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<br /> TREATMENT STRATEGIES<br /> HEMATOLOGY<br /> Volume 2 Issue 1<br /> ISSN 2047-7600<br /> • Angiogenesis<br /> • Bone Marrow Failures<br /> • Leukemia<br /> • Multiple Myeloma<br /> • Non-Hodgkin Lymphomas<br /> • Relapsed/Refractory AML<br /> • Von Willebrand Disease<br /> Articles include:<br /> Paroxysmal Nocturnal Hemoglobinuria<br /> New Challenges in the Management of Diffuse Large<br /> B-Cell Lymphoma<br /> Checkpoint and DNA Repair Inhibition in Leukemias<br /> The Use of Vorinostat in Multiple Myeloma – An Update<br /> from ASH 2011<br /> New Weapons and Strategies in the Battle Against<br /> Relapsed Acute Myeloid Leukemia (AML)<br /> Includes a review of the 53rd ASH<br /> Annual Meeting and Exposition<br /> TREANDA® is her chemo.<br /> This is her therapy.<br /> Single-agent TREANDA tripled median PFS in patients with CLL*<br /> 42%!.$! IS INDICATED FOR THE TREATMENT OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA #,, <br /> %Fl<a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 1" href="http://viewer.zmags.com/publication/48a268e2?page=1"> TREATMENT STRATEGIES HEMATOLOGY Volume 2 Issue 1 </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 2" href="http://viewer.zmags.com/publication/48a268e2?page=2"> TREANDA® is her chemo. This is her therapy.</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 3" href="http://viewer.zmags.com/publication/48a268e2?page=3"> Single-agent TREANDA tripled median PFS in patien</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 4" href="http://viewer.zmags.com/publication/48a268e2?page=4"> Brief Summary of Prescribing Information INDICATI</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 5" href="http://viewer.zmags.com/publication/48a268e2?page=5"> Table 3: Non-Hematologic Adverse Reactions Occurr</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 6" href="http://viewer.zmags.com/publication/48a268e2?page=6"> C CAMBRIDGE RESEARCH CENTR</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 7" href="http://viewer.zmags.com/publication/48a268e2?page=7"> TREATMENT STRATEGIES HEMATOLOGY Treatment Stra</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 8" href="http://viewer.zmags.com/publication/48a268e2?page=8"> Pursuing new options for patients through THE S</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 9" href="http://viewer.zmags.com/publication/48a268e2?page=9"> CONTENTS... 07 11 13 15 31 </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 10" href="http://viewer.zmags.com/publication/48a268e2?page=10"> 59 63 68 74 79 85 </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 11" href="http://viewer.zmags.com/publication/48a268e2?page=11"> EDITORIALADVISORY PANEL including... Monica Be</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 12" href="http://viewer.zmags.com/publication/48a268e2?page=12"> MOST PATIENTS WITH MULTIPLE MYELOMA STILL </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 13" href="http://viewer.zmags.com/publication/48a268e2?page=13"> Treatment Strategies - Foreword Foreword </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 14" href="http://viewer.zmags.com/publication/48a268e2?page=14"> CAMBRIDGERESEARCHCENTRE HE</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 15" href="http://viewer.zmags.com/publication/48a268e2?page=15"> 53rd ASH Annual Meeting and Exposition </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 16" href="http://viewer.zmags.com/publication/48a268e2?page=16"> Treatment Strategies - Congress Review </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 17" href="http://viewer.zmags.com/publication/48a268e2?page=17"> Treatment Strategies - Congress Review Progress o</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 18" href="http://viewer.zmags.com/publication/48a268e2?page=18"> Treatment Strategies - Congress Review Telik An</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 19" href="http://viewer.zmags.com/publication/48a268e2?page=19"> Treatment Strategies - Congress Review AWARD HIGH</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 20" href="http://viewer.zmags.com/publication/48a268e2?page=20"> Treatment Strategies - Congress Review continued </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 21" href="http://viewer.zmags.com/publication/48a268e2?page=21"> Treatment Strategies - Congress Review Avila Th</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 22" href="http://viewer.zmags.com/publication/48a268e2?page=22"> Treatment Strategies - Congress Review </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 23" href="http://viewer.zmags.com/publication/48a268e2?page=23"> Treatment Strategies - Congress Review New Dat</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 24" href="http://viewer.zmags.com/publication/48a268e2?page=24"> Treatment Strategies - Congress Review continued </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 25" href="http://viewer.zmags.com/publication/48a268e2?page=25"> Treatment Strategies - Congress Review PROMISIN</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 26" href="http://viewer.zmags.com/publication/48a268e2?page=26"> Treatment Strategies - Congress Review </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 27" href="http://viewer.zmags.com/publication/48a268e2?page=27"> </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 28" href="http://viewer.zmags.com/publication/48a268e2?page=28"> Treatment Strategies - Congress Review Genetic an</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 29" href="http://viewer.zmags.com/publication/48a268e2?page=29"> C CAMBRIDGE RESEARCH CENTR</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 30" href="http://viewer.zmags.com/publication/48a268e2?page=30"> Treatment Strategies - Congress Review Summary of</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 31" href="http://viewer.zmags.com/publication/48a268e2?page=31"> Treatment Strategies - Angiogenesis TIMP-2:</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 32" href="http://viewer.zmags.com/publication/48a268e2?page=32"> Treatment Strategies - Angiogenesis tumor-indu</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 33" href="http://viewer.zmags.com/publication/48a268e2?page=33"> involved reduction of the cognate tyrosine kinase</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 34" href="http://viewer.zmags.com/publication/48a268e2?page=34"> Treatment Strategies - Angiogenesis tumor grow</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 35" href="http://viewer.zmags.com/publication/48a268e2?page=35"> Itohara S: Reduced angiogenesis and tumor progres</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 36" href="http://viewer.zmags.com/publication/48a268e2?page=36"> Treatment Strategies - Bone Marrow Failures </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 37" href="http://viewer.zmags.com/publication/48a268e2?page=37"> AB Proliferation (fold) Apoptosis (%) +/3A </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 38" href="http://viewer.zmags.com/publication/48a268e2?page=38"> Treatment Strategies - Bone Marrow Failures p5</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 39" href="http://viewer.zmags.com/publication/48a268e2?page=39"> Treatment Strategies - Bone Marrow Failures DNA</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 40" href="http://viewer.zmags.com/publication/48a268e2?page=40"> Treatment Strategies - Bone Marrow Failures he</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 41" href="http://viewer.zmags.com/publication/48a268e2?page=41"> Treatment Strategies - Leukemia Checkpoint </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 42" href="http://viewer.zmags.com/publication/48a268e2?page=42"> Treatment Strategies - Leukemia cells have mul</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 43" href="http://viewer.zmags.com/publication/48a268e2?page=43"> resistance by CHK1 inhibition with a novel agent </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 44" href="http://viewer.zmags.com/publication/48a268e2?page=44"> Treatment Strategies - Leukemia CDC25’s.59 Our</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 45" href="http://viewer.zmags.com/publication/48a268e2?page=45"> Treatment Strategies - Leukemia Emerging clini</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 46" href="http://viewer.zmags.com/publication/48a268e2?page=46"> Treatment Strategies - Leukemia of AZD7762 in </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 47" href="http://viewer.zmags.com/publication/48a268e2?page=47"> Treatment Strategies - Leukemia Chronic Lym</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 48" href="http://viewer.zmags.com/publication/48a268e2?page=48"> Treatment Strategies - Leukemia other Src fami</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 49" href="http://viewer.zmags.com/publication/48a268e2?page=49"> chain reaction.58 Furthermore, growth- and surviv</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 50" href="http://viewer.zmags.com/publication/48a268e2?page=50"> Treatment Strategies - Leukemia clones then be</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 51" href="http://viewer.zmags.com/publication/48a268e2?page=51"> leukaemia cells in vitro. British journal of haem</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 52" href="http://viewer.zmags.com/publication/48a268e2?page=52"> Treatment Strategies - Leukemia Leukemia B Ce</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 53" href="http://viewer.zmags.com/publication/48a268e2?page=53"> Treatment Strategies - Leukemia Clinical De</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 54" href="http://viewer.zmags.com/publication/48a268e2?page=54"> Treatment Strategies - Leukemia Eleven CLL pat</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 55" href="http://viewer.zmags.com/publication/48a268e2?page=55"> isoform of PI3K.26 SAR245408 (S08) is a class I p</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 56" href="http://viewer.zmags.com/publication/48a268e2?page=56"> Treatment Strategies - Leukemia preliminary st</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 57" href="http://viewer.zmags.com/publication/48a268e2?page=57"> engagement and phosphoinositide 3-kinase activati</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 58" href="http://viewer.zmags.com/publication/48a268e2?page=58"> MOST PATIENTS WITH MULTIPLE MYELOMA STILL </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 59" href="http://viewer.zmags.com/publication/48a268e2?page=59"> Treatment Strategies - Multiple Myeloma The</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 60" href="http://viewer.zmags.com/publication/48a268e2?page=60"> Treatment Strategies - Multiple Myeloma treatm</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 61" href="http://viewer.zmags.com/publication/48a268e2?page=61"> Treatment Strategies - Multiple Myeloma vorino</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 62" href="http://viewer.zmags.com/publication/48a268e2?page=62"> Treatment Strategies - Multiple Myeloma 3. Pei</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 63" href="http://viewer.zmags.com/publication/48a268e2?page=63"> Treatment Strategies - Multiple Myeloma New</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 64" href="http://viewer.zmags.com/publication/48a268e2?page=64"> Treatment Strategies - Multiple Myeloma highes</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 65" href="http://viewer.zmags.com/publication/48a268e2?page=65"> very good partial response or better in 17% and 2</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 66" href="http://viewer.zmags.com/publication/48a268e2?page=66"> Treatment Strategies - Multiple Myeloma Phase </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 67" href="http://viewer.zmags.com/publication/48a268e2?page=67"> Treatment Strategies - Multiple Myeloma 20. Pe</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 68" href="http://viewer.zmags.com/publication/48a268e2?page=68"> Treatment Strategies - Non-Hodgkin Lymphomas </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 69" href="http://viewer.zmags.com/publication/48a268e2?page=69"> enriched for ABC DLBCLs (Fisher exact test, p=0.0</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 70" href="http://viewer.zmags.com/publication/48a268e2?page=70"> Treatment Strategies - Non-Hodgkin Lymphomas p</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 71" href="http://viewer.zmags.com/publication/48a268e2?page=71"> 70%.41 Additional reports from this and other ran</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 72" href="http://viewer.zmags.com/publication/48a268e2?page=72"> Treatment Strategies - Non-Hodgkin Lymphomas c</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 73" href="http://viewer.zmags.com/publication/48a268e2?page=73"> Treatment Strategies - Non-Hodgkin Lymphomas 3</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 74" href="http://viewer.zmags.com/publication/48a268e2?page=74"> Treatment Strategies - Paroxysmal Nocturnal Hemog</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 75" href="http://viewer.zmags.com/publication/48a268e2?page=75"> Treatment Strategies - Paroxysmal Nocturnal Hemog</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 76" href="http://viewer.zmags.com/publication/48a268e2?page=76"> Treatment Strategies - Paroxysmal Nocturnal Hemog</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 77" href="http://viewer.zmags.com/publication/48a268e2?page=77"> Treatment Strategies - Paroxysmal Nocturnal Hemog</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 78" href="http://viewer.zmags.com/publication/48a268e2?page=78"> Treatment Strategies - Paroxysmal Nocturnal Hemog</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 79" href="http://viewer.zmags.com/publication/48a268e2?page=79"> Treatment Strategies - Relapsed/Refractory AML </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 80" href="http://viewer.zmags.com/publication/48a268e2?page=80"> Treatment Strategies - Relapsed/Refractory AML </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 81" href="http://viewer.zmags.com/publication/48a268e2?page=81"> Achievement of CR2, however, significantly improv</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 82" href="http://viewer.zmags.com/publication/48a268e2?page=82"> Treatment Strategies - Relapsed/Refractory AML </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 83" href="http://viewer.zmags.com/publication/48a268e2?page=83"> had no adverse prognostic factors with AML had an</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 84" href="http://viewer.zmags.com/publication/48a268e2?page=84"> Treatment Strategies - Relapsed/Refractory AML </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 85" href="http://viewer.zmags.com/publication/48a268e2?page=85"> Treatment Strategies - Thrombosis Anticoagu</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 86" href="http://viewer.zmags.com/publication/48a268e2?page=86"> Treatment Strategies - Thrombosis benign proce</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 87" href="http://viewer.zmags.com/publication/48a268e2?page=87"> Treatment Strategies - Thrombosis Conclusions I</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 88" href="http://viewer.zmags.com/publication/48a268e2?page=88"> Treatment Strategies - Von Willebrand Disease </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 89" href="http://viewer.zmags.com/publication/48a268e2?page=89"> Author (yr) 6VWD No. Pregnancies No. Postpart</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 90" href="http://viewer.zmags.com/publication/48a268e2?page=90"> Treatment Strategies - Von Willebrand Disease V</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 91" href="http://viewer.zmags.com/publication/48a268e2?page=91"> Treatment Strategies - Von Willebrand Disease </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 92" href="http://viewer.zmags.com/publication/48a268e2?page=92"> Treatment Strategies - Von Willebrand Disease </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 93" href="http://viewer.zmags.com/publication/48a268e2?page=93"> FDA approves simplified ZEVALIN treatment. RITUXI</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 94" href="http://viewer.zmags.com/publication/48a268e2?page=94"> ZEVALIN® (ibritumomab tiuxetan) for Intravenous I</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 95" href="http://viewer.zmags.com/publication/48a268e2?page=95"> Severe Hematologic Toxicity in Patients Receiving</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 96" href="http://viewer.zmags.com/publication/48a268e2?page=96"> Treatment Strategies - Events Listings Up</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 97" href="http://viewer.zmags.com/publication/48a268e2?page=97"> e rsttPaatiteiennt tanadndCaCraerer an</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 98" href="http://viewer.zmags.com/publication/48a268e2?page=98"> Treatment Strategies - Events Listings American</a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 99" href="http://viewer.zmags.com/publication/48a268e2?page=99"> </a> <a title="Treatment Strategies - Hematology - Volume 2 Issue 1 page 100" href="http://viewer.zmags.com/publication/48a268e2?page=100"> The Cambridge Research Centre Coppergate House 16</a>