progressing under standard doses of EGFR-TKI</a> <a title="EMJ Respiratory 3.1 2015 page 24" href="http://viewer.zmags.com/publication/35f950e2?page=24"> Table 1 continued. Publication n EGFR mut</a> <a title="EMJ Respiratory 3.1 2015 page 25" href="http://viewer.zmags.com/publication/35f950e2?page=25"> did not include patients treated concurrentl</a> <a title="EMJ Respiratory 3.1 2015 page 26" href="http://viewer.zmags.com/publication/35f950e2?page=26"> Figure 2: MRI image (T2W) showing hygroma develop</a> <a title="EMJ Respiratory 3.1 2015 page 27" href="http://viewer.zmags.com/publication/35f950e2?page=27"> clinical trials. If clinical trials are not avail</a> <a title="EMJ Respiratory 3.1 2015 page 28" href="http://viewer.zmags.com/publication/35f950e2?page=28"> for multiple brain metastases from non- small-cel</a> <a title="EMJ Respiratory 3.1 2015 page 29" href="http://viewer.zmags.com/publication/35f950e2?page=29"> FREQUENT EXACERBATORS IN CHRONIC OBSTRUCTIVE </a> <a title="EMJ Respiratory 3.1 2015 page 30" href="http://viewer.zmags.com/publication/35f950e2?page=30"> previous year and daily respiratory symptoms were</a> <a title="EMJ Respiratory 3.1 2015 page 31" href="http://viewer.zmags.com/publication/35f950e2?page=31"> biomarker or combination of biomarkers, and </a> <a title="EMJ Respiratory 3.1 2015 page 32" href="http://viewer.zmags.com/publication/35f950e2?page=32"> 20% of patients with FEV >50% predicted and </a> <a title="EMJ Respiratory 3.1 2015 page 33" href="http://viewer.zmags.com/publication/35f950e2?page=33"> exacerbations, compared with 40.8% of those takin</a> <a title="EMJ Respiratory 3.1 2015 page 34" href="http://viewer.zmags.com/publication/35f950e2?page=34"> phenotype alone. The beneficial clinical effects o</a> <a title="EMJ Respiratory 3.1 2015 page 35" href="http://viewer.zmags.com/publication/35f950e2?page=35"> REFERENCES 1. Halbert RJ et al. Global burden of</a> <a title="EMJ Respiratory 3.1 2015 page 36" href="http://viewer.zmags.com/publication/35f950e2?page=36"> Int J Chron Obstruct Pulmon Dis. 2014;9</a> <a title="EMJ Respiratory 3.1 2015 page 37" href="http://viewer.zmags.com/publication/35f950e2?page=37"> Would you like to write for the EMJ blog? Intera</a> <a title="EMJ Respiratory 3.1 2015 page 38" href="http://viewer.zmags.com/publication/35f950e2?page=38"> NERVES, COUGH, AND IDIOPATHIC PULMONAR</a> <a title="EMJ Respiratory 3.1 2015 page 39" href="http://viewer.zmags.com/publication/35f950e2?page=39"> The latter, which can be demonstrated using</a> <a title="EMJ Respiratory 3.1 2015 page 40" href="http://viewer.zmags.com/publication/35f950e2?page=40"> by Leslie.20 It is known that these forces</a> <a title="EMJ Respiratory 3.1 2015 page 41" href="http://viewer.zmags.com/publication/35f950e2?page=41"> COMORBIDITIES Gastro-Oesophageal Reflux Disease Th</a> <a title="EMJ Respiratory 3.1 2015 page 42" href="http://viewer.zmags.com/publication/35f950e2?page=42"> It has been proposed that these neurotrophi</a> <a title="EMJ Respiratory 3.1 2015 page 43" href="http://viewer.zmags.com/publication/35f950e2?page=43"> TREATMENT OF COUGH Treatment of IPF-associat</a> <a title="EMJ Respiratory 3.1 2015 page 44" href="http://viewer.zmags.com/publication/35f950e2?page=44"> REFERENCES 1. Gribbin J et al. Incidence and mor</a> <a title="EMJ Respiratory 3.1 2015 page 45" href="http://viewer.zmags.com/publication/35f950e2?page=45"> 43. Jung HK et al. Gastroesophageal reflux disease</a> <a title="EMJ Respiratory 3.1 2015 page 46" href="http://viewer.zmags.com/publication/35f950e2?page=46"> ESTABLISHED STATIN USE REDUCES MORTALITY FROM</a> <a title="EMJ Respiratory 3.1 2015 page 47" href="http://viewer.zmags.com/publication/35f950e2?page=47"> Statins are already a widely used group of drugs,</a> <a title="EMJ Respiratory 3.1 2015 page 48" href="http://viewer.zmags.com/publication/35f950e2?page=48"> Inclusion Criteria i) Studies in which ST was e</a> <a title="EMJ Respiratory 3.1 2015 page 49" href="http://viewer.zmags.com/publication/35f950e2?page=49"> considered in the adjusted analysis (age, s</a> <a title="EMJ Respiratory 3.1 2015 page 50" href="http://viewer.zmags.com/publication/35f950e2?page=50"> Table 1 Continued. Study Population studied D</a> <a title="EMJ Respiratory 3.1 2015 page 51" href="http://viewer.zmags.com/publication/35f950e2?page=51"> Established ST and Development of CAP Eight studi</a> <a title="EMJ Respiratory 3.1 2015 page 52" href="http://viewer.zmags.com/publication/35f950e2?page=52"> Figure 1C: Effect of established statin therapy o</a> <a title="EMJ Respiratory 3.1 2015 page 53" href="http://viewer.zmags.com/publication/35f950e2?page=53"> pooled analysis shows that this is not significant</a> <a title="EMJ Respiratory 3.1 2015 page 54" href="http://viewer.zmags.com/publication/35f950e2?page=54"> to recruit to RCTs, many have terminated early an</a> <a title="EMJ Respiratory 3.1 2015 page 55" href="http://viewer.zmags.com/publication/35f950e2?page=55"> 28. Majumdar SR et al. Statins and outcomes</a> <a title="EMJ Respiratory 3.1 2015 page 56" href="http://viewer.zmags.com/publication/35f950e2?page=56"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Respiratory 3.1 2015 page 57" href="http://viewer.zmags.com/publication/35f950e2?page=57"> DEEP NECK ABSCESSES COMPLICATING ACUTE </a> <a title="EMJ Respiratory 3.1 2015 page 58" href="http://viewer.zmags.com/publication/35f950e2?page=58"> within normal ranges. The monosticon test for the</a> <a title="EMJ Respiratory 3.1 2015 page 59" href="http://viewer.zmags.com/publication/35f950e2?page=59"> LS and Epstein–Barr virus (EBV) infecti</a> <a title="EMJ Respiratory 3.1 2015 page 60" href="http://viewer.zmags.com/publication/35f950e2?page=60"> ADVANCES IN THE DIAGNOSIS OF HIV-ASSOCIATED TUBER</a> <a title="EMJ Respiratory 3.1 2015 page 61" href="http://viewer.zmags.com/publication/35f950e2?page=61"> Addressing the scale of the TB epidemic an</a> <a title="EMJ Respiratory 3.1 2015 page 62" href="http://viewer.zmags.com/publication/35f950e2?page=62"> Early development Late development Due to be eval</a> <a title="EMJ Respiratory 3.1 2015 page 63" href="http://viewer.zmags.com/publication/35f950e2?page=63"> compared with sputum-smear microscopy, and re</a> <a title="EMJ Respiratory 3.1 2015 page 64" href="http://viewer.zmags.com/publication/35f950e2?page=64"> Loop-Mediated Isothermal Amplification The loop-me</a> <a title="EMJ Respiratory 3.1 2015 page 65" href="http://viewer.zmags.com/publication/35f950e2?page=65"> Some variation in specificity of urine-LAM assays </a> <a title="EMJ Respiratory 3.1 2015 page 66" href="http://viewer.zmags.com/publication/35f950e2?page=66"> Comparative diagnostic yield (%) 100 90 80 70 60</a> <a title="EMJ Respiratory 3.1 2015 page 67" href="http://viewer.zmags.com/publication/35f950e2?page=67"> burden settings have demonstrated that Xpert has </a> <a title="EMJ Respiratory 3.1 2015 page 68" href="http://viewer.zmags.com/publication/35f950e2?page=68"> 6. Elliott AM et al. The impact of human immunode</a> <a title="EMJ Respiratory 3.1 2015 page 69" href="http://viewer.zmags.com/publication/35f950e2?page=69"> for extrapulmonary and pulmonary tuberculos</a> <a title="EMJ Respiratory 3.1 2015 page 70" href="http://viewer.zmags.com/publication/35f950e2?page=70"> 87. Lawn SD et al. HIV-associated tuber</a> <a title="EMJ Respiratory 3.1 2015 page 71" href="http://viewer.zmags.com/publication/35f950e2?page=71"> SUBSCRIBE TO RECEIVE THE LATEST CATIONS, PUBL</a>