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<br /> NEPHROLOGY<br /> ISSN 2053-4248 Vol 4.1 • July 2016 • emjreviews.com<br /> INSIDE<br /> Review of<br /> ERA-EDTA 2016<br /> Vienna, Austria<br /> CONTENTS<br /> EDITORIAL BOARD......................................................................................................................................... 5<br /> CONGRESS REVIEW........................................................................................................................................ 10<br /> • Review of the European Renal Association - European Dialysis and Transplant<br /> Association (ERA-EDTA) Congress 2016, held in Vienna, Austria, 21st–24th May 2016<br /> INTERVIEW WITH EMJ NEPHROLOGY EDITORIAL BOARD MEMBER............................................... 24<br /> SYMPOSIUM REVIEWS<br /> • PROTECTING HEART, VESSELS, AND BONE: NEW WAYS TO CONTROL PHOSPHORUS....... 28<br /> • NEW INSIGH<a title="EMJ Nephrology 4.1 2016 page 1" href="http://viewer.zmags.com/publication/544f28a7?page=1"> NEPHROLOGY ISSN 2053-4248 </a> <a title="EMJ Nephrology 4.1 2016 page 2" href="http://viewer.zmags.com/publication/544f28a7?page=2"> CONTENTS EDITORIAL BOARD.......................</a> <a title="EMJ Nephrology 4.1 2016 page 3" href="http://viewer.zmags.com/publication/544f28a7?page=3"> NEPHROLOGY • VASCULAR AND VALVULAR CALCIFICATIO</a> <a title="EMJ Nephrology 4.1 2016 page 4" href="http://viewer.zmags.com/publication/544f28a7?page=4"> PATENTS PENDING</a> <a title="EMJ Nephrology 4.1 2016 page 5" href="http://viewer.zmags.com/publication/544f28a7?page=5"> Editorial Board Editor-in-Chief: Prof Norbert </a> <a title="EMJ Nephrology 4.1 2016 page 6" href="http://viewer.zmags.com/publication/544f28a7?page=6"> SUBSCRIBE TOTHEEMJ NEWSLETTER NwEwwW.newSs.eLmjEr</a> <a title="EMJ Nephrology 4.1 2016 page 7" href="http://viewer.zmags.com/publication/544f28a7?page=7"> Welcome Welcome to the European Medical Journa</a> <a title="EMJ Nephrology 4.1 2016 page 8" href="http://viewer.zmags.com/publication/544f28a7?page=8"> Available Now European Med</a> <a title="EMJ Nephrology 4.1 2016 page 9" href="http://viewer.zmags.com/publication/544f28a7?page=9"> Foreword </a> <a title="EMJ Nephrology 4.1 2016 page 10" href="http://viewer.zmags.com/publication/544f28a7?page=10"> 10 NEPHROLOGY • July 2016 </a> <a title="EMJ Nephrology 4.1 2016 page 11" href="http://viewer.zmags.com/publication/544f28a7?page=11"> NEPHROLOGY • July 2016 </a> <a title="EMJ Nephrology 4.1 2016 page 12" href="http://viewer.zmags.com/publication/544f28a7?page=12"> 12 NEPHROLOGY • July 2016 </a> <a title="EMJ Nephrology 4.1 2016 page 13" href="http://viewer.zmags.com/publication/544f28a7?page=13"> Congress Highlights Update on Miracl</a> <a title="EMJ Nephrology 4.1 2016 page 14" href="http://viewer.zmags.com/publication/544f28a7?page=14"> Peritoneal Dialysis: Providing Options for the El</a> <a title="EMJ Nephrology 4.1 2016 page 15" href="http://viewer.zmags.com/publication/544f28a7?page=15"> CKD patients have an excessively high cardiovascu</a> <a title="EMJ Nephrology 4.1 2016 page 16" href="http://viewer.zmags.com/publication/544f28a7?page=16"> SVR12 was achieved in 94.6% of all patients... T</a> <a title="EMJ Nephrology 4.1 2016 page 17" href="http://viewer.zmags.com/publication/544f28a7?page=17"> Dr Lina Johansson, Clinical Academic Dietitian, I</a> <a title="EMJ Nephrology 4.1 2016 page 18" href="http://viewer.zmags.com/publication/544f28a7?page=18"> Kidney disease often goes undetected and doe</a> <a title="EMJ Nephrology 4.1 2016 page 19" href="http://viewer.zmags.com/publication/544f28a7?page=19"> Although noting the strict enrolment </a> <a title="EMJ Nephrology 4.1 2016 page 20" href="http://viewer.zmags.com/publication/544f28a7?page=20"> blood pressure control and renin-angiotensin syst</a> <a title="EMJ Nephrology 4.1 2016 page 21" href="http://viewer.zmags.com/publication/544f28a7?page=21"> The unprecedented results demonstrated that highe</a> <a title="EMJ Nephrology 4.1 2016 page 22" href="http://viewer.zmags.com/publication/544f28a7?page=22"> already been validated in both the HCS and KAROLA</a> <a title="EMJ Nephrology 4.1 2016 page 23" href="http://viewer.zmags.com/publication/544f28a7?page=23"> If you are interested in submitting a paper to </a> <a title="EMJ Nephrology 4.1 2016 page 24" href="http://viewer.zmags.com/publication/544f28a7?page=24"> Thomas Ryzlewicz Senior Consultant Nephrologist,</a> <a title="EMJ Nephrology 4.1 2016 page 25" href="http://viewer.zmags.com/publication/544f28a7?page=25"> Q: You regularly work in both Italy and Germany; </a> <a title="EMJ Nephrology 4.1 2016 page 26" href="http://viewer.zmags.com/publication/544f28a7?page=26"> ions for calcification (Ca2+ and Mg2+), so </a> <a title="EMJ Nephrology 4.1 2016 page 27" href="http://viewer.zmags.com/publication/544f28a7?page=27"> EMJ EUROPEAN MEDICAL </a> <a title="EMJ Nephrology 4.1 2016 page 28" href="http://viewer.zmags.com/publication/544f28a7?page=28"> PROTECTING HEART, VESSELS, AND BONE: NEW WAYS </a> <a title="EMJ Nephrology 4.1 2016 page 29" href="http://viewer.zmags.com/publication/544f28a7?page=29"> Hyperphosphataemia: Understanding the Challenges </a> <a title="EMJ Nephrology 4.1 2016 page 30" href="http://viewer.zmags.com/publication/544f28a7?page=30"> Elevated serum phosphate levels are generall</a> <a title="EMJ Nephrology 4.1 2016 page 31" href="http://viewer.zmags.com/publication/544f28a7?page=31"> source of phosphorus in dialysis. During dialysis</a> <a title="EMJ Nephrology 4.1 2016 page 32" href="http://viewer.zmags.com/publication/544f28a7?page=32"> Randomised controlled trials investig</a> <a title="EMJ Nephrology 4.1 2016 page 33" href="http://viewer.zmags.com/publication/544f28a7?page=33"> The RIND trial follow-up arm extended </a> <a title="EMJ Nephrology 4.1 2016 page 34" href="http://viewer.zmags.com/publication/544f28a7?page=34"> included a baseline period of 3 months before SFO</a> <a title="EMJ Nephrology 4.1 2016 page 35" href="http://viewer.zmags.com/publication/544f28a7?page=35"> Chronic Kidney Failure. Biomed Res Int. 2015;2015</a> <a title="EMJ Nephrology 4.1 2016 page 36" href="http://viewer.zmags.com/publication/544f28a7?page=36"> NEW INSIGHTS INTO IRON METABOLISM </a> <a title="EMJ Nephrology 4.1 2016 page 37" href="http://viewer.zmags.com/publication/544f28a7?page=37"> the presence of inflammation. In the general</a> <a title="EMJ Nephrology 4.1 2016 page 38" href="http://viewer.zmags.com/publication/544f28a7?page=38"> This is a normal physiological process and often </a> <a title="EMJ Nephrology 4.1 2016 page 39" href="http://viewer.zmags.com/publication/544f28a7?page=39"> and increased iron utilisation (following</a> <a title="EMJ Nephrology 4.1 2016 page 40" href="http://viewer.zmags.com/publication/544f28a7?page=40"> 100 80 60 Patients (%) 40 20 0 High ferri</a> <a title="EMJ Nephrology 4.1 2016 page 41" href="http://viewer.zmags.com/publication/544f28a7?page=41"> REFERENCES 1. Peyrin-Biroulet L et al. Guideline</a> <a title="EMJ Nephrology 4.1 2016 page 42" href="http://viewer.zmags.com/publication/544f28a7?page=42"> SECONDARY CARNITINE DEFICIENCY IN DIALYSI</a> <a title="EMJ Nephrology 4.1 2016 page 43" href="http://viewer.zmags.com/publication/544f28a7?page=43"> levels and improved the acylcarnitine to free car</a> <a title="EMJ Nephrology 4.1 2016 page 44" href="http://viewer.zmags.com/publication/544f28a7?page=44"> Importantly, humans have a low capacity for</a> <a title="EMJ Nephrology 4.1 2016 page 45" href="http://viewer.zmags.com/publication/544f28a7?page=45"> Clinical signs and symptoms of OCTN2 deficiency ar</a> <a title="EMJ Nephrology 4.1 2016 page 46" href="http://viewer.zmags.com/publication/544f28a7?page=46"> replenishment of total body carnitine stores</a> <a title="EMJ Nephrology 4.1 2016 page 47" href="http://viewer.zmags.com/publication/544f28a7?page=47"> 140 120 M) Plasma L-carnitine concentration (µ</a> <a title="EMJ Nephrology 4.1 2016 page 48" href="http://viewer.zmags.com/publication/544f28a7?page=48"> L-carnitine for other dialysis-related conditions</a> <a title="EMJ Nephrology 4.1 2016 page 49" href="http://viewer.zmags.com/publication/544f28a7?page=49"> 0 -0.5 Longitudinal strain rate -1 -1.5 </a> <a title="EMJ Nephrology 4.1 2016 page 50" href="http://viewer.zmags.com/publication/544f28a7?page=50"> 25.2 µmol/L (4.4).24 The proportion of carnitine-</a> <a title="EMJ Nephrology 4.1 2016 page 51" href="http://viewer.zmags.com/publication/544f28a7?page=51"> oxidative stress and cardiac dysfunction in chil</a> <a title="EMJ Nephrology 4.1 2016 page 52" href="http://viewer.zmags.com/publication/544f28a7?page=52"> Abstract Reviews NOVEL ORAL ANTICOAGUL</a> <a title="EMJ Nephrology 4.1 2016 page 53" href="http://viewer.zmags.com/publication/544f28a7?page=53"> ERA-EDTA 2016 REFERENCES 1. Camm AJ et al. 2012 </a> <a title="EMJ Nephrology 4.1 2016 page 54" href="http://viewer.zmags.com/publication/544f28a7?page=54"> Abstract Reviews investigated. On occasions wher</a> <a title="EMJ Nephrology 4.1 2016 page 55" href="http://viewer.zmags.com/publication/544f28a7?page=55"> ERA-EDTA 2016 people in general tend to hav</a> <a title="EMJ Nephrology 4.1 2016 page 56" href="http://viewer.zmags.com/publication/544f28a7?page=56"> Abstract Reviews Table 1: RIFLE, AKIN, and KDIGO </a> <a title="EMJ Nephrology 4.1 2016 page 57" href="http://viewer.zmags.com/publication/544f28a7?page=57"> ERA-EDTA 2016 clinical context. Finally, AKI is </a> <a title="EMJ Nephrology 4.1 2016 page 58" href="http://viewer.zmags.com/publication/544f28a7?page=58"> Abstract Reviews We had hypothesised that a </a> <a title="EMJ Nephrology 4.1 2016 page 59" href="http://viewer.zmags.com/publication/544f28a7?page=59"> ERA-EDTA 2016 are therefore limited and ther</a> <a title="EMJ Nephrology 4.1 2016 page 60" href="http://viewer.zmags.com/publication/544f28a7?page=60"> Abstract Reviews (www.ARegPKD.org).2 This will h</a> <a title="EMJ Nephrology 4.1 2016 page 61" href="http://viewer.zmags.com/publication/544f28a7?page=61"> ERA-EDTA 2016 The following conclusions can be d</a> <a title="EMJ Nephrology 4.1 2016 page 62" href="http://viewer.zmags.com/publication/544f28a7?page=62"> Abstract Reviews NF-κB and JAK/signal transducer</a> <a title="EMJ Nephrology 4.1 2016 page 63" href="http://viewer.zmags.com/publication/544f28a7?page=63"> ERA-EDTA 2016 Acknowledgements </a> <a title="EMJ Nephrology 4.1 2016 page 64" href="http://viewer.zmags.com/publication/544f28a7?page=64"> Abstract Reviews MICHEL JADOUL: KEY LESSONS FROM </a> <a title="EMJ Nephrology 4.1 2016 page 65" href="http://viewer.zmags.com/publication/544f28a7?page=65"> SUBSCRIBE Follow us: FREE TO OUR YOUTUBE CHA</a> <a title="EMJ Nephrology 4.1 2016 page 66" href="http://viewer.zmags.com/publication/544f28a7?page=66"> EDITOR’S PICK Targ</a> <a title="EMJ Nephrology 4.1 2016 page 67" href="http://viewer.zmags.com/publication/544f28a7?page=67"> INTRODUCTION A number of molecularly targeted th</a> <a title="EMJ Nephrology 4.1 2016 page 68" href="http://viewer.zmags.com/publication/544f28a7?page=68"> Network (REIN) registry.10 Notably, in the Europe</a> <a title="EMJ Nephrology 4.1 2016 page 69" href="http://viewer.zmags.com/publication/544f28a7?page=69"> 2 weeks off schedule emerged as the one to be use</a> <a title="EMJ Nephrology 4.1 2016 page 70" href="http://viewer.zmags.com/publication/544f28a7?page=70"> evidenced in patients pre-treated with cytokines;</a> <a title="EMJ Nephrology 4.1 2016 page 71" href="http://viewer.zmags.com/publication/544f28a7?page=71"> Kennoki et al.48 examined PK parameters in patien</a> <a title="EMJ Nephrology 4.1 2016 page 72" href="http://viewer.zmags.com/publication/544f28a7?page=72"> patients; at 37.5 mg daily, 4 weeks on, 2 weeks o</a> <a title="EMJ Nephrology 4.1 2016 page 73" href="http://viewer.zmags.com/publication/544f28a7?page=73"> Table 1 continued. Author (year) No. of patient</a> <a title="EMJ Nephrology 4.1 2016 page 74" href="http://viewer.zmags.com/publication/544f28a7?page=74"> Table 2: Summary of literature reports on the saf</a> <a title="EMJ Nephrology 4.1 2016 page 75" href="http://viewer.zmags.com/publication/544f28a7?page=75"> to date decisions about anti-cancer drug choices </a> <a title="EMJ Nephrology 4.1 2016 page 76" href="http://viewer.zmags.com/publication/544f28a7?page=76"> metastatic renal cell carcinoma: PISCES Study. J </a> <a title="EMJ Nephrology 4.1 2016 page 77" href="http://viewer.zmags.com/publication/544f28a7?page=77"> 78. Omae K et al. Use of mammalian experience </a> <a title="EMJ Nephrology 4.1 2016 page 78" href="http://viewer.zmags.com/publication/544f28a7?page=78"> URIC ACID IN CHRONIC KIDNEY DISEASE: </a> <a title="EMJ Nephrology 4.1 2016 page 79" href="http://viewer.zmags.com/publication/544f28a7?page=79"> URIC ACID METABOLISM IN HUMANS UA is the final en</a> <a title="EMJ Nephrology 4.1 2016 page 80" href="http://viewer.zmags.com/publication/544f28a7?page=80"> of lipids and insulin resistance, both of which a</a> <a title="EMJ Nephrology 4.1 2016 page 81" href="http://viewer.zmags.com/publication/544f28a7?page=81"> Kanda et al.49 showed a U-shaped associatio</a> <a title="EMJ Nephrology 4.1 2016 page 82" href="http://viewer.zmags.com/publication/544f28a7?page=82"> of urate lowering agents in renal patients in ord</a> <a title="EMJ Nephrology 4.1 2016 page 83" href="http://viewer.zmags.com/publication/544f28a7?page=83"> 2014;29:999-1008. 18. Jalal DI et al. Uric acid a</a> <a title="EMJ Nephrology 4.1 2016 page 84" href="http://viewer.zmags.com/publication/544f28a7?page=84"> VASCULAR AND VALVULAR CALCIFICATIONS </a> <a title="EMJ Nephrology 4.1 2016 page 85" href="http://viewer.zmags.com/publication/544f28a7?page=85"> whereas medial calcification is non-inflammation ba</a> <a title="EMJ Nephrology 4.1 2016 page 86" href="http://viewer.zmags.com/publication/544f28a7?page=86"> by calcified vessel rupture.25,26 Osteoprotege</a> <a title="EMJ Nephrology 4.1 2016 page 87" href="http://viewer.zmags.com/publication/544f28a7?page=87"> MAC are thought to be an age-related process but,</a> <a title="EMJ Nephrology 4.1 2016 page 88" href="http://viewer.zmags.com/publication/544f28a7?page=88"> Figure 2: Aortic valvular calcification in a haemo</a> <a title="EMJ Nephrology 4.1 2016 page 89" href="http://viewer.zmags.com/publication/544f28a7?page=89"> TREATMENT STRATEGIES Moderate-to-severe CKD </a> <a title="EMJ Nephrology 4.1 2016 page 90" href="http://viewer.zmags.com/publication/544f28a7?page=90"> 5. Russo D et al. Multimodal treatment of calc</a> <a title="EMJ Nephrology 4.1 2016 page 91" href="http://viewer.zmags.com/publication/544f28a7?page=91"> or sclerosis in elderly patients: M mode and two </a> <a title="EMJ Nephrology 4.1 2016 page 92" href="http://viewer.zmags.com/publication/544f28a7?page=92"> TUBULAR HANDLING OF URIC ACID AND FACTORS </a> <a title="EMJ Nephrology 4.1 2016 page 93" href="http://viewer.zmags.com/publication/544f28a7?page=93"> inhibitory effects on URAT1, therefore confirming </a> <a title="EMJ Nephrology 4.1 2016 page 94" href="http://viewer.zmags.com/publication/544f28a7?page=94"> Table 1: Uric transporters, localisations, and pa</a> <a title="EMJ Nephrology 4.1 2016 page 95" href="http://viewer.zmags.com/publication/544f28a7?page=95"> metabolites, or other fixed acids excreted by the </a> <a title="EMJ Nephrology 4.1 2016 page 96" href="http://viewer.zmags.com/publication/544f28a7?page=96"> Table 2: Uric transporters, localisations, and pa</a> <a title="EMJ Nephrology 4.1 2016 page 97" href="http://viewer.zmags.com/publication/544f28a7?page=97"> hyperuricemia. Nat Commun. 2012;3:764 20. Murer </a> <a title="EMJ Nephrology 4.1 2016 page 98" href="http://viewer.zmags.com/publication/544f28a7?page=98"> TREATING THE DIABETIC HYPERTENSIVE: CONS</a> <a title="EMJ Nephrology 4.1 2016 page 99" href="http://viewer.zmags.com/publication/544f28a7?page=99"> TARGET BLOOD PRESSURE: EVOLUTION OF EVIDENCE The</a> <a title="EMJ Nephrology 4.1 2016 page 100" href="http://viewer.zmags.com/publication/544f28a7?page=100"> those with achieved systolic BP of <130 mmHg (tig</a> <a title="EMJ Nephrology 4.1 2016 page 101" href="http://viewer.zmags.com/publication/544f28a7?page=101"> ADVANCE trials were not quoted. CHEP has not revi</a> <a title="EMJ Nephrology 4.1 2016 page 102" href="http://viewer.zmags.com/publication/544f28a7?page=102"> However, despite the fact that the ADVANCE </a> <a title="EMJ Nephrology 4.1 2016 page 103" href="http://viewer.zmags.com/publication/544f28a7?page=103"> cholesterol control (51.4%).43 There is obviously</a> <a title="EMJ Nephrology 4.1 2016 page 104" href="http://viewer.zmags.com/publication/544f28a7?page=104"> Can J Diabetes. 2013;37(Suppl 1):S117-8. 33. Int</a> <a title="EMJ Nephrology 4.1 2016 page 105" href="http://viewer.zmags.com/publication/544f28a7?page=105"> EUROPEAN MEDICAL JOURNAL provides influential arti</a> <a title="EMJ Nephrology 4.1 2016 page 106" href="http://viewer.zmags.com/publication/544f28a7?page=106"> AUTOMATIC REPORTING OF CREATININE-BASED ESTIM</a> <a title="EMJ Nephrology 4.1 2016 page 107" href="http://viewer.zmags.com/publication/544f28a7?page=107"> During this review, I will assess the feasibility</a> <a title="EMJ Nephrology 4.1 2016 page 108" href="http://viewer.zmags.com/publication/544f28a7?page=108"> require chemotherapy or antibiotics are unlikely </a> <a title="EMJ Nephrology 4.1 2016 page 109" href="http://viewer.zmags.com/publication/544f28a7?page=109"> CURRENT HEIGHT-INDEPENDENT CREATININE-BASED ESTIM</a> <a title="EMJ Nephrology 4.1 2016 page 110" href="http://viewer.zmags.com/publication/544f28a7?page=110"> been incomparable. Local optimisation all</a> <a title="EMJ Nephrology 4.1 2016 page 111" href="http://viewer.zmags.com/publication/544f28a7?page=111"> Table 1 summarises the main formulae discussed in</a> <a title="EMJ Nephrology 4.1 2016 page 112" href="http://viewer.zmags.com/publication/544f28a7?page=112"> dh_digitalassets/@dh/@en/documents/ digitalasset/</a> <a title="EMJ Nephrology 4.1 2016 page 113" href="http://viewer.zmags.com/publication/544f28a7?page=113"> FRACTIONAL EXCRETION OF SURVIVIN, EXTRAC</a> <a title="EMJ Nephrology 4.1 2016 page 114" href="http://viewer.zmags.com/publication/544f28a7?page=114"> proven the essential role of TGF-β1 in fibr</a> <a title="EMJ Nephrology 4.1 2016 page 115" href="http://viewer.zmags.com/publication/544f28a7?page=115"> Table 1: Patient characteristics. Parameter M</a> <a title="EMJ Nephrology 4.1 2016 page 116" href="http://viewer.zmags.com/publication/544f28a7?page=116"> Table 2: The serum and urine concentrations, and </a> <a title="EMJ Nephrology 4.1 2016 page 117" href="http://viewer.zmags.com/publication/544f28a7?page=117"> concentrations, suggesting that the increase </a> <a title="EMJ Nephrology 4.1 2016 page 118" href="http://viewer.zmags.com/publication/544f28a7?page=118"> The essential role for survivin in tubular damage</a> <a title="EMJ Nephrology 4.1 2016 page 119" href="http://viewer.zmags.com/publication/544f28a7?page=119"> 17. He W et al. 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